Cardinals vs. Nationals
Prediction, Odds & Props
May 10 | MLB AI Picks
Updated: 2025-05-08T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The St. Louis Cardinals and Washington Nationals are set to face off on Saturday, May 10, 2025, at Nationals Park in Washington, D.C. Both teams are looking to gain momentum as they navigate the early part of the season.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

GAME INFO
Date: May 10, 2025
Start Time: 4:05 PM EST​
Venue: Nationals Park​
Nationals Record: (17-22)
Cardinals Record: (20-19)
OPENING ODDS
STL Moneyline: -114
WAS Moneyline: -105
STL Spread: -1.5
WAS Spread: +1.5
Over/Under: 9
STL
Betting Trends
- The Cardinals have struggled against the spread (ATS) recently, posting a 1-4 ATS record in their last five games.
WAS
Betting Trends
- The Nationals have been more favorable for bettors, achieving a 7-2 ATS record in their last nine games.
MATCHUP TRENDS
- Historically, the Cardinals have had the upper hand in this matchup, with a 342-319-1 record against the Nationals.
STL vs. WAS
Best Prop Bet
- Remi's searched hard and found the best prop for this matchup: J. Wood over 0.5 Total Bases.
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St. Louis vs Washington Prediction & Odds:
Free MLB Betting Insights for 5/10/25
The Nationals, meanwhile, continue to showcase pieces of a young, developing core led by shortstop C.J. Abrams, who has emerged as one of the bright spots in Washington’s lineup. Their offense, while not explosive, has proven opportunistic—averaging just over 4.1 runs per game and finding ways to manufacture scoring chances through speed and contact. However, the pitching has been a major Achilles heel, with a team ERA north of 5.20 and a WHIP of 1.43—both ranking near the bottom of the league. This has placed added pressure on the offense to deliver in high-leverage spots, a challenge for a team still refining its situational hitting. Saturday’s game pits two vulnerable pitching staffs against lineups that have shown the ability to capitalize on mistakes, suggesting the potential for a high-scoring affair if starters can’t set the tone. For the Cardinals, this game represents a crucial opportunity to finally string together back-to-back road wins and build confidence away from Busch Stadium. For the Nationals, a victory would help re-establish rhythm at home, where they’ve been more competitive in recent weeks and have shown a knack for staying close in low-margin games. Both managers will likely lean on aggressive bullpen use and small-ball tactics if their starters struggle early. Expect a game that could hinge on defensive execution and timely hitting, with both teams aware that momentum in early May can still lay the groundwork for a more stable stretch ahead. With each squad fighting for respect and consistency, this matchup is more than just a midseason filler—it’s a battle of identity, of two franchises trying to rediscover the formula that once made them postseason staples.
Erick Fedde's 1st career complete game is a shutout! pic.twitter.com/UYNVXywJMD
— St. Louis Cardinals (@Cardinals) May 10, 2025
St. Louis Cardinals MLB Preview
The St. Louis Cardinals enter Saturday’s matchup against the Washington Nationals hoping to continue their modest upswing in performance after navigating through a rocky start to the 2025 season. Following a difficult April marked by inconsistency in all facets of the game, the Cardinals have posted a 4-2 record in May and appear to be finding more rhythm at the plate, thanks in large part to the emergence of Lars Nootbaar as an offensive catalyst. Nootbaar’s presence at the top of the order has brought better discipline and table-setting for the middle of the lineup, where players like Nolan Gorman and Paul Goldschmidt are expected to deliver the heavy lifting. However, the offense has been one of the few consistent positives for a Cardinals team that has struggled mightily away from home, recording a 1-7 record in their last eight road games. Those road woes stem in part from an unreliable pitching staff that has failed to deliver quality starts with any regularity, often forcing the bullpen to absorb more innings than it’s built to handle. The rotation’s inability to get deep into games has created cascading issues, including late-inning collapses and missed opportunities to put winnable contests away. That’s especially problematic against a Nationals team that, while lacking star power, has been scrappy and effective in one-run games this season. Defensively, the Cardinals have been sound, with fewer errors and a dependable infield core, but that’s only gone so far in covering up the gap between offensive production and pitching reliability.
