Yankees vs. Orioles
Prediction, Odds & Props
Sep 20 | MLB AI Picks
Updated: 2025-09-18T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The Yankees travel to Camden Yards to face the Orioles in a matchup with significant playoff implications for New York, as they try to close the gap in the AL East and secure a strong position in the postseason. Baltimore, meanwhile, is off to a rough stretch and will be looking to defend home turf with pride and try to spoil things for the Yankees.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.
GAME INFO
Date: Sep 20, 2025
Start Time: 7:05 PM EST
Venue: Oriole Park at Camden Yards
Orioles Record: (73-81)
Yankees Record: (86-68)
OPENING ODDS
NYY Moneyline: -201
BAL Moneyline: +166
NYY Spread: -1.5
BAL Spread: +1.5
Over/Under: 9
NYY
Betting Trends
- The Yankees have historically struggled against the run line versus Baltimore; in the last 50 games vs. the Orioles, they are 20-30 vs. the run line. They also have a fairly strong win-loss edge overall at home vs. Baltimore in recent years, though that doesn’t always translate to covering large spreads.
BAL
Betting Trends
- Baltimore has a poor long-term record at home vs. New York; since 2019 they’ve gone 20-32 at Camden Yards against the Yankees. This season they are 2-1 at home vs. the Yankees in head-to-head matchups.
MATCHUP TRENDS
- Given Baltimore’s historically poor home record vs. New York, there might be value in taking the Yankees to cover, especially if the line isn’t too steep. On the other hand, Baltimore has at least split the season series so far, which suggests they aren’t totally outmatched in recent memory. Also, New York’s recent wins have come with strong starting pitching, which could tip the scales if their starter delivers. Finally, the run line history suggests that even in games Yankees win, they often leave little margin—something bettors should watch if the spread presumes dominance.
NYY vs. BAL
Best Prop Bet
- Remi's searched hard and found the best prop for this matchup: C. Mayo over 0.5 Total Bases.
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New York vs Baltimore Prediction & Odds:
Free MLB Betting Insights for 9/20/25
For Baltimore to stay in this game, they will need their starter to limit walks and home runs, as the Yankees thrive on capitalizing against mistakes and can turn a close game into a runaway with one big inning. Offensively, the Orioles have had stretches of life, particularly when their young hitters deliver timely production, but consistency has been their biggest weakness, especially against playoff-caliber pitching. Defensively, they must be sharp, as New York’s aggressive approach on the bases and ability to pressure pitchers in long at-bats means that even one error could open the floodgates. From a betting perspective, the Yankees are the clear favorite on paper, though their track record against the run line in Baltimore has been mixed, often winning but by narrow margins, which could give bettors pause. The keys for New York will be to assert themselves early, keep the Orioles’ offense contained with disciplined pitching, and play clean defense to avoid giving Baltimore unnecessary openings. Ultimately, the Yankees enter this matchup with urgency, momentum, and roster depth, making them the more likely side to control the game from start to finish, while the Orioles will need near-perfect execution across all phases to keep the contest competitive.
30 Homers. 30 Steals.
— New York Yankees (@Yankees) September 20, 2025
Congrats, @j_chisholm3! pic.twitter.com/qpKIZq9hrZ
New York Yankees MLB Preview
The New York Yankees head into Camden Yards on September 20, 2025, fully aware of the stakes as they continue their pursuit of an AL East title and work to solidify postseason positioning, and they will look to impose their will early against a Baltimore team that has struggled to match their consistency. Offensively, the Yankees remain one of the most dangerous lineups in baseball, with a mix of power hitters capable of changing the game with one swing and disciplined bats that extend at-bats, wear down pitchers, and set the table for big innings. Their formula on the road has been straightforward: score first, build momentum quickly, and force opponents into their bullpen earlier than planned, where New York’s patient approach often pays dividends. The Yankees’ pitching staff will be key, as their starter must set the tone by limiting base runners and avoiding home runs, particularly in a ballpark where Baltimore can still find offensive bursts if given opportunities.
Their bullpen, one of their most reliable units, will likely be leaned on heavily if the game stays tight, and the expectation is that if New York enters the late innings with a lead, they have the arms to shut the door. Defensively, the Yankees have been sharper this year, minimizing costly mistakes that once plagued them, and they will need to continue that discipline to avoid giving Baltimore the extra outs that could keep them in the game longer than expected. From a betting perspective, the Yankees enter as the clear favorite both on the moneyline and as a potential run-line play, though their history of close wins in Baltimore suggests caution on spreads that assume a blowout. The keys for New York will be starting fast, maintaining control on the mound, and executing situational hitting to avoid wasted opportunities with runners in scoring position. If they stick to their blueprint, the Yankees have every reason to believe they can leave Camden Yards with another divisional win and keep their playoff push firmly on track.
