Sox vs. Diamondbacks
Prediction, Odds & Props
Sep 05 | MLB AI Picks
Updated: 2025-09-03T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The Boston Red Sox (78–63) continue their road series in Phoenix against the Arizona Diamondbacks (70–71), with first pitch set for 9:40 p.m. ET on Friday, September 5, in what promises to be a high-leverage interleague matchup. Boston will send rookie left-hander Payton Tolle (0–0, 3.38 ERA in his debut) to the mound against Arizona’s Eduardo Rodríguez (6–8, 5.40 ERA), creating a compelling contrast between emerging talent and seasoned veteran.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

GAME INFO
Date: Sep 05, 2025
Start Time: 9:40 PM EST
Venue: Chase Field
Diamondbacks Record: (70-71)
Sox Record: (78-63)
OPENING ODDS
BOS Moneyline: -128
ARI Moneyline: +107
BOS Spread: -1.5
ARI Spread: +1.5
Over/Under: 8.5
BOS
Betting Trends
- Boston is 5–5 against the run line in their last ten road games, showing balanced performance but no consistent edge away from home.
ARI
Betting Trends
- The Diamondbacks are 26–24 at home this season, indicating solid home form but not runaway dominance.
MATCHUP TRENDS
- Odds place Boston as a modest favorite (roughly –128 moneyline, –1.5 run line), implying tight scoring; projections suggest a 6–5 outcome in Arizona’s favor, highlighting the potential for a close, competitive game.
BOS vs. ARI
Best Prop Bet
- Remi's searched hard and found the best prop for this matchup: C. Carroll over 5.5 Fantasy Score.
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Boston Red vs Arizona Prediction & Odds:
Free MLB Betting Insights for 9/5/25
Defensively, both clubs have been sharper in recent weeks, but Chase Field’s large gaps reward range and precision, making clean outfield play critical to preventing singles from turning into extra-base hits. The bullpens may ultimately decide the outcome, with Boston’s relief corps offering power arms that can shut down innings but occasionally losing the strike zone, while Arizona’s relievers have been steadier at home, giving manager Torey Lovullo confidence in close games. From a betting perspective, Boston has been modestly consistent on the road, splitting their last 10 games against the spread, while Arizona sits slightly above .500 at 26–24 at home, a sign that both teams tend to play close, coin-flip style contests in their respective splits. Oddsmakers peg Boston as a slight favorite, but the projected scorelines lean toward a tight finish, making the run line more volatile than the moneyline. Keys to the game include whether Tolle can extend into the sixth inning without unraveling, if Rodríguez can avoid the big inning that has haunted him in 2025, and which lineup cashes in with runners in scoring position. Ultimately, the matchup projects as a grinder’s game: Boston’s veteran bats against Rodríguez’s inconsistency, Arizona’s speed and situational hitting against Tolle’s nerves, and two bullpens positioned to decide it late, with the margin likely no larger than one swing in what promises to be a tense and entertaining Friday night clash.
Last one before we hit the road. pic.twitter.com/9wQpEOsjSX
— Red Sox (@RedSox) September 3, 2025
Boston Red Sox MLB Preview
For the Boston Red Sox, this interleague trip to Arizona is less about novelty and more about continuing to prove they belong in the postseason mix, as they sit at 78–63 and hold one of the American League Wild Card spots but know that every win matters in the tightly packed race, and their fate on Friday rests in the hands of rookie left-hander Payton Tolle, who made a strong debut by working 5⅓ innings of two-run ball and displaying a fastball-changeup mix that kept hitters off balance. Tolle’s biggest challenge against the Diamondbacks will be repeating that composure on the road in a hitter-friendly park, where Corbin Carroll’s speed, Ketel Marte’s bat control, and Geraldo Perdomo’s situational contact can quickly turn walks or mistakes into runs; to survive, he’ll need to land first-pitch strikes, elevate his fastball above barrels, and trust Boston’s defense to convert routine plays. Offensively, the Red Sox continue to lean on Trevor Story’s power production and Jarren Duran’s energy at the top of the order, with supplemental contributions from versatile bats like Wilyer Abreu and Connor Wong giving the lineup a depth that wears down opposing pitchers, and their approach against veteran lefty Eduardo Rodríguez will be to force deep counts, get into the Arizona bullpen early, and capitalize on his tendency to allow crooked innings when command wavers.