Manager Oliver Marmol has shown willingness to shuffle the lineup and bullpen usage in search of better matchups, but the team still lacks the sort of dominant ace or closer who can single-handedly tilt games. This matchup against Washington provides an ideal scenario for the Cardinals to make a statement, as the Nationals’ pitching staff has struggled even more significantly, ranking near the bottom of the league in ERA and WHIP. If the Cardinals can jump on Nationals pitching early and give their own starter a lead to protect, they’ll increase their chances of breaking out of their road funk and establishing consistency. The key for St. Louis will be to maintain offensive pressure throughout the game rather than relying solely on big innings, as their bullpen has proven shaky when protecting slim leads. More importantly, a road win here could go a long way in building confidence for a team that still harbors postseason aspirations in a tightly bunched NL Central. With the offense trending upward and a young nucleus gaining experience, the Cardinals are not far from turning the corner—Saturday’s game presents both a test of their resilience and a prime opportunity to build on recent momentum in the nation’s capital.

Credit: USA TODAY/IMAGN
Washington Nationals MLB Preview
The Washington Nationals take the field on Saturday against the St. Louis Cardinals with a clear focus on steadying their course and continuing their surprising competitiveness in what was widely expected to be another developmental year. While their overall record may still fall short of playoff relevance, the Nationals have played tough baseball through the first six weeks of the season, buoyed by a youthful core and a scrappy, contact-first offensive identity. At the heart of their resurgence is shortstop C.J. Abrams, whose bat speed, baserunning, and defensive range have turned him into one of the most exciting young players in the National League. Abrams has consistently provided spark at the top of the order and has benefited from lineup protection offered by Lane Thomas and Joey Meneses, both of whom have delivered in clutch spots throughout the early campaign. Though the Nationals are only batting .235 as a team—ranking 20th in the majors—they’ve maximized their output by capitalizing on opponent mistakes and producing well in run-scoring opportunities. They average just over four runs per game, a modest but respectable figure for a club with limited power. What’s held them back from more consistent results, however, has been their pitching staff, which ranks among the league’s worst with a 5.21 ERA and 1.43 WHIP. Their starters have often failed to get through five innings without trouble, forcing the bullpen into extended duty far too frequently and often exposing younger arms to high-leverage situations they may not be ready for.
While the rotation’s performance has been underwhelming, the Nationals’ defense has been solid, with only 0.42 errors per game—good for ninth in the league—and their execution on double plays and outfield positioning has kept them in tight games. Manager Dave Martinez has leaned into situational strategy, often using aggressive baserunning and hit-and-run tactics to disrupt opposing pitchers and manufacture runs. The Nationals have also been quietly effective against the spread (ATS), going 7-2 in their last nine games, thanks in part to their ability to hang around as underdogs and keep games within striking distance. Saturday’s matchup provides Washington a key opportunity to take advantage of the Cardinals’ well-documented road struggles and an inconsistent pitching staff. If they can apply pressure early, force St. Louis into the bullpen by the middle innings, and continue to produce with runners in scoring position, the Nationals could be well-positioned to grab a confidence-building home win. It’s these kinds of games—winnable, competitive, and against mid-tier opposition—that will define the Nationals’ 2025 season. With a fan base slowly returning to optimism and a roster that’s developing chemistry, Washington has a chance to prove they’re more than just a rebuilding team—they’re a club that’s learning how to win close games and set a new tone for the years ahead.
#FridayNightBaseball is here.
— Washington Nationals (@Nationals) May 9, 2025
watch @Cardinals at @Nationals live on @AppleTV → https://t.co/ZpwjW0PoER pic.twitter.com/RifoPe0Gb5
St. Louis vs. Washington Prop Picks (AI)
St. Louis vs. Washington Prediction (AI)

Remi, our AI sports algorithm, has been pouring over exorbitant amounts of data from every angle between the Cardinals and Nationals and using recursive machine learning and impressive AI to examine the data to a single cover probability.
