Padres vs Brewers Prediction — AI Finds CAN'T MISS MLB Lines & Props (Jun 07)

Updated: 2025-06-05T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The San Diego Padres travel to American Family Field on June 7, 2025, for a pivotal midseason matchup against the Milwaukee Brewers. Milwaukee enters as the favorite at –149 on the moneyline and –1.5 on the run line, with the total set at 8.5 runs—signaling expectations for a close, strategy-heavy game.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Jun 07, 2025

Start Time: 7:35 PM EST​

Venue: American Family Field​

Brewers Record: (34-30)

Padres Record: (36-26)

OPENING ODDS

SD Moneyline: -104

MIL Moneyline: -115

SD Spread: -1.5

MIL Spread: +1.5

Over/Under: 8.5

SD
Betting Trends

  • San Diego has split run-line decisions evenly over their last ten matchups against the Brewers, going 5–5–0 ATS in head-to-head contests this season.

MIL
Betting Trends

  • Milwaukee has gone 6–4 ATS in its last 10 home games, including a strong 3–1 mark as favorites, showcasing consistent value for bettors.

MATCHUP TRENDS

  • The Brewers have won 77.8 percent of their games as moneyline favorites of –149 or shorter, while the Padres have won 55.6 percent as underdogs of +125 or worse—creating a dynamic betting environment.

SD vs. MIL
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: J. Chourio over 6.5 Fantasy Score.

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San Diego vs Milwaukee Prediction & Odds:
Free MLB Betting Insights for 6/7/25

Saturday night’s game between the San Diego Padres and the Milwaukee Brewers at American Family Field promises to be a tight, strategic contest between two playoff contenders navigating the heart of their 2025 campaigns. The Brewers, entering with a 32–28 record and holding a narrow edge in both standings and odds, will send right-hander Brandon Woodruff to the mound, bringing veteran stability and postseason experience to a club looking to extend its dominance at home. Woodruff enters with a 3–1 record and an ERA just under 3.00, using his precision and swing-and-miss stuff to limit early-inning damage and often pitch into the seventh with minimal traffic. Across the diamond, the Padres counter with Stephen Kolek, a young right-hander still in the early stages of his MLB journey, known for his sharp command, quick tempo, and ability to keep hitters off balance with ground balls and soft contact rather than strikeout dominance. San Diego, now 33–27 and aiming to climb in a competitive NL West, will rely on its deep, disciplined lineup led by Manny Machado, Juan Soto, and Xander Bogaerts, each bringing veteran plate presence and situational awareness that can shift momentum at any point. The betting line favors Milwaukee at –149, with the total set at 8.5 runs, suggesting a mid-scoring affair shaped by starter efficiency and bullpen management, both of which will be tested.

The Brewers have gone 6–4 against the spread in their last 10 home games and 3–1 as favorites, indicating consistency when backed by their home crowd and strong bullpen, which remains one of the most effective in the league at converting saves and protecting slim leads. Milwaukee’s offense centers around Christian Yelich and William Contreras, two versatile bats capable of anchoring innings through contact and baserunning more than raw power. Defensively, Milwaukee has played clean baseball, ranking in the top third of the NL in fielding percentage and limiting big innings through sharp infield work and strong outfield range. For the Padres, success will depend on Kolek surviving the first two times through the order and handing a close game to a bullpen that has been lights-out in tight spots, led by a trio of high-leverage arms that can handle both lefties and righties. Offensively, they must cash in on runners in scoring position and avoid the base-running mistakes that have occasionally cost them in close games. Both teams are well-coached, matchup-savvy, and capable of winning one-run ballgames, making every managerial decision from the fifth inning onward potentially game-defining. With each team boasting a different style—San Diego’s patient, grind-it-out offense versus Milwaukee’s aggressive, situationally sharp execution—this game may ultimately turn on one swing, one misplay, or a single high-leverage plate appearance. Expect a playoff-like tone and a game that could come down to a ninth-inning at-bat, with neither team offering much margin for error in a battle that could foreshadow an October rematch.

