vs. Cardinals
Prediction, Odds & Props
Sep 02 | MLB AI Picks
Updated: 2025-08-31T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The Athletics visit Busch Stadium to face the Cardinals with one eye on development and the other on closing the season strong, seeking a boost from the return of veteran starter Luis Severino. Meanwhile, St. Louis still harbors faint postseason hopes, looking to maintain momentum and leverage its home field in a critical divisional clash.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

GAME INFO
Date: Sep 02, 2025
Start Time: 7:45 PM EST
Venue: Busch Stadium
Cardinals Record: (68-71)
Record: (64-75)
OPENING ODDS
ATH Moneyline: -107
STL Moneyline: -112
ATH Spread: -1.5
STL Spread: +1.5
Over/Under: 8.5
ATH
Betting Trends
- Oakland’s 2025 performance against the run line sits at 47–49, reflecting a team that stays close but rarely dominates betting margins.
STL
Betting Trends
- St. Louis holds a 53–52 ATS record overall, just above break-even—a sign of modest consistency in covering expectations.
MATCHUP TRENDS
- The Cardinals have been consistently preferred in this series and come in as on-paper favorites, though the Athletics are actually favored on the run line at –1.5, adding intrigue to betting narratives.
ATH vs. STL
Best Prop Bet
- Remi's searched hard and found the best prop for this matchup: T. Saggese over 4.5 Fantasy Score.
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Athletics vs St. Louis Prediction & Odds:
Free MLB Betting Insights for 9/2/25
The problem for Oakland has been defense and bullpen reliability—their defense ranks 24th in Outs Above Average, costing pitchers outs and extending innings, while the bullpen has been unsettled since the trade of Mason Miller, leaving journeymen like Sean Newcomb and newly added Scott McGough to handle high-leverage innings with uneven results. The Cardinals, meanwhile, bring a modestly better profile, sitting around 67–70 with a 53–52 ATS record that reflects their inconsistency in covering spreads but also their ability to grind out wins in front of their home crowd, where they’ve been stronger. St. Louis has leaned heavily on younger bats like Nolan Gorman and Ivan Herrera to provide offensive sparks alongside veterans such as Willson Contreras and Paul Goldschmidt, and while the lineup has not been as dominant as in years past, they remain capable of producing timely hits that exploit an opponent’s defensive flaws. Defensively, the Cardinals are sharper than Oakland, and their bullpen, while not elite, has been steady enough to preserve late leads, which is critical against a team like the A’s that struggles to come back once trailing. From a betting perspective, the game is interesting because despite the Cardinals’ slight edge in overall talent and playoff motivation, the Athletics opened favored on the run line, reflecting confidence in Severino’s return and their ability to play close games even against stronger opposition. Ultimately, this game will likely come down to execution: if Oakland’s defense can hold firm and Severino delivers quality innings, they could frustrate the Cardinals and steal a road win, but if St. Louis plays cleanly, leans on its more disciplined offense, and gets another reliable outing from Mikolas, their postseason push will live to fight another day.
11/10 would recommend 😄 pic.twitter.com/3YcQcyqP1S
— Athletics (@Athletics) September 1, 2025
Athletics MLB Preview
The Oakland Athletics travel to Busch Stadium on September 2, 2025, looking to play spoiler against the St. Louis Cardinals and continue showing incremental progress in a season defined more by development than contention, and while their overall record sits at roughly 63–75, their 47–49 ATS mark highlights a team that has been competitive enough to frustrate opponents and offer bettors occasional value. The biggest storyline for Oakland in this matchup is the return of Luis Severino, the veteran right-hander who had been sidelined with an oblique strain for three starts but is expected to take the mound with a chance to stabilize a young and uneven rotation; while his season ERA of 4.82 doesn’t leap off the page, he had shown promising stretches of command before his injury and represents the most reliable arm the A’s can currently deploy. Offensively, the A’s are better than their record suggests, carrying a 104 wRC+ that places them slightly above league average, thanks in large part to Brent Rooker’s power production, Tyler Soderstrom’s emerging bat, and the steady growth of Jacob Wilson and Shea Langeliers, who together give the lineup some balance between power and contact.
