Pirates vs Cardinals Prediction — AI Finds CAN'T MISS MLB Lines & Props (May 06)

Updated: 2025-05-04T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The Pittsburgh Pirates (12–21) face the St. Louis Cardinals (14–19) on Tuesday, May 6, 2025, at Busch Stadium in a National League Central matchup. Both teams are looking to gain momentum in the division standings.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: May 06, 2025

Start Time: 7:45 PM EST​

Venue: Busch Stadium​

Cardinals Record: (17-19)

Pirates Record: (12-24)

OPENING ODDS

PIT Moneyline: -130

STL Moneyline: +109

PIT Spread: -1.5

STL Spread: +1.5

Over/Under: 7

PIT
Betting Trends

  • The Pirates have struggled against the spread (ATS) recently, with a 1–6 record in their last seven games.

STL
Betting Trends

  • The Cardinals have shown better form ATS, covering in 20 of their 33 games this season.

MATCHUP TRENDS

  • In their last 10 head-to-head matchups, the total has gone OVER in 7 games, indicating a trend towards high-scoring affairs between these teams.

PIT vs. STL
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: O. Cruz over 0.5 Total Bases.

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Pittsburgh vs St. Louis Prediction & Odds:
Free MLB Betting Insights for 5/6/25

The Pittsburgh Pirates and St. Louis Cardinals face off on Tuesday, May 6, 2025, at Busch Stadium in a divisional matchup between two National League Central teams searching for identity and momentum amid underwhelming starts to the season. The Pirates enter the contest with a 12–21 record and mired in offensive woes, carrying a dismal .197 team batting average and a .302 slugging percentage that rank near the bottom of Major League Baseball. While Pittsburgh’s pitching staff has actually been serviceable with a 3.82 ERA, their inability to generate consistent offense has led to repeated missed opportunities and close losses, most recently reflected in a 1–6 record against the spread over their last seven games. On the flip side, the Cardinals, at 14–19, have been a mixed bag, showing moments of offensive brilliance fueled by stars like Brendan Donovan (.395 AVG) and Nolan Arenado (.316 AVG, .474 SLG), but consistently hampered by a shaky pitching staff that’s surrendered 154 runs across 33 games. St. Louis currently holds a team ERA of 4.31, and while not the worst in the league, it’s been enough of a liability to keep them from capitalizing on their top-tier batting metrics.

The Cardinals’ offense, with a .256 batting average and .395 slugging, has given them an edge in many matchups, and they’ve been more reliable against the spread, covering in 20 of 33 games so far this season, suggesting better in-game performance and execution compared to Pittsburgh. When these two teams meet, history leans toward high-scoring affairs—the total has gone OVER in seven of their last ten head-to-head matchups—often pointing to defensive lapses, bullpen collapses, or late-game scoring spurts. Tuesday’s game is likely to follow a similar trend unless one side can find stability from its starter and avoid giving up big innings. The Pirates will need to get out of the gate quickly and apply early pressure if they want to stay competitive, while the Cardinals should look to jump on Pittsburgh’s weak offense early and rely on their bats to build a lead too large for the Pirates to recover from. Defensively, both teams have had their share of miscues this season, meaning crisp fielding and limiting errors could very well be the difference between a win and a late-inning unraveling. St. Louis, with the home-field advantage, deeper offensive weapons, and superior recent ATS track record, holds a slight edge heading into this game, but they’ll need a reliable start and clean bullpen work to avoid letting Pittsburgh hang around. This is the kind of series that can define a stretch of the season—either as a launching pad for a much-needed run or as a continuation of early-season frustrations—and both teams will be playing with urgency as they look to climb back into the division race.

