Guardians vs. Rays
Prediction, Odds & Props
Sep 05 | MLB AI Picks

Updated: 2025-09-03T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

A pivotal AL wild-card series continues Friday at 7:35 p.m. ET when the Cleveland Guardians visit the Tampa Bay Rays at George M. Steinbrenner Field, with right-handers Gavin Williams and Ian Seymour listed as the probable starters. Tampa Bay took the opener and enters on a seven-game win streak, while Cleveland looks to square the set behind power from José Ramírez and emerging first baseman Kyle Manzardo.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Sep 05, 2025

Start Time: 7:35 PM EST​

Venue: George M. Steinbrenner Field​

Rays Record: (71-69)

Guardians Record: (69-70)

OPENING ODDS

CLE Moneyline: +119

TB Moneyline: -142

CLE Spread: +1.5

TB Spread: -1.5

Over/Under: 8

CLE
Betting Trends

  • Cleveland is 42–25 against the run line as the away team this season (62.7%).

TB
Betting Trends

  • Tampa Bay is 25–42 against the run line at home this season (37.3%).

MATCHUP TRENDS

  • The Guardians are 32–14 ATS as road underdogs (69.6%), while the Rays are 19–32 ATS as home favorites; market listings have Tampa Bay favored with a total around 8.

CLE vs. TB
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: K. Manzardo over 0.5 Total Bases.

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Cleveland vs Tampa Bay Prediction & Odds:
Free MLB Betting Insights for 9/5/25

Friday’s matchup between the Cleveland Guardians and Tampa Bay Rays at George M. Steinbrenner Field carries playoff implications and the tension of two clubs on very different recent arcs, with Tampa Bay surging on a seven-game win streak and Cleveland trying to steady itself after dropping the opener of this series, and the pitching duel of Gavin Williams versus Ian Seymour provides an intriguing contrast in styles that could dictate the outcome. Williams, a hard-throwing right-hander with a lively four-seam fastball and power slider, has the arsenal to neutralize a Rays lineup that thrives on patience and opportunistic swings, but his challenge will be to consistently get ahead in counts; when he does, hitters are forced to chase the slider, but when he falls behind, Tampa Bay’s disciplined bats like Yandy Díaz and Brandon Lowe have the leverage to work walks and extend innings. Seymour, on the other hand, is a younger lefty still finding his rhythm but one who has shown flashes of real poise with a fastball/changeup mix that plays when he can steal early strikes, and his test will be navigating José Ramírez and Kyle Manzardo, the switch-hitting and left-handed power threats who can turn games with one swing. Offensively, Cleveland depends heavily on Ramírez as the centerpiece, with Manzardo’s recent growth adding protection and Steven Kwan providing elite contact skills at the top of the order, and their formula is to scratch out runs with timely hitting rather than sheer power, then shorten games with a bullpen that has ranked among the league’s better groups when protecting small leads.

Tampa Bay, meanwhile, has found its stride behind a lineup anchored by Díaz’s table-setting, Junior Caminero’s emerging thump, and Lowe’s lefty lift, and their approach is built on grinding out at-bats, taking extra bases, and executing situational plays that turn modest opportunities into crooked numbers. Defensively, both teams have been steady of late, but the Rays’ sharper relay work during their win streak has stood out, while Cleveland’s infield efficiency has been vital to supporting pitchers like Williams who lean on contact when their swing-and-miss pitches aren’t fully biting. From a betting perspective, the edges lean toward Cleveland against the run line—they’re 42–25 ATS on the road and a remarkable 32–14 as away underdogs, profiles that show their ability to keep games within one run even in losses—while Tampa Bay has struggled in that department, just 25–42 ATS at home and 19–32 as a home favorite, a reminder that while they win often, they don’t always do so by margin. The keys to watch will be whether Williams establishes his fastball up in the zone to set up the slider, if Seymour can command the changeup against Cleveland’s right-handed bats, and which bullpen avoids the costly free pass in the late innings. In the end, Tampa Bay’s momentum and home energy tilt them toward the favorite’s side, but Cleveland’s ability to grind on the road, cover spreads, and live in one-run games suggests that this contest could come down to a single extra-base hit or defensive play, making it a tight, playoff-caliber battle where every pitch matters.

