Giants vs. Cubs
Prediction, Odds & Props
May 05 | MLB AI Picks

Updated: 2025-05-03T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The Chicago Cubs (21-14) host the San Francisco Giants (22-13) at Wrigley Field on Monday, May 5, 2025, at 6:40 PM CT. Both teams are off to strong starts in their respective divisions, making this a compelling early-season matchup.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: May 05, 2025

Start Time: 7:40 PM EST​

Venue: Wrigley Field​

Cubs Record: (21-14)

Giants Record: (22-13)

OPENING ODDS

SF Moneyline: +124

CHC Moneyline: -148

SF Spread: +1.5

CHC Spread: -1.5

Over/Under: 7.5

SF
Betting Trends

  • The Giants have a 13-19 record against the spread (ATS) this season, covering in 40.6% of their games.

CHC
Betting Trends

  • The Cubs have a 17-15 ATS record this season, covering in 53.1% of their games.

MATCHUP TRENDS

  • The Cubs are favored at -148 on the moneyline, while the Giants are underdogs at +124. The over/under for the game is set at 7.5 runs.

SF vs. CHC
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: W. Adames over 0.5 Total Bases.

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San Francisco vs Chicago Cubs Prediction & Odds:
Free MLB Betting Insights for 5/5/25

The San Francisco Giants and Chicago Cubs square off in a compelling early-May showdown at Wrigley Field on Monday, May 5, 2025, as two National League contenders look to build on impressive starts and gain separation in their respective divisions. The Giants enter the series at 22-13, riding strong offensive production and currently sitting near the top of the NL West, while the Cubs boast a 21-14 record and lead the NL Central, driven by timely hitting and a balanced pitching staff that has quietly put them ahead of the preseason expectations. Chicago will send left-hander Matthew Boyd to the mound, who has been one of the more consistent arms in their rotation with a 2-2 record, 2.70 ERA, and 30 strikeouts, limiting damage and providing quality starts that have kept the Cubs in virtually every game he’s pitched. His counterpart, Giants starter Landen Roupp, brings a less steady résumé into the opener, holding a 2-2 record and a 5.10 ERA; Roupp has flashed strikeout potential but has struggled with command and giving up runs in early innings, which could be costly against a Cubs offense that has been hot out of the gate lately. Statistically, Chicago’s team batting average of .262 leads the majors, fueled by consistent at-bats and depth across the lineup, with Kyle Tucker emerging as a driving force thanks to nine home runs and 25 RBIs, while Ian Happ enters the series red-hot, hitting .325 over his last 10 games with four doubles.

On the other side, the Giants’ offense ranks sixth in the National League in home runs (37), anchored by the consistency of Jung Hoo Lee, who is hitting .333 and getting on base at a high clip, and the power of Wilmer Flores, who leads the club with seven home runs and 27 RBIs. Defensively, both teams are solid, with the Cubs minimizing mistakes behind their pitchers and the Giants flashing range and sure-handedness, though Chicago holds the edge in team ERA and bullpen reliability, which could come into play in the later innings of what figures to be a tight contest. Betting-wise, the Cubs are favored at -148 and have rewarded bettors with a 17-15 ATS record, while the Giants, despite a strong win-loss mark, are just 13-19 ATS, a signal that while they win often, they don’t always do so by wide enough margins to cover spreads. The over/under is set at 7.5 runs, reflective of a matchup featuring one reliable starter (Boyd) and one more volatile arm (Roupp), suggesting the total may hinge on whether the Giants can keep Chicago’s top of the order in check early. With both clubs pushing to sustain early-season momentum and solidify their standing in tight divisions, this opener sets the tone for a critical series that could influence playoff positioning down the road. Expect a highly competitive game with playoff energy and pressure-packed at-bats, as two evenly matched teams look to make a statement on a big stage.