Their problem, however, has not been scoring runs but rather preventing them, as Oakland ranks 24th in Outs Above Average defensively, often giving away extra outs that put strain on a pitching staff already stretched thin, while the bullpen has been a persistent weakness since Mason Miller’s midseason trade, leaving journeymen like Sean Newcomb and recent addition Scott McGough to navigate high-leverage innings with mixed results. Managerially, the A’s know they must play aggressive baseball to succeed on the road, manufacturing runs through situational hitting and taking extra bases whenever possible to put pressure on a Cardinals defense that is sharper than their own. From a betting standpoint, Oakland’s near-even ATS record indicates that while they rarely dominate, they stay in games long enough to cover spreads, which makes them a tempting underdog play, especially with Severino back to potentially provide stability against a Cardinals lineup that has been streaky. Strategically, the A’s need Severino to give them length, their defense to avoid costly miscues, and their young hitters to deliver timely production if they are to steal a win at Busch Stadium. Ultimately, the Athletics enter this matchup as a rebuilding club with little to lose and plenty to gain in terms of evaluating their young core, but with enough offensive depth and a returning veteran arm to make life difficult for a Cardinals team still trying to keep faint playoff hopes alive.

Credit: USA TODAY/IMAGN
St. Louis Cardinals MLB Preview
The St. Louis Cardinals take the field at Busch Stadium on September 2, 2025, against the Oakland Athletics knowing that every game matters as they attempt to keep faint postseason hopes alive, and while their record has hovered around mediocrity, their slightly positive 53–52 ATS mark shows they have been able to cover just enough to maintain betting value. Offensively, the Cardinals remain a team built on a blend of veteran leadership and emerging contributors, with Paul Goldschmidt and Willson Contreras still providing steady presence in the middle of the order while Nolan Gorman and Ivan Herrera continue to grow into larger roles, offering flashes of power and timely hitting that can change games. Their approach at the plate has been inconsistent at times, but when the lineup strings together quality at-bats they are capable of putting up crooked numbers, particularly at home where Busch Stadium’s conditions play to their strengths of gap power and situational hitting. On the mound, Miles Mikolas is expected to start and will be tasked with taming an Oakland offense that has quietly been better than its record, and while Mikolas does not bring overpowering stuff, his command and ability to work deep into games have given St. Louis stability throughout an uneven season.
The bullpen, though not dominant, has provided enough reliability to close games, especially when given a lead, and the Cardinals’ defense has been sharper and cleaner than Oakland’s, giving them a crucial edge in games that often turn on extra outs and mistakes. Strategically, the Cardinals will look to pressure Oakland’s defense by putting the ball in play and forcing them to execute, while also being patient enough to drive up pitch counts against Luis Severino, who makes his return from injury in this matchup. From a betting perspective, St. Louis enters as the safer side compared to Oakland’s volatile profile, and their strong home-field edge combined with a more disciplined roster makes them a reasonable favorite even if their margin for error remains slim. For the Cardinals, this game is as much about reinforcing fundamentals as it is about the standings, as they must show they can handle business against a rebuilding team like Oakland if they are to keep any momentum alive for September. Ultimately, their path to victory hinges on Mikolas giving them six solid innings, the offense capitalizing on Oakland’s shaky defense and bullpen, and the veterans setting the tone to ensure that the younger players continue to develop in a competitive atmosphere, with the goal of walking away with a win that strengthens both their record and their confidence.
Herrera serves up a long ball into Big Mac Land! 🍔 pic.twitter.com/NRwsNfGcQO
— St. Louis Cardinals (@Cardinals) September 1, 2025
Athletics vs. St. Louis Prop Picks (AI)
Athletics vs. St. Louis Prediction (AI)

Remi, our AI sports genius, has been pouring over millions of data from every facet between the and Cardinals and using recursive machine learning and cutting-edge AI to crunch the data to a single cover probability.
Oddly enough, we’ve seen the AI has been most keyed in on the growing weight human bettors tend to put on coaching factors between a team going up against a possibly rested Cardinals team. It appears the true game analytics might reflect a strong lean against one Vegas line specifically.
Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.
