Giants vs. Padres
Prediction, Odds & Props
Apr 30 | MLB AI Picks
Updated: 2025-04-28T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The San Francisco Giants (19–11) and San Diego Padres (18–11) conclude their two-game series at Petco Park on April 30, 2025, at 4:10 PM ET. Both teams are vying for positioning in the tightly contested NL West, with the Padres looking to capitalize on their home-field advantage.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

GAME INFO
Date: Apr 30, 2025
Start Time: 4:10 PM EST
Venue: Petco Park
Padres Record: (18-11)
Giants Record: (19-11)
OPENING ODDS
SF Moneyline: +114
SD Moneyline: -135
SF Spread: +1.5
SD Spread: -1.5
Over/Under: 7
SF
Betting Trends
- The Giants have covered the run line in 6 of their last 10 games, demonstrating consistent performance against the spread.
SD
Betting Trends
- The Padres have covered the run line in 7 of their last 10 home games, highlighting their strong play at Petco Park.
MATCHUP TRENDS
- The Giants are slight favorites on the moneyline at -123, with the Padres at +104; the over/under is set at 7 runs, indicating expectations of a low-scoring affair.
SF vs. SD
Best Prop Bet
- Remi's searched hard and found the best prop for this matchup: W. Adames over 0.5 Total Bases.
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San Francisco vs San Diego Prediction & Odds:
Free MLB Betting Insights for 4/30/25
San Diego’s starting pitcher Michael King brings a 3–1 record and a sparkling 2.18 ERA into the game, and his ability to work deep into games with a versatile pitch mix has given the Padres stability during this injury-stretched stretch of the rotation. The Giants’ offense, though not explosive, has been opportunistic, with Jung Hoo Lee delivering consistent contact from the top of the order and Wilmer Flores providing clutch power in the middle of the lineup. Defensively, the Giants have been cleaner than in years past, and their baserunning—ranking seventh in baserunning runs—has added value in tight contests. With both teams excelling in pitching and displaying flashes of offensive potential, this matchup projects to be a tightly contested, low-scoring affair—reflected in the set over/under of 7 runs. Expect both managers to leverage their bullpens aggressively, with San Francisco possibly using a quicker hook on Roupp if he gets into early trouble, and San Diego leaning on their high-leverage arms to preserve a late lead should King hand off a narrow margin. Given their recent momentum, dominant home record, and the return of key bats, the Padres may hold a slight edge, but the Giants have shown a knack for executing in big games and grinding out wins with tactical baserunning and timely hitting. This series finale offers a compelling early-season test for both teams as they jockey for position in a division that could go down to the wire, and whichever club executes best in the margins—timely hitting, sharp defense, and bullpen management—will likely walk away with the win.
Within one thanks to LaMonte 👀 pic.twitter.com/cADZzt8jhh
— SFGiants (@SFGiants) April 30, 2025
San Francisco Giants MLB Preview
The San Francisco Giants enter the final game of their quick two-game series against the San Diego Padres with a strong 19–11 record, riding a wave of early-season success built on solid pitching, clutch offense, and improved fundamentals. Manager Bob Melvin’s squad has exceeded expectations through the first month of 2025, anchored by a pitching staff that ranks eighth in MLB in team fWAR, a testament to the club’s depth and development of young arms. Landen Roupp, scheduled to take the mound, is one such example, bringing a 2–1 record and a 4.56 ERA into the contest. While his ERA reflects some inconsistency, Roupp has displayed maturity on the mound, showing an ability to pitch out of trouble and give the team competitive innings. Against a Padres lineup that punishes mistakes, Roupp will need to command the zone early, avoid walks, and keep the ball down in the strike zone to minimize damage. Offensively, the Giants have leaned on outfielder Jung Hoo Lee, who has adjusted quickly to MLB pitching with consistent contact and high on-base numbers, helping set the tone at the top of the lineup. Wilmer Flores has emerged as the team’s primary power threat, leading the club in home runs and RBIs while delivering in high-leverage moments.
