Giants vs. Twins
Prediction, Odds & Props
May 11 | MLB AI Picks

Updated: 2025-05-09T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The San Francisco Giants and Minnesota Twins will conclude their three-game interleague series on Sunday, May 11, 2025, at Target Field in Minneapolis. With the series tied 1-1, both teams aim to secure the series victory and gain momentum in their respective divisions.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: May 11, 2025

Start Time: 2:10 PM EST​

Venue: Target Field​

Twins Record: (20-20)

Giants Record: (24-16)

OPENING ODDS

SF Moneyline: +122

MIN Moneyline: -145

SF Spread: +1.5

MIN Spread: -1.5

Over/Under: 8

SF
Betting Trends

  • The San Francisco Giants have an impressive 23-13 record against the spread (ATS) this season, covering in 63.9% of their games.

MIN
Betting Trends

  • The Minnesota Twins have struggled ATS recently, with a 5-14 record in their last 19 games.

MATCHUP TRENDS

  • The Twins have been strong at home, boasting a 14-6 record, while the Giants have a 12-11 record on the road. The over/under for Sunday’s game is set at 8 runs, with the Twins favored at -145 and the Giants at +122.

SF vs. MIN
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: H. Bader over 4.5 Fantasy Score.

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San Francisco vs Minnesota Prediction & Odds:
Free MLB Betting Insights for 5/11/25

The San Francisco Giants and Minnesota Twins meet for the finale of a tightly contested three-game interleague series on Sunday, May 11, 2025, at Target Field, with both teams looking to take the series and gain crucial early-May momentum. The Twins took the opener behind a strong performance from their pitching staff, while the Giants bounced back convincingly in Game 2 with timely hitting and sharp bullpen work. With both clubs entering the rubber match on relatively even ground—Minnesota at 20-20 and San Francisco at 24-16—the stakes are clear for two teams navigating tight divisional races. The Twins, currently chasing the AL Central-leading Tigers, have been dominant at home with a 14-6 record and are riding a five-game winning streak that has helped stabilize their early-season inconsistencies. On the other side, the Giants are third in the stacked NL West and continue to lean on their elite pitching staff, which ranks third in MLB with a 3.39 ERA. The series finale is expected to feature Twins right-hander Pablo López on the mound, while the Giants’ starter was yet to be confirmed as of late Saturday, though it’s expected to be a bullpen game or a spot start due to rotation alignment. López brings poise and command, having been Minnesota’s most consistent starter despite receiving limited run support. Offensively, the Giants have been powered by Wilmer Flores, who leads the club with 33 RBIs, and Matt Chapman, whose eight home runs provide the middle-of-the-order punch San Francisco has needed with others scuffling.

While the Giants’ team batting average sits at .236, they’ve made up for it with timely hits, power (39 homers), and efficient base running. The bullpen, with 12 saves already this season, has played a crucial role in converting close games, especially on the road where they sit just above .500 at 12-11. The Twins, in contrast, have struggled mightily at the plate despite their solid recent record. Their team batting average of .211 and just 16 total home runs rank near the bottom of the league, putting extra pressure on their pitchers to keep games low-scoring. Bobby Witt Jr. and Maikel Garcia remain bright spots, but the lack of production throughout the rest of the order remains a concern. Defensively, both teams are sharp, but San Francisco’s pitching edge and more well-rounded offense give them a slight advantage heading into the finale. Minnesota’s biggest opportunity lies with López—if he can stifle the Giants’ hot bats and go deep into the game, the Twins could capitalize and extend their win streak to six. But if San Francisco jumps ahead early, their bullpen has proven more than capable of closing things out. This matchup, with both teams trying to solidify themselves as legitimate playoff contenders, promises a tense, well-played battle that may ultimately be decided by which team executes better in late-game situations.
The Pirates have a 12-26 overall record, with a 12-25 ATS record, covering 32.4% of their games.