San Francisco Giants MLB Preview

The San Francisco Giants come into their Monday night opener against the Chicago Cubs riding a strong 22-13 start to the 2025 season, placing them squarely in the mix atop the NL West standings thanks to a potent offensive lineup and a resilient clubhouse that has proven capable of winning close games and powering through adversity. Although their 13-19 record against the spread suggests they haven’t always dominated in terms of margin, the Giants have consistently found ways to win tight contests and have outperformed expectations in one of the most competitive divisions in baseball. Their offense has been one of the team’s key strengths, currently ranking sixth in the National League in home runs with 37, driven by the duo of Wilmer Flores and Jung Hoo Lee. Flores has supplied much of the power, clubbing seven homers and driving in 27 runs, while Lee has been a table-setter and catalyst at the top of the lineup, hitting .333 and getting on base with a mix of contact ability and great plate discipline. The Giants’ offense isn’t overly reliant on the long ball, though—it’s been their ability to string together hits, move runners, and capitalize in key situations that has given them an edge over opponents in tight games. On the mound, they’ll turn to right-hander Landen Roupp, who enters the series opener with a 2-2 record and a 5.10 ERA, and while he’s flashed strong strikeout stuff with 35 Ks on the year, he’s also battled command issues and has given up runs early, which could be problematic against a Cubs lineup that’s known for fast starts.

Roupp’s task will be to navigate the top half of the Cubs order without letting things snowball in the early innings and to give his bullpen a chance to protect a lead or keep the team within striking distance. Defensively, San Francisco has been steady if not spectacular, playing fundamentally sound baseball and minimizing extra outs, which has helped keep games close and allowed their pitching to work with confidence. The bullpen, while tested often, has generally held up in high-leverage situations, especially when asked to cover multiple innings in support of shorter outings from the starting staff. Heading into this matchup as underdogs at +124, the Giants will look to exploit any early command lapses from Cubs starter Matthew Boyd and pressure Chicago’s defense with aggressive baserunning and line-to-line contact. Winning on the road hasn’t been a major issue for San Francisco—they’re 10-8 away from Oracle Park—and their ability to adapt to different ballparks and maintain offensive production gives them a chance to set the tone in what could be a playoff-preview series. If Roupp can contain the damage and the bats continue to support with early offense, the Giants could easily turn the tables on the oddsmakers and open the series with a signature win in one of baseball’s most iconic venues.

The Chicago Cubs (21-14) host the San Francisco Giants (22-13) at Wrigley Field on Monday, May 5, 2025, at 6:40 PM CT. Both teams are off to strong starts in their respective divisions, making this a compelling early-season matchup. San Francisco vs Chicago Cubs AI Prediction: Free MLB Betting Insights for May 05. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Chicago Cubs Cubs MLB Preview

The Chicago Cubs enter Monday night’s home game against the San Francisco Giants with a 21-14 record and the confidence of a first-place team that has steadily emerged as one of the National League’s most well-rounded and consistent contenders early in the 2025 season. They’ve built their success on a lethal combination of elite contact hitting, timely power, and steady pitching, and they now hold the highest team batting average in Major League Baseball at .262—an offensive stat that has allowed them to stay competitive in nearly every game and jump out to early leads against even top-tier opponents. Leading the charge is slugger Kyle Tucker, who continues to be a force in the middle of the order with nine home runs and 25 RBIs, while Ian Happ has caught fire in recent weeks, going 13-for-40 over the last 10 games and spraying doubles into the gaps with consistency and confidence. On the mound for the opener is veteran left-hander Matthew Boyd, who brings a 2-2 record with a sparkling 2.70 ERA and 30 strikeouts into the matchup, offering not only stability but the kind of command that allows him to minimize big innings and manage tough matchups with poise. Boyd has been particularly sharp at home, using the Wrigley Field environment to his advantage and keeping hitters off-balance with a diverse pitch mix.

Defensively, the Cubs have backed their staff with clean execution, committing few errors and making routine plays look easy, which has helped support a bullpen that has proven capable of closing out tight games and protecting slim leads with regularity. The bullpen depth—featuring effective arms in setup and closing roles—has allowed manager Craig Counsell to play matchups late in games with a high degree of success. With a 9-7 home record, the Cubs have done well protecting Wrigley Field, and their 17-15 mark against the spread shows that they’ve consistently met or exceeded expectations, especially when favored. They come into this series opener as -148 favorites, a nod to their superior starting pitching and more efficient offensive output compared to a Giants team that has been good but inconsistent when playing from behind. The key for Chicago will be to capitalize early against Giants starter Landen Roupp, who brings a 5.10 ERA into the game and has struggled with command and early-inning damage, which plays directly into the Cubs’ strength as one of the league’s most aggressive and productive lineups in the first three innings. If Boyd continues his trend of early dominance and the offense remains opportunistic with runners in scoring position, Chicago has an excellent chance to set the tone not only for this series but for another winning stretch that could provide more separation in the division. With the home crowd behind them, solid fundamentals across the board, and a team that continues to trend upward in all major statistical categories, the Cubs are poised to keep rolling and assert themselves as one of the true contenders in the National League this season.

