Cardinals vs. Orioles
Prediction, Odds & Props
May 26 | MLB AI Picks

Updated: 2025-05-24T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The St. Louis Cardinals (30–23) will face the Baltimore Orioles (18–34) on May 26, 2025, at Oriole Park at Camden Yards. The Cardinals aim to strengthen their position in the NL Central, while the Orioles seek to rebound from a challenging season.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: May 26, 2025

Start Time: 3:05 PM EST​

Venue: Oriole Park at Camden Yards​

Orioles Record: (18-34)

Cardinals Record: (30-23)

OPENING ODDS

STL Moneyline: -110

BAL Moneyline: -110

STL Spread: -1.5

BAL Spread: +1.5

Over/Under: 9.5

STL
Betting Trends

  • The Cardinals have covered the run line in 18 of their last 26 games, indicating strong recent performance against the spread.

BAL
Betting Trends

  • The Orioles have hit the team total under in 28 of their last 42 games, reflecting ongoing offensive struggles.

MATCHUP TRENDS

  • The Cardinals’ recent success against the spread contrasts with the Orioles’ tendency to fall short of their team total, suggesting a potential edge for St. Louis in this matchup.

STL vs. BAL
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: I. Herrera over 5.5 Fantasy Score.

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St. Louis vs Baltimore Prediction & Odds:
Free MLB Betting Insights for 5/26/25

The Memorial Day showdown between the St. Louis Cardinals and Baltimore Orioles at Oriole Park at Camden Yards on May 26, 2025, offers a clear disparity between a playoff-hungry team in the Cardinals and a struggling, injury-ravaged Orioles club trying to regain relevance. The Cardinals enter the matchup with a solid 30–23 record, trailing closely behind the Milwaukee Brewers in the NL Central and playing with the consistency that playoff contenders are expected to deliver. Offensively, St. Louis has seen strong contributions from Lars Nootbaar, who leads the team with 10 home runs, and Willson Contreras, who has driven in 40 RBIs and continues to be a catalyst in the middle of the lineup. Their team batting average of .262 underscores a steady and productive offensive approach that thrives on timely hitting and balanced production throughout the lineup. On the mound, they’ll turn to Erick Fedde, who has quietly been a dependable presence with a 3.77 ERA and solid command over 57.1 innings pitched, giving the team a consistent chance to win every fifth day. Fedde’s mix of off-speed stuff and fastball location has helped him keep hitters off balance and eat innings, something that will be particularly valuable against a Baltimore lineup that’s been inconsistent all season. The Orioles, by contrast, have slumped to an 18–34 record and are currently buried at the bottom of the AL East, struggling to stay competitive due to a combination of underwhelming performances, poor pitching, and multiple injuries to key players.

Their expected starter Charlie Morton has posted a bloated 7.68 ERA and a winless 0–7 record, signaling a tough season for the veteran who hasn’t been able to generate the swing-and-miss stuff or control that defined his earlier years. Baltimore’s offensive output has been pedestrian at best, often failing to reach their team total, and has relied heavily on the occasional hot streak from hitters like Gunnar Henderson or Jordan Westburg—though neither has been enough to carry the team. Injuries to stars like Adley Rutschman and Grayson Rodriguez have further hampered their ability to stay afloat. Despite a few recent bullpen highlights, including the stabilizing return of closer Félix Bautista, the Orioles have frequently found themselves trailing early and struggling to mount comebacks. Defensively, miscues and lapses in concentration have cost them dearly in several games, and their depth has been tested to the point of breaking. For the Cardinals, this matchup presents an excellent opportunity to assert dominance early, pile on runs against a vulnerable Morton, and let Fedde and the bullpen secure a clean, businesslike win. Their recent form against the spread—covering the run line in 18 of their last 26—also indicates this team doesn’t just win, it often does so comfortably, which may again be the case here. With the playoff race tightening and every game mattering in the crowded NL, expect St. Louis to come in focused, motivated, and ready to take care of business against a Baltimore squad still searching for answers and consistency in a season that has quickly veered off course.