Credit: USA TODAY/IMAGN
Baltimore Orioles MLB Preview
The Baltimore Orioles return to Camden Yards on September 20, 2025, with little more than pride and rivalry motivation driving them, as they face a New York Yankees team that is pushing hard for playoff positioning, and the Orioles will need one of their sharper all-around efforts to make this matchup competitive. Offensively, Baltimore has shown flashes of power and situational hitting throughout the season, but their inconsistency has been their downfall, particularly against stronger pitching staffs like New York’s, and their ability to sustain rallies has too often come up short. Their starting pitcher will be under pressure to set the tone, as avoiding early crooked numbers will be crucial to keeping the home crowd engaged and giving the lineup a chance to chip away rather than play from behind, which has been a common issue this year. The bullpen, which has been a weak point all season, will also need to step up, as New York’s patient hitters tend to force high pitch counts and exploit relievers who struggle with command.
Defensively, the Orioles must be near flawless, as errors and lapses have repeatedly opened the door for opponents to extend innings and pile on runs, and against a Yankees lineup that thrives on capitalizing against mistakes, those miscues could be decisive. From a betting perspective, Baltimore will enter as the underdog, and their poor long-term record at home against the Yankees reflects how challenging this matchup has been historically, though they have managed to keep a few contests close enough to offer some value against the spread. The keys for Baltimore will be disciplined pitching, timely hitting from the middle of their order, and a clean defensive effort that denies the Yankees the extra chances they typically use to break games open. Ultimately, while the Orioles face long odds in this matchup, their role as spoiler could inspire a spirited performance, and if they can combine a strong start on the mound with opportunistic hitting, they may have a chance to push their rivals deeper into a fight than expected.
Evened the series 👏 pic.twitter.com/DCOsYajWSM
— Baltimore Orioles (@Orioles) September 20, 2025
New York vs. Baltimore Prop Picks (AI)
New York vs. Baltimore Prediction (AI)
Remi, our AI sports wizard, has been pouring over mountains of data from every simulation between the Yankees and Orioles and using recursive machine learning and impressive AI to crunch the data to a single cover probability.
Oddly enough, we’ve seen the AI has been most watching on the growing emphasis human bettors often put on player performance factors between a Yankees team going up against a possibly deflated Orioles team. Trends look to say the true game analytics might reflect a moderate lean against one Vegas line specifically.
Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.
Below is our current AI New York vs Baltimore picks, computer picks Yankees vs Orioles, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
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| MLB | 10/1 | SD@CHC | UNLOCK THIS PICK | 4 |
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| MLB | 10/1 | SD@CHC | UNLOCK THIS PICK | 4 |
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| MLB | 10/1 | CIN@LAD | UNLOCK THIS PICK | 3 |
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| MLB | 10/1 | CIN@LAD | UNLOCK THIS PICK | 2 |
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| MLB | 10/1 | DET@CLE | UNLOCK THIS PICK | 2 |
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| MLB | 10/1 | DET@CLE | UNLOCK THIS PICK | 1 |
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| MLB | 10/1 | BOS@NYY | UNLOCK THIS PICK | 1 |
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| MLB | 10/1 | CIN@LAD | GET FREE PICK NOW | 1 | – | |
| MLB | 10/1 | BOS@NYY | UNLOCK THIS PICK | 0 |
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| MLB | 10/1 | BOS@NYY | GET FREE PICK NOW | 0 | – | |
These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.
Yankees Betting Trends
The Yankees have historically struggled against the run line versus Baltimore; in the last 50 games vs. the Orioles, they are 20-30 vs. the run line. They also have a fairly strong win-loss edge overall at home vs. Baltimore in recent years, though that doesn’t always translate to covering large spreads.
Orioles Betting Trends
Baltimore has a poor long-term record at home vs. New York; since 2019 they’ve gone 20-32 at Camden Yards against the Yankees. This season they are 2-1 at home vs. the Yankees in head-to-head matchups.
