Cubs vs. Pirates
Prediction, Odds & Props
Sep 17 | MLB AI Picks

Updated: 2025-09-15T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The Chicago Cubs and Pittsburgh Pirates meet at PNC Park on September 17, 2025, in a late-season clash that highlights two clubs heading in very different directions. The Cubs are fighting for playoff positioning, while the Pirates are playing out the string of another rebuilding year, making this matchup a test of urgency versus pride.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Sep 17, 2025

Start Time: 12:35 PM EST​

Venue: PNC Park​

Pirates Record: (65-87)

Cubs Record: (87-64)

OPENING ODDS

CHC Moneyline: -162

PIT Moneyline: +136

CHC Spread: -1.5

PIT Spread: +1.5

Over/Under: 8

CHC
Betting Trends

  • The Cubs have hovered just above .500 against the spread this season, showing value in games where their offense creates separation but also some inconsistency on the road when favored by larger margins.

PIT
Betting Trends

  • The Pirates have been more competitive at home against the spread than their overall record suggests, often keeping games closer at PNC Park even against stronger opponents, though their lack of consistent scoring limits long-term reliability.

MATCHUP TRENDS

  • The Cubs have dominated the season series against the Pirates, winning the majority of contests and covering frequently in the process, while the Pirates have struggled in September with both their bullpen and clutch hitting, creating a situation where Chicago enters as the heavy statistical and betting favorite.

CHC vs. PIT
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: D. Swanson over 5.5 Fantasy Score.

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Chicago vs Pittsburgh Prediction & Odds:
Free MLB Betting Insights for 9/17/25

The September 17, 2025 matchup between the Chicago Cubs and the Pittsburgh Pirates at PNC Park represents two franchises trending in very different directions, with the Cubs surging toward a postseason berth while the Pirates continue to focus on development in a rebuilding year. Chicago comes into this contest with strong momentum, driven by a lineup that has consistently produced across all spots in the order, combining home run power with disciplined at-bats that wear down opposing pitchers and create opportunities to score in bunches. Their offense has been balanced, with the heart of the order providing run production and younger players adding speed and on-base ability, making them difficult to contain even for quality pitchers. On the mound, the Cubs have relied on steady performances from their starting rotation and increased reliability from a bullpen that has learned to protect leads more effectively than in seasons past, creating a team that is capable of winning both high-scoring slugfests and lower-scoring pitching battles. Defensively, they have been sharp and disciplined, cutting down on errors and offering solid support behind their pitchers, all of which has allowed them to build a strong record against divisional opponents like the Pirates. Pittsburgh, meanwhile, enters this game at the bottom of the division and already eliminated from postseason contention, with their young roster showing flashes of talent but too often undone by inconsistency.

The Pirates’ offensive struggles have been glaring, as they rank near the bottom of the league in runs scored and frequently fail to deliver with runners in scoring position, leaving even strong pitching performances unsupported. While Paul Skenes has emerged as one of the brightest young arms in the game, the rest of the rotation has struggled to provide stability, often failing to pitch deep into games and exposing a bullpen that has not been able to consistently handle high-leverage situations. Defensively, Pittsburgh has been mistake-prone, with errors and lapses in execution compounding their offensive woes and often turning close games into decisive losses. This contest therefore projects as another uphill battle for the Pirates, as they face a Cubs team with clear advantages in lineup depth, pitching consistency, and overall execution. For Chicago, the keys will be to score early, pressure Pittsburgh’s pitching staff into mistakes, and then lean on their bullpen to hold any lead they build, while for the Pirates the path to victory requires a near-perfect performance that includes early runs, strong starting pitching, and flawless defense. Given the circumstances, the Cubs enter as clear favorites, but baseball’s unpredictability always leaves room for surprises, especially in late-season games where one team plays with urgency and the other plays with nothing to lose.

