Yankees vs. Guardians
Prediction, Odds & Props
Apr 22 | MLB AI Picks

Updated: 2025-04-20T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The New York Yankees continue their road trip with the second game of a three-game series against the Cleveland Guardians at Progressive Field. After a strong offensive showing in Game 1, the Yankees aim to maintain momentum, while the Guardians look to bounce back and even the series.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Apr 22, 2025

Start Time: 6:10 PM EST​

Venue: Progressive Field​

Guardians Record: (13-9)

Yankees Record: (14-9)

OPENING ODDS

NYY Moneyline: -113

CLE Moneyline: -106

NYY Spread: -1.5

CLE Spread: +1.5

Over/Under: 8

NYY
Betting Trends

  • The Yankees have covered the run line in 6 of their last 8 games, showcasing their recent strong performance against the spread.

CLE
Betting Trends

  • The Guardians have struggled against the spread recently, failing to cover in 4 of their last 5 home games.

MATCHUP TRENDS

  • In their last 10 matchups, the Yankees have covered the run line in 7 games against the Guardians, indicating a favorable trend for New York in this series.

NYY vs. CLE
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: B. Rocchio over 0.5 Hits+Runs+RBI.

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New York Yankees vs Cleveland Prediction & Odds:
Free MLB Betting Insights for 4/22/25

The New York Yankees and Cleveland Guardians are set to continue their three-game series on April 22, 2025, at Progressive Field, with the Yankees riding a strong wave of early-season form and the Guardians hoping to bounce back and reclaim some consistency at home. The Yankees entered the series opener with momentum, having won six of their last seven games thanks to a potent blend of elite offensive firepower and steady pitching. New York’s lineup, led by Aaron Judge and Paul Goldschmidt, has been among the most dangerous in baseball, with both stars posting batting averages above .360 and combining for double-digit home runs already this season. Judge’s resurgence at the plate has been especially encouraging for Yankees fans, with his .707 slugging percentage ranking among the league’s best and his ability to change a game with one swing reaffirming his status as one of the premier power hitters in the game. Their supporting cast has also stepped up, including surprise performances from players like Trent Grisham—who, despite currently being on paternity leave, has made a significant impact early. The Yankees’ offense is averaging nearly six runs per game during this recent hot stretch, and their patience at the plate has led to increased pressure on opposing pitchers. Cleveland, on the other hand, has been up and down to start the season. Though they swept the Pirates in a recent series, they’ve struggled against more potent lineups like the Yankees. The Guardians’ offense has relied heavily on Steven Kwan, who’s batting .325 with a 158 wRC+, and veteran José Ramírez, who remains a steady force in the middle of the order. While Kwan provides a consistent on-base presence and Ramírez offers power from both sides of the plate, Cleveland has lacked the depth to consistently support their stars, and that has shown in games where early runs are hard to come by.

Their starting pitching has been underwhelming so far, with Gavin Williams and Tanner Bibee each carrying ERAs north of 4.50, and Game 2 starter Bibee looking to bounce back from two difficult outings. The Guardians’ bullpen, however, remains a strength, anchored by reliable arms like Hunter Gaddis and Cade Smith, although closer Emmanuel Clase has not been his usual dominant self, struggling with command and allowing a high batting average against his cutter. To contend in this matchup, Cleveland must receive a quality start from Bibee and rely on its bullpen to keep the Yankees’ bats in check once the game hits the middle innings. Given recent form and offensive production, the Yankees appear poised to continue their run of dominance, particularly with their strong track record against the Guardians in recent matchups. They’ve covered the run line in seven of their last ten meetings with Cleveland, and the betting trends reflect their edge in both power and pitching. However, Progressive Field has always presented a challenge for visiting teams, and if the Guardians can jump ahead early and lean on their bullpen, they can even the series and prevent the Yankees from extending their lead atop the American League standings. As always in baseball, the outcome will hinge on execution—especially from the starting pitchers, who will either dictate tempo or put pressure on their respective bullpens. Expect a competitive atmosphere in Cleveland as both clubs look to set the tone early, with the Yankees aiming to ride their momentum and the Guardians seeking a stabilizing win at home.

New York Yankees Yankees MLB Preview

The New York Yankees enter Game 2 of their series against the Cleveland Guardians as one of the hottest teams in baseball, having won six of their last seven games and riding a powerful wave of offensive dominance and pitching consistency. Aaron Judge has returned to MVP-caliber form, currently batting .390 with a .707 slugging percentage, seven home runs, and a presence in the lineup that forces opposing pitchers to alter their approach entirely. He’s been complemented perfectly by veteran Paul Goldschmidt, who’s off to a scorching start with a .361 average and a steady flow of extra-base hits that have added depth and stability to the Yankees’ middle-of-the-order production. The offense hasn’t stopped with the superstars—Trent Grisham, prior to taking paternity leave, contributed with a .320 average and six homers, showing the kind of lineup-wide threat that makes New York one of the most complete offensive teams in the league right now. Even with Grisham temporarily sidelined, the Yankees have called up Jorbit Vivas to maintain roster flexibility and offensive depth, keeping their momentum alive during this road stretch. On the mound, the Yankees have been just as impressive. Max Fried continues to anchor the rotation with ace-level poise, carrying a 1.42 ERA over 31.2 innings and proving to be as dependable as ever. Carlos Rodón has chipped in with a 4.34 ERA and remains a vital contributor to the rotation’s durability. The bullpen, a key strength for the Yankees in recent seasons, has once again delivered results.

Clay Holmes leads the way in the closer role with four saves, while Fernando Cruz boasts a 2.25 ERA over 12 innings and has provided critical middle-inning support. This balance of frontline pitching and late-inning stability has allowed manager Aaron Boone to manage games confidently, knowing he has multiple arms capable of getting key outs in high-leverage situations. The Yankees’ ability to consistently shut down opposing offenses in the late innings has directly translated to success against the spread, as they’ve covered the run line in six of their last eight games. Looking ahead to Game 2, the Yankees are poised to continue their dominant stretch, especially against a Guardians team that’s struggled to find consistency on the mound. With Cleveland’s Tanner Bibee posting a 5.85 ERA and showing signs of vulnerability in recent outings, the Yankees’ patient and powerful offense has an opportunity to apply pressure early and often. If the top of the order sets the tone and the bullpen remains reliable, New York will be in strong position to secure another win and move closer to a series sweep. Their current form, combined with favorable historical trends against Cleveland, underscores their status as a team fully in rhythm. The Yankees understand that building momentum early in the season is critical in a loaded American League, and if they continue executing on both sides of the ball as they have been, they’ll remain one of the toughest teams to beat across all of baseball.

The New York Yankees continue their road trip with the second game of a three-game series against the Cleveland Guardians at Progressive Field. After a strong offensive showing in Game 1, the Yankees aim to maintain momentum, while the Guardians look to bounce back and even the series. New York Yankees vs Cleveland AI Prediction: Free MLB Betting Insights for Apr 22. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Cleveland Guardians MLB Preview

The Cleveland Guardians return to Progressive Field for Game 2 of their series against the New York Yankees with hopes of rebounding from a tough opening loss and finding stability after an uneven start to the 2025 season. Although the Guardians sit above .500 and recently swept the Pittsburgh Pirates, they’ve struggled to consistently match up against elite competition, particularly teams with deep lineups and power like the Yankees. Cleveland’s offense continues to be anchored by Steven Kwan, who’s batting .325 with a 158 wRC+ and showing improved power early in the season with four home runs—already matching his total from last year. José Ramírez remains the veteran cornerstone, hitting .268 with a .493 slugging percentage, and has begun heating up over the past week, while Gabriel Arias has surprised with timely hitting and opposite-field pop that’s brought much-needed energy to the lower half of the lineup. However, despite the offensive promise, Cleveland has struggled to generate enough sustained run production, often relying on timely solo homers or multi-hit efforts from Kwan and Ramírez to stay competitive in high-scoring games. On the pitching side, the Guardians’ biggest concern has been their starting rotation, which entered the series with a collective ERA of 4.49—far from the sharp, contact-controlling group that defined the team in recent years. Tanner Bibee, scheduled to start Game 2, carries a 5.85 ERA through 20 innings and has been hit hard in two of his last three outings, including struggles with command and keeping the ball in the park. Bibee has shown flashes of potential, but inconsistency has limited his ability to go deep into games, often putting pressure on the bullpen to cover multiple innings.

Fortunately for Cleveland, the bullpen has remained a strength, with Hunter Gaddis and Cade Smith posting quality numbers in high-leverage roles. Still, closer Emmanuel Clase has not been as dominant as in previous seasons, with hitters batting .300 against his signature cutter, leading to some uncertainty in tight late-game situations. If the Guardians are to contain the Yankees’ powerful lineup, they will need Bibee to command his fastball and avoid early damage, giving the bullpen a chance to work from a position of strength. The Guardians enter Game 2 understanding that it could be a pivotal contest in the early-season rhythm of their campaign. A loss would not only drop the series but reinforce a pattern of struggling against high-tier opponents—something that could carry consequences down the stretch in a tight AL Central race. To compete, Cleveland will need to execute more consistently in all phases: tighten up defensively, avoid giving away free bases, and string together competitive at-bats throughout the order. Kwan and Ramírez will be central figures again, but they’ll need support from hitters like Will Brennan and Bo Naylor to create extended rallies. Playing at home gives Cleveland a slight edge in terms of comfort and routine, and if Bibee can keep the game close while the offense capitalizes on scoring opportunities early, the Guardians have every chance to flip the narrative and grab a much-needed win against a Yankees team playing some of its best baseball of the season.