Oddly enough, we’ve seen the AI has been most focused on the growing emphasis human bettors regularly put on player performance factors between a Cardinals team going up against a possibly unhealthy Nationals team. We’ve found the true game analytics appear to reflect a strong lean against one Vegas line in particular.
Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.
Below is our current AI St. Louis vs Washington picks, computer picks Cardinals vs Nationals, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
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MLB | 9/26 | DET@BOS | UNLOCK THIS PICK | 5 |
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MLB | 9/26 | BAL@NYY | UNLOCK THIS PICK | 4 |
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MLB | 9/26 | ARI@SD | UNLOCK THIS PICK | 4 |
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MLB | 9/26 | NYM@MIA | UNLOCK THIS PICK | 1 |
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MLB | 9/26 | NYM@MIA | GET FREE PICK NOW | 1 | – | |
MLB | 9/26 | COL@SF | UNLOCK THIS PICK | 0 |
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.
Cardinals Betting Trends
The Cardinals have struggled against the spread (ATS) recently, posting a 1-4 ATS record in their last five games.
Nationals Betting Trends
The Nationals have been more favorable for bettors, achieving a 7-2 ATS record in their last nine games.
Cardinals vs. Nationals Matchup Trends
Historically, the Cardinals have had the upper hand in this matchup, with a 342-319-1 record against the Nationals.
St. Louis vs. Washington Game Info
What time does St. Louis vs Washington start on May 10, 2025?
St. Louis vs Washington starts on May 10, 2025 at 4:05 PM EST.
Where is St. Louis vs Washington being played?
Venue: Nationals Park.
What are the opening odds for St. Louis vs Washington?
Spread: Washington +1.5
Moneyline: St. Louis -114, Washington -105
Over/Under: 9
What are the records for St. Louis vs Washington?
St. Louis: (20-19) Â |Â Washington: (17-22)
What is the AI best bet for St. Louis vs Washington?
Remi's searched hard and found the best prop for this matchup: J. Wood over 0.5 Total Bases.. Prices move—always shop for the best number.
What are St. Louis vs Washington trending bets?
Historically, the Cardinals have had the upper hand in this matchup, with a 342-319-1 record against the Nationals.
What are St. Louis trending bets?
STL trend: The Cardinals have struggled against the spread (ATS) recently, posting a 1-4 ATS record in their last five games.
What are Washington trending bets?
WAS trend: The Nationals have been more favorable for bettors, achieving a 7-2 ATS record in their last nine games.
Where can I find AI Picks for St. Louis vs Washington?
See our latest MLB picks and odds pages for 2025 to compare prices before you bet.
St. Louis vs. Washington Odds
AI algorithm Remi is pouring through loads of stats on each player. In fact, anytime the St. Louis vs Washington trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme temps rarely follow normal, predictable patterns.
St. Louis vs Washington Opening Odds
STL Moneyline:
-114 WAS Moneyline: -105
STL Spread: -1.5
WAS Spread: +1.5
Over/Under: 9
St. Louis vs Washington Live Odds
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+104
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U 8.5 (-107)
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-128
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O 8 (-112)
U 8 (-103)
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+116
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+1.5 (-184)
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O 9 (+107)
U 9 (-123)
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Sep 27, 2025 6:05PM EDT
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+180
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O 8.5 (-107)
U 8.5 (-107)
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Sep 27, 2025 7:11PM EDT
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O 7.5 (-120)
U 7.5 (+105)
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+153
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O 8 (-102)
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+128
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U 7 (+103)
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+122
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O 7.5 (-113)
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-140
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-1.5 (+116)
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O 9 (-107)
U 9 (-107)
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Sep 27, 2025 9:41PM EDT
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+113
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O 7 (-116)
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+104
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U 10 (+100)
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MLB Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers St. Louis Cardinals vs. Washington Nationals on May 10, 2025 at Nationals Park.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.
