Cardinals vs. Mariners
Prediction, Odds & Props
Sep 10 | MLB AI Picks

Updated: 2025-09-08T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The St. Louis Cardinals look to halt a two-game skid and stay on the fringe of the NL Wild Card race as they visit the in-form Seattle Mariners. Seattle, fresh off back-to-back wins and with momentum building late in the season, aims to pull within striking distance in the AL West while protecting its playoff positioning.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Sep 10, 2025

Start Time: 9:40 PM EST​

Venue: T-Mobile Park​

Mariners Record: (77-68)

Cardinals Record: (72-74)

OPENING ODDS

STL Moneyline: +189

SEA Moneyline: -230

STL Spread: +1.5

SEA Spread: -1.5

Over/Under: 7.5

STL
Betting Trends

  • The Cardinals have delivered solid value against the spread this season, going 37–31 ATS, showing more consistency than their .500-ish record might suggest.

SEA
Betting Trends

  • While specific ATS figures for the Mariners aren’t available, their dominant 43–25 home record indicates strong performance at T-Mobile Park, reflecting likely ATS success as well.

MATCHUP TRENDS

  • Oddsmakers favor Seattle at around –145, with St. Louis at +125 on the moneyline. The run total is pegged at 8, with the Mariners supported by bettors expecting a controlled home win.

STL vs. SEA
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: J. Polanco over 5.5 Fantasy Score.

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St. Louis vs Seattle Prediction & Odds:
Free MLB Betting Insights for 9/10/25

The September 10, 2025 matchup between the St. Louis Cardinals and the Seattle Mariners at T-Mobile Park arrives at a moment when both teams’ seasons are reaching pivotal junctures, with Seattle building serious momentum in the American League playoff picture while St. Louis clings to fading hopes in the National League. The Mariners enter the game having won the first two of this interleague series, showcasing both their offensive depth and their bullpen’s reliability in back-to-back victories. In the opener, they erased a 2–0 Cardinals lead with a four-run sixth inning highlighted by Josh Naylor’s bases-clearing double, then turned to a bullpen trio of Matt Brash, Eduard Bazardo, and Andrés Muñoz to slam the door over the final three frames. The following night, it was Randy Arozarena’s turn to shine, blasting a three-run homer that flipped the game before Naylor added a solo shot, and once again the Seattle bullpen combined for five dominant innings with seven strikeouts and no walks to preserve a 5–3 win. This formula of steady starting pitching, clutch middle-order power, and airtight bullpen work has become the Mariners’ signature, and with Logan Gilbert set to take the mound for the series finale, they appear well-positioned to continue pressing both the division-leading Astros in the AL West and their immediate rivals in the Wild Card chase. For St. Louis, the challenge has been their inability to protect early leads and string together complete performances. Alec Burleson and Iván Herrera have provided some bright moments with timely hits, and the return of Willson Contreras from suspension adds a boost to the lineup, but inconsistent starting pitching from the likes of Matthew Liberatore and Miles Mikolas has created deficits that the bullpen, weakened by midseason trades, has been unable to cover.

Now the task falls to Michael McGreevy, a command-first starter who relies on inducing ground balls to neutralize opposing bats, but against a Mariners lineup that punishes mistakes and thrives on extending at-bats, he will need to be nearly perfect to give his team a chance. The Cardinals’ path to victory is narrow but possible: they must strike early against Gilbert, manufacture runs through aggressive baserunning and situational hitting, and hope their bullpen can reverse recent trends by holding down Seattle’s late-inning rally machine. From a betting perspective, the Mariners enter as heavy favorites around –145 with a run total of eight, reflecting both their recent dominance at home—where they boast one of the best records in the league—and the Cardinals’ ongoing struggles to close games. For Seattle, this game represents another opportunity to show they are peaking at the right time, with their stars in form and their bullpen looking postseason-ready, while for St. Louis, it is a chance to salvage pride, fight off elimination from the playoff race, and perhaps remind fans that they still have the tools to compete when everything clicks. With both teams driven by urgency but moving in opposite directions, this game is likely to hinge on execution in the middle innings and whether the Cardinals can finally flip the script against a Mariners team that seems to have discovered a winning formula.

