Cardinals vs. Mariners
Prediction, Odds & Props
Sep 08 | MLB AI Picks
Updated: 2025-09-06T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The St. Louis Cardinals (70–71) visit T-Mobile Park to take on the Seattle Mariners (73–67), with a pivotal starting pitching matchup on tap: Miles Mikolas for St. Louis and Bryan Woo for Seattle. With both teams still jockeying for positioning, this contest could tip playoff momentum—expect a classic duel between veteran control and young firepower.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

GAME INFO
Date: Sep 08, 2025
Start Time: 9:40 PM EST
Venue: T-Mobile Park
Mariners Record: (75-68)
Cardinals Record: (72-72)
OPENING ODDS
STL Moneyline: +179
SEA Moneyline: -218
STL Spread: +1.5
SEA Spread: -1.5
Over/Under: 7.5
STL
Betting Trends
- St. Louis has been solid against the run line this season, with a 37–31 mark overall, though their road ATS since the All-Star break has dipped to 1–3.
SEA
Betting Trends
- The Mariners have struggled ATS at home, particularly since the All-Star break, going just 2–5.
MATCHUP TRENDS
- Seattle is favored at –132 on the moneyline, with St. Louis at around +110. The total is set at 8.5, hinting at a tightly contested, low-scoring affair where one crooked inning or bullpen performance could determine both the winner and the cover.
STL vs. SEA
Best Prop Bet
- Remi's searched hard and found the best prop for this matchup: I. Herrera over 4.5 Fantasy Score.
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St. Louis vs Seattle Prediction & Odds:
Free MLB Betting Insights for 9/8/25
Their formula will be to extend at-bats, drive up pitch counts, and cash in on mistakes over the plate, as they have not consistently produced crooked numbers without stringing together traffic. The Mariners, meanwhile, rely on a different blueprint, with Julio Rodríguez setting the tone as their sparkplug, combining speed, power, and defense to ignite both the lineup and the crowd, while J.P. Crawford and Yoán Moncada provide balance with contact and gap power. Seattle’s path to success will be attacking Mikolas early in counts to avoid letting him dictate tempo, while using their athleticism on the bases to put pressure on St. Louis’s defense. Defensively, Seattle has the advantage, particularly in the outfield, where their range in T-Mobile’s expansive gaps can prevent doubles from turning into momentum-shifting innings, while the Cardinals must be sharper than they have been in recent weeks to avoid gifting the Mariners extra opportunities. The bullpens loom as potential swing factors: Seattle’s relief corps has been steadier but still prone to occasional meltdowns, while St. Louis has leaned on veteran arms but lacks the dominance to shut down elite lineups in the late innings, making starter efficiency paramount for both sides. From a betting perspective, the Cardinals’ stronger overall ATS record suggests they have been more reliable in keeping games close, though their recent road struggles highlight inconsistency, while Seattle’s middling home ATS record reflects volatility even when they win. With the total set around 8.5 runs, oddsmakers expect a moderately low-scoring affair, one likely decided by which starter establishes rhythm and which bullpen avoids the one mistake that flips momentum. Ultimately, this game boils down to experience versus youthful energy, with Mikolas and the veteran Cardinals trying to grind out a road win against Woo and a Mariners team that knows every September contest could be the one that tips their playoff fate.
Fiesta Cardenales! pic.twitter.com/sezjxWofLU
— St. Louis Cardinals (@Cardinals) September 7, 2025
St. Louis Cardinals MLB Preview
For the Cardinals, Monday’s September 8 game in Seattle represents both a test of resilience and an opportunity to keep their faint postseason hopes alive, and they will need veteran right-hander Miles Mikolas to set the tone in a hostile environment. Mikolas has long relied on command, sequencing, and inducing contact rather than overpowering hitters, and his ability to work efficiently through the Mariners’ order will be critical, as Seattle’s lineup has shown a knack for punishing mistakes with gap power and speed on the bases. His approach will center on getting ahead in counts, forcing hitters like Julio Rodríguez and J.P. Crawford to put the ball in play on his terms, and trusting the defense behind him to convert outs without giving away extra bases. Offensively, St. Louis continues to lean on its cornerstones, Paul Goldschmidt and Nolan Arenado, both of whom provide the discipline and power to turn tight games with one swing, but they will need support from complementary bats such as Brendan Donovan, Masyn Winn, and Willson Contreras to avoid overreliance on their veterans. Against Bryan Woo, who has shown swing-and-miss stuff but can struggle with efficiency, the Cardinals must adopt a patient approach, running up his pitch count by fouling off pitches and working deep into at-bats to force Seattle to lean on its bullpen earlier than planned.