San Diego Padres MLB Preview

The San Diego Padres head into Saturday’s matchup against the Milwaukee Brewers carrying a 33–27 record and a growing sense of urgency as they seek to build consistency in a loaded National League Wild Card race. With momentum gained from a string of quality road performances, the Padres will hand the ball to rookie right-hander Stephen Kolek, who has earned increasing trust within the rotation due to his exceptional command, efficient pitch counts, and ability to induce weak contact. Kolek isn’t a strikeout machine, but his knack for working quickly and forcing grounders allows him to keep innings short and hand the ball over to a reliable bullpen that ranks among the best in the National League in ERA and WHIP during late-inning situations. San Diego’s strength lies in its lineup balance, where stars like Manny Machado, Juan Soto, and Xander Bogaerts combine with complementary bats such as Jake Cronenworth and Ha-Seong Kim to generate offense through a patient, contact-first approach. Soto’s eye at the plate remains one of the best in baseball, while Machado continues to produce in clutch spots, providing power from the cleanup spot and leadership in the field. Bogaerts, though less explosive in 2025, remains a key contributor in driving in runners from scoring position and working tough at-bats against top-tier pitching.

The Padres are 5–5 ATS in their last 10 head-to-head games with the Brewers, including a handful of late-game covers thanks to their superior bullpen and late-inning offense. Their challenge on Saturday will be getting to Brewers ace Brandon Woodruff early, as falling behind against Milwaukee’s bullpen can be a death sentence given how efficiently they shut down games once they take the lead. Kolek’s goal will be to keep the game close through five or six innings and limit traffic ahead of Milwaukee’s middle-order hitters like Christian Yelich and William Contreras, who can change the game with one big swing or hustle play. Defensively, San Diego has been solid, particularly in the infield, where Machado and Kim form one of the best left-side duos in the game. Manager Mike Shildt will likely emphasize aggressive baserunning and double steals in key situations, knowing the Brewers rarely give up extra bases without a fight. If the Padres can capitalize early, take a lead into the seventh, and avoid mental lapses or costly errors, they’ll have a strong chance to steal this one on the road. With the season tightening and every win crucial in a crowded NL postseason picture, San Diego needs to execute cleanly, use its depth wisely, and deliver timely hitting to give their rising rookie and bullpen the run support they need to walk out of Milwaukee with a critical victory.

The San Diego Padres travel to American Family Field on June 7, 2025, for a pivotal midseason matchup against the Milwaukee Brewers. Milwaukee enters as the favorite at –149 on the moneyline and –1.5 on the run line, with the total set at 8.5 runs—signaling expectations for a close, strategy-heavy game. San Diego vs Milwaukee AI Prediction: Free MLB Betting Insights for Jun 07. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Milwaukee Brewers MLB Preview

The Milwaukee Brewers enter Saturday’s matchup against the San Diego Padres with a 32–28 record and a strong reputation for performing well at home, where they’ve gone 6–4 ATS over their last ten games and 3–1 as moneyline favorites in that span. Veteran right-hander Brandon Woodruff will take the mound for Milwaukee, bringing both experience and consistency as he continues to anchor a rotation that has been one of the National League’s most dependable over the past several seasons. Woodruff enters the contest with a 3–1 record and an ERA just under 3.00, and his ability to locate his fastball up in the zone and use his breaking ball effectively to both sides of the plate has kept hitters off balance, especially in early innings. His presence provides the Brewers with a clear advantage in terms of stability and sets the tone for a pitching staff that relies on high strikeout totals, efficient pitch counts, and minimal walk rates. Offensively, Milwaukee is led by Christian Yelich, who has regained much of his former MVP form with a balanced mix of power, patience, and speed, and William Contreras, one of the league’s most underrated catchers, who continues to be a consistent producer in the middle of the lineup.

Complemented by Willy Adames and Brice Turang, this lineup isn’t known for overwhelming slugging totals but excels in situational hitting and capitalizing on defensive lapses. The Brewers’ offensive game plan often involves extended at-bats, contact-oriented approaches, and aggressive baserunning to apply pressure and force mistakes. Milwaukee’s bullpen remains one of the most important weapons in their arsenal, led by closer Devin Williams and supported by a deep group of setup arms who have thrived in high-leverage innings, limiting opponents’ batting average in the seventh through ninth to one of the league’s lowest. This strength allows manager Pat Murphy to manage games confidently once his starter gets through five or six innings, especially when playing at home where they’ve consistently protected leads. Defensively, the Brewers have been sharp as well, particularly in the infield, where Turang and Adames form a reliable double-play duo and the outfield has avoided costly mistakes with smart positioning and accurate arms. Against a balanced San Diego lineup, the key will be limiting traffic for Soto and Machado, while staying aggressive against the Padres’ younger starter, Stephen Kolek, who will be making just his second road start. If Woodruff can pitch deep into the game and Milwaukee’s offense continues to grind out at-bats and create pressure in the middle innings, the Brewers will be well-positioned to secure a series-defining win. In a matchup that will likely come down to execution and bullpen sharpness, Milwaukee holds the home-field edge and the upper hand in both pitching depth and clutch hitting, giving them a clear path to continue climbing in the NL Central standings.