St. Louis Cardinals MLB Preview

The St. Louis Cardinals enter their Memorial Day road matchup against the Baltimore Orioles sitting at 30–23 and well within striking distance of first place in the NL Central, buoyed by steady offensive output, competent starting pitching, and solid defensive execution. This version of the Cardinals is proving to be a balanced, quietly dangerous team—one that wins without flash but with discipline, execution, and timely performances from key players. At the plate, Lars Nootbaar has become a legitimate power threat with a team-leading 10 home runs, while Willson Contreras continues to anchor the middle of the order with 40 RBIs, offering leadership and run production in high-leverage situations. The lineup as a whole is clicking, sporting a .262 team batting average and showing the ability to string together innings with both contact and power. What makes this Cardinals team especially dangerous on the road is their ability to strike early and control games from the mound, and that starts with probable starter Erick Fedde, who has posted a 3.77 ERA over 57.1 innings this season. Fedde isn’t overpowering, but he has refined his approach, mixing his pitches effectively, staying out of the heart of the zone, and limiting big innings—particularly valuable against an Orioles lineup that has struggled to find rhythm all year. St. Louis’ bullpen has done its job in protecting leads, and its defense has been one of the most fundamentally sound units in the National League, keeping pressure off the pitching staff and reducing extra outs.

The Cardinals have also been covering the run line at an impressive clip, going 18–8 in their last 26 ATS outings, which reflects their ability to not just win games but control them start to finish. That kind of performance is exactly what they’ll be looking to extend against a Baltimore team that has lost both games and confidence amid injuries, poor starting pitching, and an inconsistent lineup. For St. Louis, this matchup is about staying sharp, not playing down to the competition, and continuing to apply pressure on Milwaukee in the division standings. Manager Oliver Marmol has consistently gotten the most out of his roster, using platoons effectively and managing his bullpen with poise, and there’s every reason to expect a clean, composed effort from this group in a road setting. With Fedde taking the mound against the struggling Charlie Morton and a depleted Orioles roster, the opportunity is there for the Cardinals to build an early lead and cruise behind strong pitching and defense. Their approach doesn’t rely on gaudy stats or overwhelming talent but instead on doing the little things right—moving runners, limiting free passes, converting with runners in scoring position, and winning late innings. If they stick to that formula, St. Louis should be poised to come away from Camden Yards with a statement win and valuable momentum as they continue their pursuit of the division crown.

The St. Louis Cardinals (30–23) will face the Baltimore Orioles (18–34) on May 26, 2025, at Oriole Park at Camden Yards. The Cardinals aim to strengthen their position in the NL Central, while the Orioles seek to rebound from a challenging season. St. Louis vs Baltimore AI Prediction: Free MLB Betting Insights for May 26. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Baltimore Orioles MLB Preview

The Baltimore Orioles enter their May 26, 2025 matchup against the St. Louis Cardinals with a dismal 18–34 record and a season that continues to spiral as injuries, inconsistent pitching, and offensive underperformance have derailed any early hopes of contention. Despite flashes of talent and isolated strong individual performances, the Orioles have struggled to put together complete games and frequently find themselves playing from behind—something that has plagued both their confidence and their execution. The rotation has been a major weak point, and Monday’s starter Charlie Morton exemplifies those struggles, as the veteran right-hander comes into this game with a troubling 0–7 record and a 7.68 ERA across his starts. Once a reliable innings-eater, Morton has lost both velocity and command, and his diminished stuff has led to hard contact and early exits, leaving the bullpen overtaxed and exposed on a nightly basis. While Félix Bautista has offered some late-inning relief stability since returning, the bridge to him has been unreliable at best. Offensively, the Orioles’ production has been far too inconsistent to compensate for their pitching woes, with the team consistently hitting the under on team run totals, a trend that speaks to their inability to cash in with runners in scoring position or sustain rallies.

The injury bug has not spared Baltimore, as they continue to operate without Adley Rutschman and Grayson Rodriguez—two cornerstone pieces on both sides of the ball whose absences have left holes in leadership, lineup depth, and pitching rotation quality. Without Rutschman, the heart of the order has lacked pop and clutch hitting, and while youngsters like Gunnar Henderson have shown promise, the load has been too heavy for a developing core to carry without veteran support. Camden Yards, normally a place where the Orioles play with extra energy, has provided little advantage this season, as the team has frequently fallen behind early and failed to mount comebacks. Manager Brandon Hyde continues to preach fundamentals and patience, but the team’s defensive lapses, base-running errors, and overall inability to play clean baseball have contributed to the spiraling record. Facing a fundamentally sound and playoff-contending team like the Cardinals only increases the margin for error, and Baltimore will need an almost perfect effort—starting with Morton turning in his best outing of the season—to remain competitive. The Orioles must find a way to jump on Erick Fedde early, generate quality at-bats throughout the order, and hope for a tight, low-scoring contest that keeps them within striking distance. It’s a tall task for a team that has consistently been outplayed in nearly every phase of the game, but for the Orioles, a surprise win here could serve as the beginning of a much-needed morale boost and a rare bright spot in what has otherwise been a deeply frustrating and disappointing campaign.