Though the team is still seeking more production from key offseason acquisition Willy Adames, the rest of the lineup has stepped up with timely hits, especially in late innings. The Giants have also shown a notable improvement in baserunning, ranking seventh in baserunning runs, and their defensive play has been cleaner, limiting unforced errors that cost them in prior seasons. With a strong bullpen backing Roupp, San Francisco has managed to protect leads and keep games within reach even when starters falter. The team’s mentality under Melvin has been one of steady professionalism and opportunism, with an ability to win games in a variety of ways—whether through small ball, bullpen dominance, or late-inning heroics. In a matchup against a division rival that plays especially well at home, the Giants will look to apply pressure early, disrupt Padres starter Michael King’s rhythm, and avoid falling behind in what’s expected to be a tightly pitched affair. A win here would not only secure a key road series but also reinforce San Francisco’s staying power in a division that has become one of the most competitive in baseball. For the Giants, the formula is simple yet effective: pitch to contact, capitalize on scoring chances, and let their evolving chemistry continue to turn close games into wins.

Credit: USA TODAY/IMAGN
San Diego Padres MLB Preview
The San Diego Padres return to Petco Park for the conclusion of their two-game set against the San Francisco Giants with a 18–11 record and a clear mission to defend one of MLB’s best home-field advantages, where they’ve posted an impressive 13–4 mark. After battling through a wave of injuries to key players like Yu Darvish and rookie standout Jackson Merrill, the Padres have leaned heavily on their pitching depth and lineup resilience to remain firmly in the NL West race. Leading the charge on the mound is right-hander Michael King, who has emerged as a reliable anchor in the rotation, sporting a 3–1 record with a superb 2.18 ERA through his first five starts. King’s ability to keep hitters off balance with a mix of fastballs, cutters, and sharp-breaking secondary pitches has allowed him to work deep into games and mitigate the workload on San Diego’s bullpen. Offensively, the return of Luis Arráez has added a much-needed contact presence at the top of the order, allowing Fernando Tatis Jr. to thrive in run-producing situations and giving the Padres a spark that had been missing during their early April road swings. Tatis has found his rhythm at the plate, driving in key runs while continuing to impact games with his speed and defensive range in right field. The heart of the lineup also features steady producers like Manny Machado and Xander Bogaerts, both of whom continue to deliver in pressure moments despite not yet reaching peak form.
The Padres have complemented their power bats with aggressive base running and situational hitting, often forcing opponents to play perfect defense to avoid giving up early runs. Defensively, however, the team has shown some lapses, particularly in fielding efficiency and throw accuracy, which they’ll need to tighten up against a fundamentally sound Giants club. Even with those issues, the Padres’ pitching has largely carried them, ranking second in MLB in team fWAR, and the bullpen—anchored by closer Robert Suarez—has done a commendable job in protecting narrow leads. With the Giants entering the game just one win ahead in the standings, San Diego views this game as an early litmus test for its depth and resilience as the calendar turns to May. King will need to set the tone early and avoid the long ball, especially against a San Francisco lineup that has relied on opportunistic hitting and excellent baserunning to manufacture offense. If the Padres can jump out to an early lead and allow their bullpen to take over in the later innings, they stand a strong chance of splitting the series and sending a message that they’re not just surviving without key pieces—they’re winning. With playoff expectations hanging over this roster, these divisional matchups become critical not just for the standings but for shaping the team’s identity and chemistry heading into the heart of the season.
Back at it tomorrow. pic.twitter.com/9Adf8oKmn0
— San Diego Padres (@Padres) April 30, 2025
San Francisco vs. San Diego Prop Picks (AI)
San Francisco vs. San Diego Prediction (AI)

Remi, our AI sports algorithm, has been pouring over tons of data from every angle between the Giants and Padres and using recursive machine learning and cutting-edge AI to crunch the data to a single cover probability.
