Guardians vs. Tigers
Prediction, Odds & Props
May 25 | MLB AI Picks

Updated: 2025-05-23T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The Cleveland Guardians and Detroit Tigers will face off on Sunday, May 25, 2025, at Comerica Park in the finale of their four-game series. The Tigers, leading the AL Central, aim to solidify their division dominance, while the Guardians seek to close the gap and gain momentum.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: May 25, 2025

Start Time: 11:35 AM​

Venue: Comerica Park​

Tigers Record: (33-20)

Guardians Record: (29-22)

OPENING ODDS

CLE Moneyline: +184

DET Moneyline: -223

CLE Spread: +1.5

DET Spread: -1.5

Over/Under: 7.5

CLE
Betting Trends

  • The Cleveland Guardians have a 20–20–0 record against the spread (ATS) this season.

DET
Betting Trends

  • The Detroit Tigers hold a 32–18 record against the spread (ATS) this season.

MATCHUP TRENDS

  • The Tigers have a 17–5 home record this season, covering the spread in 77% of those games, indicating a strong home-field advantage.

CLE vs. DET
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: J. Ramirez over 5.5 Fantasy Score.

LIVE MLB ODDS

MLB ODDS COMPARISON

WANT MORE AI PICKS?

VAULT
VS. SPREAD
308-221
VAULT
NET UNITS
(INCL VIG)
+418
VAULT
NET PROFIT
(INCL VIG)
$100/UNIT
$41,803
EXECUTIVE
VS. SPREAD
1551-1329
EXECUTIVE
NET UNITS
(INCL VIG)
+365.7
EXECUTIVE
NET PROFIT
(INCL VIG)
$100/UNIT
$36,569

AI SPORTS PICK PRODUCTS

Create a Free Account

‘Create an Account’ to Get Remi’s Picks Today.

Remi Finds New Picks

Remi calculates the probability a team will cover the line.

Remi Works 24/7

Remi uses this probability to assign units to each pick.

Get Remi's AI Picks

Get Remi’s Top AI Sports Picks sent direct to your inbox.

Cleveland vs Detroit Prediction & Odds:
Free MLB Betting Insights for 5/25/25

The May 25, 2025 matchup between the Cleveland Guardians and the Detroit Tigers at Comerica Park is a high-stakes finale to a four-game AL Central series that has featured strong pitching, timely hitting, and playoff-like urgency. The Tigers enter the contest at 33–19, holding the best record in the American League and a comfortable lead atop the division, while the Guardians trail at 28–22, looking to close the gap and reestablish momentum in the race. Detroit has been on a tear at home, boasting a dominant 17–5 record at Comerica Park and covering the spread in 77% of those games, thanks in large part to a potent mix of elite pitching and surging offensive output. Their rotation, led by ace Tarik Skubal, ranks near the top of the league with a 3.32 team ERA, and the staff’s consistency has enabled the Tigers to win low-scoring games while also thriving in higher-scoring affairs. Offensively, Riley Greene has emerged as a true catalyst for Detroit’s lineup, hitting .333 with nine home runs since mid-April and ranking among the American League leaders in key offensive metrics like wRC+, OBP, and slugging. His breakout has been complemented by steady contributions from Spencer Torkelson and Kerry Carpenter, giving the Tigers a well-balanced attack that can produce against both right-handed and left-handed pitching. Meanwhile, the Guardians enter this matchup with signs of vulnerability, particularly on the mound, where they hold a 4.23 ERA—more than a full run higher than Detroit’s.

Cleveland’s offense has also lagged behind expectations, managing just a .234 team batting average and showing streakiness in run production that has cost them games against more complete opponents. However, Cleveland has performed well against divisional foes, with a 10–3 record in AL Central play, suggesting they tend to rise to the occasion in familiar matchups. The key for the Guardians will be limiting damage early, as they’ve struggled to play from behind and haven’t had the power to erase deficits quickly. If their pitching can keep the Tigers’ offense contained through the middle innings, the Guardians have enough contact hitters to generate scoring opportunities late. But any early hole against a team like Detroit—who are playing with confidence, pitching precision, and aggressive baserunning—could spell the difference between a competitive finish and a series defeat. The Tigers’ balance, depth, and home-field dominance have made them one of baseball’s early-season surprises, while the Guardians must prove they can beat elite teams on the road to be taken seriously as postseason contenders. Sunday’s game represents more than just a series finale—it’s a tone-setter for the rest of the division race. If Cleveland wants to stay in the hunt, this is the game to make a statement. For Detroit, it’s a chance to bury a key rival further down the standings and continue their remarkable early-season pace.