Below is our current AI Athletics vs St. Louis picks, computer picks vs Cardinals, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
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MLB | 10/1 | SD@CHC | UNLOCK THIS PICK | 4 |
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MLB | 10/1 | SD@CHC | UNLOCK THIS PICK | 4 |
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MLB | 10/1 | CIN@LAD | UNLOCK THIS PICK | 3 |
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MLB | 10/1 | CIN@LAD | UNLOCK THIS PICK | 2 |
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MLB | 10/1 | DET@CLE | UNLOCK THIS PICK | 2 |
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MLB | 10/1 | DET@CLE | UNLOCK THIS PICK | 1 |
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MLB | 10/1 | BOS@NYY | UNLOCK THIS PICK | 1 |
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MLB | 10/1 | CIN@LAD | GET FREE PICK NOW | 1 | – | |
MLB | 10/1 | BOS@NYY | UNLOCK THIS PICK | 0 |
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MLB | 10/1 | BOS@NYY | GET FREE PICK NOW | 0 | – |
These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.
Betting Trends
Oakland’s 2025 performance against the run line sits at 47–49, reflecting a team that stays close but rarely dominates betting margins.
Cardinals Betting Trends
St. Louis holds a 53–52 ATS record overall, just above break-even—a sign of modest consistency in covering expectations.
vs. Cardinals Matchup Trends
The Cardinals have been consistently preferred in this series and come in as on-paper favorites, though the Athletics are actually favored on the run line at –1.5, adding intrigue to betting narratives.
Athletics vs. St. Louis Game Info
What time does Athletics vs St. Louis start on September 02, 2025?
Athletics vs St. Louis starts on September 02, 2025 at 7:45 PM EST.
Where is Athletics vs St. Louis being played?
Venue: Busch Stadium.
What are the opening odds for Athletics vs St. Louis?
Spread: St. Louis +1.5
Moneyline: Athletics -107, St. Louis -112
Over/Under: 8.5
What are the records for Athletics vs St. Louis?
Athletics: (64-75) | St. Louis: (68-71)
What is the AI best bet for Athletics vs St. Louis?
Remi's searched hard and found the best prop for this matchup: T. Saggese over 4.5 Fantasy Score.. Prices move—always shop for the best number.
What are Athletics vs St. Louis trending bets?
The Cardinals have been consistently preferred in this series and come in as on-paper favorites, though the Athletics are actually favored on the run line at –1.5, adding intrigue to betting narratives.
What are Athletics trending bets?
ATH trend: Oakland’s 2025 performance against the run line sits at 47–49, reflecting a team that stays close but rarely dominates betting margins.
What are St. Louis trending bets?
STL trend: St. Louis holds a 53–52 ATS record overall, just above break-even—a sign of modest consistency in covering expectations.
Where can I find AI Picks for Athletics vs St. Louis?
See our latest MLB picks and odds pages for 2025 to compare prices before you bet.
Athletics vs. St. Louis Odds
Remi is pouring through loads of stats on each line. In fact, anytime the Athletics vs St. Louis trends are analyzed, there’s always several intriguing trends to key in on. Not to mention games played at extreme hostile environments can often follow normal, predictable betting trends.
Athletics vs St. Louis Opening Odds
ATH Moneyline:
-107 STL Moneyline: -112
ATH Spread: -1.5
STL Spread: +1.5
Over/Under: 8.5
Athletics vs St. Louis Live Odds
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Oct 2, 2025 3:08PM EDT
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Cleveland Guardians
10/2/25 3:08PM
Tigers
Guardians
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–
–
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+100
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-1.5 (+175)
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O 7 (-105)
U 7 (-115)
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–
–
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+100
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-1.5 (+172)
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O 7.5 (-110)
U 7.5 (-110)
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Oct 2, 2025 8:08PM EDT
Boston Red Sox
New York Yankees
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–
–
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+136
-162
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+1.5 (-160)
-1.5 (+130)
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O 7.5 (-120)
U 7.5 (-102)
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Oct 4, 2025 2:30PM EDT
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–
–
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+110
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pk
pk
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Oct 4, 2025 5:09PM EDT
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Philadelphia Phillies
10/4/25 5:09PM
Dodgers
Phillies
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–
–
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+108
-126
|
pk
pk
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O 7 (-135)
U 7 (+115)
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MLB Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers Athletics vs. St. Louis Cardinals on September 02, 2025 at Busch Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.
