Twins vs Guardians Prediction — AI Finds CAN'T MISS MLB Lines & Props (Apr 29)
Updated: 2025-04-27T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The Minnesota Twins and Cleveland Guardians face off at Progressive Field on April 29, 2025, in a pivotal AL Central matchup. The Guardians, aiming to extend their division lead, host the struggling Twins, who are seeking to reverse their early-season woes.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

GAME INFO
Date: Apr 29, 2025
Start Time: 6:10 PM EST
Venue: Progressive Field
Guardians Record: (15-13)
Twins Record: (13-16)
OPENING ODDS
MIN Moneyline: +129
CLE Moneyline: -154
MIN Spread: +1.5
CLE Spread: -1.5
Over/Under: 8
MIN
Betting Trends
- The Twins have a 5-5 record against the spread (ATS) in their last 10 games, with a 2-6 record on the road this season.
CLE
Betting Trends
- The Guardians are 5-1 ATS in their last 6 games, showcasing strong performance at home.
MATCHUP TRENDS
- The Guardians have been favored with a -1.5 run line at +143 odds, indicating confidence in their ability to win by multiple runs.
MIN vs. CLE
Best Prop Bet
- Remi's searched hard and found the best prop for this matchup: G. Arias over 0.5 Total Bases.
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Minnesota vs Cleveland Prediction & Odds:
Free MLB Betting Insights for 4/29/25
In contrast, the Twins’ offense has sputtered badly, averaging just 3.43 runs per game while struggling to find consistency from key hitters like Byron Buxton and Trevor Larnach, who have flashed moments of brilliance but have largely been unable to string together enough production to sustain rallies or protect slim leads. Minnesota’s pitching staff has similarly faltered, posting an ERA that ranks among the bottom third in the American League, with starters often failing to work deep into games, taxing a bullpen that has shown vulnerability under pressure. Defensively, the Twins have not helped their cause, committing costly errors in crucial moments that have extended innings and exacerbated their struggles, creating a snowball effect that opposing teams have eagerly taken advantage of. Heading into this game, the Guardians will look to continue their disciplined approach, emphasizing strong situational hitting, patient at-bats that drive up opposing pitch counts, and aggressive but smart base running that forces the Twins to execute defensively under duress. For the Twins, turning the tide will require a much sharper performance across the board: more disciplined plate appearances, cleaner defensive execution, and a starting pitcher who can give them at least six strong innings to alleviate pressure on the bullpen. Given Cleveland’s recent form, home-field advantage, and balanced attack, the Guardians enter as clear favorites, but baseball’s unpredictable nature always leaves room for surprises if the Twins can tap into the potential that has so far eluded them this season. A Cleveland win would help further solidify their early hold on the AL Central lead, while a Minnesota victory could provide a much-needed spark for a team searching for an identity and a lifeline in the early stages of a long season.
No one can throw quite like Joe pic.twitter.com/DGv3y9gSGw
— Minnesota Twins (@Twins) April 27, 2025
Minnesota Twins MLB Preview
The Minnesota Twins arrive at Progressive Field desperate for a win to halt what has been a frustrating and disappointing start to their 2025 campaign, as a 3–8 record and a string of lackluster performances have left them scrambling for answers in an AL Central division that is quickly getting away from them, especially against a Cleveland Guardians team that has already built early separation. Offensively, the Twins have been one of the least productive teams in baseball so far, averaging under 3.5 runs per game and posting a team batting average hovering around the Mendoza line, with key players like Byron Buxton and Trevor Larnach struggling to consistently drive in runs or spark big innings, leaving Minnesota too often reliant on solo home runs or hoping for defensive mistakes rather than generating their own momentum. While Buxton’s athleticism and Larnach’s raw power remain undeniable, neither has been able to consistently sustain rallies or produce when it matters most, putting even more pressure on the rest of the lineup to overcompensate. On the pitching side, the story has been similarly discouraging, as the starting rotation has failed to deliver deep outings, routinely putting the Twins’ bullpen in precarious situations by the middle innings, a pattern that has resulted in several blown leads and an ERA that ranks among the bottom third of the American League.
Defensive execution has also been a thorn in Minnesota’s side, with sloppy fielding and untimely errors leading directly to opponent runs and creating an uphill battle nearly every night. Manager Rocco Baldelli faces a difficult challenge heading into this game: finding a way to reset his team’s mindset, get better starting pitching to allow the offense time to settle in, and demand sharper, more focused baseball from a team that has shown flashes of potential but none of the consistency needed to compete in a highly competitive division. Against a disciplined and aggressive Cleveland squad, the Twins will need to be aggressive early at the plate, look for fastballs to drive rather than getting behind in counts, and play error-free defense if they want to give themselves a real chance to turn the tide. A strong performance from their starter and opportunistic hitting with runners in scoring position could shift momentum, but anything less could very easily result in another demoralizing loss that would deepen the early-season hole they are already in. For the Twins, this game represents more than just another regular-season contest—it’s a litmus test for their resilience, competitiveness, and ability to find their footing before the season slips too far out of reach.

Credit: USA TODAY/IMAGN
Cleveland Guardians MLB Preview
The Cleveland Guardians head into their April 29 matchup against the Minnesota Twins with momentum firmly on their side, fueled by a strong start to the season that has seen them take command of the AL Central standings through a winning combination of sharp pitching, timely hitting, and elite defensive execution that has made them one of the more complete teams in baseball during the early going. Offensively, the Guardians are led by the consistency of Steven Kwan at the top of the order, whose high batting average, sharp eye at the plate, and ability to set the table have created countless scoring opportunities for Cleveland’s power threats, particularly José Ramírez, who continues to deliver as the heart of the lineup with clutch hits, home runs, and a keen ability to come through when runners are in scoring position. Beyond their stars, Cleveland’s lineup has gotten meaningful contributions from up-and-coming talents and role players alike, with Andres Gimenez providing a steady presence both at the plate and defensively, and Josh Naylor showing the ability to change the course of a game with his raw power. The Guardians’ pitching staff has been a major asset, anchored by promising arms like Gavin Williams, who bring both velocity and polish to the rotation, supported by a bullpen that has locked down late leads with ruthless efficiency, reducing the margin of error for opponents in the late innings.
Defensively, Cleveland continues to excel, minimizing errors, turning double plays efficiently, and playing fundamentally sound baseball that complements their aggressive, contact-heavy offensive style. Manager Stephen Vogt has done an outstanding job keeping the team focused and maintaining a sharp competitive edge, emphasizing situational awareness, smart base running, and a relentless work ethic that has turned the Guardians into a well-oiled machine early in the 2025 campaign. Heading into this matchup against the struggling Twins, Cleveland’s game plan will be to maintain offensive pressure from the first pitch, force Minnesota’s pitchers into deep counts, and take advantage of any defensive lapses that have plagued the Twins throughout the young season. On the mound, the Guardians will look to get another strong start, aiming to neutralize Minnesota’s few offensive threats early and allow their bullpen to protect any lead they establish. With their home-field advantage, recent hot streak, and overall team balance, the Guardians are in an excellent position not only to win this game but also to further solidify their place atop the division standings, sending a message to their rivals that they are legitimate contenders to be reckoned with as the season unfolds.
Short memory.#GuardsBall pic.twitter.com/p4aWWA6UJs
— Cleveland Guardians (@CleGuardians) April 27, 2025
Minnesota vs. Cleveland Prop Picks (AI)
Minnesota vs. Cleveland Prediction (AI)

Remi, our AI sports genius, has been pouring over millions of data from every simulation between the Twins and Guardians and using recursive machine learning and cutting-edge AI to boil down the data to a single cover probability.
Oddly enough, we’ve seen the AI has been most watching on the growing emphasis knucklehead sportsbettors regularly put on Minnesota’s strength factors between a Twins team going up against a possibly rested Guardians team. It appears the true game analytics might reflect a strong lean against one Vegas line in particular.
Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.
Below is our current AI Minnesota vs Cleveland picks, computer picks Twins vs Guardians, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
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Twins Betting Trends
The Twins have a 5-5 record against the spread (ATS) in their last 10 games, with a 2-6 record on the road this season.
Guardians Betting Trends
The Guardians are 5-1 ATS in their last 6 games, showcasing strong performance at home.
Twins vs. Guardians Matchup Trends
The Guardians have been favored with a -1.5 run line at +143 odds, indicating confidence in their ability to win by multiple runs.
Minnesota vs. Cleveland Game Info
What time does Minnesota vs Cleveland start on April 29, 2025?
Minnesota vs Cleveland starts on April 29, 2025 at 6:10 PM EST.
Where is Minnesota vs Cleveland being played?
Venue: Progressive Field.
What are the opening odds for Minnesota vs Cleveland?
Spread: Cleveland -1.5
Moneyline: Minnesota +129, Cleveland -154
Over/Under: 8
What are the records for Minnesota vs Cleveland?
Minnesota: (13-16) | Cleveland: (15-13)
What is the AI best bet for Minnesota vs Cleveland?
Remi's searched hard and found the best prop for this matchup: G. Arias over 0.5 Total Bases.. Prices move—always shop for the best number.
What are Minnesota vs Cleveland trending bets?
The Guardians have been favored with a -1.5 run line at +143 odds, indicating confidence in their ability to win by multiple runs.
What are Minnesota trending bets?
MIN trend: The Twins have a 5-5 record against the spread (ATS) in their last 10 games, with a 2-6 record on the road this season.
What are Cleveland trending bets?
CLE trend: The Guardians are 5-1 ATS in their last 6 games, showcasing strong performance at home.
Where can I find AI Picks for Minnesota vs Cleveland?
See our latest MLB picks and odds pages for 2025 to compare prices before you bet.
Minnesota vs. Cleveland Odds
AI algorithm Remi is pouring through loads of stats on each team. In fact, anytime the Minnesota vs Cleveland trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme hostile environments seemingly never follow normal, predictable patterns.
Minnesota vs Cleveland Opening Odds
MIN Moneyline:
+129 CLE Moneyline: -154
MIN Spread: +1.5
CLE Spread: -1.5
Over/Under: 8
Minnesota vs Cleveland Live Odds
Games | PTS | ML | SPR | O/U | |
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Oct 19, 2025 8:04PM EDT
Seattle Mariners
Toronto Blue Jays
10/19/25 8:04PM
Mariners
Blue Jays
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–
–
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+108
-126
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+1.5 (-205)
-1.5 (+168)
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O 7.5 (-110)
U 7.5 (-110)
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MLB Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers Minnesota Twins vs. Cleveland Guardians on April 29, 2025 at Progressive Field.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.
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LEAN | %WIN | UNITS | RESULT |
---|---|---|---|---|
TOR@SEA | OVER 7 | 54.9% | 3 | WIN |
LAD@MIL | UNDER 7.5 | 56.6% | 6 | WIN |
TOR@NYY | OVER 8 | 54.9% | 4 | WIN |
TOR@NYY | CARLOS RODON OVER 1.5 TOTAL WALKS ALLOWED | 53.3% | 3 | WIN |
NYY@TOR | OVER 7.5 | 54.8% | 2 | WIN |
LAD@PHI | OVER 7 | 53.8% | 3 | WIN |
SD@CHC | CHC -109 | 53.8% | 3 | WIN |
SD@CHC | OVER 7.5 | 54.5% | 4 | LOSS |
SD@CHC | CHC -111 | 54.8% | 4 | LOSS |
CIN@LAD | SHOHEI OHTANI OVER 1.5 BASES | 53.5% | 3 | WIN |
BOS@NYY | OVER 7 | 53.8% | 3 | LOSS |
CIN@LAD | ELLY DE LA CRUZ OVER 0.5 BASES | 54.4% | 4 | LOSS |
ARI@SD | SD -131 | 57.3% | 4 | WIN |
DET@BOS | BOS -115 | 56.4% | 5 | WIN |
NYM@CHC | NYM -110 | 54.1% | 3 | WIN |
HOU@ATH | ATH +118 | 50.8% | 4 | WIN |
NYM@CHC | OVER 7 | 54.5% | 3 | WIN |
STL@SF | OVER 7.5 | 55.9% | 5 | LOSS |
KC@LAA | TYLER TOLBERT UNDER 1.5 BASES | 54.4% | 4 | WIN |
MIL@SD | UNDER 9 | 54.7% | 4 | WIN |
MIA@PHI | KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS | 53.3% | 3 | WIN |
WAS@NYM | OVER 8.5 | 56.1% | 6 | LOSS |
LAA@COL | COL +108 | 50.5% | 3 | WIN |
TOR@KC | UNDER 9 | 54.7% | 4 | LOSS |
SEA@KC | KC +1.5 | 62.3% | 5 | LOSS |
NYY@MIN | OVER 9 | 55.1% | 4 | WIN |
MIA@COL | OVER 10.5 | 55.0% | 4 | WIN |
MIA@COL | AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS | 54.3% | 4 | WIN |
SEA@KC | BOBBY WITT UNDER 0.5 SINGLES | 54.4% | 4 | LOSS |
PHI@LAD | LAD -113 | 54.7% | 4 | LOSS |
NYY@BOS | OVER 7.5 | 54.3% | 3 | WIN |
KC@PHI | PHI -130 | 58.3% | 4 | WIN |
LAD@SF | OVER 7.5 | 54.7% | 4 | LOSS |
NYM@PHI | PHI -122 | 55.6% | 4 | WIN |
KC@CLE | KC -104 | 52.0% | 3 | WIN |
CIN@SD | JAKE CRONEWORTH OVER 0.5 HITS | 53.1% | 3 | WIN |
WAS@MIA | MIA -123 | 55.2% | 4 | LOSS |
LAA@KC | UNDER 9.5 | 54.9% | 3 | WIN |
TEX@ARI | UNDER 9 | 54.2% | 4 | WIN |
SF@COL | UNDER 11.5 | 56.4% | 6 | LOSS |
SF@COL | RAFAEL DEVERS OVER 1.5 BASES | 56.1% | 6 | WIN |
MIA@WAS | WAS -110 | 54.4% | 4 | WIN |
NYM@DET | OVER 8.5 | 54.5% | 4 | WIN |
TEX@ARI | UNDER 9.5 | 56.4% | 6 | WIN |
TEX@ARI | ALEJANDRO OSUNA UNDER 1.5 BASES | 54.1% | 4 | LOSS |
ATL@CHC | CHC -116 | 55.1% | 3 | WIN |
PHI@MIL | OVER 8.5 | 55.0% | 3 | WIN |
ARI@LAD | SHOHEI OHTANI OVER 2.5 BASES | 54.2% | 4 | WIN |
SEA@CLE | CLE +1.5 | 57.2% | 3 | WIN |
CHC@SF | CHC -105 | 54.1% | 4 | LOSS |
NYY@CHW | RYAN MCMAHON OVER 0.5 BASES | 54.1% | 4 | WIN |