Giants vs. Cardinals
Prediction, Odds & Props
Sep 05 | MLB AI Picks
Updated: 2025-09-03T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The San Francisco Giants (71–69) visit the St. Louis Cardinals (70–71) for a key late-season matchup on Friday, September 5 at Busch Stadium, with first pitch at 7:15 p.m. CDT. San Francisco sends Carson Seymour (0–2, 4.74 ERA) to the mound, while St. Louis counters with Michael McGreevy (6–2, 4.17 ERA)—a duel that could hinge on who controls the strike zone early.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

GAME INFO
Date: Sep 05, 2025
Start Time: 8:15 PM EST
Venue: Busch Stadium
Cardinals Record: (70-71)
Giants Record: (71-69)
OPENING ODDS
SF Moneyline: -101
STL Moneyline: -119
SF Spread: -1.5
STL Spread: +1.5
Over/Under: 8.5
SF
Betting Trends
- On the road, the Giants have been an average ATS performer, with no standout edge in recent results but generally competitive in closely matched games.
STL
Betting Trends
- At home, the Cardinals have hovered around break-even ATS, suggesting they’re reliable in run-line matchups but not dominant.
MATCHUP TRENDS
- With nearly identical records and run-line history, this matchup shapes up as one where moneyline moves little and run-line nuances matter—a one-run or tight outcome is likely.
SF vs. STL
Best Prop Bet
- Remi's searched hard and found the best prop for this matchup: P. Pages over 0.5 Hits+Runs+RBI.
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San Francisco vs St. Louis Prediction & Odds:
Free MLB Betting Insights for 9/5/25
Offensively, the Giants don’t overwhelm with power but thrive when they extend innings, apply pressure, and let opportunistic bats like Wilmer Flores or Patrick Bailey cash in with runners in scoring position, while the Cardinals’ attack relies on situational hitting and the occasional long ball from Arenado or Lars Nootbaar to flip momentum in front of a Busch Stadium crowd that has been waiting for sustained consistency all season. Defensively, both teams have improved execution over the summer, with San Francisco leaning on cleaner infield work to support their pitchers and St. Louis cutting down the sloppy miscues that plagued them earlier, meaning this game could come down to which side avoids the costly unforced error. In the bullpens, San Francisco’s high-leverage arms offer swing-and-miss ability but have been inconsistent with command, while the Cardinals’ relief corps has recently found stability with defined roles and a reliable closer, giving them confidence if McGreevy can hand off a lead. From a betting perspective, both clubs have hovered near neutral ATS profiles, but the Giants’ ability to cover as road underdogs versus the Cardinals’ uneven run-line performance at home hints at another game that is more likely to stay within one run than swing into a blowout. Ultimately, the matchup’s outcome may hinge on whether Seymour can give San Francisco five solid innings without exposing the bullpen too early, whether McGreevy can continue to overachieve with his efficient sequencing, and which lineup capitalizes first in a game where scoring chances will be at a premium; whichever team executes in those margins will not only grab a critical late-season win but also strengthen its case to stay alive in the National League playoff conversation.
On to St. Louis 🛫
— SFGiants (@SFGiants) September 4, 2025
(#SFGiants x @NationalPro) pic.twitter.com/ueJxqp88Au
San Francisco Giants MLB Preview
For the San Francisco Giants, this trip to Busch Stadium represents a pivotal moment in their late-season push, as they arrive at 71–69 with Wild Card hopes still alive but fragile, and the challenge of facing the Cardinals on the road falls squarely on Carson Seymour, the rookie right-hander who has yet to record his first major league win and enters with a 4.74 ERA that tells the story of both promise and inconsistency. Seymour’s arsenal—a mid-90s fastball with life paired with a sweeping slider—gives him the tools to compete at this level, but his biggest hurdle has been command, as elevated pitch counts and poorly timed walks have too often forced San Francisco’s bullpen into early action, something they cannot afford against a Cardinals lineup that thrives on situational hitting. For the Giants, the offensive blueprint is built around discipline and contact: LaMonte Wade Jr.’s patient approach at the top sets the table, Jung Hoo Lee’s speed creates havoc when he gets on base, and Wilmer Flores and Patrick Bailey provide the kind of timely hitting that allows San Francisco to manufacture runs even in low-scoring environments. Power has not been their defining trait, but stringing together singles, working deep counts, and taking advantage of defensive miscues have kept them competitive in close games, and against McGreevy’s contact-oriented style, that approach could be the difference.
