Reds vs. Marlins
Prediction, Odds & Props
Apr 21 | MLB AI Picks

Updated: 2025-04-19T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The Cincinnati Reds (10–11) visit the Miami Marlins (8–12) at loanDepot park on April 21, 2025, in a matchup between two National League teams looking to gain momentum early in the season. The Reds aim to climb above .500, while the Marlins seek to snap a five-game losing streak.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Apr 21, 2025

Start Time: 6:40 PM EST​

Venue: loanDepot park​

Marlins Record: (9-12)

Reds Record: (11-11)

OPENING ODDS

CIN Moneyline: -130

MIA Moneyline: +111

CIN Spread: -1.5

MIA Spread: +1.5

Over/Under: 8

CIN
Betting Trends

  • The Reds have covered the spread in 7 of their last 10 games, indicating strong recent performance against expectations.

MIA
Betting Trends

  • The Marlins have struggled at home, covering the spread in only 2 of their last 7 games at loanDepot park.

MATCHUP TRENDS

  • The Reds have a +14 run differential, suggesting they are outperforming their record, while the Marlins have a -24 run differential, reflecting challenges in both offense and defense.

CIN vs. MIA
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: K. Stowers over 0.5 Hits+Runs+RBI.

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Cincinnati vs Miami Prediction & Odds:
Free MLB Betting Insights for 4/21/25

The April 21, 2025 matchup between the Cincinnati Reds and Miami Marlins at loanDepot park presents an opportunity for both clubs to establish much-needed rhythm in what’s been a streaky opening month of the season. The Reds enter the contest at 10–11, looking to push back to .500 and build on recent competitive performances, while the Marlins, sitting at 8–12, are reeling from a five-game losing streak and searching for answers in nearly every facet of their game. Cincinnati has shown signs of turning a corner thanks to contributions from its young core, including the versatile Elly De La Cruz, who has started to impact games not just with power but with elite speed and baserunning. Their lineup, though still inconsistent at times, has shown flashes of explosiveness, especially against right-handed pitching, and has benefited from improved plate discipline and timely extra-base hits. On the mound, the Reds will be looking for a quality start from Nick Lodolo, who returned from injury this month and has shown encouraging signs of regaining his command and pitch efficiency. Their bullpen, though not elite, has held up well in late-inning situations, giving them the chance to stay in tight contests and steal wins. The Marlins, by contrast, have had difficulty generating consistency, particularly with their offense, which ranks near the bottom of the National League in runs scored. Injuries have played a part in their early struggles, and the absence of reliable power threats has forced manager Skip Schumaker to lean on small ball tactics and aggressive baserunning to manufacture offense. Miami’s pitching, long considered a franchise strength, has also failed to meet expectations in the early going, with starters like Jesús Luzardo and Edward Cabrera struggling to pitch deep into games, leading to an overworked bullpen.

Their defense has not been as sharp as it was last season, and lapses in the field have extended innings and compounded problems for the pitching staff. Despite these setbacks, the Marlins still have dynamic talent on the roster, including Luis Arraez, whose bat-to-ball skills remain elite, and Jazz Chisholm Jr., who, while off to a slow start, brings energy and game-breaking potential at any moment. The team is hoping a return home will spark a turnaround, and loanDepot park has historically been kind to their pitching staff due to its spacious dimensions. If the Marlins can get solid innings from their starter and minimize mistakes, they’ll be in a position to stop the bleeding and avoid falling further behind in the NL East. This game is pivotal for both clubs for different reasons. For the Reds, it’s about sustaining their recent momentum, climbing back to .500, and demonstrating that their rebuild is bearing real fruit through the emergence of young stars and an improving pitching staff. For the Marlins, it’s about halting a dangerous slide and proving that last year’s postseason appearance wasn’t a fluke. The contrasting styles—Cincinnati’s youthful aggressiveness and Miami’s grind-it-out approach—make for an intriguing on-field clash, where one big inning or one defensive lapse could shift the balance. With both teams sitting in that early-season limbo between contender and pretender, this matchup offers a high-stakes setting where execution, energy, and urgency will determine the outcome. Expect a competitive battle between two motivated squads with plenty to prove and little room for error as they navigate the tough terrain of the National League.

