Guardians vs. Tigers
Prediction, Odds & Props
May 25 | MLB AI Picks
Updated: 2025-05-23T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The Cleveland Guardians and Detroit Tigers will face off on Sunday, May 25, 2025, at Comerica Park in the finale of their four-game series. The Tigers, leading the AL Central, aim to solidify their division dominance, while the Guardians seek to close the gap and gain momentum.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

GAME INFO
Date: May 25, 2025
Start Time: 11:35 AM
Venue: Comerica Park
Tigers Record: (33-20)
Guardians Record: (29-22)
OPENING ODDS
CLE Moneyline: +184
DET Moneyline: -223
CLE Spread: +1.5
DET Spread: -1.5
Over/Under: 7.5
CLE
Betting Trends
- The Cleveland Guardians have a 20–20–0 record against the spread (ATS) this season.
DET
Betting Trends
- The Detroit Tigers hold a 32–18 record against the spread (ATS) this season.
MATCHUP TRENDS
- The Tigers have a 17–5 home record this season, covering the spread in 77% of those games, indicating a strong home-field advantage.
CLE vs. DET
Best Prop Bet
- Remi's searched hard and found the best prop for this matchup: J. Ramirez over 5.5 Fantasy Score.
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Cleveland vs Detroit Prediction & Odds:
Free MLB Betting Insights for 5/25/25
Cleveland’s offense has also lagged behind expectations, managing just a .234 team batting average and showing streakiness in run production that has cost them games against more complete opponents. However, Cleveland has performed well against divisional foes, with a 10–3 record in AL Central play, suggesting they tend to rise to the occasion in familiar matchups. The key for the Guardians will be limiting damage early, as they’ve struggled to play from behind and haven’t had the power to erase deficits quickly. If their pitching can keep the Tigers’ offense contained through the middle innings, the Guardians have enough contact hitters to generate scoring opportunities late. But any early hole against a team like Detroit—who are playing with confidence, pitching precision, and aggressive baserunning—could spell the difference between a competitive finish and a series defeat. The Tigers’ balance, depth, and home-field dominance have made them one of baseball’s early-season surprises, while the Guardians must prove they can beat elite teams on the road to be taken seriously as postseason contenders. Sunday’s game represents more than just a series finale—it’s a tone-setter for the rest of the division race. If Cleveland wants to stay in the hunt, this is the game to make a statement. For Detroit, it’s a chance to bury a key rival further down the standings and continue their remarkable early-season pace.
A 4-run 10th for the good guys to take it home.#GuardsBall | #GuardiWWWWins pic.twitter.com/ImZuErgu0e
— Cleveland Guardians (@CleGuardians) May 25, 2025
Cleveland Guardians MLB Preview
The Cleveland Guardians head into their May 25 matchup against the Detroit Tigers with a 28–22 record and in need of a statement win as they wrap up a crucial four-game series at Comerica Park. Trailing the Tigers in the AL Central standings, the Guardians have shown flashes of competitiveness this season but remain hampered by inconsistency, particularly in their pitching and run production. Their pitching staff carries a 4.23 team ERA—noticeably higher than the division-leading Tigers’—and the bullpen has at times struggled to hold leads in tight games, an issue that’s proved costly in recent matchups. Offensively, Cleveland’s lineup has been underwhelming overall, batting .234 as a team and ranking near the bottom of the American League in extra-base hits and slugging percentage, making it difficult for them to capitalize on scoring opportunities or erase deficits quickly. José Ramírez remains the team’s most reliable offensive presence, but even his production hasn’t been enough to lift an offense that lacks consistent power and struggles against strong rotations like Detroit’s. That said, the Guardians have proven they can compete within the division, boasting a 10–3 record against AL Central opponents, and they’ve demonstrated the grit and late-inning resilience that’s allowed them to hang around despite statistical deficiencies.
