Giants vs. Pirates
Prediction, Odds & Props
Aug 06 | MLB AI Picks
Updated: 2025-08-04T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The San Francisco Giants (≈56–57) travel to PNC Park on Wednesday, August 6, 2025, to face the Pittsburgh Pirates (≈49–64) in a pivotal rubber game that features significant roster and pitching advantages favoring San Francisco. The Giants enter as favorites—around –150 on the money line and –1.5 on the run line, with the over/under set at roughly 7.5 runs, reflecting confidence in their elite starter and stronger overall structure.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

GAME INFO
Date: Aug 06, 2025
Start Time: 12:35 PM EST
Venue: PNC Park
Pirates Record: (49-65)
Giants Record: (57-57)
OPENING ODDS
SF Moneyline: -150
PIT Moneyline: +125
SF Spread: -1.5
PIT Spread: +1.5
Over/Under: 8
SF
Betting Trends
- San Francisco has been solid against the spread of late, winning 7 of their last 10 ATS matchups and consistently covering short spreads against Pittsburgh in this series.
PIT
Betting Trends
- Pittsburgh has struggled at home with an ATS profile around .430, showing vulnerability against stronger opponents despite occasional close games.
MATCHUP TRENDS
- In the two-game series so far, Pittsburgh has managed only one win, with Giants victories including an 8–1 rout that highlighted San Francisco’s dominance and furthered their ATS momentum.
SF vs. PIT
Best Prop Bet
- Remi's searched hard and found the best prop for this matchup: H. Ramos over 1.5 Hits+Runs+RBI.
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San Francisco vs Pittsburgh Prediction & Odds:
Free MLB Betting Insights for 8/6/25
Opposing him, Pittsburgh’s Andrew Heaney, who enters with a 4.89 ERA and modest strikeout totals, will need to deliver his best performance to keep the Pirates competitive, as his tendency to allow hard contact and elevated pitch counts has made him vulnerable to patient, power‑capable lineups like San Francisco’s. Offensively, the Giants will rely on a balanced core featuring Willy Adames, Heliot Ramos, Rafael Devers, Jung Hoo Lee, and veteran Matt Chapman, a mix of discipline, situational hitting, and timely power that has allowed them to pressure opposing starters and exploit relief arms that lack command, as shown in their Game 2 outburst. The Pirates, by contrast, depend heavily on Andrew McCutchen, Bryan Reynolds, and Oneil Cruz to produce runs, but their lineup has been inconsistent, averaging fewer than four runs per game at home against NL West opponents, and their bullpen has been unreliable in late innings, often giving up critical runs that erase any small leads they manage to build. Defensively, San Francisco holds a clear advantage as well, with efficient relay work, steady infield execution, and disciplined positioning that limits extra‑base hits, while Pittsburgh has been prone to occasional errors and lapses that compound their offensive struggles. To win and cover, the Giants’ formula is straightforward: secure a strong outing from Ray, generate early offensive pressure to force Heaney into deep counts, and allow their structured bullpen to lock down the final frames, a strategy that has proven effective throughout this series and in their recent ATS run. For the Pirates to pull an upset, they will need to capitalize on early opportunities, deliver clean defense, and hope for a standout performance from Heaney while avoiding the late‑game breakdowns that have plagued them, but given the current momentum, rotation edge, and structural advantages, San Francisco enters this matchup well‑positioned to claim the series finale and a likely run‑line cover in the process.
415 from Encarnacion 😳 pic.twitter.com/EbyetCrw9B
— SFGiants (@SFGiants) August 5, 2025
San Francisco Giants MLB Preview
The San Francisco Giants enter the August 6, 2025, matchup against the Pittsburgh Pirates at PNC Park with a record of approximately 56–57, seeking to build momentum and capture the series finale on the road, and they bring a clear structural and performance edge into this contest despite being slightly below .500. The Giants have shown solid recent form, going 7–3 ATS in their last ten games and covering spreads consistently against opponents like Pittsburgh, including an emphatic 8‑1 victory in Game 2 that highlighted their ability to combine dominant pitching with timely offense. The key to the Giants’ approach is their veteran starter Robbie Ray, who comes in with a 9–5 record, 2.85 ERA, and 140 strikeouts, excelling in generating ground balls and controlling traffic with efficiency; his profile is ideal for suppressing a Pirates lineup that leans heavily on contact and struggles to produce sustained rallies against high‑quality pitching. Offensively, San Francisco’s lineup blends patience, power, and situational hitting, featuring impact bats like Rafael Devers, Heliot Ramos, Willy Adames, Jung Hoo Lee, and veteran Matt Chapman, creating a balanced attack capable of manufacturing runs against pitchers who allow early baserunners, and their approach will be to work deep counts against Andrew Heaney to exploit his tendency for hard contact and occasional command lapses. The Giants’ offense has improved in recent weeks, emphasizing traffic generation and clutch hits, which is critical in road games where early runs can swing momentum and quiet the home crowd.
Defensively, San Francisco maintains an edge through disciplined infield positioning, efficient double‑play execution, and a reliable outfield alignment that limits extra‑base opportunities, all of which support their strong pitching staff and minimize run‑scoring chances for opponents. Their bullpen is another strength, featuring dependable late‑inning arms like Randy Rodríguez and setup relievers who have successfully managed leverage situations by preventing inherited runners from scoring, which is especially valuable in low‑scoring matchups where every baserunner matters. The Giants’ path to victory hinges on executing their structured game plan: getting a quality start from Ray, generating early offense through patient at‑bats, capitalizing on any defensive mistakes by Pittsburgh, and relying on their bullpen to seal the game in the final frames. Given their superior ATS form, recent head‑to‑head dominance, and the clear mismatch in both rotation and bullpen depth, San Francisco is well‑positioned to secure another road win and strengthen their position in the National League Wild Card chase. Their focus will be on maintaining the same disciplined approach that brought success in Game 2, ensuring they dictate the tempo and avoid giving the Pirates opportunities to steal momentum with isolated bursts of offense. If they follow this formula, the Giants have an excellent chance not only to leave Pittsburgh with a series win but also to continue building the consistency they need to climb back into postseason contention, making this game a critical checkpoint in their season trajectory.

Credit: USA TODAY/IMAGN
Pittsburgh Pirates MLB Preview
The Pittsburgh Pirates enter their August 6, 2025, series finale against the San Francisco Giants at PNC Park with a record of approximately 49–64, looking to salvage a series split and gain some momentum in a season that has been defined by inconsistency and underwhelming offensive production. At home, the Pirates have struggled both straight up and against the spread, holding an ATS record near .430, and their recent performances highlight a team that often falters against clubs with deep rotations and disciplined lineups like San Francisco. Starting pitcher Andrew Heaney will take the mound for Pittsburgh, bringing a 4.89 ERA and modest strikeout numbers into the matchup; he can provide innings and occasionally keep his team in the game, but his susceptibility to hard contact and inability to consistently miss bats pose significant risks against a patient, situationally strong Giants offense. The Pirates’ path to victory relies heavily on the core of Andrew McCutchen, Bryan Reynolds, and Oneil Cruz, as this trio represents the bulk of the team’s power and run production, yet their overall lineup has been erratic, often going cold for stretches and struggling to string together hits, which has contributed to one of the lowest home scoring averages in the league against National League West opponents.
To compete, Pittsburgh will need to generate early offense, ideally by pressuring Robbie Ray in the first two trips through the order before he can settle into a rhythm, as the Giants’ ace has dominated lineups that fail to attack early counts. Defensively, the Pirates must play clean baseball, as errors and lapses have frequently undermined competitive efforts and given opponents extra outs, which San Francisco’s disciplined hitters are quick to exploit. The bullpen is another concern for Pittsburgh, with late‑inning volatility often resulting in blown leads or an inability to contain inherited runners, a critical weakness against a Giants team that thrives on applying pressure in tight games. For the Pirates to find ATS and outright success in this matchup, everything must align: Heaney needs to deliver one of his sharpest starts of the season, the offense must capitalize on any rare mistakes from Ray, and the defense and bullpen have to hold firm in high‑leverage situations, which has not been their strength throughout 2025. This game represents more than just an attempt to even the series—it is a test of Pittsburgh’s ability to execute against a superior opponent and respond to the adversity of a long, challenging season. A victory would require precision, timely hitting, and perhaps some home‑field luck, but given their struggles with consistency and San Francisco’s advantages in rotation depth, bullpen stability, and overall roster balance, the Pirates face a significant uphill climb to secure a much‑needed home win.
Congratulations on being named our 2025 Heart & Hustle Award winner, Tommy Pham! 👏 pic.twitter.com/NBtlrnOJ2i
— Pittsburgh Pirates (@Pirates) August 5, 2025
San Francisco vs. Pittsburgh Prop Picks (AI)
San Francisco vs. Pittsburgh Prediction (AI)

Remi, our AI sports genius, has been pouring over millions of data from every simulation between the Giants and Pirates and using recursive machine learning and cutting-edge AI to crunch the data to a single cover probability.
Remi has been most keyed in on the trending emphasis knucklehead sportsbettors tend to put on coaching factors between a Giants team going up against a possibly rested Pirates team. Trends look to say the true game analytics appear to reflect a moderate lean against one Vegas line in particular.
Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.
Below is our current AI San Francisco vs Pittsburgh picks, computer picks Giants vs Pirates, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
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Giants Betting Trends
San Francisco has been solid against the spread of late, winning 7 of their last 10 ATS matchups and consistently covering short spreads against Pittsburgh in this series.
Pirates Betting Trends
Pittsburgh has struggled at home with an ATS profile around .430, showing vulnerability against stronger opponents despite occasional close games.
Giants vs. Pirates Matchup Trends
In the two-game series so far, Pittsburgh has managed only one win, with Giants victories including an 8–1 rout that highlighted San Francisco’s dominance and furthered their ATS momentum.
San Francisco vs. Pittsburgh Game Info
What time does San Francisco vs Pittsburgh start on August 06, 2025?
San Francisco vs Pittsburgh starts on August 06, 2025 at 12:35 PM EST.
Where is San Francisco vs Pittsburgh being played?
Venue: PNC Park.
What are the opening odds for San Francisco vs Pittsburgh?
Spread: Pittsburgh +1.5
Moneyline: San Francisco -150, Pittsburgh +125
Over/Under: 8
What are the records for San Francisco vs Pittsburgh?
San Francisco: (57-57) | Pittsburgh: (49-65)
What is the AI best bet for San Francisco vs Pittsburgh?
Remi's searched hard and found the best prop for this matchup: H. Ramos over 1.5 Hits+Runs+RBI.. Prices move—always shop for the best number.
What are San Francisco vs Pittsburgh trending bets?
In the two-game series so far, Pittsburgh has managed only one win, with Giants victories including an 8–1 rout that highlighted San Francisco’s dominance and furthered their ATS momentum.
What are San Francisco trending bets?
SF trend: San Francisco has been solid against the spread of late, winning 7 of their last 10 ATS matchups and consistently covering short spreads against Pittsburgh in this series.
What are Pittsburgh trending bets?
PIT trend: Pittsburgh has struggled at home with an ATS profile around .430, showing vulnerability against stronger opponents despite occasional close games.
Where can I find AI Picks for San Francisco vs Pittsburgh?
See our latest MLB picks and odds pages for 2025 to compare prices before you bet.
San Francisco vs. Pittsburgh Odds
AI algorithm Remi is pouring through tons of stats on each player. In fact, anytime the San Francisco vs Pittsburgh trends are analyzed, there’s always several intriguing trends to key in on. Not to mention games played at extreme temps seemingly never follow normal, predictable betting trends.
San Francisco vs Pittsburgh Opening Odds
SF Moneyline:
-150 PIT Moneyline: +125
SF Spread: -1.5
PIT Spread: +1.5
Over/Under: 8
San Francisco vs Pittsburgh Live Odds
Games | PTS | ML | SPR | O/U | |
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Giants
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2
3
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+190
-230
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+1.5 (-115)
-1.5 (-105)
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O 8 (-110)
U 8 (-110)
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New York Mets
Miami Marlins
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Mets
Marlins
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3
0
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-132
+110
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-1.5 (+125)
+1.5 (-145)
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O 8.5 (-110)
U 8.5 (-110)
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Boston Red Sox
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Tigers
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2
1
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-250
+185
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-1.5 (+150)
+1.5 (-200)
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O 5.5 (-105)
U 5.5 (-125)
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Chicago White Sox
Washington Nationals
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White Sox
Nationals
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4
2
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+101
-121
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+1.5 (-210)
-1.5 (+175)
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O 8.5 (-120)
U 8.5 (+100)
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Sep 27, 2025 6:05PM EDT
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9/27/25 6:05PM
Twins
Phillies
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–
–
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+169
-208
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+1.5 (-120)
-1.5 (+100)
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O 8.5 (-105)
U 8.5 (-115)
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Sep 27, 2025 7:11PM EDT
Cincinnati Reds
Milwaukee Brewers
9/27/25 7:11PM
Reds
Brewers
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–
–
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+129
-154
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+1.5 (-175)
-1.5 (+145)
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O 7.5 (-120)
U 7.5 (+100)
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Sep 27, 2025 7:15PM EDT
Pittsburgh Pirates
Atlanta Braves
9/27/25 7:15PM
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Braves
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–
–
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+148
-180
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+1.5 (-145)
-1.5 (+125)
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O 8 (-110)
U 8 (-110)
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Sep 27, 2025 7:16PM EDT
Texas Rangers
Cleveland Guardians
9/27/25 7:16PM
Rangers
Guardians
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–
–
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+138
-164
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+1.5 (-170)
-1.5 (+145)
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O 7 (-120)
U 7 (+100)
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Sep 27, 2025 8:40PM EDT
Arizona Diamondbacks
San Diego Padres
9/27/25 8:40PM
Diamondbacks
Padres
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–
–
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+119
-142
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+1.5 (-180)
-1.5 (+155)
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O 7.5 (-120)
U 7.5 (+100)
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Sep 27, 2025 9:39PM EDT
Houston Astros
Los Angeles Angels
9/27/25 9:39PM
Astros
Angels
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–
–
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-162
+136
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-1.5 (+100)
+1.5 (-120)
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O 9 (+100)
U 9 (-120)
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Sep 27, 2025 9:41PM EDT
Los Angeles Dodgers
Seattle Mariners
9/27/25 9:41PM
Dodgers
Mariners
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–
–
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+101
-121
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-1.5 (+170)
+1.5 (-200)
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O 7.5 (-110)
U 7.5 (-110)
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Sep 27, 2025 10:05PM EDT
Kansas City Royals
Oakland Athletics
9/27/25 10:05PM
Royals
Athletics
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–
–
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+100
-120
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+1.5 (-195)
-1.5 (+165)
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O 10 (-105)
U 10 (-115)
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Sep 28, 2025 3:06PM EDT
Baltimore Orioles
New York Yankees
9/28/25 3:06PM
Orioles
Yankees
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–
–
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+140
-170
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+1.5 (-125)
-1.5 (+105)
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O 9.5 (+100)
U 9.5 (-120)
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Sep 28, 2025 3:06PM EDT
Colorado Rockies
San Francisco Giants
9/28/25 3:06PM
Rockies
Giants
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–
–
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+240
-300
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+1.5 (+110)
-1.5 (-130)
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O 7.5 (-110)
U 7.5 (-110)
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Sep 28, 2025 3:06PM EDT
Minnesota Twins
Philadelphia Phillies
9/28/25 3:06PM
Twins
Phillies
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–
–
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+180
-220
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+1.5 (-115)
-1.5 (-105)
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O 8 (-115)
U 8 (-105)
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MLB Past Picks
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We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers San Francisco Giants vs. Pittsburgh Pirates on August 06, 2025 at PNC Park.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.