Defensively, the Giants have improved steadily, particularly in the infield where crisp double-play execution has helped pitchers escape jams, and their ability to play clean behind Seymour will be vital in a ballpark where extended innings often lead to crooked numbers. The bullpen, long a backbone of this team, remains capable of missing bats and protecting narrow leads, but inconsistency with control has created unnecessary drama, and the coaching staff will look for stability if handed a game in the balance in the seventh or later. From a betting perspective, San Francisco has been a reliable road underdog this season, often keeping games close enough to cover the spread even when they fail to win outright, and that trend underscores their identity as a grind-it-out club that refuses to get blown out. The formula for the Giants to succeed is straightforward but difficult: Seymour must find the strike zone early and work into at least the fifth inning, Wade and Lee must get on base to set the table, Flores or Bailey must deliver the key hit with runners in scoring position, and the bullpen must throw strikes late to prevent the Cardinals from stealing momentum. If those pieces come together, the Giants not only have the chance to earn a vital road win but also to reinforce their reputation as a resilient team built for close games, the type of resilience that can keep them alive in the playoff race into the final weeks of September.

Credit: USA TODAY/IMAGN
St. Louis Cardinals MLB Preview
For the St. Louis Cardinals, Friday’s matchup against the Giants is a chance to climb back to .500 and prove that their late-season push still has teeth, as they enter at 70–71 and lean on right-hander Michael McGreevy to steady them against a San Francisco club that has made a habit of grinding out close games. McGreevy has been one of the few bright spots in a turbulent rotation, compiling a 6–2 record and a 4.17 ERA by trusting his defense and pitching to contact, and his approach—working the edges with a low-90s fastball, mixing in sliders, and keeping the ball on the ground—suits Busch Stadium’s dimensions, provided he avoids falling behind in counts against disciplined Giants hitters like LaMonte Wade Jr. and Jung Hoo Lee. Offensively, St. Louis continues to ride the veteran presence of Nolan Arenado, whose ability to deliver extra-base hits in leverage moments remains invaluable, while Tommy Edman provides a versatile spark with contact hitting and speed, and Lars Nootbaar and Brendan Donovan round out a lineup that doesn’t overwhelm with power but thrives when it strings together quality at-bats. The Cardinals’ offensive key lies in execution with runners in scoring position, an area that has haunted them in stretches, but when they capitalize, their ability to manufacture crooked innings returns. Defensively, the team has cleaned up its play over the past month, cutting down on the errors that plagued them earlier in the season, and that improvement has directly benefited pitchers like McGreevy, who relies on sharp infield work to turn ground balls into outs.
The bullpen has also found greater clarity, with roles defined more firmly—Ryan Helsley anchoring the ninth and middle relievers embracing matchup-based assignments—giving manager Oli Marmol confidence to shorten games when his starter exits with a lead. From a betting perspective, the Cardinals have been around break-even ATS at home, which reflects their tendency to play close games but also their difficulty covering margins, making them more of a moneyline team than a run-line value at Busch Stadium. The formula for victory is clear: McGreevy must pitch efficiently and limit free passes, the lineup must find a way to push through against Carson Seymour early to avoid a late bullpen duel, and the relievers must execute cleanly without offering San Francisco the kind of late-game openings they thrive on. If St. Louis can follow that blueprint—grabbing an early lead, leaning on their defense, and letting Arenado or Edman spark the offense—they not only can even their record but also remind the league that their blend of veteran presence and emerging arms makes them dangerous down the stretch, especially at home where their fans demand meaningful September baseball.
On to St. Louis 🛫
— SFGiants (@SFGiants) September 4, 2025
(#SFGiants x @NationalPro) pic.twitter.com/ueJxqp88Au
San Francisco vs. St. Louis Prop Picks (AI)
San Francisco vs. St. Louis Prediction (AI)

Remi, our AI sports wizard, has been pouring over mountains of data from every past game between the Giants and Cardinals and using recursive machine learning and impressive AI to examine the data to a single cover probability.
Oddly enough, we’ve seen the AI has been most watching on the growing factor human bettors tend to put on San Francisco’s strength factors between a Giants team going up against a possibly improved Cardinals team. It appears the true game analytics appear to reflect a slight lean against one Vegas line specifically.
Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.