St. Louis vs. Baltimore Prop Picks (AI)

AI algorithm Remi is pouring through tons of data on each team. In fact, anytime the Cardinals and Orioles play there’s always several intriguing observations to key in on. Not to mention games played at Oriole Park at Camden Yards in May rarely follow normal, predictable patterns.
Remi's searched hard and found the best prop for this matchup: I. Herrera over 5.5 Fantasy Score.

St. Louis vs. Baltimore Prediction (AI)

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Remi, our AI sports algorithm, has been pouring over mountains of data from every simulation between the Cardinals and Orioles and using recursive machine learning and impressive AI to boil down the data to a single cover probability.

Oddly enough, we’ve seen the AI has been most watching on the growing weight human bettors tend to put on Baltimore’s strength factors between a Cardinals team going up against a possibly tired Orioles team. It appears the true game analytics might reflect a strong lean against one Vegas line in particular.

Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.

Below is our current AI St. Louis vs Baltimore picks, computer picks Cardinals vs Orioles, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
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Cardinals Betting Trends

The Cardinals have covered the run line in 18 of their last 26 games, indicating strong recent performance against the spread.

Orioles Betting Trends

The Orioles have hit the team total under in 28 of their last 42 games, reflecting ongoing offensive struggles.

Cardinals vs. Orioles Matchup Trends

The Cardinals’ recent success against the spread contrasts with the Orioles’ tendency to fall short of their team total, suggesting a potential edge for St. Louis in this matchup.

St. Louis vs. Baltimore Game Info

St. Louis vs Baltimore starts on May 26, 2025 at 3:05 PM EST.

Venue: Oriole Park at Camden Yards.

Spread: Baltimore +1.5
Moneyline: St. Louis -110, Baltimore -110
Over/Under: 9.5

St. Louis: (30-23)  |  Baltimore: (18-34)

Remi's searched hard and found the best prop for this matchup: I. Herrera over 5.5 Fantasy Score.. Prices move—always shop for the best number.

The Cardinals’ recent success against the spread contrasts with the Orioles’ tendency to fall short of their team total, suggesting a potential edge for St. Louis in this matchup.

STL trend: The Cardinals have covered the run line in 18 of their last 26 games, indicating strong recent performance against the spread.

BAL trend: The Orioles have hit the team total under in 28 of their last 42 games, reflecting ongoing offensive struggles.

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

St. Louis vs. Baltimore Odds

AI algorithm Remi is pouring through mountains of data points on each line. In fact, anytime the St. Louis vs Baltimore trends are analyzed, there’s always several intriguing trends to key in on. Not to mention games played at extreme altitude seemingly never follow normal, predictable betting trends.

St. Louis vs Baltimore Opening Odds

STL Moneyline: -110
BAL Moneyline: -110
STL Spread: -1.5
BAL Spread: +1.5
Over/Under: 9.5

St. Louis vs Baltimore Live Odds

Games PTS ML SPR O/U
In Progress
Baltimore Orioles
New York Yankees
In Progress
Orioles
Yankees
0
3
+1200
-2800
+4.5 (-115)
-4.5 (-115)
O 7.5 (-130)
U 7.5 (+100)
In Progress
St Louis Cardinals
Chicago Cubs
In Progress
Cardinals
Cubs
0
1
 
