White Sox vs Royals Prediction — AI Finds CAN'T MISS MLB Lines & Props (May 07)
Updated: 2025-05-05T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The Chicago White Sox and Kansas City Royals will face off on Wednesday, May 7, 2025, at Kauffman Stadium, concluding their four-game series. The Royals have dominated the series thus far, including a dramatic 4–3 walk-off victory on Tuesday, and aim to continue their strong play against a struggling White Sox team.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

GAME INFO
Date: May 07, 2025
Start Time: 7:40 PM EST
Venue: Kauffman Stadium
Royals Record: (21-16)
White Sox Record: (10-26)
OPENING ODDS
CHW Moneyline: +185
KC Moneyline: -224
CHW Spread: +1.5
KC Spread: -1.5
Over/Under: 8
CHW
Betting Trends
- The White Sox have struggled against the spread (ATS) this season, with a 6–17 record, reflecting their overall difficulties on the field.
KC
Betting Trends
- The Royals have been more reliable ATS, holding a 17–18 record, and have shown particular strength at home with an 11–5 record in their last 16 games at Kauffman Stadium.
MATCHUP TRENDS
- Kansas City has won 14 of their last 15 games against Chicago, including seven straight at home, outscoring the White Sox 84–34 during that span.
CHW vs. KC
Best Prop Bet
- Remi's searched hard and found the best prop for this matchup: D. Waters over 0.5 Total Bases.
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Chicago White Sox vs Kansas City Prediction & Odds:
Free MLB Betting Insights for 5/7/25
They’re batting just .216 as a team and averaging only 3.65 runs per game, while their pitching staff has combined for a 4.16 ERA that doesn’t begin to reflect the number of high-stress innings and lack of run support endured by their starters. One silver lining has been the emergence of rookie right-hander Shane Smith, who brings a 2.23 ERA into his seventh start, showing advanced poise and command, but he’s unlikely to carry the full load unless Chicago’s offense can find a way to support him with early runs. The White Sox have been terrible ATS, with a 6–17 mark that mirrors their struggles in games decided by more than a run, while the Royals are a more respectable 17–18 and 11–5 ATS in their last 16 home games. This game shapes up as another chance for Kansas City to assert its control early and ride its pitching depth to a low-scoring win, particularly if they can get Smith’s pitch count up and exploit the middle relief innings where Chicago has faltered. If the Royals can continue to apply pressure on the basepaths and execute situational hitting, they have a clear path to a series sweep, while the White Sox face an uphill climb and will need their most complete game of the season just to stay competitive. All indicators suggest another tight, possibly low-scoring affair, with Kansas City holding every major edge in pitching, defense, and recent head-to-head performance—positioning them well to put an emphatic stamp on a series that has so far been entirely one-sided.
Burke on the bump 💪 pic.twitter.com/Zk0RWcoOq8
— Chicago White Sox (@whitesox) May 7, 2025
Chicago White Sox White Sox MLB Preview
The Chicago White Sox head into the series finale at Kauffman Stadium with a 10–25 record and very little momentum, having dropped the first three games of this set and continuing to spiral in what has been a difficult start to their 2025 season. Offensively, the White Sox have been one of the least productive teams in baseball, entering this matchup with a team batting average of just .216 and scoring a mere 3.65 runs per game, which ranks among the bottom third in the league. Veterans like Andrew Benintendi and Yoán Moncada have struggled to provide consistency, while younger bats such as Oscar Colás and Lenyn Sosa have yet to deliver the kind of breakout performances that the organization hoped would inject life into the lineup. Their inability to deliver with runners in scoring position has been a major problem, and as a result, they’ve been one of the league’s worst teams against the spread, sitting at just 6–17 ATS this season and a dismal 3–13 on the road. One bright spot has been rookie pitcher Shane Smith, who enters this game with a 2.23 ERA over his first six starts and has looked like a potential cornerstone piece for the rotation, showing poise, command, and the ability to navigate tough lineups. However, Smith has received very little run support, a trend that must change if the White Sox hope to avoid a sweep.