New York Yankees vs. Cleveland Prop Picks (AI)

AI algorithm Remi is pouring through tons of datapoints on each team. In fact, anytime the Yankees and Guardians play there’s always several intriguing trends to key in on. Not to mention games played at Progressive Field in Apr can often follow normal, predictable betting trends.
Remi's searched hard and found the best prop for this matchup: B. Rocchio over 0.5 Hits+Runs+RBI.

New York Yankees vs. Cleveland Prediction (AI)

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Remi, our AI sports genius, has been pouring over mountains of data from every past game between the Yankees and Guardians and using recursive machine learning and impressive AI to examine the data to a single cover probability.

The Algorithm has been most watching on the linear correlation of weight human bettors regularly put on player performance factors between a Yankees team going up against a possibly rested Guardians team. In reality, the true game analytics appear to reflect a slight lean against one Vegas line in particular.

Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.

Below is our current AI New York Yankees vs Cleveland picks, computer picks Yankees vs Guardians, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
MLB 9/26 DET@BOS UNLOCK THIS PICK 5 EXECUTIVE Locked EXECUTIVE
MLB 9/26 BAL@NYY UNLOCK THIS PICK 4 INTEL Locked INTEL
MLB 9/26 ARI@SD UNLOCK THIS PICK 4 EXECUTIVE Locked EXECUTIVE
MLB 9/26 NYM@MIA UNLOCK THIS PICK 1 INTEL Locked INTEL
MLB 9/26 NYM@MIA GET FREE PICK NOW 1
MLB 9/26 COL@SF UNLOCK THIS PICK 0 INTEL Locked INTEL

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.

Yankees Betting Trends

The Yankees have covered the run line in 6 of their last 8 games, showcasing their recent strong performance against the spread.

Guardians Betting Trends

The Guardians have struggled against the spread recently, failing to cover in 4 of their last 5 home games.

Yankees vs. Guardians Matchup Trends

In their last 10 matchups, the Yankees have covered the run line in 7 games against the Guardians, indicating a favorable trend for New York in this series.

New York Yankees vs. Cleveland Game Info

New York Yankees vs Cleveland starts on April 22, 2025 at 6:10 PM EST.

Spread: Cleveland +1.5
Moneyline: New York Yankees -113, Cleveland -106
Over/Under: 8

New York Yankees: (14-9)  |  Cleveland: (13-9)

Remi's searched hard and found the best prop for this matchup: B. Rocchio over 0.5 Hits+Runs+RBI.. Prices move—always shop for the best number.

In their last 10 matchups, the Yankees have covered the run line in 7 games against the Guardians, indicating a favorable trend for New York in this series.

NYY trend: The Yankees have covered the run line in 6 of their last 8 games, showcasing their recent strong performance against the spread.

CLE trend: The Guardians have struggled against the spread recently, failing to cover in 4 of their last 5 home games.

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

New York Yankees vs. Cleveland Odds

Remi is pouring through mountains of stats on each line. In fact, anytime the New York Yankees vs Cleveland trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme temps almost always follow normal, predictable patterns.

New York Yankees vs Cleveland Opening Odds

NYY Moneyline: -113
CLE Moneyline: -106
NYY Spread: -1.5
CLE Spread: +1.5
Over/Under: 8

New York Yankees vs Cleveland Live Odds

Games PTS ML SPR O/U
Sep 27, 2025 1:06PM EDT
Baltimore Orioles
New York Yankees
9/27/25 1:06PM
Orioles
Yankees
+190
-235
+1.5 (-110)
-1.5 (-110)
O 8.5 (-120)
U 8.5 (+100)
Sep 27, 2025 2:21PM EDT
St Louis Cardinals
Chicago Cubs
9/27/25 2:21PM
Cardinals
Cubs
 