St. Louis Cardinals MLB Preview

The St. Louis Cardinals enter their September 10, 2025 matchup against the Seattle Mariners searching for answers and clinging to the thinnest strands of postseason hope after dropping the first two games of this interleague series in frustrating fashion. Both nights followed a similar pattern: the Cardinals struck first, only to see leads erased by Seattle’s timely power and airtight bullpen. In Game 1, Alec Burleson’s homer gave them a 2–0 cushion before a four-run Mariners sixth inning flipped the game, while in Game 2 Randy Arozarena’s three-run blast and Josh Naylor’s solo shot wiped away another promising start, leaving St. Louis once again on the wrong side of a late rally. For manager Terry Francona, the narrative has become painfully familiar—this team can score early and scrap for runs, but its pitching has proven unable to lock games down, and a bullpen weakened by trades has not been able to withstand the pressure of tight September baseball. Offensively, there are bright spots as Iván Herrera continues to show growth at the plate, Burleson provides much-needed pop, and the return of Willson Contreras from suspension gives the lineup more stability, yet these sparks have not translated into consistent scoring. The pitching staff remains the glaring concern, with Matthew Liberatore and Miles Mikolas struggling in recent outings, and now the burden falls on Michael McGreevy to deliver a start that keeps St. Louis competitive. McGreevy is a command-based pitcher who thrives when inducing ground balls and avoiding hard contact, but against a Mariners team that punishes mistakes and thrives on working deep counts, his margin for error will be razor thin.

The Cardinals must help him by playing clean defense, manufacturing runs with aggressive baserunning, and capitalizing on any chances with runners in scoring position—areas where they have too often come up short this season. From a betting standpoint, St. Louis has quietly posted a respectable record against the spread at 37–31, showing they’ve been more competitive than their overall .500-level win total suggests, but their inability to finish close games has burned both fans and bettors alike in September. Oddsmakers have installed them as underdogs again at +125, and while that presents value if McGreevy can deliver and the offense breaks through against Logan Gilbert, recent history makes it difficult to back them with confidence. Still, for a veteran-led club like St. Louis, pride remains on the line, and the Cardinals understand that even one win against a team like Seattle could spark a mini-turnaround and keep them mathematically alive in the Wild Card chase. To accomplish that, they must execute in ways they have not during this series: sharper pitching in the middle innings, disciplined at-bats against a strikeout-capable starter, and airtight defense that prevents Seattle from extending innings. This game is less about long-term projection and more about survival; if the Cardinals want to send a message that they are not finished, this is the night they must deliver a complete performance on the road.

The St. Louis Cardinals look to halt a two-game skid and stay on the fringe of the NL Wild Card race as they visit the in-form Seattle Mariners. Seattle, fresh off back-to-back wins and with momentum building late in the season, aims to pull within striking distance in the AL West while protecting its playoff positioning. St. Louis vs Seattle AI Prediction: Free MLB Betting Insights for Sep 10. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Seattle Mariners MLB Preview

The Seattle Mariners come into their September 10, 2025 matchup against the St. Louis Cardinals riding a surge of confidence, momentum, and late-season resilience, having taken the first two games of this interleague set in convincing fashion and positioning themselves as one of the most dangerous teams in the American League. Monday’s 4–2 comeback win highlighted their depth, with Josh Naylor delivering a bases-clearing double in the sixth to erase an early deficit before the bullpen trio of Matt Brash, Eduard Bazardo, and Andrés Muñoz closed the door with precision, while Tuesday’s 5–3 win was powered by Randy Arozarena’s three-run blast and Naylor’s solo shot, giving Seattle its third straight win and pulling them within a game of the AL West lead. What has separated the Mariners from their opponents in September is their ability to execute in key moments, with the bullpen throwing a combined five hitless innings in Game 2 and shutting down any hopes of a Cardinals rally, a sign that manager Scott Servais has this unit firing on all cylinders at precisely the right time. Logan Gilbert will take the ball in this contest, and his mix of strikeout stuff and ability to pitch deep into games makes him the perfect complement to an already dominant bullpen, as he has proven capable of controlling lineups and limiting damage with his fastball-slider combination. Offensively, Seattle has found its rhythm at exactly the right moment, with Arozarena’s power proving pivotal since joining the lineup and Josh Naylor providing consistent run production to back up Julio Rodríguez, who continues to anchor both the lineup and the outfield with his five-tool excellence.