The bullpen has also been a source of concern, with blown leads and walks in high-leverage situations continuing to haunt them. Defensively, the White Sox haven’t been especially sharp either, with late-game miscues costing them multiple close contests—including Tuesday night’s 4–3 walk-off loss that came on the heels of a misplayed ground ball and missed location in the zone. Manager Will Venable has tried different lineup configurations and leaned on his veterans to lead by example, but the overall performance continues to lag behind expectations. Against Kansas City specifically, the White Sox have now lost 14 of the last 15 matchups, including seven straight at Kauffman Stadium, where they’ve been outplayed in nearly every phase of the game and outscored 84–34 in that stretch. If there is any path to victory on Wednesday, it will likely hinge on Smith delivering a deep start while the offense capitalizes on any early Kansas City pitching mistakes—something that’s proven elusive in this series. The team is in desperate need of a spark to halt their slide and avoid being swept yet again, and while the odds may be against them, the presence of a promising young starter like Smith at least gives them a fighting chance if the bats can finally wake up and give him the backing he’s earned.

Credit: USA TODAY/IMAGN
Kansas City Royals MLB Preview
The Kansas City Royals enter Wednesday’s series finale against the Chicago White Sox with a 20–16 record and all the momentum, having secured three straight wins to open the series and looking to complete a sweep while continuing their dominance over a division rival they’ve thoroughly outplayed over the past two seasons. Kansas City has now won 14 of their last 15 games against Chicago and seven straight at home, outscoring the White Sox 84–34 in that span, a lopsided margin that reflects their advantage in pitching, defense, and clutch hitting. This year’s Royals team has been a pleasant surprise across the American League, built around a stellar pitching staff that ranks fourth in MLB with a 3.40 ERA and a defense that routinely makes the plays necessary to support their arms. Offensively, while they average just 3.43 runs per game, the Royals have excelled in late-game situations, often finding just enough offense to complement their strong pitching—like Tuesday night’s 4–3 walk-off win, punctuated by a Bobby Witt Jr. single that capped off a tight, well-pitched game. Witt continues to be the face of the franchise, combining athleticism, bat speed, and leadership, and he’s backed by a supporting cast that includes MJ Melendez, Vinnie Pasquantino, and Maikel Garcia, who have all contributed timely hits during the team’s recent surge.
At home, Kansas City has been particularly tough to beat, going 11–5 over their last 16 at Kauffman Stadium, where they’ve fed off strong pitching and clean defensive work to win close, low-scoring games. Their bullpen, anchored by James McArthur and John Schreiber, has been extremely effective in high-leverage situations, closing games with efficiency and minimizing late-inning drama. Manager Matt Quatraro has done an excellent job managing matchups, especially on days when the offense struggles to string together big innings, and his club has embraced a gritty, contact-driven approach that keeps pressure on opposing defenses. The Royals’ game plan entering Wednesday will be simple: continue to pitch aggressively, play clean defense, and let the top of the order, led by Witt, create scoring chances early. With a chance to sweep a division rival and keep pace in a tightly contested AL Central, Kansas City will treat this game with urgency, knowing every win matters in what is shaping up to be a competitive season. As long as their pitching staff holds form and the offense finds a few timely hits, the Royals are in prime position to put the finishing touches on a dominant series and move closer to asserting themselves as legitimate postseason contenders.
Got the job done.#HEYHEYHEYHEY pic.twitter.com/Bq1bne46lp
— Kansas City Royals (@Royals) May 7, 2025
Chicago White Sox vs. Kansas City Prop Picks (AI)
Chicago White Sox vs. Kansas City Prediction (AI)

Remi, our AI sports genius, has been pouring over mountains of data from every past game between the White Sox and Royals and using recursive machine learning and kick-ass AI to crunch the data to a single cover probability.