Yankees vs. Orioles Matchup Trends
Given Baltimore’s historically poor home record vs. New York, there might be value in taking the Yankees to cover, especially if the line isn’t too steep. On the other hand, Baltimore has at least split the season series so far, which suggests they aren’t totally outmatched in recent memory. Also, New York’s recent wins have come with strong starting pitching, which could tip the scales if their starter delivers. Finally, the run line history suggests that even in games Yankees win, they often leave little margin—something bettors should watch if the spread presumes dominance.
New York vs. Baltimore Game Info
What time does New York vs Baltimore start on September 20, 2025?
New York vs Baltimore starts on September 20, 2025 at 7:05 PM EST.
Where is New York vs Baltimore being played?
Venue: Oriole Park at Camden Yards.
What are the opening odds for New York vs Baltimore?
Spread: Baltimore +1.5
Moneyline: New York -201, Baltimore +166
Over/Under: 9
What are the records for New York vs Baltimore?
New York: (86-68) | Baltimore: (73-81)
What is the AI best bet for New York vs Baltimore?
Remi's searched hard and found the best prop for this matchup: C. Mayo over 0.5 Total Bases.. Prices move—always shop for the best number.
What are New York vs Baltimore trending bets?
Given Baltimore’s historically poor home record vs. New York, there might be value in taking the Yankees to cover, especially if the line isn’t too steep. On the other hand, Baltimore has at least split the season series so far, which suggests they aren’t totally outmatched in recent memory. Also, New York’s recent wins have come with strong starting pitching, which could tip the scales if their starter delivers. Finally, the run line history suggests that even in games Yankees win, they often leave little margin—something bettors should watch if the spread presumes dominance.
What are New York trending bets?
NYY trend: The Yankees have historically struggled against the run line versus Baltimore; in the last 50 games vs. the Orioles, they are 20-30 vs. the run line. They also have a fairly strong win-loss edge overall at home vs. Baltimore in recent years, though that doesn’t always translate to covering large spreads.
What are Baltimore trending bets?
BAL trend: Baltimore has a poor long-term record at home vs. New York; since 2019 they’ve gone 20-32 at Camden Yards against the Yankees. This season they are 2-1 at home vs. the Yankees in head-to-head matchups.
Where can I find AI Picks for New York vs Baltimore?
See our latest MLB picks and odds pages for 2025 to compare prices before you bet.
New York vs. Baltimore Odds
Remi is pouring through loads of stats on each team. In fact, anytime the New York vs Baltimore trends are analyzed, there’s always several intriguing trends to key in on. Not to mention games played at extreme altitude rarely follow normal, predictable betting trends.
New York vs Baltimore Opening Odds
NYY Moneyline:
-201 BAL Moneyline: +166
NYY Spread: -1.5
BAL Spread: +1.5
Over/Under: 9
New York vs Baltimore Live Odds
| Games | PTS | ML | SPR | O/U | |
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Oct 2, 2025 3:08PM EDT
Detroit Tigers
Cleveland Guardians
10/2/25 3:08PM
Tigers
Guardians
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–
–
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-102
-116
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-1.5 (+172)
+1.5 (-210)
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O 7 (-105)
U 7 (-115)
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Oct 2, 2025 5:08PM EDT
San Diego Padres
Chicago Cubs
10/2/25 5:08PM
Padres
Cubs
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–
–
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+100
-118
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-1.5 (+164)
+1.5 (-200)
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O 7.5 (-110)
U 7.5 (-110)
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Oct 2, 2025 8:08PM EDT
Boston Red Sox
New York Yankees
10/2/25 8:08PM
Red Sox
Yankees
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–
–
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+136
-162
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+1.5 (-160)
-1.5 (+132)
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O 7.5 (-120)
U 7.5 (-102)
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Oct 4, 2025 2:30PM EDT
Los Angeles Dodgers
Philadelphia Phillies
10/4/25 2:30PM
Dodgers
Phillies
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–
–
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+110
-130
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pk
pk
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Oct 4, 2025 5:09PM EDT
Los Angeles Dodgers
Philadelphia Phillies
10/4/25 5:09PM
Dodgers
Phillies
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–
–
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+108
-126
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pk
pk
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O 7 (-134)
U 7 (+117)
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MLB Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers New York Yankees vs. Baltimore Orioles on September 20, 2025 at Oriole Park at Camden Yards.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.