Cleveland Guardians MLB Preview

The Cleveland Guardians head into their May 25 matchup against the Detroit Tigers with a 28–22 record and in need of a statement win as they wrap up a crucial four-game series at Comerica Park. Trailing the Tigers in the AL Central standings, the Guardians have shown flashes of competitiveness this season but remain hampered by inconsistency, particularly in their pitching and run production. Their pitching staff carries a 4.23 team ERA—noticeably higher than the division-leading Tigers’—and the bullpen has at times struggled to hold leads in tight games, an issue that’s proved costly in recent matchups. Offensively, Cleveland’s lineup has been underwhelming overall, batting .234 as a team and ranking near the bottom of the American League in extra-base hits and slugging percentage, making it difficult for them to capitalize on scoring opportunities or erase deficits quickly. José Ramírez remains the team’s most reliable offensive presence, but even his production hasn’t been enough to lift an offense that lacks consistent power and struggles against strong rotations like Detroit’s. That said, the Guardians have proven they can compete within the division, boasting a 10–3 record against AL Central opponents, and they’ve demonstrated the grit and late-inning resilience that’s allowed them to hang around despite statistical deficiencies.

If they’re going to close the gap on the Tigers, Sunday’s game presents a golden opportunity—they’ve already seen Detroit’s starters several times this year and could benefit from adjustments made over the course of this series. The Guardians’ 20–20 record against the spread (ATS) reflects their rollercoaster tendencies; they can keep games close but often lack the firepower to consistently pull away or dominate inferior opponents. Manager Stephen Vogt will need to find ways to manufacture runs—through stolen bases, hit-and-run strategies, and exploiting Detroit’s defensive alignments—to compensate for the lack of raw power in the lineup. Cleveland’s defense has been mostly solid, helping the team stay in games even when the offense is quiet, and their ability to execute in tight spots will be critical in a road environment where Detroit has played exceptionally well. To come out with a win, the Guardians will need a strong start on the mound, better contact in clutch moments, and a clean defensive performance to limit the Tigers’ ability to capitalize on their offensive momentum. If they can check those boxes, they’ll give themselves a chance to steal the series finale and avoid falling further behind in what’s shaping up to be a competitive AL Central race. With the Tigers surging, this game carries added urgency for Cleveland—not just to salvage the series, but to show they have the depth, discipline, and resilience to challenge for the division title over the long haul.

The Cleveland Guardians and Detroit Tigers will face off on Sunday, May 25, 2025, at Comerica Park in the finale of their four-game series. The Tigers, leading the AL Central, aim to solidify their division dominance, while the Guardians seek to close the gap and gain momentum. Cleveland vs Detroit AI Prediction: Free MLB Betting Insights for May 25. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Detroit Tigers MLB Preview

The Detroit Tigers enter their May 25 home matchup against the Cleveland Guardians with a 33–19 record, the best in the American League, and firmly in control of the AL Central as they look to close out a dominant series at Comerica Park. Detroit has been a revelation in 2025, combining elite starting pitching, timely offense, and defensive consistency to rise from preseason underdog status to legitimate playoff contender. A major part of their success has been their dominance at home, where they own a 17–5 record and have covered the spread in 77% of those games, making Comerica Park one of the toughest venues for visiting teams this season. Offensively, Riley Greene has emerged as the spark plug and breakout star, hitting .333 with nine home runs since mid-April and ranking among the league leaders in several advanced metrics including wRC+, slugging, and hard-hit rate. Spencer Torkelson and Kerry Carpenter have provided complementary power and situational hitting, giving the Tigers a well-rounded lineup capable of grinding out runs and putting up crooked numbers when they find rhythm. On the mound, Detroit’s rotation has been nothing short of exceptional, anchored by ace Tarik Skubal and a group that leads the American League with a 3.32 ERA.

The pitching staff has not only limited damage early but also given manager A.J. Hinch the flexibility to preserve his bullpen for high-leverage situations, a luxury that few teams currently enjoy. Defensively, the Tigers have played crisp, smart baseball—turning double plays, controlling the running game, and minimizing errors—which has helped them maintain leads and control tempo even in tight contests. Against a Cleveland team that has struggled to find consistency at the plate and on the mound, the Tigers have imposed their will throughout the series with aggressive baserunning, well-timed hits, and superior execution. Their 32–18 ATS record on the season reinforces how frequently they outperform expectations, especially at home where their offense tends to ignite early and their starters settle in quickly. Detroit’s formula for success has been repeatable and sustainable: pitch efficiently, defend cleanly, and grind out runs with a balanced approach that doesn’t rely solely on the long ball. A win in the series finale would not only pad their lead in the division but send a clear message to the rest of the league that this Tigers squad is more than just a feel-good story—it’s a team with legitimate October aspirations. With a confident clubhouse, elite pitching, and a growing fan base behind them, the Tigers are playing their best baseball at the right time, and Sunday’s finale gives them a chance to further assert their dominance over a division rival and keep the pressure on every other contender in the American League.

