Nationals vs. Cubs
Prediction, Odds & Props
Sep 06 | MLB AI Picks
Updated: 2025-09-04T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The Nationals visit Wrigley Field on Saturday, September 6, 2025, first pitch 2:20 p.m. ET, with Chicago pushing to secure top Wild Card positioning while Washington leans into development and spoiler energy. The expected starters are right-hander Brad Lord for Washington and veteran lefty Matthew Boyd for Chicago in a contrast of a rising arm versus a polished craftsman.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

GAME INFO
Date: Sep 06, 2025
Start Time: 2:20 PM EST
Venue: Wrigley Field
Cubs Record: (81-60)
Nationals Record: (56-84)
OPENING ODDS
WAS Moneyline: +212
CHC Moneyline: -263
WAS Spread: +1.5
CHC Spread: -1.5
Over/Under: 9
WAS
Betting Trends
- Nationals are 67-72 against the run line this season and 3-7 over their last 10 RL decisions.
CHC
Betting Trends
- Cubs are 63-77 against the run line this season.
MATCHUP TRENDS
- Despite a strong straight-up profile at home and postseason momentum, Chicago’s season-long RL record lags below 50%, creating a market tension against a Washington club that has struggled overall but can cover late as an underdog if games stay within one swing.
WAS vs. CHC
Best Prop Bet
- Remi's searched hard and found the best prop for this matchup: D. Lile over 3.5 Fantasy Score.
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Washington vs Chicago Prediction & Odds:
Free MLB Betting Insights for 9/6/25
The Cubs’ offense can be dangerous when sequencing clicks, with power up top and situational bats in the middle, and their ability to string together doubles and patient plate appearances against a young pitcher like Lord could quickly tilt the leverage toward a middle-innings surge, but their season-long run-line record has betrayed a team that often wins without comfortable cushions, suggesting that even in victory, the door remains open for opponents to sneak inside the number late. The Nationals, meanwhile, know their limitations but embrace the spoiler role, using hustle plays, aggressive baserunning, and defensive sharpness to squeeze edges where talent gaps exist, and they will need contributions from younger bats who can lengthen innings, along with mistake-free execution in the field to prevent the avalanche inning that has too often defined their season. Strategically, both dugouts are likely to manage with urgency: Chicago to protect a lead and line up bullpen matchups against Washington’s pockets of right-handed bats, and Washington to get Lord out before damage compounds, leaning on relievers in high-leverage spots even if it means burning arms earlier than preferred. The intangible is Wrigley itself, where the day-game atmosphere and shifting wind can create unpredictable outcomes, and where the energy of a playoff push can either steady or tighten a contender’s approach. Ultimately, the matchup comes down to whether Boyd can provide six efficient frames to set the table for Chicago’s bullpen and whether the Cubs’ offense can strike early enough to avoid late-inning drama, while Washington’s path to an upset or run-line cover depends on keeping the game within a swing into the seventh, playing clean defense, and exploiting any cracks in Chicago’s sequencing; whichever side controls those middle innings will likely dictate not only the outcome but also the tone of the series.
#FridayNightBaseball is here. Watch @Nationals at @Cubs live on @AppleTV.
— Washington Nationals (@Nationals) September 5, 2025
→ https://t.co/ZpwjW0PoER pic.twitter.com/A4BYIzdPf8
Washington Nationals MLB Preview
For the Nationals, this September 6 test at Wrigley Field is as much about identity as it is about outcome, because Washington has spent most of 2025 in developmental mode, emphasizing growth opportunities for young players while trying to carve out momentum for the future, and a road matchup against a playoff-hopeful Cubs team offers the perfect crucible to see who can compete under postseason-like tension. Rookie right-hander Brad Lord draws the start, and his challenge is monumental but instructive: face a lineup that punishes mistakes in a ballpark where even well-struck fly balls can carry, while trying to show that his mix of fastball, changeup, and slider can produce quality outs at the big-league level. For Lord, the formula will be about pounding the strike zone early, staying out of hitter’s counts, and using his changeup to disrupt Chicago’s right-handed bats who otherwise could sit on velocity, because the Cubs thrive when pitchers nibble and extend innings via walks, leading to avalanche-style crooked numbers. Washington’s offense, by contrast, must focus on patience and execution, knowing that Matthew Boyd’s profile is command-heavy, meaning they’ll get pitches in the zone to hit if they don’t expand, and capitalizing on those chances with runners aboard will be key, because stranding opportunities has been one of the Nationals’ defining struggles all season. The lineup lacks consistent power, so the strategy has to be about stringing base hits, putting pressure on Chicago’s defense, and taking every extra 90 feet available, whether it’s first-to-third on a single, a delayed steal to rattle the pitcher, or forcing throws from the outfield that could go awry.