San Francisco vs. Chicago Cubs Prop Picks (AI)

Remi is pouring through tons of datapoints on each player. In fact, anytime the Giants and Cubs play there’s always several intriguing observations to key in on. Not to mention games played at Wrigley Field in May rarely follow normal, predictable betting trends.
Remi's searched hard and found the best prop for this matchup: W. Adames over 0.5 Total Bases.

San Francisco vs. Chicago Cubs Prediction (AI)

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Remi, our AI sports genius, has been pouring over mountains of data from every simulation between the Giants and Cubs and using recursive machine learning and kick-ass AI to boil down the data to a single cover probability.

Oddly enough, we’ve seen the AI has been most focused on the linear correlation of weight emotional bettors regularly put on San Francisco’s strength factors between a Giants team going up against a possibly healthy Cubs team. We’ve found the true game analytics appear to reflect a moderate lean against one Vegas line in particular.

Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.

Below is our current AI San Francisco vs Chicago Cubs picks, computer picks Giants vs Cubs, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.

Giants Betting Trends

The Giants have a 13-19 record against the spread (ATS) this season, covering in 40.6% of their games.

Cubs Betting Trends

The Cubs have a 17-15 ATS record this season, covering in 53.1% of their games.

Giants vs. Cubs Matchup Trends

The Cubs are favored at -148 on the moneyline, while the Giants are underdogs at +124. The over/under for the game is set at 7.5 runs.

San Francisco vs. Chicago Cubs Game Info

San Francisco vs Chicago Cubs starts on May 05, 2025 at 7:40 PM EST.

Spread: Chicago Cubs -1.5
Moneyline: San Francisco +124, Chicago Cubs -148
Over/Under: 7.5

San Francisco: (22-13)  |  Chicago Cubs: (21-14)

Remi's searched hard and found the best prop for this matchup: W. Adames over 0.5 Total Bases.. Prices move—always shop for the best number.

The Cubs are favored at -148 on the moneyline, while the Giants are underdogs at +124. The over/under for the game is set at 7.5 runs.

SF trend: The Giants have a 13-19 record against the spread (ATS) this season, covering in 40.6% of their games.

CHC trend: The Cubs have a 17-15 ATS record this season, covering in 53.1% of their games.

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

San Francisco vs. Chicago Cubs Odds

Remi is pouring through mountains of data on each team. In fact, anytime the San Francisco vs Chicago Cubs trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme hostile environments can often follow normal, predictable patterns.

San Francisco vs Chicago Cubs Opening Odds

SF Moneyline: +124
CHC Moneyline: -148
SF Spread: +1.5
CHC Spread: -1.5
Over/Under: 7.5

San Francisco vs Chicago Cubs Live Odds

Games PTS ML SPR O/U
Sep 27, 2025 1:06PM EDT
Baltimore Orioles
New York Yankees
9/27/25 1:06PM
Orioles
Yankees
+196
-240
+1.5 (-105)
-1.5 (-115)
O 9 (-105)
U 9 (-115)
Sep 27, 2025 2:21PM EDT
St Louis Cardinals
Chicago Cubs
9/27/25 2:21PM
Cardinals
Cubs
 