| MLB |
LEAN | %WIN | UNITS | RESULT |
|---|---|---|---|---|
| ARI@SD | SD -131 | 57.3% | 4 | WIN |
| DET@BOS | BOS -115 | 56.4% | 5 | WIN |
| NYM@CHC | NYM -110 | 54.1% | 3 | WIN |
| HOU@ATH | ATH +118 | 50.8% | 4 | WIN |
| NYM@CHC | OVER 7 | 54.5% | 3 | WIN |
| STL@SF | OVER 7.5 | 55.9% | 5 | LOSS |
| KC@LAA | TYLER TOLBERT UNDER 1.5 BASES | 54.4% | 4 | WIN |
| MIL@SD | UNDER 9 | 54.7% | 4 | WIN |
| MIA@PHI | KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS | 53.3% | 3 | WIN |
| WAS@NYM | OVER 8.5 | 56.1% | 6 | LOSS |
| LAA@COL | COL +108 | 50.5% | 3 | WIN |
| TOR@KC | UNDER 9 | 54.7% | 4 | LOSS |
| SEA@KC | KC +1.5 | 62.3% | 5 | LOSS |
| NYY@MIN | OVER 9 | 55.1% | 4 | WIN |
| MIA@COL | OVER 10.5 | 55.0% | 4 | WIN |
| MIA@COL | AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS | 54.3% | 4 | WIN |
| SEA@KC | BOBBY WITT UNDER 0.5 SINGLES | 54.4% | 4 | LOSS |
| PHI@LAD | LAD -113 | 54.7% | 4 | LOSS |
| NYY@BOS | OVER 7.5 | 54.3% | 3 | WIN |
| KC@PHI | PHI -130 | 58.3% | 4 | WIN |
| LAD@SF | OVER 7.5 | 54.7% | 4 | LOSS |
| NYM@PHI | PHI -122 | 55.6% | 4 | WIN |
| KC@CLE | KC -104 | 52.0% | 3 | WIN |
| CIN@SD | JAKE CRONEWORTH OVER 0.5 HITS | 53.1% | 3 | WIN |
| WAS@MIA | MIA -123 | 55.2% | 4 | LOSS |
| LAA@KC | UNDER 9.5 | 54.9% | 3 | WIN |
| TEX@ARI | UNDER 9 | 54.2% | 4 | WIN |
| SF@COL | UNDER 11.5 | 56.4% | 6 | LOSS |
| SF@COL | RAFAEL DEVERS OVER 1.5 BASES | 56.1% | 6 | WIN |
| MIA@WAS | WAS -110 | 54.4% | 4 | WIN |
| NYM@DET | OVER 8.5 | 54.5% | 4 | WIN |
| TEX@ARI | UNDER 9.5 | 56.4% | 6 | WIN |
| TEX@ARI | ALEJANDRO OSUNA UNDER 1.5 BASES | 54.1% | 4 | LOSS |
| ATL@CHC | CHC -116 | 55.1% | 3 | WIN |
| PHI@MIL | OVER 8.5 | 55.0% | 3 | WIN |
| ARI@LAD | SHOHEI OHTANI OVER 2.5 BASES | 54.2% | 4 | WIN |
| SEA@CLE | CLE +1.5 | 57.2% | 3 | WIN |
| CHC@SF | CHC -105 | 54.1% | 4 | LOSS |
| NYY@CHW | RYAN MCMAHON OVER 0.5 BASES | 54.1% | 4 | WIN |
| PHI@NYM | OVER 8.5 | 55.6% | 4 | LOSS |
| LAA@TEX | LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS | 54.1% | 4 | LOSS |
| KC@CHW | KC -109 | 54.2% | 4 | WIN |
| SD@SEA | DYLAN CEASE OVER 16.5 OUTS | 53.9% | 3 | LOSS |
| SD@SEA | UNDER 8.5 | 54.4% | 4 | LOSS |
| MIN@TOR | JOE RYAN UNDER 2.5 EARNED RUNS | 54.1% | 4 | LOSS |
| SF@MIL | MIL +100 | 54.0% | 6 | LOSS |
| TOR@MIA | MIA +1.5 | 62.0% | 6 | WIN |
| CHC@LAA | OVER 9.5 | 54.9% | 4 | LOSS |
| BOS@NYY | CARLOS RODON UNDER 4.5 HITS ALLOWED | 54.2% | 4 | WIN |
| KC@DET | DET -115 | 56.1% | 5 | WIN |
| CHC@LAA | LAA +1.5 | 57.6% | 5 | LOSS |