Guardians vs. Tigers
Prediction, Odds & Props
May 23 | MLB AI Picks

Updated: 2025-05-21T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

On May 23, 2025, the Cleveland Guardians (26–22) face the Detroit Tigers (33–17) at Comerica Park in Detroit, Michigan. This matchup is pivotal in the American League Central, with the Tigers leading the division and the Guardians aiming to close the gap.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: May 23, 2025

Start Time: 7:10 PM EST​

Venue: Comerica Park​

Tigers Record: (33-18)

Guardians Record: (27-22)

OPENING ODDS

CLE Moneyline: +115

DET Moneyline: -136

CLE Spread: +1.5

DET Spread: -1.5

Over/Under: 8.5

CLE
Betting Trends

  • The Cleveland Guardians have a 5–5 record against the run line in their last 10 games.

DET
Betting Trends

  • The Detroit Tigers have a 7–3 record against the run line in their last 10 games.

MATCHUP TRENDS

  • The Tigers have covered the run line in 70% of their last 10 games, indicating strong recent performance. The Guardians’ 50% cover rate in the same span suggests inconsistency in beating the spread.

CLE vs. DET
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: D. Dingler over 0.5 Total Bases.

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Cleveland vs Detroit Prediction & Odds:
Free MLB Betting Insights for 5/23/25

The May 23, 2025 matchup between the Cleveland Guardians and Detroit Tigers at Comerica Park is a critical American League Central battle between a Tigers team that has emerged as one of the league’s most complete and confident contenders and a Guardians squad still trying to maintain striking distance in the divisional race. The Tigers enter with a 33–17 record, the best in Major League Baseball, and a dominant 17–5 home record that has turned Comerica Park into a fortress where both their pitching staff and offense thrive. Detroit has covered the run line in seven of its last 10 games, a reflection of just how consistently they are outplaying expectations and closing games with authority, driven in large part by a rotation that boasts a team ERA of 3.24, one of the lowest in the majors. At the heart of their offensive attack is Riley Greene, who has been red-hot since mid-April, posting a .333 average with nine home runs and emerging as one of the league’s most dangerous and dynamic hitters. Supported by a lineup that generates power and contact throughout and backed by a deep, versatile bullpen, the Tigers have been the standard for execution and resilience. Meanwhile, the Guardians come into this contest at 26–22, a solid record but one that trails the Tigers by a full seven games, and they’ve gone 5–5 over their last 10, highlighting the inconsistency that’s prevented them from making a sustained push in the division.

Offensively, José Ramírez continues to be their heartbeat, batting .296 and providing veteran leadership and clutch hitting, while Steven Kwan and Josh Naylor have added key support, but the Guardians’ offensive ceiling still appears lower than Detroit’s, and they’ve struggled to break through against elite pitching. On the mound, Tanner Bibee gets the start with a 3–4 record and a 4.06 ERA, and while he’s been dependable in spurts, he will need to be sharper than usual to keep pace with Detroit’s balanced lineup and capitalize on any momentum Cleveland can generate early. Injuries to key pitchers like Shane Bieber and outfielder Lane Thomas have also thinned the Guardians’ depth and put more pressure on their top arms and primary offensive producers. The Guardians have a .500 record ATS over their last 10 games and a season-long trend of winning games with narrow margins, making this matchup against a surging and more explosive Tigers squad particularly challenging. For Cleveland to steal a win and chip away at Detroit’s lead, they’ll need near-flawless execution, a quality start from Bibee, and a few timely hits against a Tigers pitching staff that doesn’t give many second chances. Conversely, the Tigers are in prime position to continue their dominance, and if they get a solid start, produce early offense from Greene and company, and execute in the late innings, they could extend their division lead and continue sending a clear message that they are not only AL Central favorites, but legitimate World Series contenders.