The Algorithm has been most keyed in on the linear correlation of factor knucklehead sportsbettors tend to put on Chicago White Sox’s strength factors between a White Sox team going up against a possibly healthy Royals team. In reality, the true game analytics might reflect a slight lean against one Vegas line specifically.
Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.
Below is our current AI Chicago White Sox vs Kansas City picks, computer picks White Sox vs Royals, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
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White Sox Betting Trends
The White Sox have struggled against the spread (ATS) this season, with a 6–17 record, reflecting their overall difficulties on the field.
Royals Betting Trends
The Royals have been more reliable ATS, holding a 17–18 record, and have shown particular strength at home with an 11–5 record in their last 16 games at Kauffman Stadium.
White Sox vs. Royals Matchup Trends
Kansas City has won 14 of their last 15 games against Chicago, including seven straight at home, outscoring the White Sox 84–34 during that span.
Chicago White Sox vs. Kansas City Game Info
What time does Chicago White Sox vs Kansas City start on May 07, 2025?
Chicago White Sox vs Kansas City starts on May 07, 2025 at 7:40 PM EST.
Where is Chicago White Sox vs Kansas City being played?
Venue: Kauffman Stadium.
What are the opening odds for Chicago White Sox vs Kansas City?
Spread: Kansas City -1.5
Moneyline: Chicago White Sox +185, Kansas City -224
Over/Under: 8
What are the records for Chicago White Sox vs Kansas City?
Chicago White Sox: (10-26) | Kansas City: (21-16)
What is the AI best bet for Chicago White Sox vs Kansas City?
Remi's searched hard and found the best prop for this matchup: D. Waters over 0.5 Total Bases.. Prices move—always shop for the best number.
What are Chicago White Sox vs Kansas City trending bets?
Kansas City has won 14 of their last 15 games against Chicago, including seven straight at home, outscoring the White Sox 84–34 during that span.
What are Chicago White Sox trending bets?
CHW trend: The White Sox have struggled against the spread (ATS) this season, with a 6–17 record, reflecting their overall difficulties on the field.
What are Kansas City trending bets?
KC trend: The Royals have been more reliable ATS, holding a 17–18 record, and have shown particular strength at home with an 11–5 record in their last 16 games at Kauffman Stadium.
Where can I find AI Picks for Chicago White Sox vs Kansas City?
See our latest MLB picks and odds pages for 2025 to compare prices before you bet.
Chicago White Sox vs. Kansas City Odds
AI algorithm Remi is pouring through loads of data on each player. In fact, anytime the Chicago White Sox vs Kansas City trends are analyzed, there’s always several intriguing trends to key in on. Not to mention games played at extreme hostile environments seemingly never follow normal, predictable betting trends.
Chicago White Sox vs Kansas City Opening Odds
CHW Moneyline:
+185 KC Moneyline: -224
CHW Spread: +1.5
KC Spread: -1.5
Over/Under: 8
Chicago White Sox vs Kansas City Live Odds
Games | PTS | ML | SPR | O/U | |
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Oct 19, 2025 8:04PM EDT
Seattle Mariners
Toronto Blue Jays
10/19/25 8:04PM
Mariners
Blue Jays
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–
–
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+112
-123
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+1.5 (-195)
-1.5 (+171)
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O 7.5 (-114)
U 7.5 (-101)
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MLB Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers Chicago White Sox White Sox vs. Kansas City Royals on May 07, 2025 at Kauffman Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.