The Red Sox have shown an ability to score in bunches, but what makes them dangerous is their balance: power bats capable of the long ball combined with patient hitters who extend innings, and in Chase Field’s wide gaps, their speed on the bases can turn singles into scoring chances. Defensively, Boston has tightened up since midsummer, with improved infield coordination that supports young pitchers like Tolle who will inevitably pitch to contact in stretches, and their athletic outfield is well-suited to covering the extra ground required in Arizona. Their bullpen, though volatile at times, is built on strikeout stuff that can thrive in one-run games if it throws strikes, and manager Alex Cora’s willingness to mix and match has helped them close tight contests even when traditional roles have been shaky. From a betting perspective, Boston’s recent 5–5 ATS record on the road highlights both their ability to stay in games and the risk of margin plays, but as modest favorites, their overall offensive firepower and Tolle’s poise in his debut give them reason for optimism. To win in Arizona, the Red Sox need Tolle to hold the line for at least five innings, Story or Duran to provide a momentum-shifting hit, and the bullpen to execute in leverage spots without issuing costly walks. If that blueprint comes together, Boston not only extends its Wild Card cushion but also demonstrates that even with a rookie on the mound in a hostile environment, they have the balance, resilience, and leadership to keep grinding out wins in September.

Credit: USA TODAY/IMAGN
Arizona Diamondbacks MLB Preview
For the Arizona Diamondbacks, Friday’s clash with the Red Sox at Chase Field is a chance to reassert themselves as a dangerous spoiler and fringe Wild Card threat, as they sit at 70–71 and know that every win from here forward could determine whether they stay alive in the National League race or slip into October irrelevance, and the responsibility of giving them a chance falls to veteran left-hander Eduardo Rodríguez, whose 6–8 record and 5.40 ERA reflect an up-and-down season but whose experience gives him the tools to neutralize a potent Boston lineup if he finds early command. Rodríguez’s success hinges on staying ahead in counts and using his changeup and slider to keep right-handed hitters like Trevor Story and Jarren Duran off balance, because when forced to throw fastballs over the plate, his results have cratered; for Arizona to win, he must give them six innings of stability and avoid the crooked inning that has derailed his outings. Offensively, the Diamondbacks lean on a balanced approach rather than sheer power, with Corbin Carroll’s speed and ability to set the table at the top of the order, Ketel Marte’s steady bat control in the middle, and Geraldo Perdomo’s situational hitting forming the core of a lineup that pressures defenses with contact and baserunning, a style perfectly suited to Chase Field’s spacious outfield where gaps can be exploited.
The D-backs’ identity has long been tied to manufacturing runs with patience and aggression, and if Carroll and Marte can get on base ahead of sluggers like Christian Walker or Lourdes Gurriel Jr., Arizona can build innings that test Boston’s rookie starter Payton Tolle and force manager Alex Cora to turn to his bullpen earlier than planned. Defensively, the Diamondbacks have cleaned up much of their inconsistency, and their athleticism in the field allows them to cover the extra ground at Chase, something they’ll need against a Red Sox lineup that extends at-bats and forces balls in play. The bullpen has also been more defined recently, with roles clearer late in games, and while not overpowering, the group has been solid at protecting narrow leads at home, where Arizona has gone 26–24 this season, proving they can win close games in their own park. From a betting perspective, oddsmakers view this as a tight contest with Boston as slight favorites, but Arizona’s respectable home record and ability to hang around against stronger lineups gives them real value as an underdog play, especially in a game where Rodríguez’s veteran savvy could offset Tolle’s rookie momentum. For the Diamondbacks to take this opener, Rodríguez must attack the strike zone early and work into the middle innings with minimal damage, the top of the lineup must get on base and pressure Boston with speed and situational hitting, and the bullpen must close cleanly without free passes. If those elements align, Arizona can both slow Boston’s postseason momentum and prove that despite a middling record, their blend of speed, contact, and home-field confidence keeps them dangerous in September.
Back in the saddle. pic.twitter.com/BOfPxs305g
— Arizona Diamondbacks (@Dbacks) September 3, 2025
Boston Red vs. Arizona Prop Picks (AI)
Boston Red vs. Arizona Prediction (AI)

Remi, our AI sports genius, has been pouring over exorbitant amounts of data from every past game between the Sox and Diamondbacks and using recursive machine learning and cutting-edge AI to crunch the data to a single cover probability.
Oddly enough, we’ve seen the AI has been most focused on the growing emphasis emotional bettors regularly put on coaching factors between a Sox team going up against a possibly healthy Diamondbacks team. In reality, the true game analytics appear to reflect a slight lean against one Vegas line in particular.
Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.
