Astros vs. Guardians
Prediction, Odds & Props
Jun 07 | MLB AI Picks
Updated: 2025-06-05T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
Houston Astros visit Progressive Field on June 7, 2025 to face the Cleveland Guardians in what shapes up to be a classic pitching duel with postseason implications. With the Astros as narrow favorites and the total hovering around 7 runs, this afternoon contest promises tight matchups and strategic depth.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

GAME INFO
Date: Jun 07, 2025
Start Time: 4:10 PM EST
Venue: Progressive Field
Guardians Record: (33-29)
Astros Record: (35-28)
OPENING ODDS
HOU Moneyline: -136
CLE Moneyline: +114
HOU Spread: -1.5
CLE Spread: +1.5
Over/Under: 7
HOU
Betting Trends
- The Astros have gone 5–5 ATS in their last 10 games, including a 6–3 record when entering as moneyline favorites of –136 or shorter
CLE
Betting Trends
- The Guardians are 4–1 against the spread in their last five games and currently stand 18–13 ATS at home on the season.
MATCHUP TRENDS
- With the total at 7, trends reflect balance: Houston has gone OVER in only 4 of their last 10 games, while Cleveland has split evenly between overs and unders at home, making this game’s scoring line volatile.
HOU vs. CLE
Best Prop Bet
- Remi's searched hard and found the best prop for this matchup: C. Santana over 0.5 Total Bases.
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Houston vs Cleveland Prediction & Odds:
Free MLB Betting Insights for 6/7/25
Offensively, Cleveland leans on the consistency of José Ramírez, who enters Saturday with a .329 batting average, .382 OBP, and excellent situational hitting instincts, while Steven Kwan and Andres Gimenez offer contact-first approaches that fit the Guardians’ identity as a team that manufactures offense rather than relying on the long ball. The total for the game is set at 7, and given both starting pitchers’ recent form and each team’s comfort in low-scoring affairs, a pitchers’ duel appears likely, with the outcome depending heavily on late-inning bullpen usage, defensive sharpness, and clutch hitting. While Houston has won six of its last seven matchups against Cleveland, the Guardians have gone 4–1 ATS in their last five games and are 18–13 ATS at home this season, proving they can consistently stay competitive in games just like this. The Astros, on the other hand, are 5–5 ATS in their last ten, but 6–3 when favored at –136 or shorter, making them a viable favorite but one that hasn’t always cashed comfortably. This game will come down to execution: if Hunter Brown continues to command the strike zone, and Houston’s top half of the lineup can create early run pressure, they’ll be in position to take the series lead. But if Gavin Williams can navigate the first few innings and allow the Guardians’ offense to chip away, Cleveland has the tools, bullpen, and home-field edge to steal a low-scoring win. With both teams eyeing crucial momentum in their division races, Saturday’s game could be decided by a single mistake, one big swing, or a manager’s call in the seventh inning.
"Wanna see me do it again?" -Dubi#VoteDubi ⭐️ https://t.co/W06pfHRkGz pic.twitter.com/5V3vBQPqTi
— Houston Astros (@astros) June 6, 2025
Houston Astros MLB Preview
The Houston Astros enter Saturday’s road matchup at Progressive Field with a 35–28 record and a clear identity as a pitching-first, veteran-led contender that thrives in low-scoring, tightly contested games. They will hand the ball to their breakout ace Hunter Brown, who has been magnificent this season with an 8–3 record, 1.83 ERA, and 84 strikeouts, anchoring a rotation that has kept them afloat in a fiercely competitive AL West. Brown’s elite command, high strikeout rate, and composure in high-leverage situations have made him one of the most valuable arms in the American League, and his ability to consistently go six-plus innings has given manager Joe Espada the luxury of keeping his bullpen fresh and matchups favorable. Offensively, Houston’s veteran core continues to produce, with Jose Altuve maintaining his role as a top-of-the-order spark plug, Jeremy Peña delivering solid two-way contributions, and Teoscar Hernández providing middle-of-the-order power and run production. Yordan Alvarez and Yainer Diaz have also stepped up, adding depth to a lineup that isn’t necessarily explosive on a nightly basis but executes well with runners in scoring position and consistently applies pressure through patient, grinding at-bats.