If they’re going to close the gap on the Tigers, Sunday’s game presents a golden opportunity—they’ve already seen Detroit’s starters several times this year and could benefit from adjustments made over the course of this series. The Guardians’ 20–20 record against the spread (ATS) reflects their rollercoaster tendencies; they can keep games close but often lack the firepower to consistently pull away or dominate inferior opponents. Manager Stephen Vogt will need to find ways to manufacture runs—through stolen bases, hit-and-run strategies, and exploiting Detroit’s defensive alignments—to compensate for the lack of raw power in the lineup. Cleveland’s defense has been mostly solid, helping the team stay in games even when the offense is quiet, and their ability to execute in tight spots will be critical in a road environment where Detroit has played exceptionally well. To come out with a win, the Guardians will need a strong start on the mound, better contact in clutch moments, and a clean defensive performance to limit the Tigers’ ability to capitalize on their offensive momentum. If they can check those boxes, they’ll give themselves a chance to steal the series finale and avoid falling further behind in what’s shaping up to be a competitive AL Central race. With the Tigers surging, this game carries added urgency for Cleveland—not just to salvage the series, but to show they have the depth, discipline, and resilience to challenge for the division title over the long haul.

Credit: USA TODAY/IMAGN
Detroit Tigers MLB Preview
The Detroit Tigers enter their May 25 home matchup against the Cleveland Guardians with a 33–19 record, the best in the American League, and firmly in control of the AL Central as they look to close out a dominant series at Comerica Park. Detroit has been a revelation in 2025, combining elite starting pitching, timely offense, and defensive consistency to rise from preseason underdog status to legitimate playoff contender. A major part of their success has been their dominance at home, where they own a 17–5 record and have covered the spread in 77% of those games, making Comerica Park one of the toughest venues for visiting teams this season. Offensively, Riley Greene has emerged as the spark plug and breakout star, hitting .333 with nine home runs since mid-April and ranking among the league leaders in several advanced metrics including wRC+, slugging, and hard-hit rate. Spencer Torkelson and Kerry Carpenter have provided complementary power and situational hitting, giving the Tigers a well-rounded lineup capable of grinding out runs and putting up crooked numbers when they find rhythm. On the mound, Detroit’s rotation has been nothing short of exceptional, anchored by ace Tarik Skubal and a group that leads the American League with a 3.32 ERA.
The pitching staff has not only limited damage early but also given manager A.J. Hinch the flexibility to preserve his bullpen for high-leverage situations, a luxury that few teams currently enjoy. Defensively, the Tigers have played crisp, smart baseball—turning double plays, controlling the running game, and minimizing errors—which has helped them maintain leads and control tempo even in tight contests. Against a Cleveland team that has struggled to find consistency at the plate and on the mound, the Tigers have imposed their will throughout the series with aggressive baserunning, well-timed hits, and superior execution. Their 32–18 ATS record on the season reinforces how frequently they outperform expectations, especially at home where their offense tends to ignite early and their starters settle in quickly. Detroit’s formula for success has been repeatable and sustainable: pitch efficiently, defend cleanly, and grind out runs with a balanced approach that doesn’t rely solely on the long ball. A win in the series finale would not only pad their lead in the division but send a clear message to the rest of the league that this Tigers squad is more than just a feel-good story—it’s a team with legitimate October aspirations. With a confident clubhouse, elite pitching, and a growing fan base behind them, the Tigers are playing their best baseball at the right time, and Sunday’s finale gives them a chance to further assert their dominance over a division rival and keep the pressure on every other contender in the American League.
Welcome back Matty V! 🔥 pic.twitter.com/pvlu2zQlJ2
— Detroit Tigers (@tigers) May 24, 2025
Cleveland vs. Detroit Prop Picks (AI)
Cleveland vs. Detroit Prediction (AI)

Remi, our AI sports algorithm, has been pouring over mountains of data from every angle between the Guardians and Tigers and using recursive machine learning and industry leading AI to crunch the data to a single cover probability.