Cleveland vs. Detroit Prop Picks (AI)

Remi is pouring through loads of datapoints on each team. In fact, anytime the Guardians and Tigers play there’s always several intriguing observations to key in on. Not to mention games played at Comerica Park in May can often follow normal, predictable patterns.
Remi's searched hard and found the best prop for this matchup: J. Ramirez over 5.5 Fantasy Score.

Cleveland vs. Detroit Prediction (AI)

Remi Robot Icon

Remi, our AI sports algorithm, has been pouring over mountains of data from every angle between the Guardians and Tigers and using recursive machine learning and industry leading AI to crunch the data to a single cover probability.

Oddly enough, we’ve seen the AI has been most watching on the growing factor emotional bettors often put on player performance factors between a Guardians team going up against a possibly strong Tigers team. We’ve found the true game analytics might reflect a slight lean against one Vegas line specifically.

Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.

Below is our current AI Cleveland vs Detroit picks, computer picks Guardians vs Tigers, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
MLB 9/26 DET@BOS UNLOCK THIS PICK 5 EXECUTIVE Locked EXECUTIVE
MLB 9/26 BAL@NYY UNLOCK THIS PICK 4 INTEL Locked INTEL
MLB 9/26 ARI@SD UNLOCK THIS PICK 4 EXECUTIVE Locked EXECUTIVE
MLB 9/26 NYM@MIA UNLOCK THIS PICK 1 INTEL Locked INTEL
MLB 9/26 NYM@MIA GET FREE PICK NOW 1
MLB 9/26 COL@SF UNLOCK THIS PICK 0 INTEL Locked INTEL

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.

Guardians Betting Trends

The Cleveland Guardians have a 20–20–0 record against the spread (ATS) this season.

Tigers Betting Trends

The Detroit Tigers hold a 32–18 record against the spread (ATS) this season.

Guardians vs. Tigers Matchup Trends

The Tigers have a 17–5 home record this season, covering the spread in 77% of those games, indicating a strong home-field advantage.

Cleveland vs. Detroit Game Info

Cleveland vs Detroit starts on May 25, 2025 at 11:35 AM.

Spread: Detroit -1.5
Moneyline: Cleveland +184, Detroit -223
Over/Under: 7.5

Cleveland: (29-22)  |  Detroit: (33-20)

Remi's searched hard and found the best prop for this matchup: J. Ramirez over 5.5 Fantasy Score.. Prices move—always shop for the best number.

The Tigers have a 17–5 home record this season, covering the spread in 77% of those games, indicating a strong home-field advantage.

CLE trend: The Cleveland Guardians have a 20–20–0 record against the spread (ATS) this season.

DET trend: The Detroit Tigers hold a 32–18 record against the spread (ATS) this season.

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

Cleveland vs. Detroit Odds

AI algorithm Remi is pouring through loads of data points on each line. In fact, anytime the Cleveland vs Detroit trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme hostile environments rarely follow normal, predictable patterns.

Cleveland vs Detroit Opening Odds

CLE Moneyline: +184
DET Moneyline: -223
CLE Spread: +1.5
DET Spread: -1.5
Over/Under: 7.5

Cleveland vs Detroit Live Odds

Games PTS ML SPR O/U
Sep 27, 2025 1:06PM EDT
Baltimore Orioles
New York Yankees
9/27/25 1:06PM
Orioles
Yankees
+190
-235
+1.5 (-110)
-1.5 (-110)
O 8.5 (-120)
U 8.5 (+100)
Sep 27, 2025 2:21PM EDT
St Louis Cardinals
Chicago Cubs
9/27/25 2:21PM
Cardinals
Cubs
 