Pittsburgh Pirates MLB Preview

The Pittsburgh Pirates enter Tuesday’s matchup at Busch Stadium with a 12–21 record and a growing sense of urgency as they continue to search for answers amid an offensively stagnant start to the 2025 season. While the Pirates have shown flashes of competitiveness on the mound, boasting a respectable team ERA of 3.82, their inability to generate runs has neutralized much of the value that pitching has provided. The offense has been among the worst in baseball, with a team batting average of just .197 and a slugging percentage of .302—numbers that reflect an alarming lack of power and consistent contact. Rallies have been rare, extra-base hits even rarer, and the lineup has yet to find a rhythm, often going multiple innings without meaningful threats. As a result, even solid pitching performances have too frequently gone unrewarded, with games slipping away due to lack of run support or late-inning breakdowns when pressure mounts. Recent results reflect that frustration, as Pittsburgh has gone just 1–6 against the spread in their last seven games and seems trapped in a cycle of falling behind early, pressing at the plate, and struggling to recover. To their credit, the Pirates have seen encouraging outings from parts of their pitching staff, particularly among their young starters, who continue to gain valuable experience and often keep the team within striking distance through the middle innings.

However, the bullpen has been stretched thin due to a lack of consistent offensive production, which places additional stress on middle relievers and often leads to game-changing mistakes in high-leverage moments. Fielding has also been a liability at times, with defensive lapses compounding scoring droughts and making it difficult for Pittsburgh to build momentum. Heading into Tuesday’s divisional matchup, the Pirates need to focus on manufacturing runs—via aggressive baserunning, bunting for hits, and grinding out at-bats—instead of relying on power that has yet to materialize. A quick start is essential, not only to put pressure on the Cardinals but also to give their pitching staff some breathing room and inject some confidence into a lineup that appears tentative. If they can generate early baserunners and convert situational hitting opportunities, they might be able to turn the tide and surprise a Cardinals team that’s vulnerable on the mound despite a dangerous offense. Manager Derek Shelton has a tough challenge ahead in motivating a group that has the tools to be better than its record suggests but has yet to prove it on the field. With recent form, betting trends, and statistical output all working against them, the Pirates will need more than just decent pitching to get past St. Louis—they’ll need energy, execution, and a spark that has eluded them for most of the young season.

The Pittsburgh Pirates (12–21) face the St. Louis Cardinals (14–19) on Tuesday, May 6, 2025, at Busch Stadium in a National League Central matchup. Both teams are looking to gain momentum in the division standings. Pittsburgh vs St. Louis AI Prediction: Free MLB Betting Insights for May 06. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

St. Louis Cardinals MLB Preview

The St. Louis Cardinals return to Busch Stadium for Tuesday’s divisional battle against the struggling Pittsburgh Pirates with a 14–19 record that doesn’t fully reflect the promise and potential glimpsed in parts of their season so far. Offensively, the Cardinals have delivered consistent production, boasting a .256 team batting average and a .395 slugging percentage, both comfortably above league average and indicative of a lineup capable of inflicting damage across multiple spots in the order. Key contributors like Brendan Donovan, who is hitting an eye-popping .395, and perennial All-Star Nolan Arenado, who sports a .316 average with a .474 slugging percentage, have anchored an attack that’s been more than capable of producing runs—especially against middling pitching staffs like Pittsburgh’s. What has held the Cardinals back, however, has been inconsistent pitching; their staff holds a team ERA of 4.31 and has allowed 154 runs in just 33 games, a number that has repeatedly put the offense in catch-up mode. Their starters have had difficulty going deep into games, and while the bullpen has shown moments of stability, it has struggled in high-leverage situations, often surrendering leads late and allowing tight contests to slip away.

Still, the Cardinals have managed to cover the spread in 20 of their 33 games this season, suggesting that despite their struggles, they’ve remained competitive in most matchups and delivered when it comes to in-game execution, especially on the offensive side. Playing at home, St. Louis has an opportunity to lean into its strengths—timely hitting, veteran leadership, and a deep lineup—and set the tone early against a Pirates team that has lacked both offensive firepower and late-game poise. Manager Oli Marmol will likely emphasize the importance of jumping on Pittsburgh’s pitching early, giving his own staff a cushion to work with and reducing the pressure on a bullpen that has been overexposed at times. Defensively, the Cardinals have been solid, and if they can minimize mistakes and give their pitchers clean innings to work with, they’ll be in prime position to dictate tempo and control the flow of the game. Their ability to consistently generate traffic on the bases and create run-scoring opportunities with quality at-bats and productive outs gives them a significant advantage over a Pirates team that often struggles to even put the ball in play. This game also offers the Cardinals a much-needed chance to begin building momentum within the division, especially against a Pittsburgh team that is reeling and vulnerable. If St. Louis can execute in the early innings and play to their offensive strengths, they’ll be poised not only to win this game but to start reversing their early-season narrative and climb back into contention in what remains a very open National League Central race.