Cleveland Guardians MLB Preview

The Cleveland Guardians enter their May 23 road matchup against the Detroit Tigers with a 26–22 record and a sense of urgency as they try to gain ground in the American League Central against a division leader that has been red-hot. Despite remaining solidly in playoff contention, the Guardians have battled inconsistency in recent weeks, going 5–5 over their last 10 games and struggling to build offensive momentum, particularly against elite pitching staffs like Detroit’s. José Ramírez continues to carry the load offensively with a .296 batting average, serving as the steady veteran anchor in a lineup that has seen flashes from Steven Kwan, Josh Naylor, and a few younger players but still lacks the top-to-bottom production needed to consistently challenge teams with deeper rosters. On the mound, Tanner Bibee will take the ball for Cleveland with a 3–4 record and a 4.06 ERA—numbers that reflect a capable but not dominant presence, and he’ll need to be at his best against a Tigers team that is finding success both at home and with the bat. The Guardians’ pitching depth has taken a hit this season with injuries to frontline starter Shane Bieber and contributors like reliever James Karinchak, and while the bullpen has remained mostly competitive, the loss of rotation stability has increased the pressure on Bibee and others to deliver quality starts.

Defensively, Cleveland remains one of the more sound teams in the league, consistently converting balls in play into outs and minimizing unforced errors, but they’ll be tested by a Detroit team that puts the ball in play and capitalizes on mistakes. The Guardians’ 5–5 record against the run line over the last 10 games also reflects their recent tightrope-walking style—keeping games close but failing to separate or close out enough of them to mount a true divisional threat. Offensively, they’ve averaged just under four runs per game during this stretch, and while they’ve won their share of close contests, their margin for error remains slim, particularly when facing one of the league’s best-performing teams on the road. If Cleveland wants to stay within reach of the Tigers in the standings, it starts with Bibee pitching deep into the game, the offense capitalizing on runners in scoring position, and the bullpen protecting leads—something they’ve done well in stretches but must execute consistently to beat top-tier competition. A win against the first-place Tigers wouldn’t just add another notch in the win column—it would send a message that the Guardians are still very much a factor in the AL Central race, and with the season approaching its midpoint, there’s no better time to begin closing the gap than now.

On May 23, 2025, the Cleveland Guardians (26–22) face the Detroit Tigers (33–17) at Comerica Park in Detroit, Michigan. This matchup is pivotal in the American League Central, with the Tigers leading the division and the Guardians aiming to close the gap. Cleveland vs Detroit AI Prediction: Free MLB Betting Insights for May 23. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Detroit Tigers MLB Preview

The Detroit Tigers enter their May 23 matchup against the Cleveland Guardians riding high at the top of the American League Central with a 33–17 record, boasting the best win total in Major League Baseball and a dominant 17–5 mark at Comerica Park that reflects their comfort and confidence playing in front of their home crowd. This version of the Tigers has been a model of consistency and balance, powered by elite starting pitching, a dependable bullpen, and a lineup that has found its rhythm behind breakout star Riley Greene, who is batting .333 with nine home runs since mid-April and rapidly establishing himself as one of the most dangerous hitters in the American League. The Tigers have won seven of their last ten games and have also covered the run line in seven of those, showcasing their ability not just to win but to win convincingly, often building early leads and closing out games with authority thanks to a bullpen that ranks among the most efficient in the league. Their team ERA of 3.24 is one of the lowest in baseball, a testament to the strong performances from starters like Tarik Skubal and Casey Mize, both of whom have kept opposing lineups off-balance and handed the ball off with leads intact.

Offensively, the Tigers aren’t reliant on just one or two bats—they’ve gotten timely production from Spencer Torkelson, Kerry Carpenter, and Matt Vierling, all of whom have contributed with situational hitting and helped Detroit excel with runners in scoring position, an area where many teams falter. Defensively, the Tigers have played sharp and mistake-free baseball, with athleticism in the outfield and reliability in the infield combining to support their pitchers and prevent innings from unraveling. Manager A.J. Hinch has found the right mix of patience and aggression with his lineup and bullpen usage, allowing the Tigers to play with both structure and freedom, which has made them one of the hardest teams to rattle when they’re ahead or in tight games. As they prepare to host a Guardians team that has been solid but not spectacular, the Tigers have an opportunity not only to extend their division lead but also to assert themselves as the clear top dog in the AL Central, sending a message that they’re not just off to a hot start—they’re built to contend all season long. If they continue to get strong outings from the mound, keep Greene and the middle of the order producing, and execute with the same discipline they’ve shown over the last month, Detroit should be well-positioned to pick up another win and continue their charge toward the All-Star break with the best record in baseball.