This situational hitting, paired with aggressive baserunning when opportunities present themselves, is their clearest path to scoring in a park that can suppress home runs but reward line drives into the alleys. Defensively, St. Louis must avoid the miscues that have hurt them throughout the year, as T-Mobile Park’s wide outfield and Seattle’s speed make errors and missed coverages especially costly, and their ability to stay crisp could decide whether Mikolas’s pitch-to-contact style holds up. The bullpen, while experienced, has been inconsistent and cannot afford to enter high-leverage innings protecting a deficit, so Mikolas providing six or more steady innings would go a long way toward giving manager Oliver Marmol the flexibility to deploy relievers in optimal matchups. From a betting standpoint, the Cardinals’ 37–31 ATS mark reflects their knack for staying competitive even when they lose, though their recent 1–3 ATS skid on the road since the All-Star break underscores the inconsistency that has kept them hovering around .500. For St. Louis, the formula is clear: Mikolas must pound the zone and prevent free passes, the lineup must find ways to generate offense against Woo without relying solely on power, and the defense must play as clean a game as possible to avoid giving away extra runs. If they succeed in executing those fundamentals, the Cardinals have a realistic chance to not only cover but also steal a much-needed road win, extending their postseason hopes while reaffirming the value of their veteran core in high-stakes September baseball.

Credit: USA TODAY/IMAGN
Seattle Mariners MLB Preview
For the Mariners, Monday’s September 8 matchup against the Cardinals at T-Mobile Park is another chance to show that their youthful core is ready to carry the franchise into October, and they will place their trust in right-hander Bryan Woo, whose emergence has been one of the bright spots of their 2025 season. Woo brings a lively fastball and sharp slider that can overwhelm hitters when he stays ahead in counts, and against a veteran-laden St. Louis lineup anchored by Paul Goldschmidt and Nolan Arenado, his task will be to set the tone early by attacking the zone and not allowing patient hitters to dictate at-bats. Seattle’s offense has thrived when Julio Rodríguez sets the pace, and his ability to combine power with speed makes him the centerpiece of a lineup that also relies on J.P. Crawford’s on-base skills and Yoán Moncada’s gap power to generate rallies. The Mariners will look to pressure Miles Mikolas early, hunting first-pitch strikes before he can settle into his contact-heavy rhythm, while aggressive baserunning and situational hitting will be key to creating run-scoring opportunities in a park that often suppresses home run totals but rewards line drives into the gaps. Defensively, Seattle’s athleticism gives them an advantage, particularly in the expansive outfield at T-Mobile Park, where Rodríguez’s range and the positioning of their corner outfielders can limit extra-base hits that would otherwise spark rallies for the Cardinals.
The infield has also been reliable, with Crawford and Moncada capable of turning quick double plays that could erase traffic against Mikolas, and the Mariners will need to stay sharp to avoid gifting St. Louis additional outs. The bullpen has been solid if unspectacular, with depth in the middle innings and enough high-leverage options to close tight games when Woo hands over a lead, but manager Scott Servais must be precise in matchups to keep the Cardinals from capitalizing late. From a betting perspective, Seattle’s ATS performance at home has been shaky, particularly since the All-Star break, with a 2–5 mark that reflects their struggle to consistently convert solid play into covers, though their overall record shows they still find ways to win close games even if they don’t always clear the spread. For the Mariners, the formula to victory is straightforward: Woo must pitch aggressively and give them at least five competitive innings, Rodríguez and Crawford must ignite the offense with traffic on the bases, and the defense and bullpen must hold firm in the late innings. If they can execute those elements, Seattle not only positions itself to take a crucial win in the Wild Card race but also demonstrates that their young stars and developing pitching staff can thrive in pressure games, sending a strong message that the Mariners are building momentum at exactly the right time in September.
See you back home tomorrow! #TridentsUp
— Seattle Mariners (@Mariners) September 7, 2025
>> https://t.co/dbdDdS4eEN << pic.twitter.com/UCvKkOitRT
St. Louis vs. Seattle Prop Picks (AI)
St. Louis vs. Seattle Prediction (AI)

Remi, our AI sports algorithm, has been pouring over tons of data from every simulation between the Cardinals and Mariners and using recursive machine learning and kick-ass AI to boil down the data to a single cover probability.
Remi has been most fixated on the linear correlation of weight knucklehead sportsbettors tend to put on coaching factors between a Cardinals team going up against a possibly tired Mariners team. In reality, the true game analytics might reflect a moderate lean against one Vegas line specifically.
Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.