Oddly enough, we’ve seen the AI has been most watching on the growing factor emotional bettors often put on player performance factors between a Guardians team going up against a possibly strong Tigers team. We’ve found the true game analytics might reflect a slight lean against one Vegas line specifically.
Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.
Below is our current AI Cleveland vs Detroit picks, computer picks Guardians vs Tigers, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
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MLB | 9/26 | DET@BOS | UNLOCK THIS PICK | 5 |
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MLB | 9/26 | BAL@NYY | UNLOCK THIS PICK | 4 |
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MLB | 9/26 | ARI@SD | UNLOCK THIS PICK | 4 |
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MLB | 9/26 | NYM@MIA | UNLOCK THIS PICK | 1 |
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MLB | 9/26 | NYM@MIA | GET FREE PICK NOW | 1 | – | |
MLB | 9/26 | COL@SF | UNLOCK THIS PICK | 0 |
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.
Guardians Betting Trends
The Cleveland Guardians have a 20–20–0 record against the spread (ATS) this season.
Tigers Betting Trends
The Detroit Tigers hold a 32–18 record against the spread (ATS) this season.
Guardians vs. Tigers Matchup Trends
The Tigers have a 17–5 home record this season, covering the spread in 77% of those games, indicating a strong home-field advantage.
Cleveland vs. Detroit Game Info
What time does Cleveland vs Detroit start on May 25, 2025?
Cleveland vs Detroit starts on May 25, 2025 at 11:35 AM.
Where is Cleveland vs Detroit being played?
Venue: Comerica Park.
What are the opening odds for Cleveland vs Detroit?
Spread: Detroit -1.5
Moneyline: Cleveland +184, Detroit -223
Over/Under: 7.5
What are the records for Cleveland vs Detroit?
Cleveland: (29-22) | Detroit: (33-20)
What is the AI best bet for Cleveland vs Detroit?
Remi's searched hard and found the best prop for this matchup: J. Ramirez over 5.5 Fantasy Score.. Prices move—always shop for the best number.
What are Cleveland vs Detroit trending bets?
The Tigers have a 17–5 home record this season, covering the spread in 77% of those games, indicating a strong home-field advantage.
What are Cleveland trending bets?
CLE trend: The Cleveland Guardians have a 20–20–0 record against the spread (ATS) this season.
What are Detroit trending bets?
DET trend: The Detroit Tigers hold a 32–18 record against the spread (ATS) this season.
Where can I find AI Picks for Cleveland vs Detroit?
See our latest MLB picks and odds pages for 2025 to compare prices before you bet.
Cleveland vs. Detroit Odds
AI algorithm Remi is pouring through loads of data points on each line. In fact, anytime the Cleveland vs Detroit trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme hostile environments rarely follow normal, predictable patterns.
