Brewers vs Cardinals Prediction — AI Finds CAN'T MISS MLB Lines & Props (Apr 27)
Updated: 2025-04-25T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The Milwaukee Brewers (13–15) and St. Louis Cardinals (12–15) conclude their three-game series at Busch Stadium on Sunday, April 27, 2025, with first pitch scheduled for 1:15 PM CDT. Both teams aim to secure the series win and gain momentum as they approach the end of April.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

GAME INFO
Date: Apr 27, 2025
Start Time: 2:15 PM EST
Venue: Busch Stadium
Cardinals Record: (12-15)
Brewers Record: (13-15)
OPENING ODDS
MIL Moneyline: -109
STL Moneyline: -110
MIL Spread: -1.5
STL Spread: +1.5
Over/Under: 8
MIL
Betting Trends
- The Brewers have covered the first five innings (F5) run line in 17 of their last 22 games, yielding a +12.40 units return and a 50% ROI.
STL
Betting Trends
- The Cardinals have hit the game total under in 13 of their last 22 games, resulting in a +5.40 units return and a 22% ROI.
MATCHUP TRENDS
- The Brewers have hit the first five innings (F5) moneyline in 15 of their last 22 games, yielding a +14.00 units return and a 52% ROI.
MIL vs. STL
Best Prop Bet
- Remi's searched hard and found the best prop for this matchup: R. Hoskins over 0.5 Total Bases.
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Milwaukee vs St. Louis Prediction & Odds:
Free MLB Betting Insights for 4/27/25
Meanwhile, the Cardinals’ offense has found its footing behind the bat of Brendan Donovan, who leads the team with a .356 average, and Lars Nootbaar, who continues to deliver timely hits in crucial moments. Both teams have displayed flashes of strong pitching performances, and defensively, their bullpens have been reliable when given a lead, though the Brewers’ relievers have been called upon more frequently due to occasional short outings from their rotation. Betting trends suggest another low-scoring contest, with the Cardinals hitting the game total under in 13 of their last 22 games, and the Brewers performing well early, cashing the first five innings (F5) moneyline in 15 of their last 22 outings. Sunday’s game will likely hinge on which team can scratch across early runs against two tough starters and whether either bullpen can hold up in high-leverage late-inning situations. For the Brewers, a fast start behind Quintana and production from the top of the lineup will be critical to avoid relying on a bullpen that has been stretched thin, while for the Cardinals, early contact and pressure on Quintana will be the key to continuing their winning formula from the first two games. Both clubs know the importance of setting the tone before a pivotal stretch in May, and with divisional pride on the line, Sunday’s series finale promises to be a tightly contested battle where every pitch, baserunner, and defensive play could be the difference.
What a way to collect his fourth hit of the day‼️@Bryanchourio11 https://t.co/AllB6wKgEj pic.twitter.com/GRo6KWIoRa
— Milwaukee Brewers (@Brewers) April 26, 2025
Milwaukee Brewers MLB Preview
The Milwaukee Brewers arrive at Busch Stadium for Sunday’s finale desperate to avoid a sweep at the hands of the St. Louis Cardinals, with a 13–15 record that underscores the inconsistency that has plagued the club through the opening month of the season. Tasked with getting the Brewers back on track is left-hander José Quintana, who has been a revelation for Milwaukee early in 2025, entering the game with a flawless 3–0 record and a sparkling 0.96 ERA, using pinpoint command, a sharp curveball, and deceptive changeup to frustrate hitters. Quintana’s ability to induce soft contact and work efficiently through lineups has been a major asset for a Brewers pitching staff that has otherwise struggled with depth and bullpen overuse. Offensively, the Brewers are led by Brice Turang, who has emerged as one of the league’s top young hitters with a .346 batting average, while Jackson Chourio has injected much-needed power into the lineup with six home runs and 23 RBIs, quickly becoming a key middle-of-the-order threat.
However, beyond those bright spots, Milwaukee’s offense has too often lacked consistency, with the team struggling to string together rallies and capitalize on scoring opportunities, an issue that has led to several close losses. Defensively, the Brewers have played relatively clean baseball, but their bullpen has been stretched thin by short outings from the rotation outside of Quintana’s starts, exposing vulnerabilities late in games. Manager Pat Murphy will likely emphasize the importance of striking first, especially given the team’s success early in games, having cashed the first five innings (F5) moneyline in 15 of their last 22 contests, a trend they’ll need to continue if they hope to put pressure on St. Louis early. Quintana will be tasked with keeping the game within reach long enough for the offense to find its rhythm, and Milwaukee must avoid the defensive miscues and missed offensive opportunities that have plagued them throughout the series. A win on Sunday would not only prevent a sweep but also provide a much-needed reset before the Brewers enter a crucial upcoming stretch that could define their standing in a crowded NL Central division.

Credit: USA TODAY/IMAGN
St. Louis Cardinals MLB Preview
The St. Louis Cardinals enter Sunday’s series finale against the Milwaukee Brewers with a golden opportunity to sweep their division rivals and build momentum as the season transitions into May, sitting at 12–15 after back-to-back wins that have showcased a more complete version of their roster. Erick Fedde will take the mound for the Cardinals, carrying a 1–2 record and a 3.33 ERA into the matchup, looking to continue the solid form he has flashed through the early season by mixing speeds effectively and attacking the zone with precision. Fedde’s ability to limit hard contact has been critical for a Cardinals pitching staff that has been forced to navigate inconsistencies in the back end of their rotation, and his calm demeanor on the mound has helped stabilize the team during a rocky start. Offensively, the Cardinals have started to find their stride with Brendan Donovan leading the charge, posting an impressive .356 batting average and consistently providing quality at-bats at the top of the lineup.
Lars Nootbaar has also continued his steady contributions, showing power and patience that make him a key run producer in the heart of the order, while veterans like Paul Goldschmidt and Nolan Arenado are beginning to show signs of heating up after slow starts. Defensively, St. Louis has cleaned up mistakes that plagued them earlier in the season, and their bullpen has been increasingly reliable when protecting late leads, with Giovanny Gallegos and Ryan Helsley anchoring the final innings. Recent betting trends highlight how effective the Cardinals have been at limiting runs at home, with the under hitting in 13 of their last 22 games, reflecting their preference for grinding out close, low-scoring victories. Manager Oliver Marmol will look for Fedde to set the tone early, trust the offense to manufacture runs rather than rely solely on the long ball, and continue emphasizing crisp defensive execution that has made a noticeable difference this week. A win on Sunday would not only secure a sweep of a key divisional opponent but also give the Cardinals a major confidence boost as they prepare for a challenging stretch ahead, positioning them to make a push toward climbing back into the thick of the NL Central race.
Watching this on repeat! pic.twitter.com/B9DoIqTCgj
— St. Louis Cardinals (@Cardinals) April 26, 2025
Milwaukee vs. St. Louis Prop Picks (AI)
Milwaukee vs. St. Louis Prediction (AI)

Remi, our AI sports genius, has been pouring over mountains of data from every past game between the Brewers and Cardinals and using recursive machine learning and industry leading AI to analyze the data to a single cover probability.
Oddly enough, we’ve seen the AI has been most watching on the growing emphasis human bettors regularly put on Milwaukee’s strength factors between a Brewers team going up against a possibly tired Cardinals team. Trends look to say the true game analytics might reflect a slight lean against one Vegas line in particular.
Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.
Below is our current AI Milwaukee vs St. Louis picks, computer picks Brewers vs Cardinals, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
---|---|---|---|---|---|---|
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.
Brewers Betting Trends
The Brewers have covered the first five innings (F5) run line in 17 of their last 22 games, yielding a +12.40 units return and a 50% ROI.
Cardinals Betting Trends
The Cardinals have hit the game total under in 13 of their last 22 games, resulting in a +5.40 units return and a 22% ROI.
Brewers vs. Cardinals Matchup Trends
The Brewers have hit the first five innings (F5) moneyline in 15 of their last 22 games, yielding a +14.00 units return and a 52% ROI.
Milwaukee vs. St. Louis Game Info
What time does Milwaukee vs St. Louis start on April 27, 2025?
Milwaukee vs St. Louis starts on April 27, 2025 at 2:15 PM EST.
Where is Milwaukee vs St. Louis being played?
Venue: Busch Stadium.
What are the opening odds for Milwaukee vs St. Louis?
Spread: St. Louis +1.5
Moneyline: Milwaukee -109, St. Louis -110
Over/Under: 8
What are the records for Milwaukee vs St. Louis?
Milwaukee: (13-15) | St. Louis: (12-15)
What is the AI best bet for Milwaukee vs St. Louis?
Remi's searched hard and found the best prop for this matchup: R. Hoskins over 0.5 Total Bases.. Prices move—always shop for the best number.
What are Milwaukee vs St. Louis trending bets?
The Brewers have hit the first five innings (F5) moneyline in 15 of their last 22 games, yielding a +14.00 units return and a 52% ROI.
What are Milwaukee trending bets?
MIL trend: The Brewers have covered the first five innings (F5) run line in 17 of their last 22 games, yielding a +12.40 units return and a 50% ROI.
What are St. Louis trending bets?
STL trend: The Cardinals have hit the game total under in 13 of their last 22 games, resulting in a +5.40 units return and a 22% ROI.
Where can I find AI Picks for Milwaukee vs St. Louis?
See our latest MLB picks and odds pages for 2025 to compare prices before you bet.
Milwaukee vs. St. Louis Odds
Remi is pouring through loads of data points on each player. In fact, anytime the Milwaukee vs St. Louis trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme altitude rarely follow normal, predictable patterns.
Milwaukee vs St. Louis Opening Odds
MIL Moneyline:
-109 STL Moneyline: -110
MIL Spread: -1.5
STL Spread: +1.5
Over/Under: 8
Milwaukee vs St. Louis Live Odds
Games | PTS | ML | SPR | O/U | |
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Oct 19, 2025 8:04PM EDT
Seattle Mariners
Toronto Blue Jays
10/19/25 8:04PM
Mariners
Blue Jays
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–
–
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+112
-123
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+1.5 (-195)
-1.5 (+171)
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O 7.5 (-114)
U 7.5 (-101)
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MLB Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers Milwaukee Brewers vs. St. Louis Cardinals on April 27, 2025 at Busch Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.
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LEAN | %WIN | UNITS | RESULT |
---|---|---|---|---|
TOR@SEA | OVER 7 | 54.9% | 3 | WIN |
LAD@MIL | UNDER 7.5 | 56.6% | 6 | WIN |
TOR@NYY | OVER 8 | 54.9% | 4 | WIN |
TOR@NYY | CARLOS RODON OVER 1.5 TOTAL WALKS ALLOWED | 53.3% | 3 | WIN |
NYY@TOR | OVER 7.5 | 54.8% | 2 | WIN |
LAD@PHI | OVER 7 | 53.8% | 3 | WIN |
SD@CHC | CHC -109 | 53.8% | 3 | WIN |
SD@CHC | OVER 7.5 | 54.5% | 4 | LOSS |
SD@CHC | CHC -111 | 54.8% | 4 | LOSS |
CIN@LAD | SHOHEI OHTANI OVER 1.5 BASES | 53.5% | 3 | WIN |
BOS@NYY | OVER 7 | 53.8% | 3 | LOSS |
CIN@LAD | ELLY DE LA CRUZ OVER 0.5 BASES | 54.4% | 4 | LOSS |
ARI@SD | SD -131 | 57.3% | 4 | WIN |
DET@BOS | BOS -115 | 56.4% | 5 | WIN |
NYM@CHC | NYM -110 | 54.1% | 3 | WIN |
HOU@ATH | ATH +118 | 50.8% | 4 | WIN |
NYM@CHC | OVER 7 | 54.5% | 3 | WIN |
STL@SF | OVER 7.5 | 55.9% | 5 | LOSS |
KC@LAA | TYLER TOLBERT UNDER 1.5 BASES | 54.4% | 4 | WIN |
MIL@SD | UNDER 9 | 54.7% | 4 | WIN |
MIA@PHI | KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS | 53.3% | 3 | WIN |
WAS@NYM | OVER 8.5 | 56.1% | 6 | LOSS |
LAA@COL | COL +108 | 50.5% | 3 | WIN |
TOR@KC | UNDER 9 | 54.7% | 4 | LOSS |
SEA@KC | KC +1.5 | 62.3% | 5 | LOSS |
NYY@MIN | OVER 9 | 55.1% | 4 | WIN |
MIA@COL | OVER 10.5 | 55.0% | 4 | WIN |
MIA@COL | AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS | 54.3% | 4 | WIN |
SEA@KC | BOBBY WITT UNDER 0.5 SINGLES | 54.4% | 4 | LOSS |
PHI@LAD | LAD -113 | 54.7% | 4 | LOSS |
NYY@BOS | OVER 7.5 | 54.3% | 3 | WIN |
KC@PHI | PHI -130 | 58.3% | 4 | WIN |
LAD@SF | OVER 7.5 | 54.7% | 4 | LOSS |
NYM@PHI | PHI -122 | 55.6% | 4 | WIN |
KC@CLE | KC -104 | 52.0% | 3 | WIN |
CIN@SD | JAKE CRONEWORTH OVER 0.5 HITS | 53.1% | 3 | WIN |
WAS@MIA | MIA -123 | 55.2% | 4 | LOSS |
LAA@KC | UNDER 9.5 | 54.9% | 3 | WIN |
TEX@ARI | UNDER 9 | 54.2% | 4 | WIN |
SF@COL | UNDER 11.5 | 56.4% | 6 | LOSS |
SF@COL | RAFAEL DEVERS OVER 1.5 BASES | 56.1% | 6 | WIN |
MIA@WAS | WAS -110 | 54.4% | 4 | WIN |
NYM@DET | OVER 8.5 | 54.5% | 4 | WIN |
TEX@ARI | UNDER 9.5 | 56.4% | 6 | WIN |
TEX@ARI | ALEJANDRO OSUNA UNDER 1.5 BASES | 54.1% | 4 | LOSS |
ATL@CHC | CHC -116 | 55.1% | 3 | WIN |
PHI@MIL | OVER 8.5 | 55.0% | 3 | WIN |
ARI@LAD | SHOHEI OHTANI OVER 2.5 BASES | 54.2% | 4 | WIN |
SEA@CLE | CLE +1.5 | 57.2% | 3 | WIN |
CHC@SF | CHC -105 | 54.1% | 4 | LOSS |
NYY@CHW | RYAN MCMAHON OVER 0.5 BASES | 54.1% | 4 | WIN |