San Francisco Giants MLB Preview

The San Francisco Giants enter Sunday’s series finale at Target Field with a strong opportunity to secure yet another series win and continue their steady climb in the National League West. With a 24-16 record, the Giants sit third in one of baseball’s most competitive divisions and have relied heavily on elite pitching and timely offense to stay near the top of the standings. Saturday’s bounce-back win over the Twins was a microcosm of their season—resilient, resourceful, and fueled by a combination of bullpen efficiency and middle-of-the-order production. The Giants will likely turn to a bullpen game or a spot starter for Sunday’s contest due to rotation alignment, and while their starter is unconfirmed, their pitching depth has proven to be a major strength. Their team ERA of 3.39 ranks third in MLB, and their relievers have combined for 12 saves, showing a knack for holding late leads and minimizing damage in high-leverage innings. That strong pitching foundation allows the Giants to stay competitive even when their offense has quiet spells, which has happened on occasion due to a .236 team batting average. However, when the bats do come alive—as they did in Game 2—San Francisco is a tough team to beat.

Wilmer Flores has emerged as the team’s most consistent run producer, racking up 33 RBIs, while Matt Chapman leads the club with eight home runs and continues to deliver in clutch moments. J.D. Davis and Thairo Estrada have also chipped in with timely hits, giving the Giants a deeper lineup than they often get credit for. Their offensive style isn’t built around overwhelming power but rather on situational hitting, run manufacturing, and capitalizing on opposing mistakes. On the road, the Giants have posted a respectable 12-11 record, using their balanced roster and aggressive but smart base running to disrupt opponents in unfamiliar settings. Defensively, the club has cleaned up many of the miscues that plagued them in recent seasons, now ranking among the more efficient fielding teams in the National League. With the bullpen rested and the offense clicking, the Giants are poised to test Pablo López early and attempt to force the Twins into their shaky bullpen, which has just one save all season. Manager Bob Melvin has shown a knack for leveraging matchups effectively late in games, and with Sunday being a rubber match, he’s likely to be aggressive with substitutions and relief usage. A win on Sunday would not only give the Giants a series victory in a tough environment but also allow them to maintain pace with the Dodgers and Padres in the West. For a team that isn’t flashy but knows how to execute, Sunday represents another chance to showcase the formula that’s quietly made them one of the more consistent teams in the league this season.

The San Francisco Giants and Minnesota Twins will conclude their three-game interleague series on Sunday, May 11, 2025, at Target Field in Minneapolis. With the series tied 1-1, both teams aim to secure the series victory and gain momentum in their respective divisions. San Francisco vs Minnesota AI Prediction: Free MLB Betting Insights for May 11. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Minnesota Twins MLB Preview

The Minnesota Twins enter Sunday’s rubber match against the San Francisco Giants with renewed momentum and a shot to win their sixth straight game, aiming to cap off a strong homestand with a series victory over one of the National League’s most disciplined clubs. At 20-20 and hovering around .500 in the AL Central, the Twins are looking to continue climbing the standings behind the reliable right arm of Pablo López, who gets the start in the finale. López has been a stabilizing force in an otherwise inconsistent rotation, consistently delivering quality innings and giving his team a chance to win, even when run support has been scarce. His command and pitch sequencing allow him to navigate lineups effectively, and against a well-balanced Giants offense, he’ll need to be particularly sharp in the early innings to prevent them from building momentum. López’s presence on the mound is timely, given Minnesota’s recent struggles to close games with a bullpen that has recorded just one save all season, highlighting the importance of extending starters as far as possible. Offensively, the Twins have been on a tear during their win streak, but the broader season numbers still reflect a team struggling to hit consistently.

They’ve managed just a .211 team batting average and only 16 home runs through 40 games—ranking near the bottom of the league in both categories. Byron Buxton’s absence has hurt their power production, while veterans like Carlos Correa and Max Kepler have yet to find their offensive stride. Still, players like Royce Lewis and Edouard Julien have begun to inject energy into the lineup, drawing walks and creating chaos on the basepaths to manufacture scoring opportunities. In recent games, the Twins have leaned more into aggressive small-ball tactics—stealing bases, bunting, and taking extra bases—to compensate for the lack of consistent slugging. Defensively, Minnesota has been one of the more sound teams in the American League, with clean infield execution and strong outfield communication helping limit damage in low-scoring games. Target Field continues to be a fortress for the Twins, where they’ve posted an impressive 14-6 home record, and they’ll look to use that energy to their advantage in Sunday’s series finale. The team’s recent five-game winning streak has given them a jolt of confidence, and a win over San Francisco would not only boost their record but also mark an important benchmark in their quest to reassert themselves as contenders in the Central. With López on the mound, the defense clicking, and an improving offense learning how to win close games, the Twins are well-positioned to close out the weekend on a high note and head into the next series with momentum firmly on their side.