The Astros have gone UNDER the total in six of their last ten games, a reflection of their dominant starting pitching and a bullpen anchored by closer Josh Hader, who has been lights out in save situations and provides shutdown confidence in the ninth inning. Houston’s defense has also been sharp, especially up the middle where Altuve, Peña, and Jake Meyers have limited extra-base damage and turned timely double plays that often halt potential rallies. Strategically, the Astros will aim to jump on Guardians starter Gavin Williams early, as their offense has typically performed better when playing with a lead and forcing opposing managers into bullpen decisions by the fifth or sixth inning. Brown will be expected to control the pace of the game, neutralize Cleveland’s contact-heavy lineup, and give his offense enough room to settle into its rhythm without urgency. If Houston can scratch across a couple of early runs and avoid giving the Guardians any free baserunners, their formula of shutdown pitching, sharp defense, and smart situational hitting puts them in an excellent position to grab a win and keep pressure on the Mariners and Rangers in the division. While the Guardians have been tough at home and are playing with confidence, the Astros’ experience, pitching advantage, and bullpen depth give them a narrow edge in what figures to be a tightly played game. If Brown continues to pitch the way he has all season, and the offense can come through in one or two big spots, Houston will be poised to come out of Cleveland with a valuable win in a pivotal road stretch.

Credit: USA TODAY/IMAGN
Cleveland Guardians MLB Preview
The Cleveland Guardians return to Progressive Field for Saturday’s matchup against the Houston Astros with a 32–27 record and a noticeable uptick in form, having gone 4–1 against the spread over their last five games and continuing to exceed expectations with one of the league’s most consistent home performances at 18–13 ATS. They’ll hand the ball to promising right-hander Gavin Williams, who enters the contest with a 5–3 record, a 3.79 ERA, and 66 strikeouts across his first 12 starts, showcasing both durability and poise that have given Cleveland a chance to win nearly every time he takes the mound. Williams relies on a well-located fastball and sharp breaking ball to induce weak contact and keep hitters from squaring up, and he’ll need both working efficiently to navigate a disciplined and power-capable Astros lineup that thrives on extending counts and punishing mistakes. Cleveland’s offense continues to run through cornerstone third baseman José Ramírez, who boasts a .329 batting average and a .382 OBP while remaining one of the most clutch and consistent hitters in the game, frequently delivering in tight, late-game situations. Supporting Ramírez are Steven Kwan and Andres Gimenez, both of whom bring excellent contact rates, on-base ability, and strong baserunning instincts that allow the Guardians to play pressure baseball even when not swinging for the fences.
Cleveland doesn’t rely on the long ball to generate offense, instead leaning into situational hitting, sac flies, and hit-and-run sequences to piece together rallies, a formula that has served them well in low-scoring contests like the one expected on Saturday. The Guardians have split their recent totals between overs and unders, but with a game total of just 7 and facing Hunter Brown’s 1.83 ERA, their margin for error will be slim, making every baserunner and defensive play critical. Cleveland’s bullpen, anchored by All-Star closer Emmanuel Clase, has been reliable in high-leverage spots and has allowed manager Stephen Vogt to manage his starters more aggressively, often going to the pen in the sixth or seventh to preserve leads. Defensively, the Guardians are among the league’s most efficient, committing few errors and converting at a high rate on ground balls and routine flyouts, often turning potential big innings into quick shutdown frames. Against Houston, the Guardians will need to avoid falling behind early, stay patient at the plate, and force Brown into longer at-bats to chip away at his pitch count. If Williams can keep Houston off the scoreboard through five or six innings and Cleveland can scratch out a few runs through their contact-oriented offense, they’ll be in excellent position to take control in the late innings and extend their strong home trend. A win here would not only boost their postseason resume but also reinforce their identity as a team that can grind with the league’s best and win without fireworks—just execution.
Dude makes this look so much easier than it actually is.#GuardsBall | #VoteGuards pic.twitter.com/2sRD6Bok0s
— Cleveland Guardians (@CleGuardians) June 6, 2025
Houston vs. Cleveland Prop Picks (AI)
Houston vs. Cleveland Prediction (AI)

Remi, our AI sports wizard, has been pouring over mountains of data from every past game between the Astros and Guardians and using recursive machine learning and impressive AI to examine the data to a single cover probability.