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LEAN | %WIN | UNITS | RESULT |
---|---|---|---|---|
TOR@SEA | OVER 7 | 54.9% | 3 | WIN |
LAD@MIL | UNDER 7.5 | 56.6% | 6 | WIN |
TOR@NYY | OVER 8 | 54.9% | 4 | WIN |
TOR@NYY | CARLOS RODON OVER 1.5 TOTAL WALKS ALLOWED | 53.3% | 3 | WIN |
NYY@TOR | OVER 7.5 | 54.8% | 2 | WIN |
LAD@PHI | OVER 7 | 53.8% | 3 | WIN |
SD@CHC | CHC -109 | 53.8% | 3 | WIN |
SD@CHC | OVER 7.5 | 54.5% | 4 | LOSS |
SD@CHC | CHC -111 | 54.8% | 4 | LOSS |
CIN@LAD | SHOHEI OHTANI OVER 1.5 BASES | 53.5% | 3 | WIN |
BOS@NYY | OVER 7 | 53.8% | 3 | LOSS |
CIN@LAD | ELLY DE LA CRUZ OVER 0.5 BASES | 54.4% | 4 | LOSS |
ARI@SD | SD -131 | 57.3% | 4 | WIN |
DET@BOS | BOS -115 | 56.4% | 5 | WIN |
NYM@CHC | NYM -110 | 54.1% | 3 | WIN |
HOU@ATH | ATH +118 | 50.8% | 4 | WIN |
NYM@CHC | OVER 7 | 54.5% | 3 | WIN |
STL@SF | OVER 7.5 | 55.9% | 5 | LOSS |
KC@LAA | TYLER TOLBERT UNDER 1.5 BASES | 54.4% | 4 | WIN |
MIL@SD | UNDER 9 | 54.7% | 4 | WIN |
MIA@PHI | KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS | 53.3% | 3 | WIN |
WAS@NYM | OVER 8.5 | 56.1% | 6 | LOSS |
LAA@COL | COL +108 | 50.5% | 3 | WIN |
TOR@KC | UNDER 9 | 54.7% | 4 | LOSS |
SEA@KC | KC +1.5 | 62.3% | 5 | LOSS |
NYY@MIN | OVER 9 | 55.1% | 4 | WIN |
MIA@COL | OVER 10.5 | 55.0% | 4 | WIN |
MIA@COL | AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS | 54.3% | 4 | WIN |
SEA@KC | BOBBY WITT UNDER 0.5 SINGLES | 54.4% | 4 | LOSS |
PHI@LAD | LAD -113 | 54.7% | 4 | LOSS |
NYY@BOS | OVER 7.5 | 54.3% | 3 | WIN |
KC@PHI | PHI -130 | 58.3% | 4 | WIN |
LAD@SF | OVER 7.5 | 54.7% | 4 | LOSS |
NYM@PHI | PHI -122 | 55.6% | 4 | WIN |
KC@CLE | KC -104 | 52.0% | 3 | WIN |
CIN@SD | JAKE CRONEWORTH OVER 0.5 HITS | 53.1% | 3 | WIN |
WAS@MIA | MIA -123 | 55.2% | 4 | LOSS |
LAA@KC | UNDER 9.5 | 54.9% | 3 | WIN |
TEX@ARI | UNDER 9 | 54.2% | 4 | WIN |
SF@COL | UNDER 11.5 | 56.4% | 6 | LOSS |
SF@COL | RAFAEL DEVERS OVER 1.5 BASES | 56.1% | 6 | WIN |
MIA@WAS | WAS -110 | 54.4% | 4 | WIN |
NYM@DET | OVER 8.5 | 54.5% | 4 | WIN |
TEX@ARI | UNDER 9.5 | 56.4% | 6 | WIN |
TEX@ARI | ALEJANDRO OSUNA UNDER 1.5 BASES | 54.1% | 4 | LOSS |
ATL@CHC | CHC -116 | 55.1% | 3 | WIN |
PHI@MIL | OVER 8.5 | 55.0% | 3 | WIN |
ARI@LAD | SHOHEI OHTANI OVER 2.5 BASES | 54.2% | 4 | WIN |
SEA@CLE | CLE +1.5 | 57.2% | 3 | WIN |
CHC@SF | CHC -105 | 54.1% | 4 | LOSS |
NYY@CHW | RYAN MCMAHON OVER 0.5 BASES | 54.1% | 4 | WIN |