Cubs vs. Giants
Prediction, Odds & Props
Aug 26 | MLB AI Picks

Updated: 2025-08-24T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The Chicago Cubs head west to face the San Francisco Giants at Oracle Park in a notable interleague matchup, with the Cubs leveraging their division chase momentum while the Giants look to flex their recently bolstered roster. Despite both teams holding mid-tier ATS performances, this game overhangs with storylines of playoff positioning and a refreshed San Francisco lineup led by marquee additions.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Aug 26, 2025

Start Time: 9:45 PM EST​

Venue: Oracle Park​

Giants Record: (63-68)

Cubs Record: (76-55)

OPENING ODDS

CHC Moneyline: -142

SF Moneyline: +119

CHC Spread: -1.5

SF Spread: +1.5

Over/Under: 7.5

CHC
Betting Trends

  • Chicago holds a nearly even spread record at 28–29 against the run line, demonstrating they often stay competitive in games.

SF
Betting Trends

  • San Francisco comes in with a 24–21 run line record, visible evidence of more consistent performance in covering spreads.

MATCHUP TRENDS

  • Although the Giants have a moderate ATS edge overall, their performance on the road dips—at 19–23 on the run line away from home—suggesting the Cubs might find value as road opponents.

CHC vs. SF
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: L. Matos over 0.5 Hits+Runs+RBI.

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Chicago vs San Francisco Prediction & Odds:
Free MLB Betting Insights for 8/26/25

The August 26, 2025, matchup between the Chicago Cubs and San Francisco Giants at Oracle Park brings together two franchises navigating very different but equally compelling storylines as the season enters its stretch run, with Chicago surging toward an NL Central title push while San Francisco leans on a retooled roster to remain competitive in the West. The Cubs arrive with a 28–29 record against the spread, hovering just under even but reflecting their tendency to stay competitive in both wins and losses, often keeping margins close thanks to a well-rounded lineup and underrated pitching depth. They’ve been propelled by the rise of Pete Crow-Armstrong, who has blossomed into a legitimate five-tool threat with power, speed, and elite defense, while the midseason acquisition of Kyle Tucker has given them a formidable blend of power and on-base skills that lengthens their lineup considerably. Chicago’s offensive depth allows them to attack pitchers in waves, and when combined with consistent defensive play, they’ve built a profile that translates well to road environments like Oracle Park, where manufacturing runs can matter just as much as home-run power. On the mound, the Cubs rely on competent starting pitching rather than a true ace, but their rotation has provided enough length to keep the bullpen fresh, and that relief corps has been a steady backbone, capable of holding narrow leads in high-leverage moments. The Giants, meanwhile, bring a 24–21 ATS record into this contest, a stronger showing in betting terms that reflects their ability to cover at home, where Oracle Park’s unique dimensions often favor their contact-oriented offense and steady pitching.

San Francisco’s season has been bolstered by midseason moves that brought in Rafael Devers to add left-handed power and veteran stability, while their existing core of versatile infielders and capable outfielders has meshed into a balanced attack. Their offense may not always overwhelm, but with patient hitters and timely power, they can produce in bunches, especially when forcing opponents into defensive lapses. Pitching has been a relative strength, with a rotation built on depth rather than dominance, and their bullpen has proven capable of locking down wins when given a lead, though it remains vulnerable if overextended. Historically, San Francisco has thrived on playing crisp, fundamentally sound baseball at Oracle Park, and that remains their blueprint against a Cubs team that will push tempo and test defenses with aggressive baserunning. Strategically, the Giants will aim to pressure Chicago’s pitchers by grinding out at-bats and forcing high pitch counts, while the Cubs will look to jump on mistakes early and use their speed and power to build momentum. From a betting perspective, both teams present interesting angles: the Cubs’ recent surge in offensive production and ability to travel well makes them an appealing road underdog, while the Giants’ stronger ATS record and home-field edge provide a safer play for bettors favoring stability. Ultimately, this matchup is less about raw star power than execution under pressure, and the winner will likely be the team that plays cleaner defense, manages bullpen matchups more effectively, and finds the clutch hits with runners in scoring position, making it a game that could foreshadow the resilience both clubs will need as September approaches.