-178
 
-1.5 (+115)
O 9.5 (+100)
U 9.5 (-120)
Sep 27, 2025 3:09PM EDT
Tampa Bay Rays
Toronto Blue Jays
9/27/25 3:09PM
Rays
Blue Jays
+135
-160
+1.5 (-155)
-1.5 (+130)
O 8.5 (-105)
U 8.5 (-115)
Sep 27, 2025 4:05PM EDT
Chicago White Sox
Washington Nationals
9/27/25 4:05PM
White Sox
Nationals
+100
-120
+1.5 (-205)
-1.5 (+170)
O 8.5 (-115)
U 8.5 (-105)
Sep 27, 2025 4:06PM EDT
Colorado Rockies
San Francisco Giants
9/27/25 4:06PM
Rockies
Giants
+196
-240
+1.5 (-110)
-1.5 (-110)
O 8 (-105)
U 8 (-115)
Sep 27, 2025 4:11PM EDT
New York Mets
Miami Marlins
9/27/25 4:11PM
Mets
Marlins
-130
+110
-1.5 (+130)
+1.5 (-155)
O 8 (-115)
U 8 (-105)
Sep 27, 2025 4:11PM EDT
Detroit Tigers
Boston Red Sox
9/27/25 4:11PM
Tigers
Red Sox
+110
-130
+1.5 (-190)
-1.5 (+158)
O 9 (+100)
U 9 (-120)
Sep 27, 2025 6:05PM EDT
Minnesota Twins
Philadelphia Phillies
9/27/25 6:05PM
Twins
Phillies
+175
-210
+1.5 (-120)
-1.5 (+100)
O 8.5 (-115)
U 8.5 (-105)
Sep 27, 2025 7:11PM EDT
Cincinnati Reds
Milwaukee Brewers
9/27/25 7:11PM
Reds
Brewers
+115
-135
+1.5 (-190)
-1.5 (+158)
O 7.5 (-120)
U 7.5 (+100)
Sep 27, 2025 7:15PM EDT
Pittsburgh Pirates
Atlanta Braves
9/27/25 7:15PM
Pirates
Braves
+150
-178
+1.5 (-145)
-1.5 (+122)
O 8 (-110)
U 8 (-110)
Sep 27, 2025 7:16PM EDT
Texas Rangers
Cleveland Guardians
9/27/25 7:16PM
Rangers
Guardians
+122
-145
+1.5 (-190)
-1.5 (+158)
O 7 (-120)
U 7 (+100)
Sep 27, 2025 8:40PM EDT
Arizona Diamondbacks
San Diego Padres
9/27/25 8:40PM
Diamondbacks
Padres
+118
-140
+1.5 (-190)
-1.5 (+158)
O 7.5 (-115)
U 7.5 (-105)
Sep 27, 2025 9:39PM EDT
Houston Astros
Los Angeles Angels
9/27/25 9:39PM
Astros
Angels
-140
+118
-1.5 (+115)
+1.5 (-135)
O 9 (-110)
U 9 (-110)
Sep 27, 2025 9:41PM EDT
Los Angeles Dodgers
Seattle Mariners
9/27/25 9:41PM
Dodgers
Mariners
+100
-120
+1.5 (-220)
-1.5 (+180)
O 7 (-120)
U 7 (+100)
Sep 27, 2025 10:05PM EDT
Kansas City Royals
Oakland Athletics
9/27/25 10:05PM
Royals
Athletics
+100
-120
+1.5 (-195)
-1.5 (+162)
O 10 (-115)
U 10 (-105)

MLB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers San Francisco Giants vs. Chicago Cubs Cubs on May 05, 2025 at Wrigley Field.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
ARI@SD SD -131 57.3% 4 WIN
DET@BOS BOS -115 56.4% 5 WIN
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN
CHC@SF CHC -105 54.1% 4 LOSS
NYY@CHW RYAN MCMAHON OVER 0.5 BASES 54.1% 4 WIN
PHI@NYM OVER 8.5 55.6% 4 LOSS
LAA@TEX LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS 54.1% 4 LOSS
KC@CHW KC -109 54.2% 4 WIN
SD@SEA DYLAN CEASE OVER 16.5 OUTS 53.9% 3 LOSS
SD@SEA UNDER 8.5 54.4% 4 LOSS
MIN@TOR JOE RYAN UNDER 2.5 EARNED RUNS 54.1% 4 LOSS
SF@MIL MIL +100 54.0% 6 LOSS
TOR@MIA MIA +1.5 62.0% 6 WIN
CHC@LAA OVER 9.5 54.9% 4 LOSS
BOS@NYY CARLOS RODON UNDER 4.5 HITS ALLOWED 54.2% 4 WIN
KC@DET DET -115 56.1% 5 WIN
CHC@LAA LAA +1.5 57.6% 5 LOSS