Below is our current AI Boston Red vs Arizona picks, computer picks Sox vs Diamondbacks, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
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MLB | 10/1 | SD@CHC | UNLOCK THIS PICK | 4 |
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MLB | 10/1 | SD@CHC | UNLOCK THIS PICK | 4 |
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MLB | 10/1 | CIN@LAD | UNLOCK THIS PICK | 3 |
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MLB | 10/1 | CIN@LAD | UNLOCK THIS PICK | 2 |
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MLB | 10/1 | DET@CLE | UNLOCK THIS PICK | 2 |
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MLB | 10/1 | DET@CLE | UNLOCK THIS PICK | 1 |
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MLB | 10/1 | BOS@NYY | UNLOCK THIS PICK | 1 |
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MLB | 10/1 | CIN@LAD | GET FREE PICK NOW | 1 | – | |
MLB | 10/1 | BOS@NYY | UNLOCK THIS PICK | 0 |
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MLB | 10/1 | BOS@NYY | GET FREE PICK NOW | 0 | – |
These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.
Sox Betting Trends
Boston is 5–5 against the run line in their last ten road games, showing balanced performance but no consistent edge away from home.
Diamondbacks Betting Trends
The Diamondbacks are 26–24 at home this season, indicating solid home form but not runaway dominance.
Sox vs. Diamondbacks Matchup Trends
Odds place Boston as a modest favorite (roughly –128 moneyline, –1.5 run line), implying tight scoring; projections suggest a 6–5 outcome in Arizona’s favor, highlighting the potential for a close, competitive game.
Boston Red vs. Arizona Game Info
What time does Boston Red vs Arizona start on September 05, 2025?
Boston Red vs Arizona starts on September 05, 2025 at 9:40 PM EST.
Where is Boston Red vs Arizona being played?
Venue: Chase Field.
What are the opening odds for Boston Red vs Arizona?
Spread: Arizona +1.5
Moneyline: Boston Red -128, Arizona +107
Over/Under: 8.5
What are the records for Boston Red vs Arizona?
Boston Red: (78-63) | Arizona: (70-71)
What is the AI best bet for Boston Red vs Arizona?
Remi's searched hard and found the best prop for this matchup: C. Carroll over 5.5 Fantasy Score.. Prices move—always shop for the best number.
What are Boston Red vs Arizona trending bets?
Odds place Boston as a modest favorite (roughly –128 moneyline, –1.5 run line), implying tight scoring; projections suggest a 6–5 outcome in Arizona’s favor, highlighting the potential for a close, competitive game.
What are Boston Red trending bets?
BOS trend: Boston is 5–5 against the run line in their last ten road games, showing balanced performance but no consistent edge away from home.
What are Arizona trending bets?
ARI trend: The Diamondbacks are 26–24 at home this season, indicating solid home form but not runaway dominance.
Where can I find AI Picks for Boston Red vs Arizona?
See our latest MLB picks and odds pages for 2025 to compare prices before you bet.
Boston Red vs. Arizona Odds
AI algorithm Remi is pouring through tons of stats on each line. In fact, anytime the Boston Red vs Arizona trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme altitude can often follow normal, predictable betting trends.
Boston Red vs Arizona Opening Odds
BOS Moneyline:
-128 ARI Moneyline: +107
BOS Spread: -1.5
ARI Spread: +1.5
Over/Under: 8.5
Boston Red vs Arizona Live Odds
Games | PTS | ML | SPR | O/U | |
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Oct 2, 2025 3:08PM EDT
Detroit Tigers
Cleveland Guardians
10/2/25 3:08PM
Tigers
Guardians
|
–
–
|
+100
-120
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-1.5 (+175)
+1.5 (-215)
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O 7 (-105)
U 7 (-115)
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Oct 2, 2025 5:08PM EDT
San Diego Padres
Chicago Cubs
10/2/25 5:08PM
Padres
Cubs
|
–
–
|
+100
-118
|
-1.5 (+172)
+1.5 (-210)
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O 7.5 (-110)
U 7.5 (-110)
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|
Oct 2, 2025 8:08PM EDT
Boston Red Sox
New York Yankees
10/2/25 8:08PM
Red Sox
Yankees
|
–
–
|
+136
-162
|
+1.5 (-160)
-1.5 (+130)
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O 7.5 (-120)
U 7.5 (-102)
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|
Oct 4, 2025 2:30PM EDT
Los Angeles Dodgers
Philadelphia Phillies
10/4/25 2:30PM
Dodgers
Phillies
|
–
–
|
+110
-130
|
pk
pk
|
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Oct 4, 2025 5:09PM EDT
Los Angeles Dodgers
Philadelphia Phillies
10/4/25 5:09PM
Dodgers
Phillies
|
–
–
|
+108
-126
|
pk
pk
|
O 7 (-135)
U 7 (+115)
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MLB Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers Boston Red Sox vs. Arizona Diamondbacks on September 05, 2025 at Chase Field.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.