Cleveland Guardians MLB Preview

For the Cleveland Guardians, this matchup in Tampa represents both a challenge and an opportunity to reset after dropping the opener of the series, and with Gavin Williams on the mound, their formula is built around power pitching, tight defense, and timely hitting from a core that has kept them alive in the postseason chase all summer. Williams has the tools to quiet the Rays’ lineup when he’s commanding—his mid-to-high 90s fastball rides at the top of the zone, his slider dives late, and when paired effectively, those pitches generate whiffs and grounders that allow Cleveland’s infield to control tempo—but he must avoid falling behind early, as Tampa Bay’s disciplined bats like Yandy Díaz and Brandon Lowe thrive in hitter’s counts. Offensively, the Guardians are defined by José Ramírez, who continues to be the engine of their lineup with switch-hitting power, a knack for clutch hits, and savvy baserunning that manufactures runs in tight contests, and he’s complemented by Kyle Manzardo, whose left-handed bat has provided much-needed protection and lift, while Steven Kwan adds elite contact skills and table-setting ability at the top. Cleveland’s offense is rarely explosive, but when they string together singles, draw the occasional walk, and get one timely extra-base hit, they create enough margin for their arms to finish the job, especially with a bullpen that has been a strength all year, ranking among the league’s better units in leverage performance and strikeout rate.

Defensively, the Guardians excel at converting balls in play, with their infield in particular helping pitchers like Williams who lean on weak contact when strikeouts aren’t abundant, and that precision will be vital in a ballpark where extra outs can flip the outcome. The challenge lies in cracking Ian Seymour, a lefty whose fastball-changeup combo plays well against lineups that lack consistent power, and Cleveland must resist expanding at the bottom of the zone, force him into full counts, and capitalize on any mistakes left over the plate. From a betting perspective, Cleveland has been one of MLB’s best road teams against the spread, covering 62.7% overall and an impressive 69.6% as road underdogs, a reflection of their ability to keep games within a run even when they don’t win outright, which bodes well against a Rays team that often wins close but struggles to cover at home. The Guardians’ winning script is straightforward: Williams must command early and hold Tampa Bay’s top-of-the-order hitters in check, Ramírez and Manzardo must produce at least one key run-scoring hit, and the bullpen must carry a late lead or tie with precision and discipline. If they execute that plan, Cleveland not only has a path to evening the series but also reinforces their reputation as one of the league’s toughest underdogs, capable of frustrating streaking opponents by grinding out every pitch and living in the margins where postseason contenders are ultimately defined.

A pivotal AL wild-card series continues Friday at 7:35 p.m. ET when the Cleveland Guardians visit the Tampa Bay Rays at George M. Steinbrenner Field, with right-handers Gavin Williams and Ian Seymour listed as the probable starters. Tampa Bay took the opener and enters on a seven-game win streak, while Cleveland looks to square the set behind power from José Ramírez and emerging first baseman Kyle Manzardo.   Cleveland vs Tampa Bay AI Prediction: Free MLB Betting Insights for Sep 05. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Tampa Bay Rays MLB Preview

For the Tampa Bay Rays, this second game of the series against the Cleveland Guardians is about sustaining momentum from a seven-game win streak and proving that their brand of baseball—disciplined at-bats, situational execution, and a bullpen that thrives in leverage—can continue to carry them deeper into September. Ian Seymour, the young left-hander slated to start, represents a key piece of that plan, as his fastball/changeup mix has shown the ability to keep right-handed hitters off balance when he establishes first-pitch strikes, and the Guardians’ lineup, led by José Ramírez and Kyle Manzardo, will test whether he can execute consistently without falling into hitter’s counts. Tampa Bay’s offense has leaned on Yandy Díaz as its on-base engine, Junior Caminero’s raw power as the middle-order hammer, and Brandon Lowe’s ability to drive the ball to the pull side, and this trio has set the tone in their recent surge, providing enough balance to keep opponents on the defensive from the first inning on. The Rays’ lineup approach under manager Kevin Cash emphasizes patience and pressure, forcing pitchers to throw quality strikes while capitalizing on every extra base or defensive miscue, and at Steinbrenner Field, where the spacious gaps reward line drives and hustle, their style has translated into relentless traffic that wears down starters.