The Braves are favored in this matchup with a -207 moneyline, while the Pirates are underdogs at +172. The over/under for the game is set at 8.5 runs.

San Francisco vs. Minnesota Prop Picks (AI)

Remi is pouring through loads of data on each player. In fact, anytime the Giants and Twins play there’s always several intriguing angles to key in on. Not to mention games played at Target Field in May almost always follow normal, predictable betting trends.
Remi's searched hard and found the best prop for this matchup: H. Bader over 4.5 Fantasy Score.

San Francisco vs. Minnesota Prediction (AI)

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Remi, our AI sports algorithm, has been pouring over tons of data from every angle between the Giants and Twins and using recursive machine learning and industry leading AI to examine the data to a single cover probability.

Interestingly enough, the data has been most focused on the trending emphasis human bettors tend to put on coaching factors between a Giants team going up against a possibly improved Twins team. Trends look to say the true game analytics might reflect a moderate lean against one Vegas line in particular.

Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.

Below is our current AI San Francisco vs Minnesota picks, computer picks Giants vs Twins, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
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Giants Betting Trends

The San Francisco Giants have an impressive 23-13 record against the spread (ATS) this season, covering in 63.9% of their games.

Twins Betting Trends

The Minnesota Twins have struggled ATS recently, with a 5-14 record in their last 19 games.

Giants vs. Twins Matchup Trends

The Twins have been strong at home, boasting a 14-6 record, while the Giants have a 12-11 record on the road. The over/under for Sunday’s game is set at 8 runs, with the Twins favored at -145 and the Giants at +122.

San Francisco vs. Minnesota Game Info

San Francisco vs Minnesota starts on May 11, 2025 at 2:10 PM EST.

Spread: Minnesota -1.5
Moneyline: San Francisco +122, Minnesota -145
Over/Under: 8

San Francisco: (24-16)  |  Minnesota: (20-20)

Remi's searched hard and found the best prop for this matchup: H. Bader over 4.5 Fantasy Score.. Prices move—always shop for the best number.

The Twins have been strong at home, boasting a 14-6 record, while the Giants have a 12-11 record on the road. The over/under for Sunday’s game is set at 8 runs, with the Twins favored at -145 and the Giants at +122.

SF trend: The San Francisco Giants have an impressive 23-13 record against the spread (ATS) this season, covering in 63.9% of their games.

MIN trend: The Minnesota Twins have struggled ATS recently, with a 5-14 record in their last 19 games.

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

San Francisco vs. Minnesota Odds

Remi is pouring through tons of data on each team. In fact, anytime the San Francisco vs Minnesota trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme travel distance rarely follow normal, predictable patterns.

San Francisco vs Minnesota Opening Odds

SF Moneyline: +122
MIN Moneyline: -145
SF Spread: +1.5
MIN Spread: -1.5
Over/Under: 8

San Francisco vs Minnesota Live Odds

Games PTS ML SPR O/U
In Progress
Baltimore Orioles
New York Yankees
In Progress
Orioles
Yankees
0
3
+900
-1800
+4.5 (-150)
-4.5 (+115)
O 7.5 (-130)
U 7.5 (+100)
In Progress
St Louis Cardinals
Chicago Cubs
In Progress
Cardinals
Cubs
 