Chicago Cubs MLB Preview

The Chicago Cubs enter their September 17, 2025 matchup against the Pittsburgh Pirates at PNC Park carrying the weight of postseason urgency and the momentum of a team that has steadily improved throughout the season, making them one of the more dangerous contenders in the National League. Their approach on the road has been tested, but they have developed a resilience that has made them a tough opponent regardless of venue, and this series against Pittsburgh is another opportunity to build momentum toward October. Offensively, the Cubs have found the right balance between power and patience, with the heart of the order delivering consistent production while the supporting cast has provided timely contributions that extend innings and frustrate opposing pitchers. Sluggers in the middle have the ability to change a game with one swing, but what has set the Cubs apart is their commitment to grinding out at-bats, forcing starters to throw extra pitches, and often getting into bullpens earlier than teams would like. On the basepaths, they have also taken advantage of aggressive opportunities, adding a dimension of speed that keeps defenses honest and allows them to manufacture runs when the long ball is not available. Matthew Boyd is scheduled to take the mound in this game, and while he may not carry the name recognition of some of the league’s elite arms, his consistency has been invaluable to Chicago’s success.

He has kept his ERA in check by limiting hard contact, working effectively with his defense, and avoiding prolonged trouble, often pitching deep enough to hand a manageable game to the bullpen. That bullpen, once a source of concern, has matured into a more dependable unit over the course of the season, with key relievers finding rhythm in the late innings and giving the Cubs the ability to protect leads more confidently than in years past. Defensively, Chicago has demonstrated discipline and sharp execution, cutting down on errors and making the routine plays with consistency while also flashing enough range and athleticism to take away hits that might extend innings for their opponents. This attention to detail has allowed the Cubs to complement their pitching staff effectively and avoid the kinds of mistakes that can swing close games, particularly on the road. From a betting standpoint, the Cubs have had mixed success covering the run line away from Wrigley Field, but their dominance against Pittsburgh this season has made them a more reliable choice in head-to-head matchups. They have frequently outscored the Pirates by comfortable margins, and their ability to score early has allowed them to dictate tempo and control games. For this matchup, the blueprint for success is straightforward: establish offense in the early innings, trust Boyd to manage his start effectively, and allow the bullpen to close things down in the later frames. With postseason ambitions fueling their focus, Chicago cannot afford to stumble against a team like Pittsburgh, and if they continue executing with the balance and discipline they have shown in recent weeks, they will be positioned not only to secure another victory but also to reinforce their reputation as a well-rounded contender ready to make noise in October.

The Chicago Cubs and Pittsburgh Pirates meet at PNC Park on September 17, 2025, in a late-season clash that highlights two clubs heading in very different directions. The Cubs are fighting for playoff positioning, while the Pirates are playing out the string of another rebuilding year, making this matchup a test of urgency versus pride. Chicago vs Pittsburgh AI Prediction: Free MLB Betting Insights for Sep 17. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Pittsburgh Pirates MLB Preview

The Pittsburgh Pirates approach their September 17, 2025 matchup against the Chicago Cubs at PNC Park with the mindset of a team seeking to salvage pride and build momentum for the future, even as their postseason hopes have long been extinguished. This season has been another chapter in their rebuilding journey, one filled with flashes of promise but marred by inconsistency in nearly every aspect of the game. Offensively, the Pirates have struggled to find a reliable rhythm, often ranking near the bottom of the league in runs scored, batting average, and on-base percentage, a reflection of a lineup that too frequently stalls with runners in scoring position and lacks the depth to sustain long rallies. They have a handful of players who can produce impact performances on any given night, but the lack of continuity across the order has made it difficult to generate the kind of pressure that consistently challenges opposing pitchers. When they do break through, it often comes in isolated innings rather than steady offensive production, which leaves their pitching staff with minimal run support and little margin for error. On the mound, Paul Skenes has emerged as a beacon of hope, showing dominance and poise that suggest he could be a future ace around whom the Pirates can build, but beyond him the rotation has been erratic.