Defensively, Tampa Bay has cleaned up the mistakes that plagued them earlier in the summer, with sharper infield work and improved relay timing in the outfield, which has been instrumental in preventing teams from turning singles into runs. The bullpen, anchored by Pete Fairbanks in the ninth and supported by a mix of power righties and situational lefties, has found more stability as roles have clarified, giving the Rays confidence that if Seymour can navigate five or six innings, they have the arms to slam the door late. From a betting standpoint, Tampa Bay’s 25–42 ATS record at home and 19–32 mark as a home favorite show that while they often win outright, they don’t always do so by margin, meaning their victories frequently come in tight, one-run fashion; however, their current streak suggests they’ve begun finding ways to win both comfortably and in grind-it-out style. To continue this run, Tampa Bay must pressure Gavin Williams by extending at-bats, look to draw walks that turn into scoring chances for their power bats, and avoid chasing his high fastball that plays when hitters expand the zone. If Seymour executes his plan, Díaz and Caminero set the tone offensively, and the bullpen protects a late lead with strikes instead of walks, the Rays not only have a strong chance to take the series but also reinforce that their balanced, detail-driven approach is built to wear down opponents in September, keeping them dangerous whether they win with power, speed, or pitching precision.

Cleveland vs. Tampa Bay Prop Picks (AI)

AI algorithm Remi is pouring through mountains of data on each player. In fact, anytime the Guardians and Rays play there’s always several intriguing angles to key in on. Not to mention games played at George M. Steinbrenner Field in Sep almost always follow normal, predictable patterns.
Remi's searched hard and found the best prop for this matchup: K. Manzardo over 0.5 Total Bases.

Cleveland vs. Tampa Bay Prediction (AI)

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Remi, our AI sports genius, has been pouring over tons of data from every facet between the Guardians and Rays and using recursive machine learning and cutting-edge AI to boil down the data to a single cover probability.

Remi has been most focused on the trending emphasis knucklehead sportsbettors often put on coaching factors between a Guardians team going up against a possibly strong Rays team. We’ve found the true game analytics might reflect a moderate lean against one Vegas line specifically.

Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.

Below is our current AI Cleveland vs Tampa Bay picks, computer picks Guardians vs Rays, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
MLB 10/1 SD@CHC UNLOCK THIS PICK 4 INTEL Locked INTEL
MLB 10/1 SD@CHC UNLOCK THIS PICK 4 EXECUTIVE Locked EXECUTIVE
MLB 10/1 CIN@LAD UNLOCK THIS PICK 3 EXECUTIVE Locked EXECUTIVE
MLB 10/1 CIN@LAD UNLOCK THIS PICK 2 INTEL Locked INTEL
MLB 10/1 DET@CLE UNLOCK THIS PICK 2 INTEL Locked INTEL
MLB 10/1 DET@CLE UNLOCK THIS PICK 1 INTEL Locked INTEL
MLB 10/1 BOS@NYY UNLOCK THIS PICK 1 INTEL Locked INTEL
MLB 10/1 CIN@LAD GET FREE PICK NOW 1
MLB 10/1 BOS@NYY UNLOCK THIS PICK 0 INTEL Locked INTEL
MLB 10/1 BOS@NYY GET FREE PICK NOW 0

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.

Guardians Betting Trends

Cleveland is 42–25 against the run line as the away team this season (62.7%).

Rays Betting Trends

Tampa Bay is 25–42 against the run line at home this season (37.3%).

Guardians vs. Rays Matchup Trends

The Guardians are 32–14 ATS as road underdogs (69.6%), while the Rays are 19–32 ATS as home favorites; market listings have Tampa Bay favored with a total around 8.