-169
 
-1.5 (+113)
O 9.5 (-113)
U 9.5 (-102)
Sep 27, 2025 3:09PM EDT
Tampa Bay Rays
Toronto Blue Jays
9/27/25 3:09PM
Rays
Blue Jays
+147
-163
+1.5 (-143)
-1.5 (+127)
O 8.5 (-102)
U 8.5 (-113)
Sep 27, 2025 4:05PM EDT
Chicago White Sox
Washington Nationals
9/27/25 4:05PM
White Sox
Nationals
-105
-105
+1.5 (-207)
-1.5 (+181)
O 8.5 (-110)
U 8.5 (-104)
Sep 27, 2025 4:06PM EDT
Colorado Rockies
San Francisco Giants
9/27/25 4:06PM
Rockies
Giants
+201
-225
+1.5 (-103)
-1.5 (-111)
O 8 (-104)
U 8 (-110)
Sep 27, 2025 4:11PM EDT
New York Mets
Miami Marlins
9/27/25 4:11PM
Mets
Marlins
-131
+119
-1.5 (+127)
+1.5 (-143)
O 8 (-102)
U 8 (-113)
Sep 27, 2025 4:11PM EDT
Detroit Tigers
Boston Red Sox
9/27/25 4:11PM
Tigers
Red Sox
+107
-118
+1.5 (-190)
-1.5 (+166)
O 8.5 (-107)
U 8.5 (-107)
Sep 27, 2025 6:05PM EDT
Minnesota Twins
Philadelphia Phillies
9/27/25 6:05PM
Twins
Phillies
+184
-205
+1.5 (-112)
-1.5 (-102)
O 8.5 (-110)
U 8.5 (-104)
Sep 27, 2025 7:11PM EDT
Cincinnati Reds
Milwaukee Brewers
9/27/25 7:11PM
Reds
Brewers
+114
-126
+1.5 (-185)
-1.5 (+162)
O 8 (-107)
U 8 (-107)
Sep 27, 2025 7:15PM EDT
Pittsburgh Pirates
Atlanta Braves
9/27/25 7:15PM
Pirates
Braves
+150
-166
+1.5 (-141)
-1.5 (+125)
O 8 (-102)
U 8 (-113)
Sep 27, 2025 7:16PM EDT
Texas Rangers
Cleveland Guardians
9/27/25 7:16PM
Rangers
Guardians
+125
-138
+1.5 (-183)
-1.5 (+161)
O 7 (-118)
U 7 (+103)
Sep 27, 2025 8:40PM EDT
Arizona Diamondbacks
San Diego Padres
9/27/25 8:40PM
Diamondbacks
Padres
+122
-135
+1.5 (-177)
-1.5 (+156)
O 7.5 (-116)
U 7.5 (+101)
Sep 27, 2025 9:39PM EDT
Houston Astros
Los Angeles Angels
9/27/25 9:39PM
Astros
Angels
-138
+125
-1.5 (+117)
+1.5 (-132)
O 9 (-107)
U 9 (-107)
Sep 27, 2025 9:41PM EDT
Los Angeles Dodgers
Seattle Mariners
9/27/25 9:41PM
Dodgers
Mariners
+104
-115
+1.5 (-209)
-1.5 (+182)
O 7 (-113)
U 7 (-102)
Sep 27, 2025 10:05PM EDT
Kansas City Royals
Oakland Athletics
9/27/25 10:05PM
Royals
Athletics
+107
-118
+1.5 (-190)
-1.5 (+166)
O 10 (-114)
U 10 (-101)

MLB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers San Francisco Giants vs. Minnesota Twins on May 11, 2025 at Target Field.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
ARI@SD SD -131 57.3% 4 WIN
DET@BOS BOS -115 56.4% 5 WIN
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN
CHC@SF CHC -105 54.1% 4 LOSS
NYY@CHW RYAN MCMAHON OVER 0.5 BASES 54.1% 4 WIN
PHI@NYM OVER 8.5 55.6% 4 LOSS
LAA@TEX LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS 54.1% 4 LOSS
KC@CHW KC -109 54.2% 4 WIN
SD@SEA DYLAN CEASE OVER 16.5 OUTS 53.9% 3 LOSS
SD@SEA UNDER 8.5 54.4% 4 LOSS
MIN@TOR JOE RYAN UNDER 2.5 EARNED RUNS 54.1% 4 LOSS
SF@MIL MIL +100 54.0% 6 LOSS
TOR@MIA MIA +1.5 62.0% 6 WIN
CHC@LAA OVER 9.5 54.9% 4 LOSS
BOS@NYY CARLOS RODON UNDER 4.5 HITS ALLOWED 54.2% 4 WIN
KC@DET DET -115 56.1% 5 WIN
CHC@LAA LAA +1.5 57.6% 5 LOSS