Cardinals vs. Nationals
Prediction, Odds & Props
May 10 | MLB AI Picks

Updated: 2025-05-08T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The St. Louis Cardinals and Washington Nationals are set to face off on Saturday, May 10, 2025, at Nationals Park in Washington, D.C. Both teams are looking to gain momentum as they navigate the early part of the season.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: May 10, 2025

Start Time: 4:05 PM EST​

Venue: Nationals Park​

Nationals Record: (17-22)

Cardinals Record: (20-19)

OPENING ODDS

STL Moneyline: -114

WAS Moneyline: -105

STL Spread: -1.5

WAS Spread: +1.5

Over/Under: 9

STL
Betting Trends

  • The Cardinals have struggled against the spread (ATS) recently, posting a 1-4 ATS record in their last five games.

WAS
Betting Trends

  • The Nationals have been more favorable for bettors, achieving a 7-2 ATS record in their last nine games.

MATCHUP TRENDS

  • Historically, the Cardinals have had the upper hand in this matchup, with a 342-319-1 record against the Nationals.

STL vs. WAS
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: J. Wood over 0.5 Total Bases.

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St. Louis vs Washington Prediction & Odds:
Free MLB Betting Insights for 5/10/25

The St. Louis Cardinals and Washington Nationals prepare to square off on Saturday, May 10, 2025, at Nationals Park in a matchup between two clubs seeking identity and momentum during a season marked by inconsistency. The Cardinals enter the game with a 4-2 record in May, showing signs of turning the corner after a rocky April, while the Nationals continue to fight for respectability in the early going, fueled by young talent and flashes of competitive grit. Friday’s opener served as a reminder that both clubs, despite being far from postseason favorites, possess enough firepower and volatility to make every matchup unpredictable. The Cardinals, still haunted by a 1-7 record in their last eight road games, have shown they can string together wins when their bats wake up and their bullpen holds the line. Lars Nootbaar has emerged as a steady offensive force, providing spark atop the lineup and contributing to a more balanced approach from a team that had previously leaned too heavily on streaky middle-order production. Still, St. Louis’ pitching remains a glaring concern, with the rotation often struggling to get through five innings cleanly and the bullpen overexposed late in games.

The Nationals, meanwhile, continue to showcase pieces of a young, developing core led by shortstop C.J. Abrams, who has emerged as one of the bright spots in Washington’s lineup. Their offense, while not explosive, has proven opportunistic—averaging just over 4.1 runs per game and finding ways to manufacture scoring chances through speed and contact. However, the pitching has been a major Achilles heel, with a team ERA north of 5.20 and a WHIP of 1.43—both ranking near the bottom of the league. This has placed added pressure on the offense to deliver in high-leverage spots, a challenge for a team still refining its situational hitting. Saturday’s game pits two vulnerable pitching staffs against lineups that have shown the ability to capitalize on mistakes, suggesting the potential for a high-scoring affair if starters can’t set the tone. For the Cardinals, this game represents a crucial opportunity to finally string together back-to-back road wins and build confidence away from Busch Stadium. For the Nationals, a victory would help re-establish rhythm at home, where they’ve been more competitive in recent weeks and have shown a knack for staying close in low-margin games. Both managers will likely lean on aggressive bullpen use and small-ball tactics if their starters struggle early. Expect a game that could hinge on defensive execution and timely hitting, with both teams aware that momentum in early May can still lay the groundwork for a more stable stretch ahead. With each squad fighting for respect and consistency, this matchup is more than just a midseason filler—it’s a battle of identity, of two franchises trying to rediscover the formula that once made them postseason staples.

St. Louis Cardinals MLB Preview

The St. Louis Cardinals enter Saturday’s matchup against the Washington Nationals hoping to continue their modest upswing in performance after navigating through a rocky start to the 2025 season. Following a difficult April marked by inconsistency in all facets of the game, the Cardinals have posted a 4-2 record in May and appear to be finding more rhythm at the plate, thanks in large part to the emergence of Lars Nootbaar as an offensive catalyst. Nootbaar’s presence at the top of the order has brought better discipline and table-setting for the middle of the lineup, where players like Nolan Gorman and Paul Goldschmidt are expected to deliver the heavy lifting. However, the offense has been one of the few consistent positives for a Cardinals team that has struggled mightily away from home, recording a 1-7 record in their last eight road games. Those road woes stem in part from an unreliable pitching staff that has failed to deliver quality starts with any regularity, often forcing the bullpen to absorb more innings than it’s built to handle. The rotation’s inability to get deep into games has created cascading issues, including late-inning collapses and missed opportunities to put winnable contests away. That’s especially problematic against a Nationals team that, while lacking star power, has been scrappy and effective in one-run games this season. Defensively, the Cardinals have been sound, with fewer errors and a dependable infield core, but that’s only gone so far in covering up the gap between offensive production and pitching reliability.