Below is our current AI St. Louis vs Seattle picks, computer picks Cardinals vs Mariners, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
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MLB | 10/1 | SD@CHC | UNLOCK THIS PICK | 4 |
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MLB | 10/1 | SD@CHC | UNLOCK THIS PICK | 4 |
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MLB | 10/1 | CIN@LAD | UNLOCK THIS PICK | 3 |
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MLB | 10/1 | CIN@LAD | UNLOCK THIS PICK | 2 |
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MLB | 10/1 | DET@CLE | UNLOCK THIS PICK | 2 |
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MLB | 10/1 | DET@CLE | UNLOCK THIS PICK | 1 |
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MLB | 10/1 | BOS@NYY | UNLOCK THIS PICK | 1 |
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MLB | 10/1 | CIN@LAD | GET FREE PICK NOW | 1 | – | |
MLB | 10/1 | BOS@NYY | UNLOCK THIS PICK | 0 |
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MLB | 10/1 | BOS@NYY | GET FREE PICK NOW | 0 | – |
These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.
Cardinals Betting Trends
St. Louis has been solid against the run line this season, with a 37–31 mark overall, though their road ATS since the All-Star break has dipped to 1–3.
Mariners Betting Trends
The Mariners have struggled ATS at home, particularly since the All-Star break, going just 2–5.
Cardinals vs. Mariners Matchup Trends
Seattle is favored at –132 on the moneyline, with St. Louis at around +110. The total is set at 8.5, hinting at a tightly contested, low-scoring affair where one crooked inning or bullpen performance could determine both the winner and the cover.
St. Louis vs. Seattle Game Info
What time does St. Louis vs Seattle start on September 08, 2025?
St. Louis vs Seattle starts on September 08, 2025 at 9:40 PM EST.
Where is St. Louis vs Seattle being played?
Venue: T-Mobile Park.
What are the opening odds for St. Louis vs Seattle?
Spread: Seattle -1.5
Moneyline: St. Louis +179, Seattle -218
Over/Under: 7.5
What are the records for St. Louis vs Seattle?
St. Louis: (72-72) | Seattle: (75-68)
What is the AI best bet for St. Louis vs Seattle?
Remi's searched hard and found the best prop for this matchup: I. Herrera over 4.5 Fantasy Score.. Prices move—always shop for the best number.
What are St. Louis vs Seattle trending bets?
Seattle is favored at –132 on the moneyline, with St. Louis at around +110. The total is set at 8.5, hinting at a tightly contested, low-scoring affair where one crooked inning or bullpen performance could determine both the winner and the cover.
What are St. Louis trending bets?
STL trend: St. Louis has been solid against the run line this season, with a 37–31 mark overall, though their road ATS since the All-Star break has dipped to 1–3.
What are Seattle trending bets?
SEA trend: The Mariners have struggled ATS at home, particularly since the All-Star break, going just 2–5.
Where can I find AI Picks for St. Louis vs Seattle?
See our latest MLB picks and odds pages for 2025 to compare prices before you bet.
St. Louis vs. Seattle Odds
Remi is pouring through loads of stats on each line. In fact, anytime the St. Louis vs Seattle trends are analyzed, there’s always several intriguing trends to key in on. Not to mention games played at extreme hostile environments rarely follow normal, predictable betting trends.
St. Louis vs Seattle Opening Odds
STL Moneyline:
+179 SEA Moneyline: -218
STL Spread: +1.5
SEA Spread: -1.5
Over/Under: 7.5
St. Louis vs Seattle Live Odds
Games | PTS | ML | SPR | O/U | |
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Oct 2, 2025 3:08PM EDT
Detroit Tigers
Cleveland Guardians
10/2/25 3:08PM
Tigers
Guardians
|
–
–
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+100
-120
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-1.5 (+175)
+1.5 (-215)
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O 7 (-105)
U 7 (-115)
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Oct 2, 2025 5:08PM EDT
San Diego Padres
Chicago Cubs
10/2/25 5:08PM
Padres
Cubs
|
–
–
|
+100
-118
|
-1.5 (+172)
+1.5 (-210)
|
O 7.5 (-110)
U 7.5 (-110)
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Oct 2, 2025 8:08PM EDT
Boston Red Sox
New York Yankees
10/2/25 8:08PM
Red Sox
Yankees
|
–
–
|
+136
-162
|
+1.5 (-160)
-1.5 (+130)
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O 7.5 (-120)
U 7.5 (-102)
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Oct 4, 2025 2:30PM EDT
Los Angeles Dodgers
Philadelphia Phillies
10/4/25 2:30PM
Dodgers
Phillies
|
–
–
|
+110
-130
|
pk
pk
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Oct 4, 2025 5:09PM EDT
Los Angeles Dodgers
Philadelphia Phillies
10/4/25 5:09PM
Dodgers
Phillies
|
–
–
|
+108
-126
|
pk
pk
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O 7 (-135)
U 7 (+115)
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MLB Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers St. Louis Cardinals vs. Seattle Mariners on September 08, 2025 at T-Mobile Park.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.
