Giants vs. Cardinals
Prediction, Odds & Props
Sep 06 | MLB AI Picks
Updated: 2025-09-04T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The San Francisco Giants travel to Busch Stadium on Saturday, September 6, 2025, as Justin Verlander takes the mound for the Cardinals in a late-season duel that has high stakes for both clubs still clinging to postseason hopes. With both teams sitting just above or at .500, this matchup is rife with playoff implications and could hinge on execution and timely pitching.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

GAME INFO
Date: Sep 06, 2025
Start Time: 7:15 PM EST
Venue: Busch Stadium
Cardinals Record: (70-72)
Giants Record: (72-69)
OPENING ODDS
SF Moneyline: -129
STL Moneyline: +109
SF Spread: -1.5
STL Spread: +1.5
Over/Under: 8.5
SF
Betting Trends
- The Giants have struggled against the run line this season, posting a cumulative record of 14–17.
STL
Betting Trends
- The Cardinals have faired better on the run line, holding a strong 26–18 record.
MATCHUP TRENDS
- This is shaping up as a gamesmanship-filled duel—Giants weak ATS performance meets Cardinals solid thumb on the run line, with an over/under pegged near 8. In this tight betting landscape, a single crooked inning or bullpen breakdown could determine not just the winner, but also who covers.
SF vs. STL
Best Prop Bet
- Remi's searched hard and found the best prop for this matchup: R. Devers over 6.5 Fantasy Score.
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San Francisco vs St. Louis Prediction & Odds:
Free MLB Betting Insights for 9/6/25
Defensively, St. Louis holds an edge in clean play, with above-average infield execution and reliable outfield coverage, while San Francisco has been below average in outs above average and must avoid giving away extra chances that could flip the game. The bullpens are another swing factor: the Giants’ relief corps has been shaky at times, making it imperative that Verlander provides length, while the Cardinals’ bullpen has been more matchup-oriented and could be deployed aggressively by Oliver Marmol to protect slim leads or keep the game within reach. From a betting standpoint, the Giants have been weak against the run line at 14–17, often winning tight games without creating separation, while the Cardinals are a strong 26–18 ATS, suggesting they are built to cover close margins, particularly at home, and with an over/under hovering around eight, the expectation is for a low-scoring, tightly managed contest where one crooked inning could decide both outcome and cover. Ultimately, the game hinges on two parallel questions: can Verlander suppress St. Louis’ contact-driven attack long enough for San Francisco’s offense to break through against Pallante, and can the Giants’ defense and bullpen avoid the one mistake that has so often swung their ATS struggles. If San Francisco rides its hot streak and Verlander delivers vintage form, the Giants are well-positioned to extend their surge, but if Pallante keeps them quiet and the Cardinals scratch out situational runs, Busch Stadium may once again prove to be a house of pain for a visiting contender in a September duel where every pitch feels like it carries postseason weight.
Stay hot! ☝️ pic.twitter.com/C9kdmIEUOW
— SFGiants (@SFGiants) September 6, 2025
San Francisco Giants MLB Preview
For the Giants, Saturday’s game at Busch Stadium against the Cardinals is as much about sustaining momentum as it is about climbing further into playoff position, because after ripping off 10 wins in their last 11, San Francisco suddenly looks like a team capable of forcing its way into October and they cannot afford to waste the cushion they’ve built by dropping games to direct Wild Card rivals. The responsibility falls on Justin Verlander, the 42-year-old veteran who continues to defy time with his ability to command the strike zone, manipulate pace, and frustrate hitters who might expect diminished stuff but instead find a fastball that still touches the mid-90s paired with a cutter and changeup that generate weak contact. His challenge against St. Louis is to stay efficient, because the Cardinals’ offense, while not explosive, thrives on contact, pressure, and forcing pitchers into long at-bats that can shorten outings, so Verlander’s ability to induce grounders and work ahead will be pivotal. Offensively, San Francisco leans on a balanced middle order anchored by Rafael Devers, Matt Chapman, and Willy Adames, a trio that has carried the scoring load during this hot stretch, with Devers capable of delivering the long ball and Chapman providing patient, grinding at-bats that extend innings. Around them, role players like Thairo Estrada and Mike Yastrzemski have chipped in with timely hits, and the Giants have demonstrated a knack for stringing together rallies when opponents falter defensively, something they’ll need to pressure a St. Louis team that is more reliable with the glove.
On the bases, San Francisco has embraced opportunism, not necessarily stealing often but pushing first-to-third and forcing outfielders to make perfect throws, an approach that can generate the extra run in a game likely to be close. Defensively, however, the Giants must be sharper than they have been, as their negative outs-above-average rating reflects occasional miscues, and against a Cardinals offense that relies on manufacturing runs, even one missed double-play chance or errant throw could swing momentum. Manager Bob Melvin’s handling of the bullpen will also be crucial, as San Francisco’s relievers have been ordinary this season, so the Giants need Verlander to carry them deep and allow Melvin to reserve his best arms for the eighth and ninth innings. From a betting perspective, San Francisco’s 14–17 run-line record underscores their tendency to win without covering, often playing tight games that turn into one-run finishes, and that places extra emphasis on capitalizing with runners in scoring position rather than leaving the door open for St. Louis to stay within a swing. The formula for the Giants is clear: lean on Verlander’s veteran savvy, get timely production from the middle of the order, and play a crisp defensive game that eliminates the freebies that have haunted them at times. If they execute that plan, they can extend their surge, take another step toward a playoff berth, and continue proving that their late-season charge is no fluke but rather the result of a team gelling at the most important time of the year.

Credit: USA TODAY/IMAGN
St. Louis Cardinals MLB Preview
For the Cardinals, Saturday’s meeting with the Giants at Busch Stadium is a game that carries both symbolic and practical weight, because while their record around .500 leaves them hanging just outside the playoff picture, a strong showing against a surging San Francisco club could tighten the race and reenergize their own postseason aspirations. The assignment falls to Andre Pallante, a young arm whose profile leans heavily on contact management, ground-ball induction, and efficiency rather than overpowering strikeouts, and his job against a Giants team in the midst of a 10–1 tear is to stay in the strike zone early, avoid walks, and trust his defense to convert outs cleanly. St. Louis’ offense has struggled to generate consistent power with Nolan Arenado sidelined, but they still feature capable bats in Paul Goldschmidt, Willson Contreras, and younger contributors who have embraced a situational approach, stringing together singles, leveraging bunts, and running aggressively to create scoring chances against veteran pitchers like Justin Verlander. The Cardinals’ blueprint is clear: scratch out runs early to force Verlander into the stretch, play small ball to manufacture crooked innings, and then rely on a bullpen that manager Oliver Marmol is unafraid to deploy aggressively in matchups, even as early as the fifth or sixth inning if needed.
Defensively, the Cardinals hold an edge, with their infield execution and outfield coverage ranking above league average, and in a game likely to hinge on mistakes, their ability to avoid giving San Francisco extra outs could be the separator. On the bases, St. Louis has shown a willingness to take risks, and that style could pay off if they can force San Francisco’s defense, which has been below average in outs above average, into rushed throws or poor routes in the spacious Busch Stadium outfield. The crowd factor also looms, as Busch remains one of the more energized September ballparks, and if Pallante can deliver a quick first inning followed by an early run from the offense, the environment could tilt pressure onto the Giants. From a betting angle, the Cardinals’ 26–18 run-line record suggests they are adept at covering close contests, particularly at home, and that resilience often comes from their ability to keep games within reach and capitalize late when opponents falter. For St. Louis, the formula is about execution and resilience: limit the big inning against Verlander, push for runs with situational hitting rather than trying to slug their way through, and turn the game into a bullpen chess match where Marmol’s aggressive leverage usage can shine. If they succeed in executing that plan, the Cardinals not only have the chance to steal a critical win from a red-hot Giants team but also to signal that their own season still has life, reminding both themselves and the league that while they may not boast the same star power as in years past, they remain a tough and dangerous out in September.
Lining up for our 1985 Reunion! pic.twitter.com/mtZW8MXKxI
— St. Louis Cardinals (@Cardinals) September 5, 2025
San Francisco vs. St. Louis Prop Picks (AI)
San Francisco vs. St. Louis Prediction (AI)

Remi, our AI sports wizard, has been pouring over millions of data from every past game between the Giants and Cardinals and using recursive machine learning and impressive AI to boil down the data to a single cover probability.
Interestingly enough, the data has been most fixated on the growing factor knucklehead sportsbettors tend to put on player performance factors between a Giants team going up against a possibly improved Cardinals team. Trends look to say the true game analytics might reflect a slight lean against one Vegas line specifically.
Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.
Below is our current AI San Francisco vs St. Louis picks, computer picks Giants vs Cardinals, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
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MLB | 10/1 | SD@CHC | UNLOCK THIS PICK | 4 |
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MLB | 10/1 | SD@CHC | UNLOCK THIS PICK | 4 |
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MLB | 10/1 | CIN@LAD | UNLOCK THIS PICK | 3 |
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MLB | 10/1 | CIN@LAD | UNLOCK THIS PICK | 2 |
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MLB | 10/1 | DET@CLE | UNLOCK THIS PICK | 2 |
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MLB | 10/1 | DET@CLE | UNLOCK THIS PICK | 1 |
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MLB | 10/1 | BOS@NYY | UNLOCK THIS PICK | 1 |
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MLB | 10/1 | CIN@LAD | GET FREE PICK NOW | 1 | – | |
MLB | 10/1 | BOS@NYY | UNLOCK THIS PICK | 0 |
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MLB | 10/1 | BOS@NYY | GET FREE PICK NOW | 0 | – |
These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.
Giants Betting Trends
The Giants have struggled against the run line this season, posting a cumulative record of 14–17.
Cardinals Betting Trends
The Cardinals have faired better on the run line, holding a strong 26–18 record.
Giants vs. Cardinals Matchup Trends
This is shaping up as a gamesmanship-filled duel—Giants weak ATS performance meets Cardinals solid thumb on the run line, with an over/under pegged near 8. In this tight betting landscape, a single crooked inning or bullpen breakdown could determine not just the winner, but also who covers.
San Francisco vs. St. Louis Game Info
What time does San Francisco vs St. Louis start on September 06, 2025?
San Francisco vs St. Louis starts on September 06, 2025 at 7:15 PM EST.
Where is San Francisco vs St. Louis being played?
Venue: Busch Stadium.
What are the opening odds for San Francisco vs St. Louis?
Spread: St. Louis +1.5
Moneyline: San Francisco -129, St. Louis +109
Over/Under: 8.5
What are the records for San Francisco vs St. Louis?
San Francisco: (72-69) | St. Louis: (70-72)
What is the AI best bet for San Francisco vs St. Louis?
Remi's searched hard and found the best prop for this matchup: R. Devers over 6.5 Fantasy Score.. Prices move—always shop for the best number.
What are San Francisco vs St. Louis trending bets?
This is shaping up as a gamesmanship-filled duel—Giants weak ATS performance meets Cardinals solid thumb on the run line, with an over/under pegged near 8. In this tight betting landscape, a single crooked inning or bullpen breakdown could determine not just the winner, but also who covers.
What are San Francisco trending bets?
SF trend: The Giants have struggled against the run line this season, posting a cumulative record of 14–17.
What are St. Louis trending bets?
STL trend: The Cardinals have faired better on the run line, holding a strong 26–18 record.
Where can I find AI Picks for San Francisco vs St. Louis?
See our latest MLB picks and odds pages for 2025 to compare prices before you bet.
San Francisco vs. St. Louis Odds
AI algorithm Remi is pouring through mountains of stats on each player. In fact, anytime the San Francisco vs St. Louis trends are analyzed, there’s always several intriguing trends to key in on. Not to mention games played at extreme altitude rarely follow normal, predictable patterns.
San Francisco vs St. Louis Opening Odds
SF Moneyline:
-129 STL Moneyline: +109
SF Spread: -1.5
STL Spread: +1.5
Over/Under: 8.5
San Francisco vs St. Louis Live Odds
Games | PTS | ML | SPR | O/U | |
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Oct 2, 2025 3:08PM EDT
Detroit Tigers
Cleveland Guardians
10/2/25 3:08PM
Tigers
Guardians
|
–
–
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+100
-120
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-1.5 (+175)
+1.5 (-215)
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O 7 (-105)
U 7 (-115)
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Oct 2, 2025 5:08PM EDT
San Diego Padres
Chicago Cubs
10/2/25 5:08PM
Padres
Cubs
|
–
–
|
+100
-118
|
-1.5 (+172)
+1.5 (-210)
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O 7.5 (-110)
U 7.5 (-110)
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Oct 2, 2025 8:08PM EDT
Boston Red Sox
New York Yankees
10/2/25 8:08PM
Red Sox
Yankees
|
–
–
|
+136
-162
|
+1.5 (-160)
-1.5 (+130)
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O 7.5 (-120)
U 7.5 (-102)
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Oct 4, 2025 2:30PM EDT
Los Angeles Dodgers
Philadelphia Phillies
10/4/25 2:30PM
Dodgers
Phillies
|
–
–
|
+110
-130
|
pk
pk
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Oct 4, 2025 5:09PM EDT
Los Angeles Dodgers
Philadelphia Phillies
10/4/25 5:09PM
Dodgers
Phillies
|
–
–
|
+108
-126
|
pk
pk
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O 7 (-135)
U 7 (+115)
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MLB Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers San Francisco Giants vs. St. Louis Cardinals on September 06, 2025 at Busch Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.
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LEAN | %WIN | UNITS | RESULT |
---|---|---|---|---|
ARI@SD | SD -131 | 57.3% | 4 | WIN |
DET@BOS | BOS -115 | 56.4% | 5 | WIN |
NYM@CHC | NYM -110 | 54.1% | 3 | WIN |
HOU@ATH | ATH +118 | 50.8% | 4 | WIN |
NYM@CHC | OVER 7 | 54.5% | 3 | WIN |
STL@SF | OVER 7.5 | 55.9% | 5 | LOSS |
KC@LAA | TYLER TOLBERT UNDER 1.5 BASES | 54.4% | 4 | WIN |
MIL@SD | UNDER 9 | 54.7% | 4 | WIN |
MIA@PHI | KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS | 53.3% | 3 | WIN |
WAS@NYM | OVER 8.5 | 56.1% | 6 | LOSS |
LAA@COL | COL +108 | 50.5% | 3 | WIN |
TOR@KC | UNDER 9 | 54.7% | 4 | LOSS |
SEA@KC | KC +1.5 | 62.3% | 5 | LOSS |
NYY@MIN | OVER 9 | 55.1% | 4 | WIN |
MIA@COL | OVER 10.5 | 55.0% | 4 | WIN |
MIA@COL | AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS | 54.3% | 4 | WIN |
SEA@KC | BOBBY WITT UNDER 0.5 SINGLES | 54.4% | 4 | LOSS |
PHI@LAD | LAD -113 | 54.7% | 4 | LOSS |
NYY@BOS | OVER 7.5 | 54.3% | 3 | WIN |
KC@PHI | PHI -130 | 58.3% | 4 | WIN |
LAD@SF | OVER 7.5 | 54.7% | 4 | LOSS |
NYM@PHI | PHI -122 | 55.6% | 4 | WIN |
KC@CLE | KC -104 | 52.0% | 3 | WIN |
CIN@SD | JAKE CRONEWORTH OVER 0.5 HITS | 53.1% | 3 | WIN |
WAS@MIA | MIA -123 | 55.2% | 4 | LOSS |
LAA@KC | UNDER 9.5 | 54.9% | 3 | WIN |
TEX@ARI | UNDER 9 | 54.2% | 4 | WIN |
SF@COL | UNDER 11.5 | 56.4% | 6 | LOSS |
SF@COL | RAFAEL DEVERS OVER 1.5 BASES | 56.1% | 6 | WIN |
MIA@WAS | WAS -110 | 54.4% | 4 | WIN |
NYM@DET | OVER 8.5 | 54.5% | 4 | WIN |
TEX@ARI | UNDER 9.5 | 56.4% | 6 | WIN |
TEX@ARI | ALEJANDRO OSUNA UNDER 1.5 BASES | 54.1% | 4 | LOSS |
ATL@CHC | CHC -116 | 55.1% | 3 | WIN |
PHI@MIL | OVER 8.5 | 55.0% | 3 | WIN |
ARI@LAD | SHOHEI OHTANI OVER 2.5 BASES | 54.2% | 4 | WIN |
SEA@CLE | CLE +1.5 | 57.2% | 3 | WIN |
CHC@SF | CHC -105 | 54.1% | 4 | LOSS |
NYY@CHW | RYAN MCMAHON OVER 0.5 BASES | 54.1% | 4 | WIN |
PHI@NYM | OVER 8.5 | 55.6% | 4 | LOSS |
LAA@TEX | LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS | 54.1% | 4 | LOSS |
KC@CHW | KC -109 | 54.2% | 4 | WIN |
SD@SEA | DYLAN CEASE OVER 16.5 OUTS | 53.9% | 3 | LOSS |
SD@SEA | UNDER 8.5 | 54.4% | 4 | LOSS |
MIN@TOR | JOE RYAN UNDER 2.5 EARNED RUNS | 54.1% | 4 | LOSS |
SF@MIL | MIL +100 | 54.0% | 6 | LOSS |
TOR@MIA | MIA +1.5 | 62.0% | 6 | WIN |
CHC@LAA | OVER 9.5 | 54.9% | 4 | LOSS |
BOS@NYY | CARLOS RODON UNDER 4.5 HITS ALLOWED | 54.2% | 4 | WIN |
KC@DET | DET -115 | 56.1% | 5 | WIN |
CHC@LAA | LAA +1.5 | 57.6% | 5 | LOSS |