Scheduled starter Johan Oviedo has shown glimpses of potential, with stretches where his stuff has kept even strong lineups in check, but his inability to consistently pitch deep into games has put a heavy burden on a bullpen that has been overexposed and ineffective in too many critical moments. The bullpen’s struggles have been particularly costly, as late-inning collapses have erased competitive efforts earlier in games, eroding confidence and frustrating both players and fans. Defensively, the Pirates have been inconsistent as well, committing untimely errors and lapses in execution that not only extend innings but also lead to unearned runs, a crippling issue for a team already struggling to generate offense. At PNC Park, they have been slightly more competitive against the spread, suggesting they can keep games closer at home, but moral victories have not been enough to change the trajectory of their season. From a betting perspective, the Pirates present value only as a spoiler, as they occasionally rise to the occasion when underestimated, but those moments have been too rare to trust. For this contest, their path to victory is narrow but not impossible: they must score early to give themselves confidence and take pressure off Oviedo, they must play sharp defense to avoid giving Chicago extra opportunities, and the bullpen must rise above its season-long struggles to hold any lead or close deficit intact. The Pirates are well aware that the Cubs have dominated the season series, and this knowledge can either serve as discouragement or as motivation to prove capable of competing against a superior opponent. Ultimately, this game is less about standings and more about evaluation for Pittsburgh, as their young players have a chance to test themselves against a playoff-bound club, and a win here would serve as a small but meaningful reminder that progress, even in a difficult season, remains possible.

Chicago vs. Pittsburgh Prop Picks (AI)

AI algorithm Remi is pouring through mountains of stats on each player. In fact, anytime the Cubs and Pirates play there’s always several intriguing angles to key in on. Not to mention games played at PNC Park in Sep seemingly never follow normal, predictable patterns.
Remi's searched hard and found the best prop for this matchup: D. Swanson over 5.5 Fantasy Score.

Chicago vs. Pittsburgh Prediction (AI)

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Remi, our AI sports genius, has been pouring over exorbitant amounts of data from every simulation between the Cubs and Pirates and using recursive machine learning and impressive AI to examine the data to a single cover probability.

Interestingly enough, the data has been most keyed in on the linear correlation of factor human bettors tend to put on Chicago’s strength factors between a Cubs team going up against a possibly improved Pirates team. We’ve found the true game analytics appear to reflect a slight lean against one Vegas line in particular.

Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.

Below is our current AI Chicago vs Pittsburgh picks, computer picks Cubs vs Pirates, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
MLB 10/1 SD@CHC UNLOCK THIS PICK 4 INTEL Locked INTEL
MLB 10/1 SD@CHC UNLOCK THIS PICK 4 EXECUTIVE Locked EXECUTIVE
MLB 10/1 CIN@LAD UNLOCK THIS PICK 3 EXECUTIVE Locked EXECUTIVE
MLB 10/1 CIN@LAD UNLOCK THIS PICK 2 INTEL Locked INTEL
MLB 10/1 DET@CLE UNLOCK THIS PICK 2 INTEL Locked INTEL
MLB 10/1 DET@CLE UNLOCK THIS PICK 1 INTEL Locked INTEL
MLB 10/1 BOS@NYY UNLOCK THIS PICK 1 INTEL Locked INTEL
MLB 10/1 CIN@LAD GET FREE PICK NOW 1
MLB 10/1 BOS@NYY UNLOCK THIS PICK 0 INTEL Locked INTEL
MLB 10/1 BOS@NYY GET FREE PICK NOW 0

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.

Cubs Betting Trends

The Cubs have hovered just above .500 against the spread this season, showing value in games where their offense creates separation but also some inconsistency on the road when favored by larger margins.

Pirates Betting Trends

The Pirates have been more competitive at home against the spread than their overall record suggests, often keeping games closer at PNC Park even against stronger opponents, though their lack of consistent scoring limits long-term reliability.

Cubs vs. Pirates Matchup Trends

The Cubs have dominated the season series against the Pirates, winning the majority of contests and covering frequently in the process, while the Pirates have struggled in September with both their bullpen and clutch hitting, creating a situation where Chicago enters as the heavy statistical and betting favorite.