Cleveland vs Detroit Opening Odds
CLE Moneyline:
+184 DET Moneyline: -223
CLE Spread: +1.5
DET Spread: -1.5
Over/Under: 7.5
Cleveland vs Detroit Live Odds
Games | PTS | ML | SPR | O/U | |
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Sep 27, 2025 1:06PM EDT
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New York Yankees
9/27/25 1:06PM
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–
–
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+190
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+1.5 (-110)
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O 8.5 (-120)
U 8.5 (+100)
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Chicago Cubs
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–
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-180
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-1.5 (+115)
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O 9.5 (-105)
U 9.5 (-115)
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Sep 27, 2025 3:09PM EDT
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Toronto Blue Jays
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–
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+130
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+1.5 (-155)
-1.5 (+130)
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O 8.5 (-110)
U 8.5 (-110)
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Sep 27, 2025 4:06PM EDT
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Washington Nationals
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–
–
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+100
-120
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-1.5 (+165)
+1.5 (-200)
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O 8.5 (-110)
U 8.5 (-110)
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Sep 27, 2025 4:06PM EDT
Colorado Rockies
San Francisco Giants
9/27/25 4:06PM
Rockies
Giants
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–
–
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+185
-225
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+1.5 (-110)
-1.5 (-110)
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O 8 (-105)
U 8 (-115)
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Sep 27, 2025 4:11PM EDT
New York Mets
Miami Marlins
9/27/25 4:11PM
Mets
Marlins
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–
–
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-130
+110
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-1.5 (+125)
+1.5 (-150)
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O 8 (-115)
U 8 (-105)
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Sep 27, 2025 4:11PM EDT
Detroit Tigers
Boston Red Sox
9/27/25 4:11PM
Tigers
Red Sox
|
–
–
|
+125
-150
|
+1.5 (-180)
-1.5 (+150)
|
O 9 (+100)
U 9 (-120)
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Sep 27, 2025 6:05PM EDT
Minnesota Twins
Philadelphia Phillies
9/27/25 6:05PM
Twins
Phillies
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–
–
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+170
-205
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+1.5 (-120)
-1.5 (+100)
|
O 8.5 (-115)
U 8.5 (-105)
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Sep 27, 2025 7:11PM EDT
Cincinnati Reds
Milwaukee Brewers
9/27/25 7:11PM
Reds
Brewers
|
–
–
|
+125
-150
|
+1.5 (-180)
-1.5 (+150)
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O 8 (-105)
U 8 (-115)
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Sep 27, 2025 7:15PM EDT
Pittsburgh Pirates
Atlanta Braves
9/27/25 7:15PM
Pirates
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–
–
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+145
-175
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+1.5 (-155)
-1.5 (+130)
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O 8 (-110)
U 8 (-110)
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Sep 27, 2025 7:16PM EDT
Texas Rangers
Cleveland Guardians
9/27/25 7:16PM
Rangers
Guardians
|
–
–
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+135
-165
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+1.5 (-180)
-1.5 (+150)
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O 7 (-120)
U 7 (+100)
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Sep 27, 2025 8:40PM EDT
Arizona Diamondbacks
San Diego Padres
9/27/25 8:40PM
Diamondbacks
Padres
|
–
–
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+115
-140
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+1.5 (-195)
-1.5 (+160)
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O 7.5 (-120)
U 7.5 (+100)
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Sep 27, 2025 9:39PM EDT
Houston Astros
Los Angeles Angels
9/27/25 9:39PM
Astros
Angels
|
–
–
|
-165
+135
|
-1.5 (+105)
+1.5 (-125)
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O 9 (+100)
U 9 (-120)
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|
Sep 27, 2025 9:41PM EDT
Los Angeles Dodgers
Seattle Mariners
9/27/25 9:41PM
Dodgers
Mariners
|
–
–
|
+105
-125
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+1.5 (-205)
-1.5 (+170)
|
O 7.5 (+105)
U 7.5 (-125)
|
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Sep 27, 2025 10:05PM EDT
Kansas City Royals
Oakland Athletics
9/27/25 10:05PM
Royals
Athletics
|
–
–
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+100
-120
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-1.5 (+150)
+1.5 (-180)
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O 10 (-110)
U 10 (-110)
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MLB Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers Cleveland Guardians vs. Detroit Tigers on May 25, 2025 at Comerica Park.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.