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   LEAN |    %WIN |    UNITS | RESULT |
---|---|---|---|---|
NYM@CHC | NYM -110 | 54.1% | 3 | WIN |
HOU@ATH | ATH +118 | 50.8% | 4 | WIN |
NYM@CHC | OVER 7 | 54.5% | 3 | WIN |
STL@SF | OVER 7.5 | 55.9% | 5 | LOSS |
KC@LAA | TYLER TOLBERT UNDER 1.5 BASES | 54.4% | 4 | WIN |
MIL@SD | UNDER 9 | 54.7% | 4 | WIN |
MIA@PHI | KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS | 53.3% | 3 | WIN |
WAS@NYM | OVER 8.5 | 56.1% | 6 | LOSS |
LAA@COL | COL +108 | 50.5% | 3 | WIN |
TOR@KC | UNDER 9 | 54.7% | 4 | LOSS |
SEA@KC | KC +1.5 | 62.3% | 5 | LOSS |
NYY@MIN | OVER 9 | 55.1% | 4 | WIN |
MIA@COL | OVER 10.5 | 55.0% | 4 | WIN |
MIA@COL | AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS | 54.3% | 4 | WIN |
SEA@KC | BOBBY WITT UNDER 0.5 SINGLES | 54.4% | 4 | LOSS |
PHI@LAD | LAD -113 | 54.7% | 4 | LOSS |
NYY@BOS | OVER 7.5 | 54.3% | 3 | WIN |
KC@PHI | PHI -130 | 58.3% | 4 | WIN |
LAD@SF | OVER 7.5 | 54.7% | 4 | LOSS |
NYM@PHI | PHI -122 | 55.6% | 4 | WIN |
KC@CLE | KC -104 | 52.0% | 3 | WIN |
CIN@SD | JAKE CRONEWORTH OVER 0.5 HITS | 53.1% | 3 | WIN |
WAS@MIA | MIA -123 | 55.2% | 4 | LOSS |
LAA@KC | UNDER 9.5 | 54.9% | 3 | WIN |
TEX@ARI | UNDER 9 | 54.2% | 4 | WIN |
SF@COL | UNDER 11.5 | 56.4% | 6 | LOSS |
SF@COL | RAFAEL DEVERS OVER 1.5 BASES | 56.1% | 6 | WIN |
MIA@WAS | WAS -110 | 54.4% | 4 | WIN |
NYM@DET | OVER 8.5 | 54.5% | 4 | WIN |
TEX@ARI | UNDER 9.5 | 56.4% | 6 | WIN |
TEX@ARI | ALEJANDRO OSUNA UNDER 1.5 BASES | 54.1% | 4 | LOSS |
ATL@CHC | CHC -116 | 55.1% | 3 | WIN |
PHI@MIL | OVER 8.5 | 55.0% | 3 | WIN |
ARI@LAD | SHOHEI OHTANI OVER 2.5 BASES | 54.2% | 4 | WIN |
SEA@CLE | CLE +1.5 | 57.2% | 3 | WIN |
CHC@SF | CHC -105 | 54.1% | 4 | LOSS |
NYY@CHW | RYAN MCMAHON OVER 0.5 BASES | 54.1% | 4 | WIN |
PHI@NYM | OVER 8.5 | 55.6% | 4 | LOSS |
LAA@TEX | LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS | 54.1% | 4 | LOSS |
KC@CHW | KC -109 | 54.2% | 4 | WIN |
SD@SEA | DYLAN CEASE OVER 16.5 OUTS | 53.9% | 3 | LOSS |
SD@SEA | UNDER 8.5 | 54.4% | 4 | LOSS |
MIN@TOR | JOE RYAN UNDER 2.5 EARNED RUNS | 54.1% | 4 | LOSS |
SF@MIL | MIL +100 | 54.0% | 6 | LOSS |
TOR@MIA | MIA +1.5 | 62.0% | 6 | WIN |
CHC@LAA | OVER 9.5 | 54.9% | 4 | LOSS |
BOS@NYY | CARLOS RODON UNDER 4.5 HITS ALLOWED | 54.2% | 4 | WIN |
KC@DET | DET -115 | 56.1% | 5 | WIN |
CHC@LAA | LAA +1.5 | 57.6% | 5 | LOSS |
CIN@ARI | KEBRYAN HAYES STRIKEOUTS UNDER 0.5 | 56.2% | 6 | WIN |
LAD@SD | SD +110 | 50.9% | 6 | WIN |