Remi has been most keyed in on the growing factor human bettors regularly put on coaching factors between a Astros team going up against a possibly unhealthy Guardians team. It appears the true game analytics might reflect a strong lean against one Vegas line specifically.
Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.
Below is our current AI Houston vs Cleveland picks, computer picks Astros vs Guardians, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
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MLB | 9/26 | DET@BOS | UNLOCK THIS PICK | 5 |
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MLB | 9/26 | BAL@NYY | UNLOCK THIS PICK | 4 |
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MLB | 9/26 | ARI@SD | UNLOCK THIS PICK | 4 |
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MLB | 9/26 | NYM@MIA | UNLOCK THIS PICK | 1 |
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MLB | 9/26 | NYM@MIA | GET FREE PICK NOW | 1 | – | |
MLB | 9/26 | COL@SF | UNLOCK THIS PICK | 0 |
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.
Astros Betting Trends
The Astros have gone 5–5 ATS in their last 10 games, including a 6–3 record when entering as moneyline favorites of –136 or shorter
Guardians Betting Trends
The Guardians are 4–1 against the spread in their last five games and currently stand 18–13 ATS at home on the season.
Astros vs. Guardians Matchup Trends
With the total at 7, trends reflect balance: Houston has gone OVER in only 4 of their last 10 games, while Cleveland has split evenly between overs and unders at home, making this game’s scoring line volatile.
Houston vs. Cleveland Game Info
What time does Houston vs Cleveland start on June 07, 2025?
Houston vs Cleveland starts on June 07, 2025 at 4:10 PM EST.
Where is Houston vs Cleveland being played?
Venue: Progressive Field.
What are the opening odds for Houston vs Cleveland?
Spread: Cleveland +1.5
Moneyline: Houston -136, Cleveland +114
Over/Under: 7
What are the records for Houston vs Cleveland?
Houston: (35-28) | Cleveland: (33-29)
What is the AI best bet for Houston vs Cleveland?
Remi's searched hard and found the best prop for this matchup: C. Santana over 0.5 Total Bases.. Prices move—always shop for the best number.
What are Houston vs Cleveland trending bets?
With the total at 7, trends reflect balance: Houston has gone OVER in only 4 of their last 10 games, while Cleveland has split evenly between overs and unders at home, making this game’s scoring line volatile.
What are Houston trending bets?
HOU trend: The Astros have gone 5–5 ATS in their last 10 games, including a 6–3 record when entering as moneyline favorites of –136 or shorter
What are Cleveland trending bets?
CLE trend: The Guardians are 4–1 against the spread in their last five games and currently stand 18–13 ATS at home on the season.
Where can I find AI Picks for Houston vs Cleveland?
See our latest MLB picks and odds pages for 2025 to compare prices before you bet.
Houston vs. Cleveland Odds
Remi is pouring through mountains of stats on each player. In fact, anytime the Houston vs Cleveland trends are analyzed, there’s always several intriguing trends to key in on. Not to mention games played at extreme hostile environments almost always follow normal, predictable patterns.
Houston vs Cleveland Opening Odds
HOU Moneyline:
-136 CLE Moneyline: +114
HOU Spread: -1.5
CLE Spread: +1.5
Over/Under: 7
Houston vs Cleveland Live Odds
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+102
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O 8 (-108)
U 8 (-112)
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-124
+106
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-1.5 (+130)
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O 8.5 (-112)
U 8.5 (-108)
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Sep 27, 2025 6:05PM EDT
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Twins
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+177
-197
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+1.5 (-118)
-1.5 (-102)
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O 8.5 (-118)
U 8.5 (-102)
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Sep 27, 2025 7:11PM EDT
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+128
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+1.5 (-178)
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O 7.5 (-120)
U 7.5 (-102)
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Sep 27, 2025 7:15PM EDT
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+143
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O 8.5 (+100)
U 8.5 (-120)
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+132
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O 7 (-120)
U 7 (-102)
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+120
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O 7.5 (-115)
U 7.5 (-105)
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+102
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+1.5 (-215)
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O 7.5 (-110)
U 7.5 (-110)
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+104
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O 10 (-110)
U 10 (-110)
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MLB Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers Houston Astros vs. Cleveland Guardians on June 07, 2025 at Progressive Field.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.
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LEAN | %WIN | UNITS | RESULT |
---|---|---|---|---|
NYM@CHC | NYM -110 | 54.1% | 3 | WIN |
HOU@ATH | ATH +118 | 50.8% | 4 | WIN |
NYM@CHC | OVER 7 | 54.5% | 3 | WIN |
STL@SF | OVER 7.5 | 55.9% | 5 | LOSS |
KC@LAA | TYLER TOLBERT UNDER 1.5 BASES | 54.4% | 4 | WIN |
MIL@SD | UNDER 9 | 54.7% | 4 | WIN |
MIA@PHI | KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS | 53.3% | 3 | WIN |
WAS@NYM | OVER 8.5 | 56.1% | 6 | LOSS |
LAA@COL | COL +108 | 50.5% | 3 | WIN |
TOR@KC | UNDER 9 | 54.7% | 4 | LOSS |
SEA@KC | KC +1.5 | 62.3% | 5 | LOSS |
NYY@MIN | OVER 9 | 55.1% | 4 | WIN |
MIA@COL | OVER 10.5 | 55.0% | 4 | WIN |
MIA@COL | AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS | 54.3% | 4 | WIN |
SEA@KC | BOBBY WITT UNDER 0.5 SINGLES | 54.4% | 4 | LOSS |
PHI@LAD | LAD -113 | 54.7% | 4 | LOSS |
NYY@BOS | OVER 7.5 | 54.3% | 3 | WIN |
KC@PHI | PHI -130 | 58.3% | 4 | WIN |
LAD@SF | OVER 7.5 | 54.7% | 4 | LOSS |
NYM@PHI | PHI -122 | 55.6% | 4 | WIN |
KC@CLE | KC -104 | 52.0% | 3 | WIN |
CIN@SD | JAKE CRONEWORTH OVER 0.5 HITS | 53.1% | 3 | WIN |
WAS@MIA | MIA -123 | 55.2% | 4 | LOSS |
LAA@KC | UNDER 9.5 | 54.9% | 3 | WIN |
TEX@ARI | UNDER 9 | 54.2% | 4 | WIN |
SF@COL | UNDER 11.5 | 56.4% | 6 | LOSS |
SF@COL | RAFAEL DEVERS OVER 1.5 BASES | 56.1% | 6 | WIN |
MIA@WAS | WAS -110 | 54.4% | 4 | WIN |
NYM@DET | OVER 8.5 | 54.5% | 4 | WIN |
TEX@ARI | UNDER 9.5 | 56.4% | 6 | WIN |
TEX@ARI | ALEJANDRO OSUNA UNDER 1.5 BASES | 54.1% | 4 | LOSS |
ATL@CHC | CHC -116 | 55.1% | 3 | WIN |
PHI@MIL | OVER 8.5 | 55.0% | 3 | WIN |
ARI@LAD | SHOHEI OHTANI OVER 2.5 BASES | 54.2% | 4 | WIN |
SEA@CLE | CLE +1.5 | 57.2% | 3 | WIN |
CHC@SF | CHC -105 | 54.1% | 4 | LOSS |
NYY@CHW | RYAN MCMAHON OVER 0.5 BASES | 54.1% | 4 | WIN |
PHI@NYM | OVER 8.5 | 55.6% | 4 | LOSS |
LAA@TEX | LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS | 54.1% | 4 | LOSS |
KC@CHW | KC -109 | 54.2% | 4 | WIN |
SD@SEA | DYLAN CEASE OVER 16.5 OUTS | 53.9% | 3 | LOSS |
SD@SEA | UNDER 8.5 | 54.4% | 4 | LOSS |
MIN@TOR | JOE RYAN UNDER 2.5 EARNED RUNS | 54.1% | 4 | LOSS |
SF@MIL | MIL +100 | 54.0% | 6 | LOSS |
TOR@MIA | MIA +1.5 | 62.0% | 6 | WIN |
CHC@LAA | OVER 9.5 | 54.9% | 4 | LOSS |
BOS@NYY | CARLOS RODON UNDER 4.5 HITS ALLOWED | 54.2% | 4 | WIN |
KC@DET | DET -115 | 56.1% | 5 | WIN |
CHC@LAA | LAA +1.5 | 57.6% | 5 | LOSS |
CIN@ARI | KEBRYAN HAYES STRIKEOUTS UNDER 0.5 | 56.2% | 6 | WIN |
LAD@SD | SD +110 | 50.9% | 6 | WIN |