Reds vs. Marlins
Prediction, Odds & Props
Apr 21 | MLB AI Picks
Updated: 2025-04-19T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The Cincinnati Reds (10–11) visit the Miami Marlins (8–12) at loanDepot park on April 21, 2025, in a matchup between two National League teams looking to gain momentum early in the season. The Reds aim to climb above .500, while the Marlins seek to snap a five-game losing streak.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

GAME INFO
Date: Apr 21, 2025
Start Time: 6:40 PM EST
Venue: loanDepot park
Marlins Record: (9-12)
Reds Record: (11-11)
OPENING ODDS
CIN Moneyline: -130
MIA Moneyline: +111
CIN Spread: -1.5
MIA Spread: +1.5
Over/Under: 8
CIN
Betting Trends
- The Reds have covered the spread in 7 of their last 10 games, indicating strong recent performance against expectations.
MIA
Betting Trends
- The Marlins have struggled at home, covering the spread in only 2 of their last 7 games at loanDepot park.
MATCHUP TRENDS
- The Reds have a +14 run differential, suggesting they are outperforming their record, while the Marlins have a -24 run differential, reflecting challenges in both offense and defense.
CIN vs. MIA
Best Prop Bet
- Remi's searched hard and found the best prop for this matchup: K. Stowers over 0.5 Hits+Runs+RBI.
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Cincinnati vs Miami Prediction & Odds:
Free MLB Betting Insights for 4/21/25
Their defense has not been as sharp as it was last season, and lapses in the field have extended innings and compounded problems for the pitching staff. Despite these setbacks, the Marlins still have dynamic talent on the roster, including Luis Arraez, whose bat-to-ball skills remain elite, and Jazz Chisholm Jr., who, while off to a slow start, brings energy and game-breaking potential at any moment. The team is hoping a return home will spark a turnaround, and loanDepot park has historically been kind to their pitching staff due to its spacious dimensions. If the Marlins can get solid innings from their starter and minimize mistakes, they’ll be in a position to stop the bleeding and avoid falling further behind in the NL East. This game is pivotal for both clubs for different reasons. For the Reds, it’s about sustaining their recent momentum, climbing back to .500, and demonstrating that their rebuild is bearing real fruit through the emergence of young stars and an improving pitching staff. For the Marlins, it’s about halting a dangerous slide and proving that last year’s postseason appearance wasn’t a fluke. The contrasting styles—Cincinnati’s youthful aggressiveness and Miami’s grind-it-out approach—make for an intriguing on-field clash, where one big inning or one defensive lapse could shift the balance. With both teams sitting in that early-season limbo between contender and pretender, this matchup offers a high-stakes setting where execution, energy, and urgency will determine the outcome. Expect a competitive battle between two motivated squads with plenty to prove and little room for error as they navigate the tough terrain of the National League.
Austin Wynns and Noelvi Marte are the first pair of Reds teammates since 1920 with 6+ RBI in the same game‼️ pic.twitter.com/AJWA6ik17t
— Cincinnati Reds (@Reds) April 20, 2025
Cincinnati Reds MLB Preview
The Cincinnati Reds head into their April 21, 2025 matchup against the Miami Marlins at loanDepot park with momentum on their side and a roster beginning to come into its own. Sitting at 10–11 on the season, the Reds are a team on the rise, propelled by a youthful core that has added energy, athleticism, and legitimate upside to a club once mired in transition. Elly De La Cruz continues to emerge as one of the most dynamic players in the National League, combining jaw-dropping speed, improving plate discipline, and electric defensive range to give Cincinnati a weapon few teams can match. Around him, Matt McLain and Spencer Steer have become reliable contributors, helping form a well-rounded and surprisingly potent offense that thrives on putting the ball in play and putting pressure on defenses with aggressive baserunning. The Reds’ +14 run differential tells the story of a team that may be better than its record suggests, often staying competitive in games due to timely hitting and an increasingly dependable bullpen that has held leads in late innings. Nick Lodolo is expected to start for Cincinnati in this contest, and he arrives healthy and poised after working through his early season rhythm. The left-hander has shown excellent command and movement on his fastball and curveball combination and appears ready to settle into a frontline role if he can maintain durability. Against a Marlins lineup that has struggled mightily to string together hits or generate sustained rallies, Lodolo’s ability to get ahead in counts and induce ground balls will be critical.
He’ll need to work efficiently in a park that suppresses home runs but rewards contact hitters with speed on the basepaths, something Miami leans on in the absence of power bats. Cincinnati’s defense, led by the athleticism of De La Cruz and the sure hands of McLain, will be tested in this environment and must stay sharp to avoid giving the Marlins extra outs in what’s likely to be a low-scoring affair. With seven covers in their last 10 games against the spread, the Reds have become a consistent bet for outperforming expectations, and this road trip represents an opportunity to continue that trend. Though their 4–7 road record leaves room for improvement, the overall direction of the team is clearly positive. Manager David Bell has embraced a more aggressive playing style, emphasizing contact hitting, hustle plays, and using the team’s speed to take extra bases and rattle opposing pitchers. Against a Miami squad that has lost five straight and is reeling on both sides of the ball, Cincinnati has a golden opportunity to continue its climb back to .500 and further assert itself as one of the National League’s most exciting emerging teams. A win on Monday night could not only give them a strong start to the series but also send a clear message that the Reds’ youth movement is translating into real-time results.

Credit: USA TODAY/IMAGN
Miami Marlins MLB Preview
The Miami Marlins return home to loanDepot park on April 21, 2025, searching for answers as they face the Cincinnati Reds and attempt to halt a damaging five-game losing streak that has dropped them to 8–12 on the season. The early promise that defined their 2023 playoff push feels increasingly distant as the team struggles to establish consistency both offensively and defensively. A -24 run differential reflects the growing gap between expectation and execution, with the Marlins failing to string together productive innings or protect leads in late-game situations. Their offensive struggles have been most glaring, with the team ranked near the bottom of the National League in runs scored and slugging percentage. While contact hitters like Luis Arraez continue to do their part—he enters this game hitting over .320—Miami has failed to convert baserunners into runs, frequently leaving men stranded and falling short in high-leverage moments. Jazz Chisholm Jr., expected to be a breakout force, has started slowly, and injuries to key contributors have only compounded Miami’s issues at the plate. On the mound, the Marlins will turn to right-hander Max Meyer, who is 1–2 on the season with a promising 2.63 ERA despite receiving minimal run support in his first three starts. The 2020 first-round pick brings a lively fastball and wipeout slider, and he’s shown poise beyond his experience level. Meyer has been one of the few bright spots for a rotation that’s struggled with depth and inconsistency, especially following the absence of Sandy Alcántara due to injury. In this matchup, Meyer will be asked to neutralize a Reds lineup that is young, fast, and aggressive, with rising star Elly De La Cruz leading the charge.
For Meyer to succeed, he’ll need support from his defense—an area that has been uncharacteristically shaky during the losing streak, with errors and mental lapses extending innings and turning small problems into big ones. Miami’s bullpen has also been overextended, and the Marlins desperately need a quality start that can reduce pressure on their late-inning arms. To reverse their fortunes, the Marlins must rediscover their identity: pitching-first, defensively sound, and opportunistic on the bases. loanDepot park’s spacious dimensions offer an advantage to teams that play with speed and discipline, but Miami has yet to consistently leverage that edge in 2025. They’ve covered the spread in just two of their last seven home games, a reflection of their inability to meet even modest performance expectations on their own turf. Monday’s game presents more than just a chance to snap a skid—it’s an opportunity for the Marlins to reset their approach and regain confidence against a Reds team that, while talented, is still learning how to win on the road. A strong outing from Meyer, a clean defensive effort, and timely hitting from the top of the lineup could be the formula that helps Miami get back on track and remind the National League that they remain a dangerous team when playing to their strengths. The urgency is high, and the margin for error is narrowing—if the Marlins are going to make a statement, it has to begin now.
Two words: Fightin’ Fish! 🐟 pic.twitter.com/a7m9xUi9RU
— Miami Marlins (@Marlins) April 20, 2025
Cincinnati vs. Miami Prop Picks (AI)
Cincinnati vs. Miami Prediction (AI)

Remi, our AI sports wizard, has been pouring over exorbitant amounts of data from every angle between the Reds and Marlins and using recursive machine learning and cutting-edge AI to analyze the data to a single cover probability.
Oddly enough, we’ve seen the AI has been most keyed in on the growing weight emotional bettors regularly put on Miami’s strength factors between a Reds team going up against a possibly tired Marlins team. It appears the true game analytics appear to reflect a slight lean against one Vegas line in particular.
Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.
Below is our current AI Cincinnati vs Miami picks, computer picks Reds vs Marlins, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
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MLB | 9/26 | DET@BOS | UNLOCK THIS PICK | 5 |
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MLB | 9/26 | BAL@NYY | UNLOCK THIS PICK | 4 |
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MLB | 9/26 | ARI@SD | UNLOCK THIS PICK | 4 |
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MLB | 9/26 | NYM@MIA | UNLOCK THIS PICK | 1 |
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MLB | 9/26 | NYM@MIA | GET FREE PICK NOW | 1 | – | |
MLB | 9/26 | COL@SF | UNLOCK THIS PICK | 0 |
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.
Reds Betting Trends
The Reds have covered the spread in 7 of their last 10 games, indicating strong recent performance against expectations.
Marlins Betting Trends
The Marlins have struggled at home, covering the spread in only 2 of their last 7 games at loanDepot park.
Reds vs. Marlins Matchup Trends
The Reds have a +14 run differential, suggesting they are outperforming their record, while the Marlins have a -24 run differential, reflecting challenges in both offense and defense.
Cincinnati vs. Miami Game Info
What time does Cincinnati vs Miami start on April 21, 2025?
Cincinnati vs Miami starts on April 21, 2025 at 6:40 PM EST.
Where is Cincinnati vs Miami being played?
Venue: loanDepot park.
What are the opening odds for Cincinnati vs Miami?
Spread: Miami +1.5
Moneyline: Cincinnati -130, Miami +111
Over/Under: 8
What are the records for Cincinnati vs Miami?
Cincinnati: (11-11) | Miami: (9-12)
What is the AI best bet for Cincinnati vs Miami?
Remi's searched hard and found the best prop for this matchup: K. Stowers over 0.5 Hits+Runs+RBI.. Prices move—always shop for the best number.
What are Cincinnati vs Miami trending bets?
The Reds have a +14 run differential, suggesting they are outperforming their record, while the Marlins have a -24 run differential, reflecting challenges in both offense and defense.
What are Cincinnati trending bets?
CIN trend: The Reds have covered the spread in 7 of their last 10 games, indicating strong recent performance against expectations.
What are Miami trending bets?
MIA trend: The Marlins have struggled at home, covering the spread in only 2 of their last 7 games at loanDepot park.
Where can I find AI Picks for Cincinnati vs Miami?
See our latest MLB picks and odds pages for 2025 to compare prices before you bet.
Cincinnati vs. