Brewers vs. Cardinals
Prediction, Odds & Props
Apr 27 | MLB AI Picks

Updated: 2025-04-25T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The Milwaukee Brewers (13–15) and St. Louis Cardinals (12–15) conclude their three-game series at Busch Stadium on Sunday, April 27, 2025, with first pitch scheduled for 1:15 PM CDT. Both teams aim to secure the series win and gain momentum as they approach the end of April.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Apr 27, 2025

Start Time: 2:15 PM EST​

Venue: Busch Stadium​

Cardinals Record: (12-15)

Brewers Record: (13-15)

OPENING ODDS

MIL Moneyline: -109

STL Moneyline: -110

MIL Spread: -1.5

STL Spread: +1.5

Over/Under: 8

MIL
Betting Trends

  • The Brewers have covered the first five innings (F5) run line in 17 of their last 22 games, yielding a +12.40 units return and a 50% ROI.

STL
Betting Trends

  • The Cardinals have hit the game total under in 13 of their last 22 games, resulting in a +5.40 units return and a 22% ROI.

MATCHUP TRENDS

  • The Brewers have hit the first five innings (F5) moneyline in 15 of their last 22 games, yielding a +14.00 units return and a 52% ROI.

MIL vs. STL
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: R. Hoskins over 0.5 Total Bases.

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Milwaukee vs St. Louis Prediction & Odds:
Free MLB Betting Insights for 4/27/25

The Milwaukee Brewers and St. Louis Cardinals meet on Sunday afternoon at Busch Stadium to wrap up their three-game series, with both teams seeking to tilt momentum in their favor as April winds down and the divisional race heats up. The Cardinals, sitting at 12–15, have captured the first two games of the series and are looking to complete a sweep that would put them back in striking distance of the top of the NL Central, while the Brewers, currently at 13–15, are hoping to salvage the finale and prevent a deeper slide. The Brewers will send left-hander José Quintana to the mound, who has been one of the biggest surprises of the young season, entering Sunday with a perfect 3–0 record and a sparkling 0.96 ERA, showcasing elite command and the ability to induce soft contact at a high rate. Opposing him will be Erick Fedde for St. Louis, who holds a 1–2 record with a strong 3.33 ERA, relying on a solid mix of fastballs and cutters to keep opposing hitters off balance and give his team quality innings. Offensively, Milwaukee has leaned heavily on the emergence of Brice Turang, who leads the club with a .346 batting average, and top prospect Jackson Chourio, who has delivered early power production with six home runs and 23 RBIs, providing a much-needed spark to a lineup that otherwise has struggled with consistency.

Meanwhile, the Cardinals’ offense has found its footing behind the bat of Brendan Donovan, who leads the team with a .356 average, and Lars Nootbaar, who continues to deliver timely hits in crucial moments. Both teams have displayed flashes of strong pitching performances, and defensively, their bullpens have been reliable when given a lead, though the Brewers’ relievers have been called upon more frequently due to occasional short outings from their rotation. Betting trends suggest another low-scoring contest, with the Cardinals hitting the game total under in 13 of their last 22 games, and the Brewers performing well early, cashing the first five innings (F5) moneyline in 15 of their last 22 outings. Sunday’s game will likely hinge on which team can scratch across early runs against two tough starters and whether either bullpen can hold up in high-leverage late-inning situations. For the Brewers, a fast start behind Quintana and production from the top of the lineup will be critical to avoid relying on a bullpen that has been stretched thin, while for the Cardinals, early contact and pressure on Quintana will be the key to continuing their winning formula from the first two games. Both clubs know the importance of setting the tone before a pivotal stretch in May, and with divisional pride on the line, Sunday’s series finale promises to be a tightly contested battle where every pitch, baserunner, and defensive play could be the difference.

Milwaukee Brewers MLB Preview

The Milwaukee Brewers arrive at Busch Stadium for Sunday’s finale desperate to avoid a sweep at the hands of the St. Louis Cardinals, with a 13–15 record that underscores the inconsistency that has plagued the club through the opening month of the season. Tasked with getting the Brewers back on track is left-hander José Quintana, who has been a revelation for Milwaukee early in 2025, entering the game with a flawless 3–0 record and a sparkling 0.96 ERA, using pinpoint command, a sharp curveball, and deceptive changeup to frustrate hitters. Quintana’s ability to induce soft contact and work efficiently through lineups has been a major asset for a Brewers pitching staff that has otherwise struggled with depth and bullpen overuse. Offensively, the Brewers are led by Brice Turang, who has emerged as one of the league’s top young hitters with a .346 batting average, while Jackson Chourio has injected much-needed power into the lineup with six home runs and 23 RBIs, quickly becoming a key middle-of-the-order threat.

However, beyond those bright spots, Milwaukee’s offense has too often lacked consistency, with the team struggling to string together rallies and capitalize on scoring opportunities, an issue that has led to several close losses. Defensively, the Brewers have played relatively clean baseball, but their bullpen has been stretched thin by short outings from the rotation outside of Quintana’s starts, exposing vulnerabilities late in games. Manager Pat Murphy will likely emphasize the importance of striking first, especially given the team’s success early in games, having cashed the first five innings (F5) moneyline in 15 of their last 22 contests, a trend they’ll need to continue if they hope to put pressure on St. Louis early. Quintana will be tasked with keeping the game within reach long enough for the offense to find its rhythm, and Milwaukee must avoid the defensive miscues and missed offensive opportunities that have plagued them throughout the series. A win on Sunday would not only prevent a sweep but also provide a much-needed reset before the Brewers enter a crucial upcoming stretch that could define their standing in a crowded NL Central division.

The Milwaukee Brewers (13–15) and St. Louis Cardinals (12–15) conclude their three-game series at Busch Stadium on Sunday, April 27, 2025, with first pitch scheduled for 1:15 PM CDT. Both teams aim to secure the series win and gain momentum as they approach the end of April. Milwaukee vs St. Louis AI Prediction: Free MLB Betting Insights for Apr 27. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

St. Louis Cardinals MLB Preview

The St. Louis Cardinals enter Sunday’s series finale against the Milwaukee Brewers with a golden opportunity to sweep their division rivals and build momentum as the season transitions into May, sitting at 12–15 after back-to-back wins that have showcased a more complete version of their roster. Erick Fedde will take the mound for the Cardinals, carrying a 1–2 record and a 3.33 ERA into the matchup, looking to continue the solid form he has flashed through the early season by mixing speeds effectively and attacking the zone with precision. Fedde’s ability to limit hard contact has been critical for a Cardinals pitching staff that has been forced to navigate inconsistencies in the back end of their rotation, and his calm demeanor on the mound has helped stabilize the team during a rocky start. Offensively, the Cardinals have started to find their stride with Brendan Donovan leading the charge, posting an impressive .356 batting average and consistently providing quality at-bats at the top of the lineup.

Lars Nootbaar has also continued his steady contributions, showing power and patience that make him a key run producer in the heart of the order, while veterans like Paul Goldschmidt and Nolan Arenado are beginning to show signs of heating up after slow starts. Defensively, St. Louis has cleaned up mistakes that plagued them earlier in the season, and their bullpen has been increasingly reliable when protecting late leads, with Giovanny Gallegos and Ryan Helsley anchoring the final innings. Recent betting trends highlight how effective the Cardinals have been at limiting runs at home, with the under hitting in 13 of their last 22 games, reflecting their preference for grinding out close, low-scoring victories. Manager Oliver Marmol will look for Fedde to set the tone early, trust the offense to manufacture runs rather than rely solely on the long ball, and continue emphasizing crisp defensive execution that has made a noticeable difference this week. A win on Sunday would not only secure a sweep of a key divisional opponent but also give the Cardinals a major confidence boost as they prepare for a challenging stretch ahead, positioning them to make a push toward climbing back into the thick of the NL Central race.

Milwaukee vs. St. Louis Prop Picks (AI)

Remi is pouring through loads of data on each player. In fact, anytime the Brewers and Cardinals play there’s always several intriguing trends to key in on. Not to mention games played at Busch Stadium in Apr seemingly never follow normal, predictable betting trends.
Remi's searched hard and found the best prop for this matchup: R. Hoskins over 0.5 Total Bases.