-180
 
-1.5 (+115)
O 9.5 (-105)
U 9.5 (-115)
Sep 27, 2025 3:09PM EDT
Tampa Bay Rays
Toronto Blue Jays
9/27/25 3:09PM
Rays
Blue Jays
+130
-155
+1.5 (-155)
-1.5 (+130)
O 8.5 (-110)
U 8.5 (-110)
Sep 27, 2025 4:06PM EDT
Chicago White Sox
Washington Nationals
9/27/25 4:06PM
White Sox
Nationals
+100
-120
-1.5 (+165)
+1.5 (-200)
O 8.5 (-110)
U 8.5 (-110)
Sep 27, 2025 4:06PM EDT
Colorado Rockies
San Francisco Giants
9/27/25 4:06PM
Rockies
Giants
+185
-225
+1.5 (-110)
-1.5 (-110)
O 8 (-105)
U 8 (-115)
Sep 27, 2025 4:11PM EDT
New York Mets
Miami Marlins
9/27/25 4:11PM
Mets
Marlins
-130
+110
-1.5 (+125)
+1.5 (-150)
O 8 (-115)
U 8 (-105)
Sep 27, 2025 4:11PM EDT
Detroit Tigers
Boston Red Sox
9/27/25 4:11PM
Tigers
Red Sox
+125
-150
+1.5 (-180)
-1.5 (+150)
O 9 (+100)
U 9 (-120)
Sep 27, 2025 6:05PM EDT
Minnesota Twins
Philadelphia Phillies
9/27/25 6:05PM
Twins
Phillies
+170
-205
+1.5 (-120)
-1.5 (+100)
O 8.5 (-115)
U 8.5 (-105)
Sep 27, 2025 7:11PM EDT
Cincinnati Reds
Milwaukee Brewers
9/27/25 7:11PM
Reds
Brewers
+125
-150
+1.5 (-180)
-1.5 (+150)
O 8 (-105)
U 8 (-115)
Sep 27, 2025 7:15PM EDT
Pittsburgh Pirates
Atlanta Braves
9/27/25 7:15PM
Pirates
Braves
+145
-175
+1.5 (-155)
-1.5 (+130)
O 8 (-110)
U 8 (-110)
Sep 27, 2025 7:16PM EDT
Texas Rangers
Cleveland Guardians
9/27/25 7:16PM
Rangers
Guardians
+135
-165
+1.5 (-180)
-1.5 (+150)
O 7 (-120)
U 7 (+100)
Sep 27, 2025 8:40PM EDT
Arizona Diamondbacks
San Diego Padres
9/27/25 8:40PM
Diamondbacks
Padres
+115
-140
+1.5 (-195)
-1.5 (+160)
O 7.5 (-120)
U 7.5 (+100)
Sep 27, 2025 9:39PM EDT
Houston Astros
Los Angeles Angels
9/27/25 9:39PM
Astros
Angels
-165
+135
-1.5 (+105)
+1.5 (-125)
O 9 (+100)
U 9 (-120)
Sep 27, 2025 9:41PM EDT
Los Angeles Dodgers
Seattle Mariners
9/27/25 9:41PM
Dodgers
Mariners
+105
-125
+1.5 (-205)
-1.5 (+170)
O 7.5 (+105)
U 7.5 (-125)
Sep 27, 2025 10:05PM EDT
Kansas City Royals
Oakland Athletics
9/27/25 10:05PM
Royals
Athletics
+100
-120
-1.5 (+150)
+1.5 (-180)
O 10 (-110)
U 10 (-110)

MLB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Cleveland Guardians vs. Detroit Tigers on May 25, 2025 at Comerica Park.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN
CHC@SF CHC -105 54.1% 4 LOSS
NYY@CHW RYAN MCMAHON OVER 0.5 BASES 54.1% 4 WIN
PHI@NYM OVER 8.5 55.6% 4 LOSS
LAA@TEX LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS 54.1% 4 LOSS
KC@CHW KC -109 54.2% 4 WIN
SD@SEA DYLAN CEASE OVER 16.5 OUTS 53.9% 3 LOSS
SD@SEA UNDER 8.5 54.4% 4 LOSS
MIN@TOR JOE RYAN UNDER 2.5 EARNED RUNS 54.1% 4 LOSS
SF@MIL MIL +100 54.0% 6 LOSS
TOR@MIA MIA +1.5 62.0% 6 WIN
CHC@LAA OVER 9.5 54.9% 4 LOSS
BOS@NYY CARLOS RODON UNDER 4.5 HITS ALLOWED 54.2% 4 WIN
KC@DET DET -115 56.1% 5 WIN
CHC@LAA LAA +1.5 57.6% 5 LOSS
CIN@ARI KEBRYAN HAYES STRIKEOUTS UNDER 0.5 56.2% 6 WIN
LAD@SD SD +110 50.9% 6 WIN