Pittsburgh vs. St. Louis Prop Picks (AI)

AI algorithm Remi is pouring through mountains of stats on each team. In fact, anytime the Pirates and Cardinals play there’s always several intriguing observations to key in on. Not to mention games played at Busch Stadium in May almost always follow normal, predictable betting trends.
Remi's searched hard and found the best prop for this matchup: O. Cruz over 0.5 Total Bases.

Pittsburgh vs. St. Louis Prediction (AI)

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Remi, our AI sports genius, has been pouring over exorbitant amounts of data from every past game between the Pirates and Cardinals and using recursive machine learning and industry leading AI to examine the data to a single cover probability.

Oddly enough, we’ve seen the AI has been most fixated on the growing factor emotional bettors often put on coaching factors between a Pirates team going up against a possibly deflated Cardinals team. It appears the true game analytics appear to reflect a slight lean against one Vegas line specifically.

Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.

Below is our current AI Pittsburgh vs St. Louis picks, computer picks Pirates vs Cardinals, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.

Pirates Betting Trends

The Pirates have struggled against the spread (ATS) recently, with a 1–6 record in their last seven games.

Cardinals Betting Trends

The Cardinals have shown better form ATS, covering in 20 of their 33 games this season.

Pirates vs. Cardinals Matchup Trends

In their last 10 head-to-head matchups, the total has gone OVER in 7 games, indicating a trend towards high-scoring affairs between these teams.

Pittsburgh vs. St. Louis Game Info

Pittsburgh vs St. Louis starts on May 06, 2025 at 7:45 PM EST.

Spread: St. Louis +1.5
Moneyline: Pittsburgh -130, St. Louis +109
Over/Under: 7

Pittsburgh: (12-24)  |  St. Louis: (17-19)

Remi's searched hard and found the best prop for this matchup: O. Cruz over 0.5 Total Bases.. Prices move—always shop for the best number.

In their last 10 head-to-head matchups, the total has gone OVER in 7 games, indicating a trend towards high-scoring affairs between these teams.

PIT trend: The Pirates have struggled against the spread (ATS) recently, with a 1–6 record in their last seven games.

STL trend: The Cardinals have shown better form ATS, covering in 20 of their 33 games this season.

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

Pittsburgh vs. St. Louis Odds

AI algorithm Remi is pouring through tons of stats on each team. In fact, anytime the Pittsburgh vs St. Louis trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme hostile environments seemingly never follow normal, predictable betting trends.

Pittsburgh vs St. Louis Opening Odds

PIT Moneyline: -130
STL Moneyline: +109
PIT Spread: -1.5
STL Spread: +1.5
Over/Under: 7

Pittsburgh vs St. Louis Live Odds

Games PTS ML SPR O/U

MLB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Pittsburgh Pirates vs. St. Louis Cardinals on May 06, 2025 at Busch Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
LAD@TOR TOR +1.5 56.7% 2 WIN
TOR@LAD TOR +1.5 55.3% 4 WIN
TOR@SEA OVER 7 54.9% 3 WIN
LAD@MIL UNDER 7.5 56.6% 6 WIN
TOR@NYY OVER 8 54.9% 4 WIN
TOR@NYY CARLOS RODON OVER 1.5 TOTAL WALKS ALLOWED 53.3% 3 WIN
NYY@TOR OVER 7.5 54.8% 2 WIN
LAD@PHI OVER 7 53.8% 3 WIN
SD@CHC CHC -109 53.8% 3 WIN
SD@CHC OVER 7.5 54.5% 4 LOSS
SD@CHC CHC -111 54.8% 4 LOSS
CIN@LAD SHOHEI OHTANI OVER 1.5 BASES 53.5% 3 WIN
BOS@NYY OVER 7 53.8% 3 LOSS
CIN@LAD ELLY DE LA CRUZ OVER 0.5 BASES 54.4% 4 LOSS
ARI@SD SD -131 57.3% 4 WIN
DET@BOS BOS -115 56.4% 5 WIN
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN