Red Sox vs. Giants
Prediction, Odds & Props
Jun 21 | MLB AI Picks

Updated: 2025-06-19T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The Boston Red Sox travel to Oracle Park to face the San Francisco Giants on June 21, 2025, with first pitch scheduled for 4:05 p.m. ET. San Francisco opens as a moderate favorite (around −130 on the moneyline and −1.5 on the run line), with the total set at 7.5—suggesting a low-to-mid scoring, tightly contested matchup.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Jun 21, 2025

Start Time: 4:05 PM EST​

Venue: Oracle Park​

Giants Record: (42-34)

Red Sox Record: (40-37)

OPENING ODDS

BOS Moneyline: +115

SF Moneyline: -136

BOS Spread: +1.5

SF Spread: -1.5

Over/Under: 8

BOS
Betting Trends

  • The Red Sox have a 35–38 record ATS this season, including a solid 7–3 mark in their last 10 road games—proving they’ve been scrappy on the road despite their middling lineup.

SF
Betting Trends

  • The Giants have gone 4–6 ATS in their last 10 outings and are 3–7 ATS as home favorites, reflecting occasional underperformance when expectations are high.

MATCHUP TRENDS

  • San Francisco’s games have gone under in 16 of their last 24 (~67%) outings, while Boston’s recent road contests lean under as well—so the 7.5 total could be ripe for the under play.

BOS vs. SF
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: B. Bello over 16.5 Fantasy Score.

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Boston vs San Francisco Prediction & Odds:
Free MLB Betting Insights for 6/21/25

Saturday’s interleague contest between the Boston Red Sox and San Francisco Giants at Oracle Park serves as an intriguing midseason measuring stick for two clubs navigating very different trajectories. Boston enters the game at 39–37, hovering in the middle of the AL East with a blend of young potential and growing pains, while San Francisco sits at 41–33, holding tight to second place in the NL West and looking to tighten its grip on a postseason berth. The Red Sox come into this matchup having recently parted ways with franchise cornerstone Rafael Devers, who now ironically joins the opposing dugout, adding an emotional subplot to the game. Boston’s offense remains fluid, relying on a mix of emerging contributors like Roman Anthony and Jarren Duran alongside veteran bats such as Trevor Story and Triston Casas to generate timely offense. Their pitching, while not elite, has stabilized behind arms like Cooper Criswell or Lucas Giolito, both of whom offer capable innings with some swing-and-miss potential. They’ll need a solid outing from their starter, particularly in Oracle Park, a venue that rewards contact-oriented teams and penalizes free-swinging power hitters. On the other side, San Francisco has leaned heavily on its pitching and defense to maintain consistency, with a team ERA hovering in the low threes and a defense that ranks among the best in fielding percentage and double plays turned.

Probable starter Logan Webb or Keaton Winn should give the Giants a strong chance at keeping Boston’s bats quiet early, especially if they can get ahead in counts and limit Boston’s baserunning game, which has become a strength. San Francisco’s offense doesn’t rely on the long ball but instead thrives on situational hitting and discipline, drawing walks and waiting for opponents to make mistakes. The addition of Devers adds another layer of danger to a lineup already featuring Matt Chapman, Heliot Ramos, and Thairo Estrada, all of whom have had their share of clutch moments. Oracle Park’s pitcher-friendly dimensions and thick coastal air make home runs harder to come by, so this game is likely to hinge on execution, particularly in the middle innings where bullpens will be tested. Boston’s relief corps has struggled in the middle innings, and if their starter can’t get through five or six cleanly, San Francisco’s offense could pounce. However, Boston has shown they can hang on the road—going 7–3 ATS in their last 10 away games—and has found ways to scrape across runs in tight contests. The Giants, while favored, are just 3–7 ATS as home favorites over their last 10 games, which suggests that they’ve let weaker teams linger too long before putting them away. The game total sits at 7.5, and considering both teams have trended under recently—particularly in Oracle—this figures to be a low-scoring chess match defined by two or three high-leverage moments. If the Red Sox can strike early and force San Francisco to play catch-up, they may be able to steal another road win. But if the Giants control tempo, get six innings from their starter, and let their bullpen and defense close it out, expect a narrow San Francisco win in the 4–2 or 3–1 range.

Boston Red Sox MLB Preview

The Boston Red Sox enter Saturday’s interleague clash against the San Francisco Giants at Oracle Park looking to maintain momentum in a season that has been both transitional and encouraging. With a 39–37 overall record and a particularly strong 7–3 performance against the spread in their last 10 road games, Boston has quietly found ways to be competitive despite a roster that’s undergone considerable change, including the midseason departure of longtime slugger Rafael Devers. Now built around a mix of emerging youth and experienced leadership, the Red Sox are finding new identity in players like Triston Casas, Jarren Duran, Roman Anthony, and Ceddanne Rafaela, who are combining to give the offense speed, energy, and occasional power. Trevor Story and Masataka Yoshida provide veteran presence and stability, offering much-needed plate discipline and situational hitting. Boston’s offense, while not among the league’s elite, is capable of producing runs in bunches, particularly if they establish tempo early and apply pressure on opposing starters. Their expected starting pitcher—likely Cooper Criswell or Lucas Giolito—brings mid-rotation reliability, the ability to work through lineups two or three times, and enough swing-and-miss potential to neutralize contact-heavy opponents. The key will be navigating the Giants’ patient offense and avoiding prolonged innings that tax a bullpen which has been inconsistent in middle-relief spots.

Late-inning arms like Kenley Jansen and Chris Martin offer veteran poise, but bridging to them without damage has been a challenge. Boston’s road defense has improved, cutting down errors and making more efficient infield plays, thanks in part to Rafaela’s versatility and Story’s dependable glove at shortstop. That will be tested at Oracle Park, where vast outfield dimensions and windy conditions can turn routine fly balls into chaos. Boston’s offensive approach in this environment will need to shift from home-run hunting to line-drive consistency and smart baserunning, where Duran and Anthony can make a significant difference. If the Red Sox are going to secure a win, it will depend heavily on their starter going at least five strong innings, avoiding the kind of big frames that have haunted them in recent losses. Offensively, if Casas and Yoshida can get on base early and allow players like Rafaela or Enmanuel Valdez to hit with runners in motion, the Red Sox can take advantage of San Francisco’s occasionally shaky middle relief. Betting-wise, Boston has been an underdog that covers—posting solid ATS results despite inconsistent win totals—and this game sets up for another close contest where Boston could very well stay within the number, if not steal the win outright. For that to happen, they’ll need to play a nearly mistake-free game, continue to execute in scoring opportunities, and hope their bullpen holds up under Oracle’s tense late-inning atmosphere. If all of that aligns, the Red Sox could pull off a 4–3 or 5–4 upset and make another strong statement in what’s become an increasingly gritty and growth-focused season.

The Boston Red Sox travel to Oracle Park to face the San Francisco Giants on June 21, 2025, with first pitch scheduled for 4:05 p.m. ET. San Francisco opens as a moderate favorite (around −130 on the moneyline and −1.5 on the run line), with the total set at 7.5—suggesting a low-to-mid scoring, tightly contested matchup. Boston vs San Francisco AI Prediction: Free MLB Betting Insights for Jun 21. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

San Francisco Giants MLB Preview

The San Francisco Giants enter Saturday’s game against the Boston Red Sox with a 41–33 record and strong aspirations of making a legitimate postseason run in the National League, leaning heavily on a formula of elite pitching, disciplined offense, and defensive execution. At Oracle Park, they’ve built a home-field identity centered on manufacturing runs and shutting down opponents late, though their recent 3–7 ATS mark as home favorites shows they’ve occasionally played down to competition. Manager Bob Melvin’s squad is constructed with veteran poise and reliable structure, starting from a rotation that likely features either Logan Webb or Keaton Winn on Saturday. Webb, in particular, has been dominant at Oracle, sporting a sub-3.00 ERA and excellent ground-ball rate that plays perfectly in a park where fly balls tend to die short of the wall. Behind him, the bullpen is a deep and versatile group featuring Tyler Rogers, Gregory Santos, Erik Miller, and closer Camilo Doval, all of whom thrive in low-scoring, high-pressure situations, often limiting opponents to soft contact and stranded runners. Offensively, the Giants are a contact-first group, ranking among the best in the league in walks and fewest strikeouts—an approach that thrives in Oracle’s pitcher-friendly confines. Heliot Ramos and Matt Chapman offer dependable power, while Thairo Estrada and Michael Conforto contribute in situational hitting roles.