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LEAN | %WIN | UNITS | RESULT |
---|---|---|---|---|
ARI@SD | SD -131 | 57.3% | 4 | WIN |
DET@BOS | BOS -115 | 56.4% | 5 | WIN |
NYM@CHC | NYM -110 | 54.1% | 3 | WIN |
HOU@ATH | ATH +118 | 50.8% | 4 | WIN |
NYM@CHC | OVER 7 | 54.5% | 3 | WIN |
STL@SF | OVER 7.5 | 55.9% | 5 | LOSS |
KC@LAA | TYLER TOLBERT UNDER 1.5 BASES | 54.4% | 4 | WIN |
MIL@SD | UNDER 9 | 54.7% | 4 | WIN |
MIA@PHI | KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS | 53.3% | 3 | WIN |
WAS@NYM | OVER 8.5 | 56.1% | 6 | LOSS |
LAA@COL | COL +108 | 50.5% | 3 | WIN |
TOR@KC | UNDER 9 | 54.7% | 4 | LOSS |
SEA@KC | KC +1.5 | 62.3% | 5 | LOSS |
NYY@MIN | OVER 9 | 55.1% | 4 | WIN |
MIA@COL | OVER 10.5 | 55.0% | 4 | WIN |
MIA@COL | AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS | 54.3% | 4 | WIN |
SEA@KC | BOBBY WITT UNDER 0.5 SINGLES | 54.4% | 4 | LOSS |
PHI@LAD | LAD -113 | 54.7% | 4 | LOSS |
NYY@BOS | OVER 7.5 | 54.3% | 3 | WIN |
KC@PHI | PHI -130 | 58.3% | 4 | WIN |
LAD@SF | OVER 7.5 | 54.7% | 4 | LOSS |
NYM@PHI | PHI -122 | 55.6% | 4 | WIN |
KC@CLE | KC -104 | 52.0% | 3 | WIN |
CIN@SD | JAKE CRONEWORTH OVER 0.5 HITS | 53.1% | 3 | WIN |
WAS@MIA | MIA -123 | 55.2% | 4 | LOSS |
LAA@KC | UNDER 9.5 | 54.9% | 3 | WIN |
TEX@ARI | UNDER 9 | 54.2% | 4 | WIN |
SF@COL | UNDER 11.5 | 56.4% | 6 | LOSS |
SF@COL | RAFAEL DEVERS OVER 1.5 BASES | 56.1% | 6 | WIN |
MIA@WAS | WAS -110 | 54.4% | 4 | WIN |
NYM@DET | OVER 8.5 | 54.5% | 4 | WIN |
TEX@ARI | UNDER 9.5 | 56.4% | 6 | WIN |
TEX@ARI | ALEJANDRO OSUNA UNDER 1.5 BASES | 54.1% | 4 | LOSS |
ATL@CHC | CHC -116 | 55.1% | 3 | WIN |
PHI@MIL | OVER 8.5 | 55.0% | 3 | WIN |
ARI@LAD | SHOHEI OHTANI OVER 2.5 BASES | 54.2% | 4 | WIN |
SEA@CLE | CLE +1.5 | 57.2% | 3 | WIN |
CHC@SF | CHC -105 | 54.1% | 4 | LOSS |
NYY@CHW | RYAN MCMAHON OVER 0.5 BASES | 54.1% | 4 | WIN |
PHI@NYM | OVER 8.5 | 55.6% | 4 | LOSS |
LAA@TEX | LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS | 54.1% | 4 | LOSS |
KC@CHW | KC -109 | 54.2% | 4 | WIN |
SD@SEA | DYLAN CEASE OVER 16.5 OUTS | 53.9% | 3 | LOSS |
SD@SEA | UNDER 8.5 | 54.4% | 4 | LOSS |
MIN@TOR | JOE RYAN UNDER 2.5 EARNED RUNS | 54.1% | 4 | LOSS |
SF@MIL | MIL +100 | 54.0% | 6 | LOSS |
TOR@MIA | MIA +1.5 | 62.0% | 6 | WIN |
CHC@LAA | OVER 9.5 | 54.9% | 4 | LOSS |
BOS@NYY | CARLOS RODON UNDER 4.5 HITS ALLOWED | 54.2% | 4 | WIN |
KC@DET | DET -115 | 56.1% | 5 | WIN |
CHC@LAA | LAA +1.5 | 57.6% | 5 | LOSS |