-180
 
-1.5 (+115)
O 9.5 (-105)
U 9.5 (-115)
Sep 27, 2025 3:09PM EDT
Tampa Bay Rays
Toronto Blue Jays
9/27/25 3:09PM
Rays
Blue Jays
+130
-155
+1.5 (-155)
-1.5 (+130)
O 8.5 (-110)
U 8.5 (-110)
Sep 27, 2025 4:06PM EDT
Chicago White Sox
Washington Nationals
9/27/25 4:06PM
White Sox
Nationals
+100
-120
-1.5 (+165)
+1.5 (-200)
O 8.5 (-110)
U 8.5 (-110)
Sep 27, 2025 4:06PM EDT
Colorado Rockies
San Francisco Giants
9/27/25 4:06PM
Rockies
Giants
+185
-225
+1.5 (-110)
-1.5 (-110)
O 8 (-105)
U 8 (-115)
Sep 27, 2025 4:11PM EDT
New York Mets
Miami Marlins
9/27/25 4:11PM
Mets
Marlins
-130
+110
-1.5 (+125)
+1.5 (-150)
O 8 (-115)
U 8 (-105)
Sep 27, 2025 4:11PM EDT
Detroit Tigers
Boston Red Sox
9/27/25 4:11PM
Tigers
Red Sox
+125
-150
+1.5 (-180)
-1.5 (+150)
O 9 (+100)
U 9 (-120)
Sep 27, 2025 6:05PM EDT
Minnesota Twins
Philadelphia Phillies
9/27/25 6:05PM
Twins
Phillies
+170
-205
+1.5 (-120)
-1.5 (+100)
O 8.5 (-115)
U 8.5 (-105)
Sep 27, 2025 7:11PM EDT
Cincinnati Reds
Milwaukee Brewers
9/27/25 7:11PM
Reds
Brewers
+125
-150
+1.5 (-180)
-1.5 (+150)
O 8 (-105)
U 8 (-115)
Sep 27, 2025 7:15PM EDT
Pittsburgh Pirates
Atlanta Braves
9/27/25 7:15PM
Pirates
Braves
+145
-175
+1.5 (-155)
-1.5 (+130)
O 8 (-110)
U 8 (-110)
Sep 27, 2025 7:16PM EDT
Texas Rangers
Cleveland Guardians
9/27/25 7:16PM
Rangers
Guardians
+135
-165
+1.5 (-180)
-1.5 (+150)
O 7 (-120)
U 7 (+100)
Sep 27, 2025 8:40PM EDT
Arizona Diamondbacks
San Diego Padres
9/27/25 8:40PM
Diamondbacks
Padres
+115
-140
+1.5 (-195)
-1.5 (+160)
O 7.5 (-120)
U 7.5 (+100)
Sep 27, 2025 9:39PM EDT
Houston Astros
Los Angeles Angels
9/27/25 9:39PM
Astros
Angels
-165
+135
-1.5 (+105)
+1.5 (-125)
O 9 (+100)
U 9 (-120)
Sep 27, 2025 9:41PM EDT
Los Angeles Dodgers
Seattle Mariners
9/27/25 9:41PM
Dodgers
Mariners
+105
-125
+1.5 (-205)
-1.5 (+170)
O 7.5 (+105)
U 7.5 (-125)
Sep 27, 2025 10:05PM EDT
Kansas City Royals
Oakland Athletics
9/27/25 10:05PM
Royals
Athletics
+100
-120
-1.5 (+150)
+1.5 (-180)
O 10 (-110)
U 10 (-110)

MLB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers New York Yankees Yankees vs. Cleveland Guardians on April 22, 2025 at Progressive Field.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN
CHC@SF CHC -105 54.1% 4 LOSS
NYY@CHW RYAN MCMAHON OVER 0.5 BASES 54.1% 4 WIN
PHI@NYM OVER 8.5 55.6% 4 LOSS
LAA@TEX LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS 54.1% 4 LOSS
KC@CHW KC -109 54.2% 4 WIN
SD@SEA DYLAN CEASE OVER 16.5 OUTS 53.9% 3 LOSS
SD@SEA UNDER 8.5 54.4% 4 LOSS
MIN@TOR JOE RYAN UNDER 2.5 EARNED RUNS 54.1% 4 LOSS
SF@MIL MIL +100 54.0% 6 LOSS
TOR@MIA MIA +1.5 62.0% 6 WIN
CHC@LAA OVER 9.5 54.9% 4 LOSS
BOS@NYY CARLOS RODON UNDER 4.5 HITS ALLOWED 54.2% 4 WIN
KC@DET DET -115 56.1% 5 WIN
CHC@LAA LAA +1.5 57.6% 5 LOSS
CIN@ARI KEBRYAN HAYES STRIKEOUTS UNDER 0.5 56.2% 6 WIN
LAD@SD SD +110 50.9% 6 WIN