Cincinnati Reds MLB Preview

The Cincinnati Reds head into their April 21, 2025 matchup against the Miami Marlins at loanDepot park with momentum on their side and a roster beginning to come into its own. Sitting at 10–11 on the season, the Reds are a team on the rise, propelled by a youthful core that has added energy, athleticism, and legitimate upside to a club once mired in transition. Elly De La Cruz continues to emerge as one of the most dynamic players in the National League, combining jaw-dropping speed, improving plate discipline, and electric defensive range to give Cincinnati a weapon few teams can match. Around him, Matt McLain and Spencer Steer have become reliable contributors, helping form a well-rounded and surprisingly potent offense that thrives on putting the ball in play and putting pressure on defenses with aggressive baserunning. The Reds’ +14 run differential tells the story of a team that may be better than its record suggests, often staying competitive in games due to timely hitting and an increasingly dependable bullpen that has held leads in late innings. Nick Lodolo is expected to start for Cincinnati in this contest, and he arrives healthy and poised after working through his early season rhythm. The left-hander has shown excellent command and movement on his fastball and curveball combination and appears ready to settle into a frontline role if he can maintain durability. Against a Marlins lineup that has struggled mightily to string together hits or generate sustained rallies, Lodolo’s ability to get ahead in counts and induce ground balls will be critical.

He’ll need to work efficiently in a park that suppresses home runs but rewards contact hitters with speed on the basepaths, something Miami leans on in the absence of power bats. Cincinnati’s defense, led by the athleticism of De La Cruz and the sure hands of McLain, will be tested in this environment and must stay sharp to avoid giving the Marlins extra outs in what’s likely to be a low-scoring affair. With seven covers in their last 10 games against the spread, the Reds have become a consistent bet for outperforming expectations, and this road trip represents an opportunity to continue that trend. Though their 4–7 road record leaves room for improvement, the overall direction of the team is clearly positive. Manager David Bell has embraced a more aggressive playing style, emphasizing contact hitting, hustle plays, and using the team’s speed to take extra bases and rattle opposing pitchers. Against a Miami squad that has lost five straight and is reeling on both sides of the ball, Cincinnati has a golden opportunity to continue its climb back to .500 and further assert itself as one of the National League’s most exciting emerging teams. A win on Monday night could not only give them a strong start to the series but also send a clear message that the Reds’ youth movement is translating into real-time results.

The Cincinnati Reds (10–11) visit the Miami Marlins (8–12) at loanDepot park on April 21, 2025, in a matchup between two National League teams looking to gain momentum early in the season. The Reds aim to climb above .500, while the Marlins seek to snap a five-game losing streak. Cincinnati vs Miami AI Prediction: Free MLB Betting Insights for Apr 21. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Miami Marlins MLB Preview

The Miami Marlins return home to loanDepot park on April 21, 2025, searching for answers as they face the Cincinnati Reds and attempt to halt a damaging five-game losing streak that has dropped them to 8–12 on the season. The early promise that defined their 2023 playoff push feels increasingly distant as the team struggles to establish consistency both offensively and defensively. A -24 run differential reflects the growing gap between expectation and execution, with the Marlins failing to string together productive innings or protect leads in late-game situations. Their offensive struggles have been most glaring, with the team ranked near the bottom of the National League in runs scored and slugging percentage. While contact hitters like Luis Arraez continue to do their part—he enters this game hitting over .320—Miami has failed to convert baserunners into runs, frequently leaving men stranded and falling short in high-leverage moments. Jazz Chisholm Jr., expected to be a breakout force, has started slowly, and injuries to key contributors have only compounded Miami’s issues at the plate. On the mound, the Marlins will turn to right-hander Max Meyer, who is 1–2 on the season with a promising 2.63 ERA despite receiving minimal run support in his first three starts. The 2020 first-round pick brings a lively fastball and wipeout slider, and he’s shown poise beyond his experience level. Meyer has been one of the few bright spots for a rotation that’s struggled with depth and inconsistency, especially following the absence of Sandy Alcántara due to injury. In this matchup, Meyer will be asked to neutralize a Reds lineup that is young, fast, and aggressive, with rising star Elly De La Cruz leading the charge.

For Meyer to succeed, he’ll need support from his defense—an area that has been uncharacteristically shaky during the losing streak, with errors and mental lapses extending innings and turning small problems into big ones. Miami’s bullpen has also been overextended, and the Marlins desperately need a quality start that can reduce pressure on their late-inning arms. To reverse their fortunes, the Marlins must rediscover their identity: pitching-first, defensively sound, and opportunistic on the bases. loanDepot park’s spacious dimensions offer an advantage to teams that play with speed and discipline, but Miami has yet to consistently leverage that edge in 2025. They’ve covered the spread in just two of their last seven home games, a reflection of their inability to meet even modest performance expectations on their own turf. Monday’s game presents more than just a chance to snap a skid—it’s an opportunity for the Marlins to reset their approach and regain confidence against a Reds team that, while talented, is still learning how to win on the road. A strong outing from Meyer, a clean defensive effort, and timely hitting from the top of the lineup could be the formula that helps Miami get back on track and remind the National League that they remain a dangerous team when playing to their strengths. The urgency is high, and the margin for error is narrowing—if the Marlins are going to make a statement, it has to begin now.