Milwaukee vs. St. Louis Prediction (AI)

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Remi, our AI sports genius, has been pouring over mountains of data from every angle between the Brewers and Cardinals and using recursive machine learning and impressive AI to crunch the data to a single cover probability.

Oddly enough, we’ve seen the AI has been most fixated on the trending factor human bettors often put on St. Louis’s strength factors between a Brewers team going up against a possibly strong Cardinals team. In reality, the true game analytics appear to reflect a slight lean against one Vegas line specifically.

Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.

Below is our current AI Milwaukee vs St. Louis picks, computer picks Brewers vs Cardinals, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
MLB 9/26 DET@BOS UNLOCK THIS PICK 5 EXECUTIVE Locked EXECUTIVE
MLB 9/26 BAL@NYY UNLOCK THIS PICK 4 INTEL Locked INTEL
MLB 9/26 ARI@SD UNLOCK THIS PICK 4 EXECUTIVE Locked EXECUTIVE
MLB 9/26 NYM@MIA UNLOCK THIS PICK 1 INTEL Locked INTEL
MLB 9/26 NYM@MIA GET FREE PICK NOW 1
MLB 9/26 COL@SF UNLOCK THIS PICK 0 INTEL Locked INTEL

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.

Brewers Betting Trends

The Brewers have covered the first five innings (F5) run line in 17 of their last 22 games, yielding a +12.40 units return and a 50% ROI.

Cardinals Betting Trends

The Cardinals have hit the game total under in 13 of their last 22 games, resulting in a +5.40 units return and a 22% ROI.

Brewers vs. Cardinals Matchup Trends

The Brewers have hit the first five innings (F5) moneyline in 15 of their last 22 games, yielding a +14.00 units return and a 52% ROI.

Milwaukee vs. St. Louis Game Info

Milwaukee vs St. Louis starts on April 27, 2025 at 2:15 PM EST.

Spread: St. Louis +1.5
Moneyline: Milwaukee -109, St. Louis -110
Over/Under: 8

Milwaukee: (13-15)  |  St. Louis: (12-15)

Remi's searched hard and found the best prop for this matchup: R. Hoskins over 0.5 Total Bases.. Prices move—always shop for the best number.

The Brewers have hit the first five innings (F5) moneyline in 15 of their last 22 games, yielding a +14.00 units return and a 52% ROI.

MIL trend: The Brewers have covered the first five innings (F5) run line in 17 of their last 22 games, yielding a +12.40 units return and a 50% ROI.

STL trend: The Cardinals have hit the game total under in 13 of their last 22 games, resulting in a +5.40 units return and a 22% ROI.

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

Milwaukee vs. St. Louis Odds

AI algorithm Remi is pouring through mountains of data points on each team. In fact, anytime the Milwaukee vs St. Louis trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme travel distance almost always follow normal, predictable betting trends.

Milwaukee vs St. Louis Opening Odds

MIL Moneyline: -109
STL Moneyline: -110
MIL Spread: -1.5
STL Spread: +1.5
Over/Under: 8

Milwaukee vs St. Louis Live Odds

Games PTS ML SPR O/U
Sep 27, 2025 1:06PM EDT
Baltimore Orioles
New York Yankees
9/27/25 1:06PM
Orioles
Yankees
+190
-235
+1.5 (-110)
-1.5 (-110)
O 8.5 (-120)
U 8.5 (+100)
Sep 27, 2025 2:21PM EDT
St Louis Cardinals
Chicago Cubs
9/27/25 2:21PM
Cardinals
Cubs
 
-180
 
-1.5 (+115)
O 9.5 (-105)
U 9.5 (-115)
Sep 27, 2025 3:09PM EDT
Tampa Bay Rays
Toronto Blue Jays
9/27/25 3:09PM
Rays
Blue Jays
+130
-155
+1.5 (-155)
-1.5 (+130)
O 8.5 (-110)
U 8.5 (-110)
Sep 27, 2025 4:06PM EDT
Chicago White Sox
Washington Nationals
9/27/25 4:06PM
White Sox
Nationals
+100
-120
-1.5 (+165)
+1.5 (-200)
O 8.5 (-110)
U 8.5 (-110)
Sep 27, 2025 4:06PM EDT
Colorado Rockies
San Francisco Giants
9/27/25 4:06PM
Rockies
Giants
+185
-225
+1.5 (-110)
-1.5 (-110)
O 8 (-105)
U 8 (-115)
Sep 27, 2025 4:11PM EDT
New York Mets
Miami Marlins
9/27/25 4:11PM
Mets
Marlins
-130
+110
-1.5 (+125)
+1.5 (-150)
O 8 (-115)
U 8 (-105)
Sep 27, 2025 4:11PM EDT
Detroit Tigers
Boston Red Sox
9/27/25 4:11PM
Tigers
Red Sox
+125
-150
+1.5 (-180)
-1.5 (+150)
O 9 (+100)
U 9 (-120)
Sep 27, 2025 6:05PM EDT
Minnesota Twins
Philadelphia Phillies
9/27/25 6:05PM
Twins
Phillies
+170
-205
+1.5 (-120)
-1.5 (+100)
O 8.5 (-115)
U 8.5 (-105)
Sep 27, 2025 7:11PM EDT
Cincinnati Reds
Milwaukee Brewers
9/27/25 7:11PM
Reds
Brewers
+125
-150
+1.5 (-180)
-1.5 (+150)
O 8 (-105)
U 8 (-115)
Sep 27, 2025 7:15PM EDT
Pittsburgh Pirates
Atlanta Braves
9/27/25 7:15PM
Pirates
Braves
+145
-175
+1.5 (-155)
-1.5 (+130)
O 8 (-110)
U 8 (-110)
Sep 27, 2025 7:16PM EDT
Texas Rangers
Cleveland Guardians
9/27/25 7:16PM
Rangers
Guardians
+135
-165
+1.5 (-180)
-1.5 (+150)
O 7 (-120)
U 7 (+100)
Sep 27, 2025 8:40PM EDT
Arizona Diamondbacks
San Diego Padres
9/27/25 8:40PM
Diamondbacks
Padres
+115
-140
+1.5 (-195)
-1.5 (+160)
O 7.5 (-120)
U 7.5 (+100)
Sep 27, 2025 9:39PM EDT
Houston Astros
Los Angeles Angels
9/27/25 9:39PM
Astros
Angels
-165
+135
-1.5 (+105)
+1.5 (-125)
O 9 (+100)
U 9 (-120)
Sep 27, 2025 9:41PM EDT
Los Angeles Dodgers
Seattle Mariners
9/27/25 9:41PM
Dodgers
Mariners
+105
-125
+1.5 (-205)
-1.5 (+170)
O 7.5 (+105)
U 7.5 (-125)
Sep 27, 2025 10:05PM EDT
Kansas City Royals
Oakland Athletics
9/27/25 10:05PM
Royals
Athletics
+100
-120
-1.5 (+150)
+1.5 (-180)
O 10 (-110)
U 10 (-110)

MLB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Milwaukee Brewers vs. St. Louis Cardinals on April 27, 2025 at Busch Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN
CHC@SF CHC -105 54.1% 4 LOSS
NYY@CHW RYAN MCMAHON OVER 0.5 BASES 54.1% 4 WIN
PHI@NYM OVER 8.5 55.6% 4 LOSS
LAA@TEX LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS 54.1% 4 LOSS
KC@CHW KC -109 54.2% 4 WIN
SD@SEA DYLAN CEASE OVER 16.5 OUTS 53.9% 3 LOSS
SD@SEA UNDER 8.5 54.4% 4 LOSS
MIN@TOR JOE RYAN UNDER 2.5 EARNED RUNS 54.1% 4 LOSS
SF@MIL MIL +100 54.0% 6 LOSS
TOR@MIA MIA +1.5 62.0% 6 WIN
CHC@LAA OVER 9.5 54.9% 4 LOSS
BOS@NYY CARLOS RODON UNDER 4.5 HITS ALLOWED 54.2% 4 WIN
KC@DET DET -115 56.1% 5 WIN
CHC@LAA LAA +1.5 57.6% 5 LOSS
CIN@ARI KEBRYAN HAYES STRIKEOUTS UNDER 0.5 56.2% 6 WIN
LAD@SD SD +110 50.9% 6 WIN