Even role players have contributed in big spots, from clutch hits to defensive gems, showing a balanced roster that doesn’t rely on one or two stars to carry the load. At home, the Mariners have been among the league’s best all year, boasting a 43–25 record at T-Mobile Park and feeding off one of baseball’s most passionate fan bases, who have turned each September game into a playoff-like atmosphere. The oddsmakers reflect Seattle’s form, installing them as –145 favorites with a run total set at eight, a betting line that mirrors both their current dominance and the public’s heavy backing of the Mariners to continue their run. For Seattle, the keys remain the same: get early run support for Gilbert, maintain pressure through disciplined at-bats that extend innings, and trust their bullpen to hold the lead when the game tightens late. With their recent streak showing a perfect blend of timely hitting, strong starting pitching, and bullpen dominance, the Mariners have positioned themselves not just to win this series but to make a statement to the rest of the league that they are ready to contend deep into October. This game, then, is less about the opponent and more about continuing to build momentum, sharpen their execution, and solidify their place as one of the most complete teams in baseball as the postseason approaches.

St. Louis vs. Seattle Prop Picks (AI)

AI algorithm Remi is pouring through mountains of datapoints on each team. In fact, anytime the Cardinals and Mariners play there’s always several intriguing angles to key in on. Not to mention games played at T-Mobile Park in Sep rarely follow normal, predictable patterns.
Remi's searched hard and found the best prop for this matchup: J. Polanco over 5.5 Fantasy Score.

St. Louis vs. Seattle Prediction (AI)

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Remi, our AI sports algorithm, has been pouring over exorbitant amounts of data from every past game between the Cardinals and Mariners and using recursive machine learning and industry leading AI to crunch the data to a single cover probability.

Interestingly enough, the data has been most focused on the trending factor human bettors often put on St. Louis’s strength factors between a Cardinals team going up against a possibly improved Mariners team. Trends look to say the true game analytics might reflect a moderate lean against one Vegas line in particular.

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Below is our current AI St. Louis vs Seattle picks, computer picks Cardinals vs Mariners, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
MLB 10/1 SD@CHC UNLOCK THIS PICK 4 INTEL Locked INTEL
MLB 10/1 SD@CHC UNLOCK THIS PICK 4 EXECUTIVE Locked EXECUTIVE
MLB 10/1 CIN@LAD UNLOCK THIS PICK 3 EXECUTIVE Locked EXECUTIVE
MLB 10/1 CIN@LAD UNLOCK THIS PICK 2 INTEL Locked INTEL
MLB 10/1 DET@CLE UNLOCK THIS PICK 2 INTEL Locked INTEL
MLB 10/1 DET@CLE UNLOCK THIS PICK 1 INTEL Locked INTEL
MLB 10/1 BOS@NYY UNLOCK THIS PICK 1 INTEL Locked INTEL
MLB 10/1 CIN@LAD GET FREE PICK NOW 1
MLB 10/1 BOS@NYY UNLOCK THIS PICK 0 INTEL Locked INTEL
MLB 10/1 BOS@NYY GET FREE PICK NOW 0

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.

Cardinals Betting Trends

The Cardinals have delivered solid value against the spread this season, going 37–31 ATS, showing more consistency than their .500-ish record might suggest.

Mariners Betting Trends

While specific ATS figures for the Mariners aren’t available, their dominant 43–25 home record indicates strong performance at T-Mobile Park, reflecting likely ATS success as well.

Cardinals vs. Mariners Matchup Trends

Oddsmakers favor Seattle at around –145, with St. Louis at +125 on the moneyline. The run total is pegged at 8, with the Mariners supported by bettors expecting a controlled home win.