Chicago Cubs MLB Preview

The Chicago Cubs travel to Oracle Park on August 26, 2025, to face the San Francisco Giants carrying the confidence of a 70–54 record and the steady form of a team that has proven itself a real contender in the National League Central. While their 28–29 mark against the spread is just shy of breakeven, it reflects how competitive they’ve been in tight games, staying within margins and rarely being blown out, which is a critical factor when playing on the road in a pitcher-friendly park like San Francisco’s. The Cubs’ offensive engine is powered by a mix of youth and veteran leadership, highlighted by the breakout of Pete Crow-Armstrong, who has grown into one of baseball’s most dynamic talents with a rare blend of power, speed, and elite defense, while the midseason trade for Kyle Tucker has injected left-handed power and patience that adds another layer of danger to an already potent lineup. Around them, steady contributors like Dansby Swanson, Nico Hoerner, and Seiya Suzuki provide balance, creating an order that forces pitchers to labor without many weak spots to exploit. On the pitching side, Chicago’s rotation has delivered consistency rather than dominance, with starters capable of giving five to six quality innings before handing games over to a bullpen that has been one of the most reliable in baseball, led by high-leverage arms who thrive under pressure and give manager Craig Counsell confidence in close games.

Defensively, the Cubs have been sharp, turning double plays efficiently and minimizing errors, a necessity when playing on the road against a Giants team that thrives on taking advantage of mistakes. Strategically, Chicago’s approach in San Francisco must be to strike early, using patience to build pitch counts, aggressive baserunning to pressure the Giants’ defense, and trusting their bullpen to secure a lead once established. From a betting perspective, the Cubs’ combination of steady competitiveness and offensive upside makes them an intriguing underdog option, particularly given San Francisco’s own vulnerabilities, and their ability to cover games on the road gives bettors reason to back them in this spot. Ultimately, the Cubs come into this matchup as a confident, balanced club with the tools to compete in any environment, and if their stars deliver at the plate while their pitching holds steady, they have every opportunity to walk out of Oracle Park with a win that strengthens both their divisional position and their postseason credentials.

The Chicago Cubs head west to face the San Francisco Giants at Oracle Park in a notable interleague matchup, with the Cubs leveraging their division chase momentum while the Giants look to flex their recently bolstered roster. Despite both teams holding mid-tier ATS performances, this game overhangs with storylines of playoff positioning and a refreshed San Francisco lineup led by marquee additions. Chicago vs San Francisco AI Prediction: Free MLB Betting Insights for Aug 26. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

San Francisco Giants MLB Preview

The San Francisco Giants return to Oracle Park on August 26, 2025, to host the Chicago Cubs in a matchup that not only pits two playoff-hopeful franchises against one another but also gives the Giants an opportunity to flex their strength at home, where their 24–21 record against the spread illustrates their ability to deliver in front of their fans. This season has been one of transition for San Francisco, but the midseason acquisition of Rafael Devers has reenergized the roster, adding a powerful left-handed bat and veteran leadership that has helped balance a lineup which had at times lacked consistent production. Around Devers, the Giants feature a collection of versatile contributors like Thairo Estrada and LaMonte Wade Jr., who lengthen the order with contact skills and patience, while younger players provide flashes of energy that keep opponents on edge. Their pitching staff, though not built around a singular ace, has been steady, with the rotation consistently providing innings and keeping the bullpen in favorable situations. That bullpen has been anchored by breakout closer Randy Rodríguez, whose dominance in high-leverage situations has turned late innings into a strength, giving San Francisco the confidence to protect leads when games tighten at Oracle Park.

Defensively, the Giants remain sound and efficient, minimizing errors and using their familiarity with their spacious home field to prevent extra-base hits, a crucial edge in matchups against clubs like the Cubs who can thrive on manufacturing runs through speed and hustle. Strategically, manager Bob Melvin will look to extend at-bats, wear down Chicago’s starters, and capitalize on mistakes with runners in scoring position, while relying on his pitching staff to hold a Cubs offense that has become increasingly potent since acquiring Kyle Tucker. From a betting perspective, the Giants’ solid ATS mark at home, paired with their ability to play fundamentally clean baseball, makes them a strong option, especially against a Cubs team that has been resilient but still streaky in terms of offensive production. The key for San Francisco will be to assert themselves early, use Devers and Wade Jr. to set the tone in the middle of the order, and trust Rodríguez and the bullpen to slam the door if they secure a late lead. Ultimately, the Giants enter this contest with the confidence of being at home, the energy of a rejuvenated roster, and the balance of experience and youth that makes them dangerous in close games, and if they execute their game plan effectively, they are well positioned to protect their turf and add another critical win in their pursuit of staying alive in the playoff race.

Chicago vs. San Francisco Prop Picks (AI)

AI algorithm Remi is pouring through tons of datapoints on each line. In fact, anytime the Cubs and Giants play there’s always several intriguing observations to key in on. Not to mention games played at Oracle Park in Aug can often follow normal, predictable patterns.
Remi's searched hard and found the best prop for this matchup: L. Matos over 0.5 Hits+Runs+RBI.

Chicago vs. San Francisco Prediction (AI)

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Remi, our AI sports wizard, has been pouring over millions of data from every past game between the Cubs and Giants and using recursive machine learning and kick-ass AI to analyze the data to a single cover probability.

The Algorithm has been most fixated on the growing emphasis human bettors tend to put on San Francisco’s strength factors between a Cubs team going up against a possibly deflated Giants team. We’ve found the true game analytics might reflect a moderate lean against one Vegas line specifically.

Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.

Below is our current AI Chicago vs San Francisco picks, computer picks Cubs vs Giants, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
MLB 9/26 DET@BOS UNLOCK THIS PICK 5 EXECUTIVE Locked EXECUTIVE
MLB 9/26 BAL@NYY UNLOCK THIS PICK 4 INTEL Locked INTEL
MLB 9/26 ARI@SD UNLOCK THIS PICK 4 EXECUTIVE Locked EXECUTIVE
MLB 9/26 NYM@MIA UNLOCK THIS PICK 1 INTEL Locked INTEL
MLB 9/26 NYM@MIA GET FREE PICK NOW 1
MLB 9/26 COL@SF UNLOCK THIS PICK 0 INTEL Locked INTEL

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.

Cubs Betting Trends

Chicago holds a nearly even spread record at 28–29 against the run line, demonstrating they often stay competitive in games.

Giants Betting Trends

San Francisco comes in with a 24–21 run line record, visible evidence of more consistent performance in covering spreads.

Cubs vs. Giants Matchup Trends

Although the Giants have a moderate ATS edge overall, their performance on the road dips—at 19–23 on the run line away from home—suggesting the Cubs might find value as road opponents.

Chicago vs. San Francisco Game Info

Chicago vs San Francisco starts on August 26, 2025 at 9:45 PM EST.

Spread: San Francisco +1.5
Moneyline: Chicago -142, San Francisco +119
Over/Under: 7.5

Chicago: (76-55)  |  San Francisco: (63-68)

Remi's searched hard and found the best prop for this matchup: L. Matos over 0.5 Hits+Runs+RBI.. Prices move—always shop for the best number.

Although the Giants have a moderate ATS edge overall, their performance on the road dips—at 19–23 on the run line away from home—suggesting the Cubs might find value as road opponents.

CHC trend: Chicago holds a nearly even spread record at 28–29 against the run line, demonstrating they often stay competitive in games.

SF trend: San Francisco comes in with a 24–21 run line record, visible evidence of more consistent performance in covering spreads.

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

Chicago vs. San Francisco Odds

Remi is pouring through loads of data on each team. In fact, anytime the Chicago vs San Francisco trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme temps almost always follow normal, predictable patterns.

Chicago vs San Francisco Opening Odds

CHC Moneyline: -142
SF Moneyline: +119
CHC Spread: -1.5
SF Spread: +1.5
Over/Under: 7.5

Chicago vs San Francisco Live Odds

Games PTS ML SPR O/U
Sep 27, 2025 1:06PM EDT
Baltimore Orioles
New York Yankees
9/27/25 1:06PM
Orioles
Yankees
+194
-235
+1.5 (-105)
-1.5 (-114)
O 8.5 (-122)
U 8.5 (+100)
Sep 27, 2025 2:21PM EDT
St Louis Cardinals
Chicago Cubs
9/27/25 2:21PM
Cardinals
Cubs
 