Oddly enough, we’ve seen the AI has been most fixated on the linear correlation of emphasis human bettors regularly put on San Diego’s strength factors between a Giants team going up against a possibly strong Padres team. Trends look to say the true game analytics might reflect a strong lean against one Vegas line in particular.
Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.
Below is our current AI San Francisco vs San Diego picks, computer picks Giants vs Padres, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.
Giants Betting Trends
The Giants have covered the run line in 6 of their last 10 games, demonstrating consistent performance against the spread.
Padres Betting Trends
The Padres have covered the run line in 7 of their last 10 home games, highlighting their strong play at Petco Park.
Giants vs. Padres Matchup Trends
The Giants are slight favorites on the moneyline at -123, with the Padres at +104; the over/under is set at 7 runs, indicating expectations of a low-scoring affair.
San Francisco vs. San Diego Game Info
What time does San Francisco vs San Diego start on April 30, 2025?
San Francisco vs San Diego starts on April 30, 2025 at 4:10 PM EST.
Where is San Francisco vs San Diego being played?
Venue: Petco Park.
What are the opening odds for San Francisco vs San Diego?
Spread: San Diego -1.5
Moneyline: San Francisco +114, San Diego -135
Over/Under: 7
What are the records for San Francisco vs San Diego?
San Francisco: (19-11) | San Diego: (18-11)
What is the AI best bet for San Francisco vs San Diego?
Remi's searched hard and found the best prop for this matchup: W. Adames over 0.5 Total Bases.. Prices move—always shop for the best number.
What are San Francisco vs San Diego trending bets?
The Giants are slight favorites on the moneyline at -123, with the Padres at +104; the over/under is set at 7 runs, indicating expectations of a low-scoring affair.
What are San Francisco trending bets?
SF trend: The Giants have covered the run line in 6 of their last 10 games, demonstrating consistent performance against the spread.
What are San Diego trending bets?
SD trend: The Padres have covered the run line in 7 of their last 10 home games, highlighting their strong play at Petco Park.
Where can I find AI Picks for San Francisco vs San Diego?
See our latest MLB picks and odds pages for 2025 to compare prices before you bet.
San Francisco vs. San Diego Odds
AI algorithm Remi is pouring through mountains of stats on each line. In fact, anytime the San Francisco vs San Diego trends are analyzed, there’s always several intriguing trends to key in on. Not to mention games played at extreme temps almost always follow normal, predictable betting trends.
San Francisco vs San Diego Opening Odds
SF Moneyline:
+114 SD Moneyline: -135