Cincinnati vs. Miami Prop Picks (AI)

AI algorithm Remi is pouring through mountains of datapoints on each team. In fact, anytime the Reds and Marlins play there’s always several intriguing angles to key in on. Not to mention games played at loanDepot park in Apr can often follow normal, predictable betting trends.
Remi's searched hard and found the best prop for this matchup: K. Stowers over 0.5 Hits+Runs+RBI.

Cincinnati vs. Miami Prediction (AI)

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Remi, our AI sports wizard, has been pouring over exorbitant amounts of data from every angle between the Reds and Marlins and using recursive machine learning and cutting-edge AI to analyze the data to a single cover probability.

Oddly enough, we’ve seen the AI has been most keyed in on the growing weight emotional bettors regularly put on Miami’s strength factors between a Reds team going up against a possibly tired Marlins team. It appears the true game analytics appear to reflect a slight lean against one Vegas line in particular.

Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.

Below is our current AI Cincinnati vs Miami picks, computer picks Reds vs Marlins, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
MLB 9/26 DET@BOS UNLOCK THIS PICK 5 EXECUTIVE Locked EXECUTIVE
MLB 9/26 BAL@NYY UNLOCK THIS PICK 4 INTEL Locked INTEL
MLB 9/26 ARI@SD UNLOCK THIS PICK 4 EXECUTIVE Locked EXECUTIVE
MLB 9/26 NYM@MIA UNLOCK THIS PICK 1 INTEL Locked INTEL
MLB 9/26 NYM@MIA GET FREE PICK NOW 1
MLB 9/26 COL@SF UNLOCK THIS PICK 0 INTEL Locked INTEL

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.

Reds Betting Trends

The Reds have covered the spread in 7 of their last 10 games, indicating strong recent performance against expectations.

Marlins Betting Trends

The Marlins have struggled at home, covering the spread in only 2 of their last 7 games at loanDepot park.

Reds vs. Marlins Matchup Trends

The Reds have a +14 run differential, suggesting they are outperforming their record, while the Marlins have a -24 run differential, reflecting challenges in both offense and defense.

Cincinnati vs. Miami Game Info

Cincinnati vs Miami starts on April 21, 2025 at 6:40 PM EST.

Spread: Miami +1.5
Moneyline: Cincinnati -130, Miami +111
Over/Under: 8

Cincinnati: (11-11)  |  Miami: (9-12)

Remi's searched hard and found the best prop for this matchup: K. Stowers over 0.5 Hits+Runs+RBI.. Prices move—always shop for the best number.

The Reds have a +14 run differential, suggesting they are outperforming their record, while the Marlins have a -24 run differential, reflecting challenges in both offense and defense.

CIN trend: The Reds have covered the spread in 7 of their last 10 games, indicating strong recent performance against expectations.

MIA trend: The Marlins have struggled at home, covering the spread in only 2 of their last 7 games at loanDepot park.

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

Cincinnati vs. Miami Odds

Remi is pouring through tons of stats on each team. In fact, anytime the Cincinnati vs Miami trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme altitude rarely follow normal, predictable betting trends.

Cincinnati vs Miami Opening Odds

CIN Moneyline: -130
MIA Moneyline: +111
CIN Spread: -1.5
MIA Spread: +1.5
Over/Under: 8

Cincinnati vs Miami Live Odds

Games PTS ML SPR O/U
Sep 27, 2025 1:06PM EDT
Baltimore Orioles
New York Yankees
9/27/25 1:06PM
Orioles
Yankees
+190
-235
+1.5 (-110)
-1.5 (-110)
O 8.5 (-120)
U 8.5 (+100)
Sep 27, 2025 2:21PM EDT
St Louis Cardinals
Chicago Cubs
9/27/25 2:21PM
Cardinals
Cubs
 
-175
 
-1.5 (+115)
O 9.5 (-105)
U 9.5 (-115)
Sep 27, 2025 3:09PM EDT
Tampa Bay Rays
Toronto Blue Jays
9/27/25 3:09PM
Rays
Blue Jays
+130
-155
+1.5 (-155)
-1.5 (+130)
O 8.5 (-110)
U 8.5 (-110)
Sep 27, 2025 4:06PM EDT
Chicago White Sox
Washington Nationals
9/27/25 4:06PM
White Sox
Nationals
+100
-120
-1.5 (+165)
+1.5 (-200)
O 8.5 (-110)
U 8.5 (-110)
Sep 27, 2025 4:06PM EDT
Colorado Rockies
San Francisco Giants
9/27/25 4:06PM
Rockies
Giants
+185
-225
+1.5 (-110)
-1.5 (-110)
O 8 (-105)
U 8 (-115)
Sep 27, 2025 4:11PM EDT
New York Mets
Miami Marlins
9/27/25 4:11PM
Mets
Marlins
-130
+110
-1.5 (+125)
+1.5 (-150)
O 8.5 (-105)
U 8.5 (-115)
Sep 27, 2025 6:05PM EDT
Minnesota Twins
Philadelphia Phillies
9/27/25 6:05PM
Twins
Phillies
+170
-205
+1.5 (-120)
-1.5 (+100)
O 8.5 (-115)
U 8.5 (-105)
Sep 27, 2025 7:11PM EDT
Cincinnati Reds
Milwaukee Brewers
9/27/25 7:11PM
Reds
Brewers
+125
-150
+1.5 (-180)
-1.5 (+150)
O 8 (-105)
U 8 (-115)
Sep 27, 2025 7:15PM EDT
Pittsburgh Pirates
Atlanta Braves
9/27/25 7:15PM
Pirates
Braves
+140
-170
+1.5 (-155)
-1.5 (+130)
O 8 (-110)
U 8 (-110)
Sep 27, 2025 7:16PM EDT
Texas Rangers
Cleveland Guardians
9/27/25 7:16PM
Rangers
Guardians
+135
-165
+1.5 (-180)
-1.5 (+150)
O 7 (-120)
U 7 (+100)
Sep 27, 2025 8:40PM EDT
Arizona Diamondbacks
San Diego Padres
9/27/25 8:40PM
Diamondbacks
Padres
+115
-140
+1.5 (-190)
-1.5 (+155)
O 7.5 (-120)
U 7.5 (+100)
Sep 27, 2025 9:39PM EDT
Houston Astros
Los Angeles Angels
9/27/25 9:39PM
Astros
Angels
-165
+135
-1.5 (+105)
+1.5 (-125)
O 9 (+100)
U 9 (-120)
Sep 27, 2025 9:41PM EDT
Los Angeles Dodgers
Seattle Mariners
9/27/25 9:41PM
Dodgers
Mariners
+100
-120
-1.5 (+170)
+1.5 (-205)
O 7.5 (-110)
U 7.5 (-110)
Sep 27, 2025 10:05PM EDT
Kansas City Royals
Oakland Athletics
9/27/25 10:05PM
Royals
Athletics
+100
-120
-1.5 (+150)
+1.5 (-180)
O 10 (-110)
U 10 (-110)

MLB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Cincinnati Reds vs. Miami Marlins on April 21, 2025 at loanDepot park.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN
CHC@SF CHC -105 54.1% 4 LOSS
NYY@CHW RYAN MCMAHON OVER 0.5 BASES 54.1% 4 WIN
PHI@NYM OVER 8.5 55.6% 4 LOSS
LAA@TEX LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS 54.1% 4 LOSS
KC@CHW KC -109 54.2% 4 WIN
SD@SEA DYLAN CEASE OVER 16.5 OUTS 53.9% 3 LOSS
SD@SEA UNDER 8.5 54.4% 4 LOSS
MIN@TOR JOE RYAN UNDER 2.5 EARNED RUNS 54.1% 4 LOSS
SF@MIL MIL +100 54.0% 6 LOSS
TOR@MIA MIA +1.5 62.0% 6 WIN
CHC@LAA OVER 9.5 54.9% 4 LOSS
BOS@NYY CARLOS RODON UNDER 4.5 HITS ALLOWED 54.2% 4 WIN
KC@DET DET -115 56.1% 5 WIN
CHC@LAA LAA +1.5 57.6% 5 LOSS
CIN@ARI KEBRYAN HAYES STRIKEOUTS UNDER 0.5 56.2% 6 WIN
LAD@SD SD +110 50.9% 6 WIN