-300
 
-1.5 (-140)
O 9.5 (+100)
U 9.5 (-130)
Sep 27, 2025 3:09PM EDT
Tampa Bay Rays
Toronto Blue Jays
9/27/25 3:09PM
Rays
Blue Jays
+140
-170
+1.5 (-155)
-1.5 (+130)
O 8.5 (-105)
U 8.5 (-115)
Sep 27, 2025 4:05PM EDT
Chicago White Sox
Washington Nationals
9/27/25 4:05PM
White Sox
Nationals
-105
-115
-1.5 (+155)
+1.5 (-190)
O 8.5 (-115)
U 8.5 (-105)
Sep 27, 2025 4:06PM EDT
Colorado Rockies
San Francisco Giants
9/27/25 4:06PM
Rockies
Giants
+190
-235
+1.5 (-105)
-1.5 (-115)
O 8 (-105)
U 8 (-115)
Sep 27, 2025 4:11PM EDT
New York Mets
Miami Marlins
9/27/25 4:11PM
Mets
Marlins
-140
+115
-1.5 (+125)
+1.5 (-150)
O 8 (-105)
U 8 (-115)
Sep 27, 2025 4:11PM EDT
Detroit Tigers
Boston Red Sox
9/27/25 4:11PM
Tigers
Red Sox
+105
-125
-1.5 (+165)
+1.5 (-200)
O 8.5 (-110)
U 8.5 (-110)
Sep 27, 2025 6:05PM EDT
Minnesota Twins
Philadelphia Phillies
9/27/25 6:05PM
Twins
Phillies
+185
-225
+1.5 (-110)
-1.5 (-110)
O 8.5 (-115)
U 8.5 (-105)
Sep 27, 2025 7:11PM EDT
Cincinnati Reds
Milwaukee Brewers
9/27/25 7:11PM
Reds
Brewers
+110
-130
+1.5 (-190)
-1.5 (+155)
O 8 (-110)
U 8 (-110)
Sep 27, 2025 7:15PM EDT
Pittsburgh Pirates
Atlanta Braves
9/27/25 7:15PM
Pirates
Braves
+145
-175
+1.5 (-150)
-1.5 (+125)
O 8 (-105)
U 8 (-115)
Sep 27, 2025 7:16PM EDT
Texas Rangers
Cleveland Guardians
9/27/25 7:16PM
Rangers
Guardians
+120
-145
+1.5 (-190)
-1.5 (+155)
O 7 (-120)
U 7 (+100)
Sep 27, 2025 8:40PM EDT
Arizona Diamondbacks
San Diego Padres
9/27/25 8:40PM
Diamondbacks
Padres
+115
-140
+1.5 (-180)
-1.5 (+150)
O 7.5 (-120)
U 7.5 (+100)
Sep 27, 2025 9:39PM EDT
Houston Astros
Los Angeles Angels
9/27/25 9:39PM
Astros
Angels
-145
+120
-1.5 (+110)
+1.5 (-130)
O 9 (-110)
U 9 (-110)
Sep 27, 2025 9:41PM EDT
Los Angeles Dodgers
Seattle Mariners
9/27/25 9:41PM
Dodgers
Mariners
+100
-120
-1.5 (+175)
+1.5 (-215)
O 7 (-115)
U 7 (-105)
Sep 27, 2025 10:05PM EDT
Kansas City Royals
Oakland Athletics
9/27/25 10:05PM
Royals
Athletics
+100
-120
-1.5 (+155)
+1.5 (-190)
O 10 (-115)
U 10 (-105)

MLB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers St. Louis Cardinals vs. Baltimore Orioles on May 26, 2025 at Oriole Park at Camden Yards.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
ARI@SD SD -131 57.3% 4 WIN
DET@BOS BOS -115 56.4% 5 WIN
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN
CHC@SF CHC -105 54.1% 4 LOSS
NYY@CHW RYAN MCMAHON OVER 0.5 BASES 54.1% 4 WIN
PHI@NYM OVER 8.5 55.6% 4 LOSS
LAA@TEX LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS 54.1% 4 LOSS
KC@CHW KC -109 54.2% 4 WIN
SD@SEA DYLAN CEASE OVER 16.5 OUTS 53.9% 3 LOSS
SD@SEA UNDER 8.5 54.4% 4 LOSS
MIN@TOR JOE RYAN UNDER 2.5 EARNED RUNS 54.1% 4 LOSS
SF@MIL MIL +100 54.0% 6 LOSS
TOR@MIA MIA +1.5 62.0% 6 WIN
CHC@LAA OVER 9.5 54.9% 4 LOSS
BOS@NYY CARLOS RODON UNDER 4.5 HITS ALLOWED 54.2% 4 WIN
KC@DET DET -115 56.1% 5 WIN
CHC@LAA LAA +1.5 57.6% 5 LOSS