Cleveland vs. Tampa Bay Game Info

Cleveland vs Tampa Bay starts on September 05, 2025 at 7:35 PM EST.

Venue: George M. Steinbrenner Field.

Spread: Tampa Bay -1.5
Moneyline: Cleveland +119, Tampa Bay -142
Over/Under: 8

Cleveland: (69-70)  |  Tampa Bay: (71-69)

Remi's searched hard and found the best prop for this matchup: K. Manzardo over 0.5 Total Bases.. Prices move—always shop for the best number.

The Guardians are 32–14 ATS as road underdogs (69.6%), while the Rays are 19–32 ATS as home favorites; market listings have Tampa Bay favored with a total around 8.

CLE trend: Cleveland is 42–25 against the run line as the away team this season (62.7%).

TB trend: Tampa Bay is 25–42 against the run line at home this season (37.3%).

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

Cleveland vs. Tampa Bay Odds

Remi is pouring through loads of data on each line. In fact, anytime the Cleveland vs Tampa Bay trends are analyzed, there’s always several intriguing trends to key in on. Not to mention games played at extreme temps seemingly never follow normal, predictable betting trends.

Cleveland vs Tampa Bay Opening Odds

CLE Moneyline: +119
TB Moneyline: -142
CLE Spread: +1.5
TB Spread: -1.5
Over/Under: 8

Cleveland vs Tampa Bay Live Odds

Games PTS ML SPR O/U
Oct 2, 2025 3:08PM EDT
Detroit Tigers
Cleveland Guardians
10/2/25 3:08PM
Tigers
Guardians
+100
-120
-1.5 (+175)
+1.5 (-215)
O 7 (-105)
U 7 (-115)
Oct 2, 2025 5:08PM EDT
San Diego Padres
Chicago Cubs
10/2/25 5:08PM
Padres
Cubs
+100
-118
-1.5 (+172)
+1.5 (-210)
O 7.5 (-110)
U 7.5 (-110)
Oct 2, 2025 8:08PM EDT
Boston Red Sox
New York Yankees
10/2/25 8:08PM
Red Sox
Yankees
+136
-162
+1.5 (-160)
-1.5 (+130)
O 7.5 (-120)
U 7.5 (-102)
Oct 4, 2025 2:30PM EDT
Los Angeles Dodgers
Philadelphia Phillies
10/4/25 2:30PM
Dodgers
Phillies
+110
-130
pk
pk
Oct 4, 2025 5:09PM EDT
Los Angeles Dodgers
Philadelphia Phillies
10/4/25 5:09PM
Dodgers
Phillies
+108
-126
pk
pk
O 7 (-135)
U 7 (+115)

MLB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Cleveland Guardians vs. Tampa Bay Rays on September 05, 2025 at George M. Steinbrenner Field.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
ARI@SD SD -131 57.3% 4 WIN
DET@BOS BOS -115 56.4% 5 WIN
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN
CHC@SF CHC -105 54.1% 4 LOSS
NYY@CHW RYAN MCMAHON OVER 0.5 BASES 54.1% 4 WIN
PHI@NYM OVER 8.5 55.6% 4 LOSS
LAA@TEX LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS 54.1% 4 LOSS
KC@CHW KC -109 54.2% 4 WIN
SD@SEA DYLAN CEASE OVER 16.5 OUTS 53.9% 3 LOSS
SD@SEA UNDER 8.5 54.4% 4 LOSS
MIN@TOR JOE RYAN UNDER 2.5 EARNED RUNS 54.1% 4 LOSS
SF@MIL MIL +100 54.0% 6 LOSS
TOR@MIA MIA +1.5 62.0% 6 WIN
CHC@LAA OVER 9.5 54.9% 4 LOSS
BOS@NYY CARLOS RODON UNDER 4.5 HITS ALLOWED 54.2% 4 WIN
KC@DET DET -115 56.1% 5 WIN
CHC@LAA LAA +1.5 57.6% 5 LOSS