The recent addition of Rafael Devers—ironically acquired from Boston—has bolstered the lineup with another left-handed threat capable of working deep counts, hitting to all fields, and driving in runs in key spots. Though not prolific in home runs, the Giants excel at working counts, drawing walks, and hitting with two strikes—traits that grind down opposing pitchers and create fatigue by the middle innings. Defensively, the Giants have committed few errors and turned double plays at an elite rate, with Chapman and Estrada combining for excellent infield defense and solid throw accuracy across the diamond. In a game that projects to be tight, those routine plays could easily swing a win or loss, especially against a Boston team that likes to force action with speed and aggressive baserunning. Strategically, San Francisco will look to jump on early fastballs, build a lead through contact and base hits, and turn the game over to their bullpen by the seventh. If their starter can give six innings and avoid big innings—particularly from the heart of Boston’s order—the Giants will be in good shape to execute their blueprint. From a betting perspective, they’re moderate favorites at home with the total set around 7.5, suggesting a game that leans toward the under, consistent with how they’ve performed recently. They’ve seen the total go under in 16 of their last 24 games, and that trend seems likely to continue in a matchup against Boston’s inconsistent but capable rotation and a ballpark that suppresses slugfests. If the Giants get timely hitting, limit mistakes, and control the pace through their pitching depth, a 4–2 or 3–1 win is a likely outcome as they aim to strengthen their playoff position and improve their home betting value.

Boston vs. San Francisco Prop Picks (AI)

Remi is pouring through tons of stats on each line. In fact, anytime the Red Sox and Giants play there’s always several intriguing trends to key in on. Not to mention games played at Oracle Park in Jun seemingly never follow normal, predictable betting trends.
Remi's searched hard and found the best prop for this matchup: B. Bello over 16.5 Fantasy Score.

Boston vs. San Francisco Prediction (AI)

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Remi, our AI sports wizard, has been pouring over mountains of data from every past game between the Red Sox and Giants and using recursive machine learning and impressive AI to boil down the data to a single cover probability.

Interestingly enough, the data has been most keyed in on the trending emphasis emotional bettors often put on Boston’s strength factors between a Red Sox team going up against a possibly improved Giants team. In reality, the true game analytics might reflect a strong lean against one Vegas line specifically.

Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.

Below is our current AI Boston vs San Francisco picks, computer picks Red Sox vs Giants, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
MLB 9/26 DET@BOS UNLOCK THIS PICK 5 EXECUTIVE Locked EXECUTIVE
MLB 9/26 BAL@NYY UNLOCK THIS PICK 4 INTEL Locked INTEL
MLB 9/26 ARI@SD UNLOCK THIS PICK 4 EXECUTIVE Locked EXECUTIVE
MLB 9/26 NYM@MIA UNLOCK THIS PICK 1 INTEL Locked INTEL
MLB 9/26 NYM@MIA GET FREE PICK NOW 1
MLB 9/26 COL@SF UNLOCK THIS PICK 0 INTEL Locked INTEL

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.

Red Sox Betting Trends

The Red Sox have a 35–38 record ATS this season, including a solid 7–3 mark in their last 10 road games—proving they’ve been scrappy on the road despite their middling lineup.

Giants Betting Trends

The Giants have gone 4–6 ATS in their last 10 outings and are 3–7 ATS as home favorites, reflecting occasional underperformance when expectations are high.

Red Sox vs. Giants Matchup Trends

San Francisco’s games have gone under in 16 of their last 24 (~67%) outings, while Boston’s recent road contests lean under as well—so the 7.5 total could be ripe for the under play.

Boston vs. San Francisco Game Info

Boston vs San Francisco starts on June 21, 2025 at 4:05 PM EST.

Spread: San Francisco -1.5
Moneyline: Boston +115, San Francisco -136
Over/Under: 8

Boston: (40-37)  |  San Francisco: (42-34)

Remi's searched hard and found the best prop for this matchup: B. Bello over 16.5 Fantasy Score.. Prices move—always shop for the best number.

San Francisco’s games have gone under in 16 of their last 24 (~67%) outings, while Boston’s recent road contests lean under as well—so the 7.5 total could be ripe for the under play.

BOS trend: The Red Sox have a 35–38 record ATS this season, including a solid 7–3 mark in their last 10 road games—proving they’ve been scrappy on the road despite their middling lineup.

SF trend: The Giants have gone 4–6 ATS in their last 10 outings and are 3–7 ATS as home favorites, reflecting occasional underperformance when expectations are high.

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

Boston vs. San Francisco Odds

AI algorithm Remi is pouring through tons of data points on each line. In fact, anytime the Boston vs San Francisco trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme temps almost always follow normal, predictable patterns.