Cleveland vs. Detroit Prop Picks (AI)

AI algorithm Remi is pouring through tons of data on each line. In fact, anytime the Guardians and Tigers play there’s always several intriguing observations to key in on. Not to mention games played at Comerica Park in May rarely follow normal, predictable patterns.
Remi's searched hard and found the best prop for this matchup: D. Dingler over 0.5 Total Bases.

Cleveland vs. Detroit Prediction (AI)

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Remi, our AI sports genius, has been pouring over exorbitant amounts of data from every angle between the Guardians and Tigers and using recursive machine learning and kick-ass AI to crunch the data to a single cover probability.

Interestingly enough, the data has been most focused on the linear correlation of emphasis human bettors tend to put on player performance factors between a Guardians team going up against a possibly healthy Tigers team. In reality, the true game analytics appear to reflect a slight lean against one Vegas line in particular.

Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.

Below is our current AI Cleveland vs Detroit picks, computer picks Guardians vs Tigers, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
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Guardians Betting Trends

The Cleveland Guardians have a 5–5 record against the run line in their last 10 games.

Tigers Betting Trends

The Detroit Tigers have a 7–3 record against the run line in their last 10 games.

Guardians vs. Tigers Matchup Trends

The Tigers have covered the run line in 70% of their last 10 games, indicating strong recent performance. The Guardians’ 50% cover rate in the same span suggests inconsistency in beating the spread.

Cleveland vs. Detroit Game Info

Cleveland vs Detroit starts on May 23, 2025 at 7:10 PM EST.

Spread: Detroit -1.5
Moneyline: Cleveland +115, Detroit -136
Over/Under: 8.5

Cleveland: (27-22)  |  Detroit: (33-18)

Remi's searched hard and found the best prop for this matchup: D. Dingler over 0.5 Total Bases.. Prices move—always shop for the best number.

The Tigers have covered the run line in 70% of their last 10 games, indicating strong recent performance. The Guardians’ 50% cover rate in the same span suggests inconsistency in beating the spread.

CLE trend: The Cleveland Guardians have a 5–5 record against the run line in their last 10 games.

DET trend: The Detroit Tigers have a 7–3 record against the run line in their last 10 games.

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

Cleveland vs. Detroit Odds

AI algorithm Remi is pouring through loads of data points on each player. In fact, anytime the Cleveland vs Detroit trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme temps can often follow normal, predictable patterns.

Cleveland vs Detroit Opening Odds

CLE Moneyline: +115
DET Moneyline: -136
CLE Spread: +1.5
DET Spread: -1.5
Over/Under: 8.5

Cleveland vs Detroit Live Odds

Games PTS ML SPR O/U
In Progress
Baltimore Orioles
New York Yankees
In Progress
Orioles
Yankees
0
6
+2500
-20000
+6.5 (-140)
-6.5 (+110)
O 8.5 (-125)
U 8.5 (-105)
In Progress
St Louis Cardinals
Chicago Cubs
In Progress
Cardinals
Cubs
0
1
 