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LEAN | %WIN | UNITS | RESULT |
---|---|---|---|---|
ARI@SD | SD -131 | 57.3% | 4 | WIN |
DET@BOS | BOS -115 | 56.4% | 5 | WIN |
NYM@CHC | NYM -110 | 54.1% | 3 | WIN |
HOU@ATH | ATH +118 | 50.8% | 4 | WIN |
NYM@CHC | OVER 7 | 54.5% | 3 | WIN |
STL@SF | OVER 7.5 | 55.9% | 5 | LOSS |
KC@LAA | TYLER TOLBERT UNDER 1.5 BASES | 54.4% | 4 | WIN |
MIL@SD | UNDER 9 | 54.7% | 4 | WIN |
MIA@PHI | KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS | 53.3% | 3 | WIN |
WAS@NYM | OVER 8.5 | 56.1% | 6 | LOSS |
LAA@COL | COL +108 | 50.5% | 3 | WIN |
TOR@KC | UNDER 9 | 54.7% | 4 | LOSS |
SEA@KC | KC +1.5 | 62.3% | 5 | LOSS |
NYY@MIN | OVER 9 | 55.1% | 4 | WIN |
MIA@COL | OVER 10.5 | 55.0% | 4 | WIN |
MIA@COL | AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS | 54.3% | 4 | WIN |
SEA@KC | BOBBY WITT UNDER 0.5 SINGLES | 54.4% | 4 | LOSS |
PHI@LAD | LAD -113 | 54.7% | 4 | LOSS |
NYY@BOS | OVER 7.5 | 54.3% | 3 | WIN |
KC@PHI | PHI -130 | 58.3% | 4 | WIN |
LAD@SF | OVER 7.5 | 54.7% | 4 | LOSS |
NYM@PHI | PHI -122 | 55.6% | 4 | WIN |
KC@CLE | KC -104 | 52.0% | 3 | WIN |
CIN@SD | JAKE CRONEWORTH OVER 0.5 HITS | 53.1% | 3 | WIN |
WAS@MIA | MIA -123 | 55.2% | 4 | LOSS |
LAA@KC | UNDER 9.5 | 54.9% | 3 | WIN |
TEX@ARI | UNDER 9 | 54.2% | 4 | WIN |
SF@COL | UNDER 11.5 | 56.4% | 6 | LOSS |
SF@COL | RAFAEL DEVERS OVER 1.5 BASES | 56.1% | 6 | WIN |
MIA@WAS | WAS -110 | 54.4% | 4 | WIN |
NYM@DET | OVER 8.5 | 54.5% | 4 | WIN |
TEX@ARI | UNDER 9.5 | 56.4% | 6 | WIN |
TEX@ARI | ALEJANDRO OSUNA UNDER 1.5 BASES | 54.1% | 4 | LOSS |
ATL@CHC | CHC -116 | 55.1% | 3 | WIN |
PHI@MIL | OVER 8.5 | 55.0% | 3 | WIN |
ARI@LAD | SHOHEI OHTANI OVER 2.5 BASES | 54.2% | 4 | WIN |
SEA@CLE | CLE +1.5 | 57.2% | 3 | WIN |
CHC@SF | CHC -105 | 54.1% | 4 | LOSS |
NYY@CHW | RYAN MCMAHON OVER 0.5 BASES | 54.1% | 4 | WIN |
PHI@NYM | OVER 8.5 | 55.6% | 4 | LOSS |
LAA@TEX | LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS | 54.1% | 4 | LOSS |
KC@CHW | KC -109 | 54.2% | 4 | WIN |
SD@SEA | DYLAN CEASE OVER 16.5 OUTS | 53.9% | 3 | LOSS |
SD@SEA | UNDER 8.5 | 54.4% | 4 | LOSS |
MIN@TOR | JOE RYAN UNDER 2.5 EARNED RUNS | 54.1% | 4 | LOSS |
SF@MIL | MIL +100 | 54.0% | 6 | LOSS |
TOR@MIA | MIA +1.5 | 62.0% | 6 | WIN |
CHC@LAA | OVER 9.5 | 54.9% | 4 | LOSS |
BOS@NYY | CARLOS RODON UNDER 4.5 HITS ALLOWED | 54.2% | 4 | WIN |
KC@DET | DET -115 | 56.1% | 5 | WIN |
CHC@LAA | LAA +1.5 | 57.6% | 5 | LOSS |