Defensively, the Nationals must be airtight, especially in the outfield where Wrigley’s dimensions can turn routine liners into doubles if routes are inefficient, and in the infield where double-play opportunities must be converted to keep Lord or the bullpen from facing extended innings. In terms of bullpen usage, Washington’s relievers have improved since their rough first half, but the group still carries volatility, which means manager Davey Martinez will likely have a quick hook with Lord if trouble arises, using matchup relievers aggressively in the middle innings to keep the game within reach. Their path to a win or even a backdoor run-line cover lies in keeping the contest tight until the seventh or eighth, where variance and the unpredictability of baseball can tilt outcomes, particularly if Chicago continues its trend of winning games without covering run lines consistently. The intangible for Washington is the freedom of having nothing to lose; with no standings pressure, the team can play aggressively, take risks, and treat every chance to spoil as a teaching moment, and that looseness can sometimes trip up opponents burdened with higher stakes. For the Nationals, success isn’t just about the scoreboard but about proving they can hang in a pressure environment, execute their fundamentals, and make a contender sweat, and if they can do that on a Saturday afternoon at Wrigley, the young core will gain both confidence and credibility while perhaps sneaking away with a result that matters more for their development than for the standings.

Credit: USA TODAY/IMAGN
Chicago Cubs MLB Preview
For the Cubs, Saturday’s September 6 clash with the Nationals is the kind of late-season home game that demands precision and maturity, because while Washington is mired in a developmental year, Chicago cannot afford to take anything for granted as they pursue Wild Card security, and their ability to impose order from the opening pitch will dictate whether the afternoon unfolds comfortably or devolves into another nerve-rattler. Matthew Boyd takes the ball for Chicago, and his profile as a strike-throwing lefty fits the assignment well: his command of the four-seam fastball up in the zone, paired with a slider that tunnels late, allows him to attack a Nationals lineup that has been inconsistent in producing runs and overly reliant on stringing together singles, and if Boyd gets ahead consistently, his sequencing becomes much harder to crack. The Cubs’ offense, meanwhile, must seize the opportunity presented by rookie starter Brad Lord, who has talent but is still learning how to manage big-league lineups, and Chicago’s plan should be to pressure him early by attacking fastballs in the zone, forcing him to elevate pitch counts, and making sure that if he misses over the plate, the damage is immediate and loud. With power bats capable of flipping a game quickly and enough contact hitters to sustain rallies, the Cubs have the tools to produce crooked innings that could force Washington’s bullpen into action before the middle innings, an outcome that tilts leverage toward Chicago given the Nationals’ relief inconsistencies.
On the bases, the Cubs should look to be opportunistic, testing Lord’s pickoff move, pushing first-to-third on singles, and applying situational pressure that magnifies the inexperience of both the pitcher and Washington’s defense. Defensively, Chicago has to play crisp, because Washington’s best route to staying competitive is manufacturing runs from hustle and forcing errors, so cutting off the gaps, hitting cutoff men cleanly, and converting double-play opportunities will be nonnegotiable if they want to keep momentum fully on their side. Strategically, manager Craig Counsell can afford to be proactive, pulling Boyd if trouble arises and matching relievers to Washington’s weaker lineup pockets, while also leaning on late-game leverage arms if the lead is narrow, knowing that September baseball leaves no room for letting an underdog hang around. The Cubs’ run-line record this season suggests that while they often win, they haven’t always built comfortable margins, which makes it critical to score first and create separation rather than leaving it to late-game variance, and against a Nationals team with no pressure and every incentive to play spoiler, Chicago must lean on fundamentals and discipline to avoid giving away free bases or extra outs. More than anything, this is the type of game where the home crowd, the energy of the pennant chase, and the team’s veteran leadership should combine to enforce order, and if Boyd delivers a steady six innings and the bats punish Lord’s inevitable mistakes, the Cubs can control the narrative, win with margin, and move one step closer to locking in their postseason path.
— Chicago Cubs (@Cubs) September 5, 2025
Washington vs. Chicago Prop Picks (AI)
Washington vs. Chicago Prediction (AI)

Remi, our AI sports algorithm, has been pouring over millions of data from every simulation between the Nationals and Cubs and using recursive machine learning and industry leading AI to boil down the data to a single cover probability.
Oddly enough, we’ve seen the AI has been most watching on the linear correlation of weight knucklehead sportsbettors regularly put on Washington’s strength factors between a Nationals team going up against a possibly unhealthy Cubs team. Trends look to say the true game analytics appear to reflect a strong lean against one Vegas line specifically.
Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.
Below is our current AI Washington vs Chicago picks, computer picks Nationals vs Cubs, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
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MLB | 10/1 | SD@CHC | UNLOCK THIS PICK | 4 |
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MLB | 10/1 | SD@CHC | UNLOCK THIS PICK | 4 |
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MLB | 10/1 | CIN@LAD | UNLOCK THIS PICK | 3 |
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MLB | 10/1 | CIN@LAD | UNLOCK THIS PICK | 2 |
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MLB | 10/1 | DET@CLE | UNLOCK THIS PICK | 2 |
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MLB | 10/1 | DET@CLE | UNLOCK THIS PICK | 1 |
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MLB | 10/1 | BOS@NYY | UNLOCK THIS PICK | 1 |
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MLB | 10/1 | CIN@LAD | GET FREE PICK NOW | 1 | – | |
MLB | 10/1 | BOS@NYY | UNLOCK THIS PICK | 0 |
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MLB | 10/1 | BOS@NYY | GET FREE PICK NOW | 0 | – |
These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.
Nationals Betting Trends
Nationals are 67-72 against the run line this season and 3-7 over their last 10 RL decisions.
Cubs Betting Trends
Cubs are 63-77 against the run line this season.
Nationals vs. Cubs Matchup Trends
Despite a strong straight-up profile at home and postseason momentum, Chicago’s season-long RL record lags below 50%, creating a market tension against a Washington club that has struggled overall but can cover late as an underdog if games stay within one swing.
Washington vs. Chicago Game Info
What time does Washington vs Chicago start on September 06, 2025?
Washington vs Chicago starts on September 06, 2025 at 2:20 PM EST.
Where is Washington vs Chicago being played?
Venue: Wrigley Field.
What are the opening odds for Washington vs Chicago?
Spread: Chicago -1.5
Moneyline: Washington +212, Chicago -263
Over/Under: 9
What are the records for Washington vs Chicago?
Washington: (56-84) | Chicago: (81-60)
What is the AI best bet for Washington vs Chicago?
Remi's searched hard and found the best prop for this matchup: D. Lile over 3.5 Fantasy Score.. Prices move—always shop for the best number.
What are Washington vs Chicago trending bets?
Despite a strong straight-up profile at home and postseason momentum, Chicago’s season-long RL record lags below 50%, creating a market tension against a Washington club that has struggled overall but can cover late as an underdog if games stay within one swing.
What are Washington trending bets?
WAS trend: Nationals are 67-72 against the run line this season and 3-7 over their last 10 RL decisions.
What are Chicago trending bets?
CHC trend: Cubs are 63-77 against the run line this season.
Where can I find AI Picks for Washington vs Chicago?
See our latest MLB picks and odds pages for 2025 to compare prices before you bet.
Washington vs. Chicago Odds
Remi is pouring through mountains of data points on each line. In fact, anytime the Washington vs Chicago trends are analyzed, there’s always several intriguing trends to key in on. Not to mention games played at extreme travel distance rarely follow normal, predictable betting trends.
Washington vs Chicago Opening Odds
WAS Moneyline:
+212 CHC Moneyline: -263
WAS Spread: +1.5
CHC Spread: -1.5
Over/Under: 9
Washington vs Chicago Live Odds
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Oct 2, 2025 3:08PM EDT
Detroit Tigers
Cleveland Guardians
10/2/25 3:08PM
Tigers
Guardians
|
–
–
|
+100
-120
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-1.5 (+175)
+1.5 (-215)
|
O 7 (-105)
U 7 (-115)
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Oct 2, 2025 5:08PM EDT
San Diego Padres
Chicago Cubs
10/2/25 5:08PM
Padres
Cubs
|
–
–
|
+100
-118
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-1.5 (+172)
+1.5 (-210)
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O 7.5 (-110)
U 7.5 (-110)
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|
Oct 2, 2025 8:08PM EDT
Boston Red Sox
New York Yankees
10/2/25 8:08PM
Red Sox
Yankees
|
–
–
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+136
-162
|
+1.5 (-160)
-1.5 (+130)
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O 7.5 (-120)
U 7.5 (-102)
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Oct 4, 2025 2:30PM EDT
Los Angeles Dodgers
Philadelphia Phillies
10/4/25 2:30PM
Dodgers
Phillies
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–
–
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+110
-130
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pk
pk
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Oct 4, 2025 5:09PM EDT
Los Angeles Dodgers
Philadelphia Phillies
10/4/25 5:09PM
Dodgers
Phillies
|
–
–
|
+108
-126
|
pk
pk
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O 7 (-135)
U 7 (+115)
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MLB Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers Washington Nationals vs. Chicago Cubs on September 06, 2025 at Wrigley Field.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.