-300
 
-1.5 (-130)
O 7.5 (-130)
U 7.5 (+100)
Sep 27, 2025 3:09PM EDT
Tampa Bay Rays
Toronto Blue Jays
9/27/25 3:09PM
Rays
Blue Jays
+143
-170
+1.5 (-145)
-1.5 (+122)
O 8.5 (-105)
U 8.5 (-115)
Sep 27, 2025 4:05PM EDT
Chicago White Sox
Washington Nationals
9/27/25 4:05PM
White Sox
Nationals
-110
-110
+1.5 (-210)
-1.5 (+175)
O 8.5 (-115)
U 8.5 (-105)
Sep 27, 2025 4:06PM EDT
Colorado Rockies
San Francisco Giants
9/27/25 4:06PM
Rockies
Giants
+196
-240
+1.5 (-105)
-1.5 (-115)
O 8 (-105)
U 8 (-115)
Sep 27, 2025 4:11PM EDT
New York Mets
Miami Marlins
9/27/25 4:11PM
Mets
Marlins
-140
+118
-1.5 (+118)
+1.5 (-140)
O 8 (-110)
U 8 (-110)
Sep 27, 2025 4:11PM EDT
Detroit Tigers
Boston Red Sox
9/27/25 4:11PM
Tigers
Red Sox
+100
-120
+1.5 (-205)
-1.5 (+170)
O 8.5 (-110)
U 8.5 (-110)
Sep 27, 2025 6:05PM EDT
Minnesota Twins
Philadelphia Phillies
9/27/25 6:05PM
Twins
Phillies
+185
-225
+1.5 (-110)
-1.5 (-110)
O 8.5 (-115)
U 8.5 (-105)
Sep 27, 2025 7:11PM EDT
Cincinnati Reds
Milwaukee Brewers
9/27/25 7:11PM
Reds
Brewers
+115
-135
+1.5 (-190)
-1.5 (+158)
O 8 (-110)
U 8 (-110)
Sep 27, 2025 7:15PM EDT
Pittsburgh Pirates
Atlanta Braves
9/27/25 7:15PM
Pirates
Braves
+150
-178
+1.5 (-145)
-1.5 (+122)
O 8 (-110)
U 8 (-110)
Sep 27, 2025 7:16PM EDT
Texas Rangers
Cleveland Guardians
9/27/25 7:16PM
Rangers
Guardians
+126
-150
+1.5 (-190)
-1.5 (+158)
O 7 (-120)
U 7 (+100)
Sep 27, 2025 8:40PM EDT
Arizona Diamondbacks
San Diego Padres
9/27/25 8:40PM
Diamondbacks
Padres
+130
-155
+1.5 (-170)
-1.5 (+143)
O 7.5 (-105)
U 7.5 (-115)
Sep 27, 2025 9:39PM EDT
Houston Astros
Los Angeles Angels
9/27/25 9:39PM
Astros
Angels
-140
+118
-1.5 (+115)
+1.5 (-135)
O 9 (-110)
U 9 (-110)
Sep 27, 2025 9:41PM EDT
Los Angeles Dodgers
Seattle Mariners
9/27/25 9:41PM
Dodgers
Mariners
+100
-120
+1.5 (-210)
-1.5 (+175)
O 7 (-120)
U 7 (+100)
Sep 27, 2025 10:05PM EDT
Kansas City Royals
Oakland Athletics
9/27/25 10:05PM
Royals
Athletics
+100
-120
+1.5 (-195)
-1.5 (+162)
O 10 (-115)
U 10 (-105)

MLB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Cleveland Guardians vs. Detroit Tigers on May 23, 2025 at Comerica Park.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
ARI@SD SD -131 57.3% 4 WIN
DET@BOS BOS -115 56.4% 5 WIN
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN
CHC@SF CHC -105 54.1% 4 LOSS
NYY@CHW RYAN MCMAHON OVER 0.5 BASES 54.1% 4 WIN
PHI@NYM OVER 8.5 55.6% 4 LOSS
LAA@TEX LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS 54.1% 4 LOSS
KC@CHW KC -109 54.2% 4 WIN
SD@SEA DYLAN CEASE OVER 16.5 OUTS 53.9% 3 LOSS
SD@SEA UNDER 8.5 54.4% 4 LOSS
MIN@TOR JOE RYAN UNDER 2.5 EARNED RUNS 54.1% 4 LOSS
SF@MIL MIL +100 54.0% 6 LOSS
TOR@MIA MIA +1.5 62.0% 6 WIN
CHC@LAA OVER 9.5 54.9% 4 LOSS
BOS@NYY CARLOS RODON UNDER 4.5 HITS ALLOWED 54.2% 4 WIN
KC@DET DET -115 56.1% 5 WIN
CHC@LAA LAA +1.5 57.6% 5 LOSS