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LEAN | %WIN | UNITS | RESULT |
---|---|---|---|---|
NYM@CHC | NYM -110 | 54.1% | 3 | WIN |
HOU@ATH | ATH +118 | 50.8% | 4 | WIN |
NYM@CHC | OVER 7 | 54.5% | 3 | WIN |
STL@SF | OVER 7.5 | 55.9% | 5 | LOSS |
KC@LAA | TYLER TOLBERT UNDER 1.5 BASES | 54.4% | 4 | WIN |
MIL@SD | UNDER 9 | 54.7% | 4 | WIN |
MIA@PHI | KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS | 53.3% | 3 | WIN |
WAS@NYM | OVER 8.5 | 56.1% | 6 | LOSS |
LAA@COL | COL +108 | 50.5% | 3 | WIN |
TOR@KC | UNDER 9 | 54.7% | 4 | LOSS |
SEA@KC | KC +1.5 | 62.3% | 5 | LOSS |
NYY@MIN | OVER 9 | 55.1% | 4 | WIN |
MIA@COL | OVER 10.5 | 55.0% | 4 | WIN |
MIA@COL | AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS | 54.3% | 4 | WIN |
SEA@KC | BOBBY WITT UNDER 0.5 SINGLES | 54.4% | 4 | LOSS |
PHI@LAD | LAD -113 | 54.7% | 4 | LOSS |
NYY@BOS | OVER 7.5 | 54.3% | 3 | WIN |
KC@PHI | PHI -130 | 58.3% | 4 | WIN |
LAD@SF | OVER 7.5 | 54.7% | 4 | LOSS |
NYM@PHI | PHI -122 | 55.6% | 4 | WIN |
KC@CLE | KC -104 | 52.0% | 3 | WIN |
CIN@SD | JAKE CRONEWORTH OVER 0.5 HITS | 53.1% | 3 | WIN |
WAS@MIA | MIA -123 | 55.2% | 4 | LOSS |
LAA@KC | UNDER 9.5 | 54.9% | 3 | WIN |
TEX@ARI | UNDER 9 | 54.2% | 4 | WIN |
SF@COL | UNDER 11.5 | 56.4% | 6 | LOSS |
SF@COL | RAFAEL DEVERS OVER 1.5 BASES | 56.1% | 6 | WIN |
MIA@WAS | WAS -110 | 54.4% | 4 | WIN |
NYM@DET | OVER 8.5 | 54.5% | 4 | WIN |
TEX@ARI | UNDER 9.5 | 56.4% | 6 | WIN |
TEX@ARI | ALEJANDRO OSUNA UNDER 1.5 BASES | 54.1% | 4 | LOSS |
ATL@CHC | CHC -116 | 55.1% | 3 | WIN |
PHI@MIL | OVER 8.5 | 55.0% | 3 | WIN |
ARI@LAD | SHOHEI OHTANI OVER 2.5 BASES | 54.2% | 4 | WIN |
SEA@CLE | CLE +1.5 | 57.2% | 3 | WIN |
CHC@SF | CHC -105 | 54.1% | 4 | LOSS |
NYY@CHW | RYAN MCMAHON OVER 0.5 BASES | 54.1% | 4 | WIN |
PHI@NYM | OVER 8.5 | 55.6% | 4 | LOSS |
LAA@TEX | LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS | 54.1% | 4 | LOSS |
KC@CHW | KC -109 | 54.2% | 4 | WIN |
SD@SEA | DYLAN CEASE OVER 16.5 OUTS | 53.9% | 3 | LOSS |
SD@SEA | UNDER 8.5 | 54.4% | 4 | LOSS |
MIN@TOR | JOE RYAN UNDER 2.5 EARNED RUNS | 54.1% | 4 | LOSS |
SF@MIL | MIL +100 | 54.0% | 6 | LOSS |
TOR@MIA | MIA +1.5 | 62.0% | 6 | WIN |
CHC@LAA | OVER 9.5 | 54.9% | 4 | LOSS |
BOS@NYY | CARLOS RODON UNDER 4.5 HITS ALLOWED | 54.2% | 4 | WIN |
KC@DET | DET -115 | 56.1% | 5 | WIN |
CHC@LAA | LAA +1.5 | 57.6% | 5 | LOSS |
CIN@ARI | KEBRYAN HAYES STRIKEOUTS UNDER 0.5 | 56.2% | 6 | WIN |
LAD@SD | SD +110 | 50.9% | 6 | WIN |