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LEAN | %WIN | UNITS | RESULT |
---|---|---|---|---|
ARI@SD | SD -131 | 57.3% | 4 | WIN |
DET@BOS | BOS -115 | 56.4% | 5 | WIN |
NYM@CHC | NYM -110 | 54.1% | 3 | WIN |
HOU@ATH | ATH +118 | 50.8% | 4 | WIN |
NYM@CHC | OVER 7 | 54.5% | 3 | WIN |
STL@SF | OVER 7.5 | 55.9% | 5 | LOSS |
KC@LAA | TYLER TOLBERT UNDER 1.5 BASES | 54.4% | 4 | WIN |
MIL@SD | UNDER 9 | 54.7% | 4 | WIN |
MIA@PHI | KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS | 53.3% | 3 | WIN |
WAS@NYM | OVER 8.5 | 56.1% | 6 | LOSS |
LAA@COL | COL +108 | 50.5% | 3 | WIN |
TOR@KC | UNDER 9 | 54.7% | 4 | LOSS |
SEA@KC | KC +1.5 | 62.3% | 5 | LOSS |
NYY@MIN | OVER 9 | 55.1% | 4 | WIN |
MIA@COL | OVER 10.5 | 55.0% | 4 | WIN |
MIA@COL | AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS | 54.3% | 4 | WIN |
SEA@KC | BOBBY WITT UNDER 0.5 SINGLES | 54.4% | 4 | LOSS |
PHI@LAD | LAD -113 | 54.7% | 4 | LOSS |
NYY@BOS | OVER 7.5 | 54.3% | 3 | WIN |
KC@PHI | PHI -130 | 58.3% | 4 | WIN |
LAD@SF | OVER 7.5 | 54.7% | 4 | LOSS |
NYM@PHI | PHI -122 | 55.6% | 4 | WIN |
KC@CLE | KC -104 | 52.0% | 3 | WIN |
CIN@SD | JAKE CRONEWORTH OVER 0.5 HITS | 53.1% | 3 | WIN |
WAS@MIA | MIA -123 | 55.2% | 4 | LOSS |
LAA@KC | UNDER 9.5 | 54.9% | 3 | WIN |
TEX@ARI | UNDER 9 | 54.2% | 4 | WIN |
SF@COL | UNDER 11.5 | 56.4% | 6 | LOSS |
SF@COL | RAFAEL DEVERS OVER 1.5 BASES | 56.1% | 6 | WIN |
MIA@WAS | WAS -110 | 54.4% | 4 | WIN |
NYM@DET | OVER 8.5 | 54.5% | 4 | WIN |
TEX@ARI | UNDER 9.5 | 56.4% | 6 | WIN |
TEX@ARI | ALEJANDRO OSUNA UNDER 1.5 BASES | 54.1% | 4 | LOSS |
ATL@CHC | CHC -116 | 55.1% | 3 | WIN |
PHI@MIL | OVER 8.5 | 55.0% | 3 | WIN |
ARI@LAD | SHOHEI OHTANI OVER 2.5 BASES | 54.2% | 4 | WIN |
SEA@CLE | CLE +1.5 | 57.2% | 3 | WIN |
CHC@SF | CHC -105 | 54.1% | 4 | LOSS |
NYY@CHW | RYAN MCMAHON OVER 0.5 BASES | 54.1% | 4 | WIN |
PHI@NYM | OVER 8.5 | 55.6% | 4 | LOSS |
LAA@TEX | LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS | 54.1% | 4 | LOSS |
KC@CHW | KC -109 | 54.2% | 4 | WIN |
SD@SEA | DYLAN CEASE OVER 16.5 OUTS | 53.9% | 3 | LOSS |
SD@SEA | UNDER 8.5 | 54.4% | 4 | LOSS |
MIN@TOR | JOE RYAN UNDER 2.5 EARNED RUNS | 54.1% | 4 | LOSS |
SF@MIL | MIL +100 | 54.0% | 6 | LOSS |
TOR@MIA | MIA +1.5 | 62.0% | 6 | WIN |
CHC@LAA | OVER 9.5 | 54.9% | 4 | LOSS |
BOS@NYY | CARLOS RODON UNDER 4.5 HITS ALLOWED | 54.2% | 4 | WIN |
KC@DET | DET -115 | 56.1% | 5 | WIN |
CHC@LAA | LAA +1.5 | 57.6% | 5 | LOSS |