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LEAN | %WIN | UNITS | RESULT |
---|---|---|---|---|
ARI@SD | SD -131 | 57.3% | 4 | WIN |
DET@BOS | BOS -115 | 56.4% | 5 | WIN |
NYM@CHC | NYM -110 | 54.1% | 3 | WIN |
HOU@ATH | ATH +118 | 50.8% | 4 | WIN |
NYM@CHC | OVER 7 | 54.5% | 3 | WIN |
STL@SF | OVER 7.5 | 55.9% | 5 | LOSS |
KC@LAA | TYLER TOLBERT UNDER 1.5 BASES | 54.4% | 4 | WIN |
MIL@SD | UNDER 9 | 54.7% | 4 | WIN |
MIA@PHI | KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS | 53.3% | 3 | WIN |
WAS@NYM | OVER 8.5 | 56.1% | 6 | LOSS |
LAA@COL | COL +108 | 50.5% | 3 | WIN |
TOR@KC | UNDER 9 | 54.7% | 4 | LOSS |
SEA@KC | KC +1.5 | 62.3% | 5 | LOSS |
NYY@MIN | OVER 9 | 55.1% | 4 | WIN |
MIA@COL | OVER 10.5 | 55.0% | 4 | WIN |
MIA@COL | AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS | 54.3% | 4 | WIN |
SEA@KC | BOBBY WITT UNDER 0.5 SINGLES | 54.4% | 4 | LOSS |
PHI@LAD | LAD -113 | 54.7% | 4 | LOSS |
NYY@BOS | OVER 7.5 | 54.3% | 3 | WIN |
KC@PHI | PHI -130 | 58.3% | 4 | WIN |
LAD@SF | OVER 7.5 | 54.7% | 4 | LOSS |
NYM@PHI | PHI -122 | 55.6% | 4 | WIN |
KC@CLE | KC -104 | 52.0% | 3 | WIN |
CIN@SD | JAKE CRONEWORTH OVER 0.5 HITS | 53.1% | 3 | WIN |
WAS@MIA | MIA -123 | 55.2% | 4 | LOSS |
LAA@KC | UNDER 9.5 | 54.9% | 3 | WIN |
TEX@ARI | UNDER 9 | 54.2% | 4 | WIN |
SF@COL | UNDER 11.5 | 56.4% | 6 | LOSS |
SF@COL | RAFAEL DEVERS OVER 1.5 BASES | 56.1% | 6 | WIN |
MIA@WAS | WAS -110 | 54.4% | 4 | WIN |
NYM@DET | OVER 8.5 | 54.5% | 4 | WIN |
TEX@ARI | UNDER 9.5 | 56.4% | 6 | WIN |
TEX@ARI | ALEJANDRO OSUNA UNDER 1.5 BASES | 54.1% | 4 | LOSS |
ATL@CHC | CHC -116 | 55.1% | 3 | WIN |
PHI@MIL | OVER 8.5 | 55.0% | 3 | WIN |
ARI@LAD | SHOHEI OHTANI OVER 2.5 BASES | 54.2% | 4 | WIN |
SEA@CLE | CLE +1.5 | 57.2% | 3 | WIN |
CHC@SF | CHC -105 | 54.1% | 4 | LOSS |
NYY@CHW | RYAN MCMAHON OVER 0.5 BASES | 54.1% | 4 | WIN |
PHI@NYM | OVER 8.5 | 55.6% | 4 | LOSS |
LAA@TEX | LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS | 54.1% | 4 | LOSS |
KC@CHW | KC -109 | 54.2% | 4 | WIN |
SD@SEA | DYLAN CEASE OVER 16.5 OUTS | 53.9% | 3 | LOSS |
SD@SEA | UNDER 8.5 | 54.4% | 4 | LOSS |
MIN@TOR | JOE RYAN UNDER 2.5 EARNED RUNS | 54.1% | 4 | LOSS |
SF@MIL | MIL +100 | 54.0% | 6 | LOSS |
TOR@MIA | MIA +1.5 | 62.0% | 6 | WIN |
CHC@LAA | OVER 9.5 | 54.9% | 4 | LOSS |
BOS@NYY | CARLOS RODON UNDER 4.5 HITS ALLOWED | 54.2% | 4 | WIN |
KC@DET | DET -115 | 56.1% | 5 | WIN |
CHC@LAA | LAA +1.5 | 57.6% | 5 | LOSS |