Chicago vs. Pittsburgh Game Info

Chicago vs Pittsburgh starts on September 17, 2025 at 12:35 PM EST.

Spread: Pittsburgh +1.5
Moneyline: Chicago -162, Pittsburgh +136
Over/Under: 8

Chicago: (87-64)  |  Pittsburgh: (65-87)

Remi's searched hard and found the best prop for this matchup: D. Swanson over 5.5 Fantasy Score.. Prices move—always shop for the best number.

The Cubs have dominated the season series against the Pirates, winning the majority of contests and covering frequently in the process, while the Pirates have struggled in September with both their bullpen and clutch hitting, creating a situation where Chicago enters as the heavy statistical and betting favorite.

CHC trend: The Cubs have hovered just above .500 against the spread this season, showing value in games where their offense creates separation but also some inconsistency on the road when favored by larger margins.

PIT trend: The Pirates have been more competitive at home against the spread than their overall record suggests, often keeping games closer at PNC Park even against stronger opponents, though their lack of consistent scoring limits long-term reliability.

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

Chicago vs. Pittsburgh Odds

AI algorithm Remi is pouring through loads of data points on each player. In fact, anytime the Chicago vs Pittsburgh trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme altitude almost always follow normal, predictable betting trends.

Chicago vs Pittsburgh Opening Odds

CHC Moneyline: -162
PIT Moneyline: +136
CHC Spread: -1.5
PIT Spread: +1.5
Over/Under: 8

Chicago vs Pittsburgh Live Odds

Games PTS ML SPR O/U
Oct 2, 2025 3:08PM EDT
Detroit Tigers
Cleveland Guardians
10/2/25 3:08PM
Tigers
Guardians
+100
-120
-1.5 (+175)
+1.5 (-215)
O 7 (-105)
U 7 (-115)
Oct 2, 2025 5:08PM EDT
San Diego Padres
Chicago Cubs
10/2/25 5:08PM
Padres
Cubs
+100
-118
-1.5 (+172)
+1.5 (-210)
O 7.5 (-110)
U 7.5 (-110)
Oct 2, 2025 8:08PM EDT
Boston Red Sox
New York Yankees
10/2/25 8:08PM
Red Sox
Yankees
+136
-162
+1.5 (-160)
-1.5 (+130)
O 7.5 (-120)
U 7.5 (-102)
Oct 4, 2025 2:30PM EDT
Los Angeles Dodgers
Philadelphia Phillies
10/4/25 2:30PM
Dodgers
Phillies
+110
-130
pk
pk
Oct 4, 2025 5:09PM EDT
Los Angeles Dodgers
Philadelphia Phillies
10/4/25 5:09PM
Dodgers
Phillies
+108
-126
pk
pk
O 7 (-135)
U 7 (+115)

MLB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Chicago Cubs vs. Pittsburgh Pirates on September 17, 2025 at PNC Park.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
ARI@SD SD -131 57.3% 4 WIN
DET@BOS BOS -115 56.4% 5 WIN
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN
CHC@SF CHC -105 54.1% 4 LOSS
NYY@CHW RYAN MCMAHON OVER 0.5 BASES 54.1% 4 WIN
PHI@NYM OVER 8.5 55.6% 4 LOSS
LAA@TEX LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS 54.1% 4 LOSS
KC@CHW KC -109 54.2% 4 WIN
SD@SEA DYLAN CEASE OVER 16.5 OUTS 53.9% 3 LOSS
SD@SEA UNDER 8.5 54.4% 4 LOSS
MIN@TOR JOE RYAN UNDER 2.5 EARNED RUNS 54.1% 4 LOSS
SF@MIL MIL +100 54.0% 6 LOSS
TOR@MIA MIA +1.5 62.0% 6 WIN
CHC@LAA OVER 9.5 54.9% 4 LOSS
BOS@NYY CARLOS RODON UNDER 4.5 HITS ALLOWED 54.2% 4 WIN
KC@DET DET -115 56.1% 5 WIN
CHC@LAA LAA +1.5 57.6% 5 LOSS