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LEAN | %WIN | UNITS | RESULT |
---|---|---|---|---|
ARI@SD | SD -131 | 57.3% | 4 | WIN |
DET@BOS | BOS -115 | 56.4% | 5 | WIN |
NYM@CHC | NYM -110 | 54.1% | 3 | WIN |
HOU@ATH | ATH +118 | 50.8% | 4 | WIN |
NYM@CHC | OVER 7 | 54.5% | 3 | WIN |
STL@SF | OVER 7.5 | 55.9% | 5 | LOSS |
KC@LAA | TYLER TOLBERT UNDER 1.5 BASES | 54.4% | 4 | WIN |
MIL@SD | UNDER 9 | 54.7% | 4 | WIN |
MIA@PHI | KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS | 53.3% | 3 | WIN |
WAS@NYM | OVER 8.5 | 56.1% | 6 | LOSS |
LAA@COL | COL +108 | 50.5% | 3 | WIN |
TOR@KC | UNDER 9 | 54.7% | 4 | LOSS |
SEA@KC | KC +1.5 | 62.3% | 5 | LOSS |
NYY@MIN | OVER 9 | 55.1% | 4 | WIN |
MIA@COL | OVER 10.5 | 55.0% | 4 | WIN |
MIA@COL | AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS | 54.3% | 4 | WIN |
SEA@KC | BOBBY WITT UNDER 0.5 SINGLES | 54.4% | 4 | LOSS |
PHI@LAD | LAD -113 | 54.7% | 4 | LOSS |
NYY@BOS | OVER 7.5 | 54.3% | 3 | WIN |
KC@PHI | PHI -130 | 58.3% | 4 | WIN |
LAD@SF | OVER 7.5 | 54.7% | 4 | LOSS |
NYM@PHI | PHI -122 | 55.6% | 4 | WIN |
KC@CLE | KC -104 | 52.0% | 3 | WIN |
CIN@SD | JAKE CRONEWORTH OVER 0.5 HITS | 53.1% | 3 | WIN |
WAS@MIA | MIA -123 | 55.2% | 4 | LOSS |
LAA@KC | UNDER 9.5 | 54.9% | 3 | WIN |
TEX@ARI | UNDER 9 | 54.2% | 4 | WIN |
SF@COL | UNDER 11.5 | 56.4% | 6 | LOSS |
SF@COL | RAFAEL DEVERS OVER 1.5 BASES | 56.1% | 6 | WIN |
MIA@WAS | WAS -110 | 54.4% | 4 | WIN |
NYM@DET | OVER 8.5 | 54.5% | 4 | WIN |
TEX@ARI | UNDER 9.5 | 56.4% | 6 | WIN |
TEX@ARI | ALEJANDRO OSUNA UNDER 1.5 BASES | 54.1% | 4 | LOSS |
ATL@CHC | CHC -116 | 55.1% | 3 | WIN |
PHI@MIL | OVER 8.5 | 55.0% | 3 | WIN |
ARI@LAD | SHOHEI OHTANI OVER 2.5 BASES | 54.2% | 4 | WIN |
SEA@CLE | CLE +1.5 | 57.2% | 3 | WIN |
CHC@SF | CHC -105 | 54.1% | 4 | LOSS |
NYY@CHW | RYAN MCMAHON OVER 0.5 BASES | 54.1% | 4 | WIN |
PHI@NYM | OVER 8.5 | 55.6% | 4 | LOSS |
LAA@TEX | LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS | 54.1% | 4 | LOSS |
KC@CHW | KC -109 | 54.2% | 4 | WIN |
SD@SEA | DYLAN CEASE OVER 16.5 OUTS | 53.9% | 3 | LOSS |
SD@SEA | UNDER 8.5 | 54.4% | 4 | LOSS |
MIN@TOR | JOE RYAN UNDER 2.5 EARNED RUNS | 54.1% | 4 | LOSS |
SF@MIL | MIL +100 | 54.0% | 6 | LOSS |
TOR@MIA | MIA +1.5 | 62.0% | 6 | WIN |
CHC@LAA | OVER 9.5 | 54.9% | 4 | LOSS |
BOS@NYY | CARLOS RODON UNDER 4.5 HITS ALLOWED | 54.2% | 4 | WIN |
KC@DET | DET -115 | 56.1% | 5 | WIN |
CHC@LAA | LAA +1.5 | 57.6% | 5 | LOSS |