SF Spread: +1.5
SD Spread: -1.5
Over/Under: 7
San Francisco vs San Diego Live Odds
Games | PTS | ML | SPR | O/U | |
---|---|---|---|---|---|
Sep 27, 2025 1:06PM EDT
Baltimore Orioles
New York Yankees
9/27/25 1:06PM
Orioles
Yankees
|
–
–
|
+196
-240
|
+1.5 (-105)
-1.5 (-115)
|
O 9 (-105)
U 9 (-115)
|
|
Sep 27, 2025 2:21PM EDT
St Louis Cardinals
Chicago Cubs
9/27/25 2:21PM
Cardinals
Cubs
|
–
–
|
-178
|
-1.5 (+115)
|
O 9.5 (+100)
U 9.5 (-120)
|
|
Sep 27, 2025 3:09PM EDT
Tampa Bay Rays
Toronto Blue Jays
9/27/25 3:09PM
Rays
Blue Jays
|
–
–
|
+135
-160
|
+1.5 (-155)
-1.5 (+130)
|
O 8.5 (-105)
U 8.5 (-115)
|
|
Sep 27, 2025 4:05PM EDT
Chicago White Sox
Washington Nationals
9/27/25 4:05PM
White Sox
Nationals
|
–
–
|
+100
-120
|
+1.5 (-205)
-1.5 (+170)
|
O 8.5 (-115)
U 8.5 (-105)
|
|
Sep 27, 2025 4:06PM EDT
Colorado Rockies
San Francisco Giants
9/27/25 4:06PM
Rockies
Giants
|
–
–
|
+196
-240
|
+1.5 (-110)
-1.5 (-110)
|
O 8 (-105)
U 8 (-115)
|
|
Sep 27, 2025 4:11PM EDT
New York Mets
Miami Marlins
9/27/25 4:11PM
Mets
Marlins
|
–
–
|
-130
+110
|
-1.5 (+130)
+1.5 (-155)
|
O 8 (-115)
U 8 (-105)
|
|
Sep 27, 2025 4:11PM EDT
Detroit Tigers
Boston Red Sox
9/27/25 4:11PM
Tigers
Red Sox
|
–
–
|
+110
-130
|
+1.5 (-190)
-1.5 (+158)
|
O 9 (+100)
U 9 (-120)
|
|
Sep 27, 2025 6:05PM EDT
Minnesota Twins
Philadelphia Phillies
9/27/25 6:05PM
Twins
Phillies
|
–
–
|
+175
-210
|
+1.5 (-120)
-1.5 (+100)
|
O 8.5 (-115)
U 8.5 (-105)
|
|
Sep 27, 2025 7:11PM EDT
Cincinnati Reds
Milwaukee Brewers
9/27/25 7:11PM
Reds
Brewers
|
–
–
|
+115
-135
|
+1.5 (-190)
-1.5 (+158)
|
O 7.5 (-120)
U 7.5 (+100)
|
|
Sep 27, 2025 7:15PM EDT
Pittsburgh Pirates
Atlanta Braves
9/27/25 7:15PM
Pirates
Braves
|
–
–
|
+150
-178
|
+1.5 (-145)
-1.5 (+122)
|
O 8 (-110)
U 8 (-110)
|
|
Sep 27, 2025 7:16PM EDT
Texas Rangers
Cleveland Guardians
9/27/25 7:16PM
Rangers
Guardians
|
–
–
|
+122
-145
|
+1.5 (-190)
-1.5 (+158)
|
O 7 (-120)
U 7 (+100)
|
|
Sep 27, 2025 8:40PM EDT
Arizona Diamondbacks
San Diego Padres
9/27/25 8:40PM
Diamondbacks
Padres
|
–
–
|
+118
-140
|
+1.5 (-190)
-1.5 (+158)
|
O 7.5 (-115)
U 7.5 (-105)
|
|
Sep 27, 2025 9:39PM EDT
Houston Astros
Los Angeles Angels
9/27/25 9:39PM
Astros
Angels
|
–
–
|
-140
+118
|
-1.5 (+115)
+1.5 (-135)
|
O 9 (-110)
U 9 (-110)
|
|
Sep 27, 2025 9:41PM EDT
Los Angeles Dodgers
Seattle Mariners
9/27/25 9:41PM
Dodgers
Mariners
|
–
–
|
+100
-120
|
+1.5 (-220)
-1.5 (+180)
|
O 7 (-120)
U 7 (+100)
|
|
Sep 27, 2025 10:05PM EDT
Kansas City Royals
Oakland Athletics
9/27/25 10:05PM
Royals
Athletics
|
–
–
|
+100
-120
|
+1.5 (-195)
-1.5 (+162)
|
O 10 (-115)
U 10 (-105)
|
MLB Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers San Francisco Giants vs. San Diego Padres on April 30, 2025 at Petco Park.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.
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LEAN | %WIN | UNITS | RESULT |
---|---|---|---|---|
ARI@SD | SD -131 | 57.3% | 4 | WIN |
DET@BOS | BOS -115 | 56.4% | 5 | WIN |
NYM@CHC | NYM -110 | 54.1% | 3 | WIN |
HOU@ATH | ATH +118 | 50.8% | 4 | WIN |
NYM@CHC | OVER 7 | 54.5% | 3 | WIN |
STL@SF | OVER 7.5 | 55.9% | 5 | LOSS |
KC@LAA | TYLER TOLBERT UNDER 1.5 BASES | 54.4% | 4 | WIN |
MIL@SD | UNDER 9 | 54.7% | 4 | WIN |
MIA@PHI | KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS | 53.3% | 3 | WIN |
WAS@NYM | OVER 8.5 | 56.1% | 6 | LOSS |
LAA@COL | COL +108 | 50.5% | 3 | WIN |
TOR@KC | UNDER 9 | 54.7% | 4 | LOSS |
SEA@KC | KC +1.5 | 62.3% | 5 | LOSS |
NYY@MIN | OVER 9 | 55.1% | 4 | WIN |
MIA@COL | OVER 10.5 | 55.0% | 4 | WIN |
MIA@COL | AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS | 54.3% | 4 | WIN |
SEA@KC | BOBBY WITT UNDER 0.5 SINGLES | 54.4% | 4 | LOSS |
PHI@LAD | LAD -113 | 54.7% | 4 | LOSS |
NYY@BOS | OVER 7.5 | 54.3% | 3 | WIN |
KC@PHI | PHI -130 | 58.3% | 4 | WIN |
LAD@SF | OVER 7.5 | 54.7% | 4 | LOSS |
NYM@PHI | PHI -122 | 55.6% | 4 | WIN |
KC@CLE | KC -104 | 52.0% | 3 | WIN |
CIN@SD | JAKE CRONEWORTH OVER 0.5 HITS | 53.1% | 3 | WIN |
WAS@MIA | MIA -123 | 55.2% | 4 | LOSS |
LAA@KC | UNDER 9.5 | 54.9% | 3 | WIN |
TEX@ARI | UNDER 9 | 54.2% | 4 | WIN |
SF@COL | UNDER 11.5 | 56.4% | 6 | LOSS |
SF@COL | RAFAEL DEVERS OVER 1.5 BASES | 56.1% | 6 | WIN |
MIA@WAS | WAS -110 | 54.4% | 4 | WIN |
NYM@DET | OVER 8.5 | 54.5% | 4 | WIN |
TEX@ARI | UNDER 9.5 | 56.4% | 6 | WIN |
TEX@ARI | ALEJANDRO OSUNA UNDER 1.5 BASES | 54.1% | 4 | LOSS |
ATL@CHC | CHC -116 | 55.1% | 3 | WIN |
PHI@MIL | OVER 8.5 | 55.0% | 3 | WIN |
ARI@LAD | SHOHEI OHTANI OVER 2.5 BASES | 54.2% | 4 | WIN |
SEA@CLE | CLE +1.5 | 57.2% | 3 | WIN |
CHC@SF | CHC -105 | 54.1% | 4 | LOSS |
NYY@CHW | RYAN MCMAHON OVER 0.5 BASES | 54.1% | 4 | WIN |
PHI@NYM | OVER 8.5 | 55.6% | 4 | LOSS |
LAA@TEX | LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS | 54.1% | 4 | LOSS |
KC@CHW | KC -109 | 54.2% | 4 | WIN |
SD@SEA | DYLAN CEASE OVER 16.5 OUTS | 53.9% | 3 | LOSS |
SD@SEA | UNDER 8.5 | 54.4% | 4 | LOSS |
MIN@TOR | JOE RYAN UNDER 2.5 EARNED RUNS | 54.1% | 4 | LOSS |
SF@MIL | MIL +100 | 54.0% | 6 | LOSS |
TOR@MIA | MIA +1.5 | 62.0% | 6 | WIN |
CHC@LAA | OVER 9.5 | 54.9% | 4 | LOSS |
BOS@NYY | CARLOS RODON UNDER 4.5 HITS ALLOWED | 54.2% | 4 | WIN |
KC@DET | DET -115 | 56.1% | 5 | WIN |
CHC@LAA | LAA +1.5 | 57.6% | 5 | LOSS |