Below is our current AI San Francisco vs St. Louis picks, computer picks Giants vs Cardinals, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
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MLB | 10/1 | SD@CHC | UNLOCK THIS PICK | 4 |
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MLB | 10/1 | SD@CHC | UNLOCK THIS PICK | 4 |
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MLB | 10/1 | CIN@LAD | UNLOCK THIS PICK | 3 |
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MLB | 10/1 | CIN@LAD | UNLOCK THIS PICK | 2 |
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MLB | 10/1 | DET@CLE | UNLOCK THIS PICK | 2 |
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MLB | 10/1 | DET@CLE | UNLOCK THIS PICK | 1 |
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MLB | 10/1 | BOS@NYY | UNLOCK THIS PICK | 1 |
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MLB | 10/1 | CIN@LAD | GET FREE PICK NOW | 1 | – | |
MLB | 10/1 | BOS@NYY | UNLOCK THIS PICK | 0 |
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MLB | 10/1 | BOS@NYY | GET FREE PICK NOW | 0 | – |
These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.
Giants Betting Trends
On the road, the Giants have been an average ATS performer, with no standout edge in recent results but generally competitive in closely matched games.
Cardinals Betting Trends
At home, the Cardinals have hovered around break-even ATS, suggesting they’re reliable in run-line matchups but not dominant.
Giants vs. Cardinals Matchup Trends
With nearly identical records and run-line history, this matchup shapes up as one where moneyline moves little and run-line nuances matter—a one-run or tight outcome is likely.
San Francisco vs. St. Louis Game Info
What time does San Francisco vs St. Louis start on September 05, 2025?
San Francisco vs St. Louis starts on September 05, 2025 at 8:15 PM EST.
Where is San Francisco vs St. Louis being played?
Venue: Busch Stadium.
What are the opening odds for San Francisco vs St. Louis?
Spread: St. Louis +1.5
Moneyline: San Francisco -101, St. Louis -119
Over/Under: 8.5
What are the records for San Francisco vs St. Louis?
San Francisco: (71-69) | St. Louis: (70-71)
What is the AI best bet for San Francisco vs St. Louis?
Remi's searched hard and found the best prop for this matchup: P. Pages over 0.5 Hits+Runs+RBI.. Prices move—always shop for the best number.
What are San Francisco vs St. Louis trending bets?
With nearly identical records and run-line history, this matchup shapes up as one where moneyline moves little and run-line nuances matter—a one-run or tight outcome is likely.
What are San Francisco trending bets?
SF trend: On the road, the Giants have been an average ATS performer, with no standout edge in recent results but generally competitive in closely matched games.
What are St. Louis trending bets?
STL trend: At home, the Cardinals have hovered around break-even ATS, suggesting they’re reliable in run-line matchups but not dominant.
Where can I find AI Picks for San Francisco vs St. Louis?
See our latest MLB picks and odds pages for 2025 to compare prices before you bet.
San Francisco vs. St. Louis Odds
AI algorithm Remi is pouring through tons of data on each team. In fact, anytime the San Francisco vs St. Louis trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme temps seemingly never follow normal, predictable patterns.
San Francisco vs St. Louis Opening Odds
SF Moneyline:
-101 STL Moneyline: -119
SF Spread: -1.5
STL Spread: +1.5
Over/Under: 8.5
San Francisco vs St. Louis Live Odds
Games | PTS | ML | SPR | O/U | |
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Oct 2, 2025 3:08PM EDT
Detroit Tigers
Cleveland Guardians
10/2/25 3:08PM
Tigers
Guardians
|
–
–
|
+100
-120
|
-1.5 (+175)
+1.5 (-215)
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O 7 (-105)
U 7 (-115)
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Oct 2, 2025 5:08PM EDT
San Diego Padres
Chicago Cubs
10/2/25 5:08PM
Padres
Cubs
|
–
–
|
+100
-118
|
-1.5 (+172)
+1.5 (-210)
|
O 7.5 (-110)
U 7.5 (-110)
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Oct 2, 2025 8:08PM EDT
Boston Red Sox
New York Yankees
10/2/25 8:08PM
Red Sox
Yankees
|
–
–
|
+136
-162
|
+1.5 (-160)
-1.5 (+130)
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O 7.5 (-120)
U 7.5 (-102)
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Oct 4, 2025 2:30PM EDT
Los Angeles Dodgers
Philadelphia Phillies
10/4/25 2:30PM
Dodgers
Phillies
|
–
–
|
+110
-130
|
pk
pk
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Oct 4, 2025 5:09PM EDT
Los Angeles Dodgers
Philadelphia Phillies
10/4/25 5:09PM
Dodgers
Phillies
|
–
–
|
+108
-126
|
pk
pk
|
O 7 (-135)
U 7 (+115)
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MLB Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers San Francisco Giants vs. St. Louis Cardinals on September 05, 2025 at Busch Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.