-168
 
-1.5 (+118)
O 9 (-122)
U 9 (+100)
Sep 27, 2025 3:09PM EDT
Tampa Bay Rays
Toronto Blue Jays
9/27/25 3:09PM
Rays
Blue Jays
+132
-156
+1.5 (-154)
-1.5 (+128)
O 8.5 (-106)
U 8.5 (-114)
Sep 27, 2025 4:06PM EDT
Chicago White Sox
Washington Nationals
9/27/25 4:06PM
White Sox
Nationals
+102
-120
-1.5 (+162)
+1.5 (-196)
O 8.5 (-110)
U 8.5 (-110)
Sep 27, 2025 4:06PM EDT
Colorado Rockies
San Francisco Giants
9/27/25 4:06PM
Rockies
Giants
+198
-240
+1.5 (-110)
-1.5 (-110)
O 8 (-108)
U 8 (-112)
Sep 27, 2025 4:11PM EDT
New York Mets
Miami Marlins
9/27/25 4:11PM
Mets
Marlins
-124
+106
-1.5 (+130)
+1.5 (-156)
O 8.5 (-112)
U 8.5 (-108)
Sep 27, 2025 6:05PM EDT
Minnesota Twins
Philadelphia Phillies
9/27/25 6:05PM
Twins
Phillies
+177
-197
+1.5 (-118)
-1.5 (-102)
O 8.5 (-118)
U 8.5 (-102)
Sep 27, 2025 7:11PM EDT
Cincinnati Reds
Milwaukee Brewers
9/27/25 7:11PM
Reds
Brewers
+128
-152
+1.5 (-178)
-1.5 (+146)
O 7.5 (-120)
U 7.5 (-102)
Sep 27, 2025 7:15PM EDT
Pittsburgh Pirates
Atlanta Braves
9/27/25 7:15PM
Pirates
Braves
+143
-158
+1.5 (-150)
-1.5 (+130)
O 8.5 (+100)
U 8.5 (-120)
Sep 27, 2025 7:16PM EDT
Texas Rangers
Cleveland Guardians
9/27/25 7:16PM
Rangers
Guardians
+132
-156
+1.5 (-172)
-1.5 (+142)
O 7 (-120)
U 7 (-102)
Sep 27, 2025 8:40PM EDT
Arizona Diamondbacks
San Diego Padres
9/27/25 8:40PM
Diamondbacks
Padres
+120
-132
+1.5 (-180)
-1.5 (+157)
O 7.5 (-115)
U 7.5 (-105)
Sep 27, 2025 9:41PM EDT
Los Angeles Dodgers
Seattle Mariners
9/27/25 9:41PM
Dodgers
Mariners
+102
-120
+1.5 (-215)
-1.5 (+180)
O 7.5 (-110)
U 7.5 (-110)
Sep 27, 2025 10:05PM EDT
Kansas City Royals
Oakland Athletics
9/27/25 10:05PM
Royals
Athletics
+104
-115
+1.5 (-185)
-1.5 (+161)
O 10 (-110)
U 10 (-110)

MLB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Chicago Cubs vs. San Francisco Giants on August 26, 2025 at Oracle Park.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN
CHC@SF CHC -105 54.1% 4 LOSS
NYY@CHW RYAN MCMAHON OVER 0.5 BASES 54.1% 4 WIN
PHI@NYM OVER 8.5 55.6% 4 LOSS
LAA@TEX LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS 54.1% 4 LOSS
KC@CHW KC -109 54.2% 4 WIN
SD@SEA DYLAN CEASE OVER 16.5 OUTS 53.9% 3 LOSS
SD@SEA UNDER 8.5 54.4% 4 LOSS
MIN@TOR JOE RYAN UNDER 2.5 EARNED RUNS 54.1% 4 LOSS
SF@MIL MIL +100 54.0% 6 LOSS
TOR@MIA MIA +1.5 62.0% 6 WIN
CHC@LAA OVER 9.5 54.9% 4 LOSS
BOS@NYY CARLOS RODON UNDER 4.5 HITS ALLOWED 54.2% 4 WIN
KC@DET DET -115 56.1% 5 WIN
CHC@LAA LAA +1.5 57.6% 5 LOSS
CIN@ARI KEBRYAN HAYES STRIKEOUTS UNDER 0.5 56.2% 6 WIN
LAD@SD SD +110 50.9% 6 WIN