St. Louis vs. Seattle Game Info

St. Louis vs Seattle starts on September 10, 2025 at 9:40 PM EST.

Spread: Seattle -1.5
Moneyline: St. Louis +189, Seattle -230
Over/Under: 7.5

St. Louis: (72-74)  |  Seattle: (77-68)

Remi's searched hard and found the best prop for this matchup: J. Polanco over 5.5 Fantasy Score.. Prices move—always shop for the best number.

Oddsmakers favor Seattle at around –145, with St. Louis at +125 on the moneyline. The run total is pegged at 8, with the Mariners supported by bettors expecting a controlled home win.

STL trend: The Cardinals have delivered solid value against the spread this season, going 37–31 ATS, showing more consistency than their .500-ish record might suggest.

SEA trend: While specific ATS figures for the Mariners aren’t available, their dominant 43–25 home record indicates strong performance at T-Mobile Park, reflecting likely ATS success as well.

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

St. Louis vs. Seattle Odds

AI algorithm Remi is pouring through loads of data on each player. In fact, anytime the St. Louis vs Seattle trends are analyzed, there’s always several intriguing trends to key in on. Not to mention games played at extreme altitude can often follow normal, predictable patterns.

St. Louis vs Seattle Opening Odds

STL Moneyline: +189
SEA Moneyline: -230
STL Spread: +1.5
SEA Spread: -1.5
Over/Under: 7.5

St. Louis vs Seattle Live Odds

Games PTS ML SPR O/U
Oct 2, 2025 3:08PM EDT
Detroit Tigers
Cleveland Guardians
10/2/25 3:08PM
Tigers
Guardians
+100
-120
-1.5 (+175)
+1.5 (-215)
O 7 (-105)
U 7 (-115)
Oct 2, 2025 5:08PM EDT
San Diego Padres
Chicago Cubs
10/2/25 5:08PM
Padres
Cubs
+100
-118
-1.5 (+172)
+1.5 (-210)
O 7.5 (-110)
U 7.5 (-110)
Oct 2, 2025 8:08PM EDT
Boston Red Sox
New York Yankees
10/2/25 8:08PM
Red Sox
Yankees
+136
-162
+1.5 (-160)
-1.5 (+130)
O 7.5 (-120)
U 7.5 (-102)
Oct 4, 2025 2:30PM EDT
Los Angeles Dodgers
Philadelphia Phillies
10/4/25 2:30PM
Dodgers
Phillies
+110
-130
pk
pk
Oct 4, 2025 5:09PM EDT
Los Angeles Dodgers
Philadelphia Phillies
10/4/25 5:09PM
Dodgers
Phillies
+108
-126
pk
pk
O 7 (-135)
U 7 (+115)

MLB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers St. Louis Cardinals vs. Seattle Mariners on September 10, 2025 at T-Mobile Park.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
ARI@SD SD -131 57.3% 4 WIN
DET@BOS BOS -115 56.4% 5 WIN
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN
CHC@SF CHC -105 54.1% 4 LOSS
NYY@CHW RYAN MCMAHON OVER 0.5 BASES 54.1% 4 WIN
PHI@NYM OVER 8.5 55.6% 4 LOSS
LAA@TEX LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS 54.1% 4 LOSS
KC@CHW KC -109 54.2% 4 WIN
SD@SEA DYLAN CEASE OVER 16.5 OUTS 53.9% 3 LOSS
SD@SEA UNDER 8.5 54.4% 4 LOSS
MIN@TOR JOE RYAN UNDER 2.5 EARNED RUNS 54.1% 4 LOSS
SF@MIL MIL +100 54.0% 6 LOSS
TOR@MIA MIA +1.5 62.0% 6 WIN
CHC@LAA OVER 9.5 54.9% 4 LOSS
BOS@NYY CARLOS RODON UNDER 4.5 HITS ALLOWED 54.2% 4 WIN
KC@DET DET -115 56.1% 5 WIN
CHC@LAA LAA +1.5 57.6% 5 LOSS