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LEAN | %WIN | UNITS | RESULT |
---|---|---|---|---|
ARI@SD | SD -131 | 57.3% | 4 | WIN |
DET@BOS | BOS -115 | 56.4% | 5 | WIN |
NYM@CHC | NYM -110 | 54.1% | 3 | WIN |
HOU@ATH | ATH +118 | 50.8% | 4 | WIN |
NYM@CHC | OVER 7 | 54.5% | 3 | WIN |
STL@SF | OVER 7.5 | 55.9% | 5 | LOSS |
KC@LAA | TYLER TOLBERT UNDER 1.5 BASES | 54.4% | 4 | WIN |
MIL@SD | UNDER 9 | 54.7% | 4 | WIN |
MIA@PHI | KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS | 53.3% | 3 | WIN |
WAS@NYM | OVER 8.5 | 56.1% | 6 | LOSS |
LAA@COL | COL +108 | 50.5% | 3 | WIN |
TOR@KC | UNDER 9 | 54.7% | 4 | LOSS |
SEA@KC | KC +1.5 | 62.3% | 5 | LOSS |
NYY@MIN | OVER 9 | 55.1% | 4 | WIN |
MIA@COL | OVER 10.5 | 55.0% | 4 | WIN |
MIA@COL | AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS | 54.3% | 4 | WIN |
SEA@KC | BOBBY WITT UNDER 0.5 SINGLES | 54.4% | 4 | LOSS |
PHI@LAD | LAD -113 | 54.7% | 4 | LOSS |
NYY@BOS | OVER 7.5 | 54.3% | 3 | WIN |
KC@PHI | PHI -130 | 58.3% | 4 | WIN |
LAD@SF | OVER 7.5 | 54.7% | 4 | LOSS |
NYM@PHI | PHI -122 | 55.6% | 4 | WIN |
KC@CLE | KC -104 | 52.0% | 3 | WIN |
CIN@SD | JAKE CRONEWORTH OVER 0.5 HITS | 53.1% | 3 | WIN |
WAS@MIA | MIA -123 | 55.2% | 4 | LOSS |
LAA@KC | UNDER 9.5 | 54.9% | 3 | WIN |
TEX@ARI | UNDER 9 | 54.2% | 4 | WIN |
SF@COL | UNDER 11.5 | 56.4% | 6 | LOSS |
SF@COL | RAFAEL DEVERS OVER 1.5 BASES | 56.1% | 6 | WIN |
MIA@WAS | WAS -110 | 54.4% | 4 | WIN |
NYM@DET | OVER 8.5 | 54.5% | 4 | WIN |
TEX@ARI | UNDER 9.5 | 56.4% | 6 | WIN |
TEX@ARI | ALEJANDRO OSUNA UNDER 1.5 BASES | 54.1% | 4 | LOSS |
ATL@CHC | CHC -116 | 55.1% | 3 | WIN |
PHI@MIL | OVER 8.5 | 55.0% | 3 | WIN |
ARI@LAD | SHOHEI OHTANI OVER 2.5 BASES | 54.2% | 4 | WIN |
SEA@CLE | CLE +1.5 | 57.2% | 3 | WIN |
CHC@SF | CHC -105 | 54.1% | 4 | LOSS |
NYY@CHW | RYAN MCMAHON OVER 0.5 BASES | 54.1% | 4 | WIN |
PHI@NYM | OVER 8.5 | 55.6% | 4 | LOSS |
LAA@TEX | LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS | 54.1% | 4 | LOSS |
KC@CHW | KC -109 | 54.2% | 4 | WIN |
SD@SEA | DYLAN CEASE OVER 16.5 OUTS | 53.9% | 3 | LOSS |
SD@SEA | UNDER 8.5 | 54.4% | 4 | LOSS |
MIN@TOR | JOE RYAN UNDER 2.5 EARNED RUNS | 54.1% | 4 | LOSS |
SF@MIL | MIL +100 | 54.0% | 6 | LOSS |
TOR@MIA | MIA +1.5 | 62.0% | 6 | WIN |
CHC@LAA | OVER 9.5 | 54.9% | 4 | LOSS |
BOS@NYY | CARLOS RODON UNDER 4.5 HITS ALLOWED | 54.2% | 4 | WIN |
KC@DET | DET -115 | 56.1% | 5 | WIN |
CHC@LAA | LAA +1.5 | 57.6% | 5 | LOSS |