San Diego vs. Milwaukee Prop Picks (AI)

AI algorithm Remi is pouring through tons of datapoints on each team. In fact, anytime the Padres and Brewers play there’s always several intriguing trends to key in on. Not to mention games played at American Family Field in Jun rarely follow normal, predictable betting trends.
Remi's searched hard and found the best prop for this matchup: J. Chourio over 6.5 Fantasy Score.

San Diego vs. Milwaukee Prediction (AI)

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Remi, our AI sports genius, has been pouring over millions of data from every facet between the Padres and Brewers and using recursive machine learning and cutting-edge AI to examine the data to a single cover probability.

Remi has been most fixated on the growing factor emotional bettors tend to put on San Diego’s strength factors between a Padres team going up against a possibly deflated Brewers team. In reality, the true game analytics might reflect a strong lean against one Vegas line specifically.

Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.

Below is our current AI San Diego vs Milwaukee picks, computer picks Padres vs Brewers, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
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Padres Betting Trends

San Diego has split run-line decisions evenly over their last ten matchups against the Brewers, going 5–5–0 ATS in head-to-head contests this season.

Brewers Betting Trends

Milwaukee has gone 6–4 ATS in its last 10 home games, including a strong 3–1 mark as favorites, showcasing consistent value for bettors.

Padres vs. Brewers Matchup Trends

The Brewers have won 77.8 percent of their games as moneyline favorites of –149 or shorter, while the Padres have won 55.6 percent as underdogs of +125 or worse—creating a dynamic betting environment.

San Diego vs. Milwaukee Game Info

San Diego vs Milwaukee starts on June 07, 2025 at 7:35 PM EST.

Venue: American Family Field.

Spread: Milwaukee +1.5
Moneyline: San Diego -104, Milwaukee -115
Over/Under: 8.5

San Diego: (36-26)  |  Milwaukee: (34-30)

Remi's searched hard and found the best prop for this matchup: J. Chourio over 6.5 Fantasy Score.. Prices move—always shop for the best number.

The Brewers have won 77.8 percent of their games as moneyline favorites of –149 or shorter, while the Padres have won 55.6 percent as underdogs of +125 or worse—creating a dynamic betting environment.

SD trend: San Diego has split run-line decisions evenly over their last ten matchups against the Brewers, going 5–5–0 ATS in head-to-head contests this season.

MIL trend: Milwaukee has gone 6–4 ATS in its last 10 home games, including a strong 3–1 mark as favorites, showcasing consistent value for bettors.

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

San Diego vs. Milwaukee Odds

Remi is pouring through tons of stats on each team. In fact, anytime the San Diego vs Milwaukee trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme temps can often follow normal, predictable betting trends.

San Diego vs Milwaukee Opening Odds

SD Moneyline: -104
MIL Moneyline: -115
SD Spread: -1.5
MIL Spread: +1.5
Over/Under: 8.5

San Diego vs Milwaukee Live Odds

Games PTS ML SPR O/U
Oct 24, 2025 8:00PM EDT
Los Angeles Dodgers
Toronto Blue Jays
10/24/25 8PM
Dodgers
Blue Jays
-154
+130
-1.5 (+118)
+1.5 (-142)
O 7.5 (+100)
U 7.5 (-122)

MLB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers San Diego Padres vs. Milwaukee Brewers on June 07, 2025 at American Family Field.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
TOR@SEA OVER 7 54.9% 3 WIN
LAD@MIL UNDER 7.5 56.6% 6 WIN
TOR@NYY OVER 8 54.9% 4 WIN
TOR@NYY CARLOS RODON OVER 1.5 TOTAL WALKS ALLOWED 53.3% 3 WIN
NYY@TOR OVER 7.5 54.8% 2 WIN
LAD@PHI OVER 7 53.8% 3 WIN
SD@CHC CHC -109 53.8% 3 WIN
SD@CHC OVER 7.5 54.5% 4 LOSS
SD@CHC CHC -111 54.8% 4 LOSS
CIN@LAD SHOHEI OHTANI OVER 1.5 BASES 53.5% 3 WIN
BOS@NYY OVER 7 53.8% 3 LOSS
CIN@LAD ELLY DE LA CRUZ OVER 0.5 BASES 54.4% 4 LOSS
ARI@SD SD -131 57.3% 4 WIN
DET@BOS BOS -115 56.4% 5 WIN
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN
CHC@SF CHC -105 54.1% 4 LOSS
NYY@CHW RYAN MCMAHON OVER 0.5 BASES 54.1% 4 WIN