Manager Oliver Marmol has shown willingness to shuffle the lineup and bullpen usage in search of better matchups, but the team still lacks the sort of dominant ace or closer who can single-handedly tilt games. This matchup against Washington provides an ideal scenario for the Cardinals to make a statement, as the Nationals’ pitching staff has struggled even more significantly, ranking near the bottom of the league in ERA and WHIP. If the Cardinals can jump on Nationals pitching early and give their own starter a lead to protect, they’ll increase their chances of breaking out of their road funk and establishing consistency. The key for St. Louis will be to maintain offensive pressure throughout the game rather than relying solely on big innings, as their bullpen has proven shaky when protecting slim leads. More importantly, a road win here could go a long way in building confidence for a team that still harbors postseason aspirations in a tightly bunched NL Central. With the offense trending upward and a young nucleus gaining experience, the Cardinals are not far from turning the corner—Saturday’s game presents both a test of their resilience and a prime opportunity to build on recent momentum in the nation’s capital.

The St. Louis Cardinals and Washington Nationals are set to face off on Saturday, May 10, 2025, at Nationals Park in Washington, D.C. Both teams are looking to gain momentum as they navigate the early part of the season. St. Louis vs Washington AI Prediction: Free MLB Betting Insights for May 10. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Washington Nationals MLB Preview

The Washington Nationals take the field on Saturday against the St. Louis Cardinals with a clear focus on steadying their course and continuing their surprising competitiveness in what was widely expected to be another developmental year. While their overall record may still fall short of playoff relevance, the Nationals have played tough baseball through the first six weeks of the season, buoyed by a youthful core and a scrappy, contact-first offensive identity. At the heart of their resurgence is shortstop C.J. Abrams, whose bat speed, baserunning, and defensive range have turned him into one of the most exciting young players in the National League. Abrams has consistently provided spark at the top of the order and has benefited from lineup protection offered by Lane Thomas and Joey Meneses, both of whom have delivered in clutch spots throughout the early campaign. Though the Nationals are only batting .235 as a team—ranking 20th in the majors—they’ve maximized their output by capitalizing on opponent mistakes and producing well in run-scoring opportunities. They average just over four runs per game, a modest but respectable figure for a club with limited power. What’s held them back from more consistent results, however, has been their pitching staff, which ranks among the league’s worst with a 5.21 ERA and 1.43 WHIP. Their starters have often failed to get through five innings without trouble, forcing the bullpen into extended duty far too frequently and often exposing younger arms to high-leverage situations they may not be ready for.

While the rotation’s performance has been underwhelming, the Nationals’ defense has been solid, with only 0.42 errors per game—good for ninth in the league—and their execution on double plays and outfield positioning has kept them in tight games. Manager Dave Martinez has leaned into situational strategy, often using aggressive baserunning and hit-and-run tactics to disrupt opposing pitchers and manufacture runs. The Nationals have also been quietly effective against the spread (ATS), going 7-2 in their last nine games, thanks in part to their ability to hang around as underdogs and keep games within striking distance. Saturday’s matchup provides Washington a key opportunity to take advantage of the Cardinals’ well-documented road struggles and an inconsistent pitching staff. If they can apply pressure early, force St. Louis into the bullpen by the middle innings, and continue to produce with runners in scoring position, the Nationals could be well-positioned to grab a confidence-building home win. It’s these kinds of games—winnable, competitive, and against mid-tier opposition—that will define the Nationals’ 2025 season. With a fan base slowly returning to optimism and a roster that’s developing chemistry, Washington has a chance to prove they’re more than just a rebuilding team—they’re a club that’s learning how to win close games and set a new tone for the years ahead.

St. Louis vs. Washington Prop Picks (AI)

AI algorithm Remi is pouring through loads of datapoints on each team. In fact, anytime the Cardinals and Nationals play there’s always several intriguing trends to key in on. Not to mention games played at Nationals Park in May seemingly never follow normal, predictable betting trends.
Remi's searched hard and found the best prop for this matchup: J. Wood over 0.5 Total Bases.

St. Louis vs. Washington Prediction (AI)

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Remi, our AI sports algorithm, has been pouring over exorbitant amounts of data from every angle between the Cardinals and Nationals and using recursive machine learning and impressive AI to examine the data to a single cover probability.

Oddly enough, we’ve seen the AI has been most focused on the growing emphasis human bettors regularly put on player performance factors between a Cardinals team going up against a possibly unhealthy Nationals team. We’ve found the true game analytics appear to reflect a strong lean against one Vegas line in particular.

Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.

Below is our current AI St. Louis vs Washington picks, computer picks Cardinals vs Nationals, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
MLB 9/26 DET@BOS UNLOCK THIS PICK 5 EXECUTIVE Locked EXECUTIVE
MLB 9/26 BAL@NYY UNLOCK THIS PICK 4 INTEL Locked INTEL
MLB 9/26 ARI@SD UNLOCK THIS PICK 4 EXECUTIVE Locked EXECUTIVE
MLB 9/26 NYM@MIA UNLOCK THIS PICK 1 INTEL Locked INTEL
MLB 9/26 NYM@MIA GET FREE PICK NOW 1
MLB 9/26 COL@SF UNLOCK THIS PICK 0 INTEL Locked INTEL

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.

Cardinals Betting Trends

The Cardinals have struggled against the spread (ATS) recently, posting a 1-4 ATS record in their last five games.

Nationals Betting Trends

The Nationals have been more favorable for bettors, achieving a 7-2 ATS record in their last nine games.

Cardinals vs. Nationals Matchup Trends

Historically, the Cardinals have had the upper hand in this matchup, with a 342-319-1 record against the Nationals.

St. Louis vs. Washington Game Info

St. Louis vs Washington starts on May 10, 2025 at 4:05 PM EST.

Spread: Washington +1.5
Moneyline: St. Louis -114, Washington -105
Over/Under: 9

St. Louis: (20-19)  |  Washington: (17-22)

Remi's searched hard and found the best prop for this matchup: J. Wood over 0.5 Total Bases.. Prices move—always shop for the best number.

Historically, the Cardinals have had the upper hand in this matchup, with a 342-319-1 record against the Nationals.

STL trend: The Cardinals have struggled against the spread (ATS) recently, posting a 1-4 ATS record in their last five games.

WAS trend: The Nationals have been more favorable for bettors, achieving a 7-2 ATS record in their last nine games.

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

St. Louis vs. Washington Odds

AI algorithm Remi is pouring through loads of stats on each player. In fact, anytime the St. Louis vs Washington trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme temps rarely follow normal, predictable patterns.

St. Louis vs Washington Opening Odds

STL Moneyline: -114
WAS Moneyline: -105
STL Spread: -1.5
WAS Spread: +1.5
Over/Under: 9

St. Louis vs Washington Live Odds

Games PTS ML SPR O/U
Sep 27, 2025 1:06PM EDT
Baltimore Orioles
New York Yankees
9/27/25 1:06PM
Orioles
Yankees
+195
-218
+1.5 (-109)
-1.5 (-105)
O 8.5 (-124)
U 8.5 (+108)
Sep 27, 2025 2:21PM EDT
St Louis Cardinals
Chicago Cubs
9/27/25 2:21PM
Cardinals
Cubs
 
-168
 
-1.5 (+118)
O 9 (-119)
U 9 (+104)
Sep 27, 2025 3:09PM EDT
Tampa Bay Rays
Toronto Blue Jays
9/27/25 3:09PM
Rays
Blue Jays
+138
-152
+1.5 (-152)
-1.5 (+134)
O 8.5 (-113)
U 8.5 (-102)
Sep 27, 2025 4:06PM EDT
Chicago White Sox
Washington Nationals
9/27/25 4:06PM
White Sox
Nationals
+104
-115
+1.5 (-198)
-1.5 (+174)
O 8.5 (-107)
U 8.5 (-107)
Sep 27, 2025 4:06PM EDT
Colorado Rockies
San Francisco Giants
9/27/25 4:06PM
Rockies
Giants
+195
-218
+1.5 (-107)
-1.5 (-107)
O 8 (+101)
U 8 (-116)
Sep 27, 2025 4:11PM EDT
New York Mets
Miami Marlins
9/27/25 4:11PM
Mets
Marlins
-128
+116
-1.5 (+129)
+1.5 (-146)
O 8 (-112)
U 8 (-103)
Sep 27, 2025 4:11PM EDT
Detroit Tigers
Boston Red Sox
9/27/25 4:11PM
Tigers
Red Sox
+116
-128
+1.5 (-184)
-1.5 (+162)
O 9 (+107)
U 9 (-123)
Sep 27, 2025 6:05PM EDT
Minnesota Twins
Philadelphia Phillies
9/27/25 6:05PM
Twins
Phillies
+180
-200
+1.5 (-117)
-1.5 (+103)
O 8.5 (-107)
U 8.5 (-107)
Sep 27, 2025 7:11PM EDT
Cincinnati Reds
Milwaukee Brewers
9/27/25 7:11PM
Reds
Brewers
+120
-132
+1.5 (-183)
-1.5 (+161)
O 7.5 (-120)
U 7.5 (+105)
Sep 27, 2025 7:15PM EDT
Pittsburgh Pirates
Atlanta Braves
9/27/25 7:15PM
Pirates
Braves
+153
-169
+1.5 (-141)
-1.5 (+125)
O 8 (-102)
U 8 (-113)
Sep 27, 2025 7:16PM EDT
Texas Rangers
Cleveland Guardians
9/27/25 7:16PM
Rangers
Guardians
+128
-141
+1.5 (-183)
-1.5 (+161)
O 7 (-118)
U 7 (+103)
Sep 27, 2025 8:40PM EDT
Arizona Diamondbacks
San Diego Padres
9/27/25 8:40PM
Diamondbacks
Padres
+122
-135
+1.5 (-177)
-1.5 (+156)
O 7.5 (-113)
U 7.5 (-102)
Sep 27, 2025 9:39PM EDT
Houston Astros
Los Angeles Angels
9/27/25 9:39PM
Astros
Angels
-140
+127
-1.5 (+116)
+1.5 (-131)
O 9 (-107)
U 9 (-107)
Sep 27, 2025 9:41PM EDT
Los Angeles Dodgers
Seattle Mariners
9/27/25 9:41PM
Dodgers
Mariners
+113
-125
+1.5 (-197)
-1.5 (+173)
O 7 (-116)
U 7 (+101)
Sep 27, 2025 10:05PM EDT
Kansas City Royals
Oakland Athletics
9/27/25 10:05PM
Royals
Athletics
+104
-115
+1.5 (-190)
-1.5 (+166)
O 10 (-115)
U 10 (+100)

MLB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers St. Louis Cardinals vs. Washington Nationals on May 10, 2025 at Nationals Park.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN
CHC@SF CHC -105 54.1% 4 LOSS
NYY@CHW RYAN MCMAHON OVER 0.5 BASES 54.1% 4 WIN
PHI@NYM OVER 8.5 55.6% 4 LOSS
LAA@TEX LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS 54.1% 4 LOSS
KC@CHW KC -109 54.2% 4 WIN
SD@SEA DYLAN CEASE OVER 16.5 OUTS 53.9% 3 LOSS
SD@SEA UNDER 8.5 54.4% 4 LOSS
MIN@TOR JOE RYAN UNDER 2.5 EARNED RUNS 54.1% 4 LOSS
SF@MIL MIL +100 54.0% 6 LOSS
TOR@MIA MIA +1.5 62.0% 6 WIN
CHC@LAA OVER 9.5 54.9% 4 LOSS
BOS@NYY CARLOS RODON UNDER 4.5 HITS ALLOWED 54.2% 4 WIN
KC@DET DET -115 56.1% 5 WIN
CHC@LAA LAA +1.5 57.6% 5 LOSS
CIN@ARI KEBRYAN HAYES STRIKEOUTS UNDER 0.5 56.2% 6 WIN
LAD@SD SD +110 50.9% 6 WIN