Boston vs San Francisco Opening Odds

BOS Moneyline: +115
SF Moneyline: -136
BOS Spread: +1.5
SF Spread: -1.5
Over/Under: 8

Boston vs San Francisco Live Odds

Games PTS ML SPR O/U
Sep 27, 2025 1:06PM EDT
Baltimore Orioles
New York Yankees
9/27/25 1:06PM
Orioles
Yankees
+194
-235
+1.5 (-105)
-1.5 (-114)
O 8.5 (-122)
U 8.5 (+100)
Sep 27, 2025 2:21PM EDT
St Louis Cardinals
Chicago Cubs
9/27/25 2:21PM
Cardinals
Cubs
 
-168
 
-1.5 (+118)
O 9 (-122)
U 9 (+100)
Sep 27, 2025 3:09PM EDT
Tampa Bay Rays
Toronto Blue Jays
9/27/25 3:09PM
Rays
Blue Jays
+132
-156
+1.5 (-154)
-1.5 (+128)
O 8.5 (-106)
U 8.5 (-114)
Sep 27, 2025 4:06PM EDT
Chicago White Sox
Washington Nationals
9/27/25 4:06PM
White Sox
Nationals
+102
-120
-1.5 (+162)
+1.5 (-196)
O 8.5 (-110)
U 8.5 (-110)
Sep 27, 2025 4:06PM EDT
Colorado Rockies
San Francisco Giants
9/27/25 4:06PM
Rockies
Giants
+198
-240
+1.5 (-110)
-1.5 (-110)
O 8 (-108)
U 8 (-112)
Sep 27, 2025 4:11PM EDT
New York Mets
Miami Marlins
9/27/25 4:11PM
Mets
Marlins
-124
+106
-1.5 (+130)
+1.5 (-156)
O 8.5 (-112)
U 8.5 (-108)
Sep 27, 2025 6:05PM EDT
Minnesota Twins
Philadelphia Phillies
9/27/25 6:05PM
Twins
Phillies
+172
-205
+1.5 (-118)
-1.5 (+100)
O 8.5 (-115)
U 8.5 (-105)
Sep 27, 2025 7:11PM EDT
Cincinnati Reds
Milwaukee Brewers
9/27/25 7:11PM
Reds
Brewers
+128
-152
+1.5 (-178)
-1.5 (+146)
O 7.5 (-120)
U 7.5 (-102)
Sep 27, 2025 7:15PM EDT
Pittsburgh Pirates
Atlanta Braves
9/27/25 7:15PM
Pirates
Braves
+136
-162
+1.5 (-150)
-1.5 (+125)
O 8 (-105)
U 8 (-115)
Sep 27, 2025 7:16PM EDT
Texas Rangers
Cleveland Guardians
9/27/25 7:16PM
Rangers
Guardians
+138
-164
+1.5 (-164)
-1.5 (+136)
O 7.5 (-110)
U 7.5 (-110)
Sep 27, 2025 8:40PM EDT
Arizona Diamondbacks
San Diego Padres
9/27/25 8:40PM
Diamondbacks
Padres
+120
-142
+1.5 (-182)
-1.5 (+150)
O 7.5 (-118)
U 7.5 (-104)
Sep 27, 2025 9:39PM EDT
Houston Astros
Los Angeles Angels
9/27/25 9:39PM
Astros
Angels
-162
+136
-1.5 (+100)
+1.5 (-120)
O 9 (+100)
U 9 (-122)
Sep 27, 2025 9:41PM EDT
Los Angeles Dodgers
Seattle Mariners
9/27/25 9:41PM
Dodgers
Mariners
+102
-120
+1.5 (-215)
-1.5 (+180)
O 7.5 (-110)
U 7.5 (-110)
Sep 27, 2025 10:05PM EDT
Kansas City Royals
Oakland Athletics
9/27/25 10:05PM
Royals
Athletics
+100
-118
-1.5 (+152)
+1.5 (-184)
O 10 (-110)
U 10 (-110)

MLB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Boston Red Sox vs. San Francisco Giants on June 21, 2025 at Oracle Park.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN
CHC@SF CHC -105 54.1% 4 LOSS
NYY@CHW RYAN MCMAHON OVER 0.5 BASES 54.1% 4 WIN
PHI@NYM OVER 8.5 55.6% 4 LOSS
LAA@TEX LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS 54.1% 4 LOSS
KC@CHW KC -109 54.2% 4 WIN
SD@SEA DYLAN CEASE OVER 16.5 OUTS 53.9% 3 LOSS
SD@SEA UNDER 8.5 54.4% 4 LOSS
MIN@TOR JOE RYAN UNDER 2.5 EARNED RUNS 54.1% 4 LOSS
SF@MIL MIL +100 54.0% 6 LOSS
TOR@MIA MIA +1.5 62.0% 6 WIN
CHC@LAA OVER 9.5 54.9% 4 LOSS
BOS@NYY CARLOS RODON UNDER 4.5 HITS ALLOWED 54.2% 4 WIN
KC@DET DET -115 56.1% 5 WIN
CHC@LAA LAA +1.5 57.6% 5 LOSS
CIN@ARI KEBRYAN HAYES STRIKEOUTS UNDER 0.5 56.2% 6 WIN
LAD@SD SD +110 50.9% 6 WIN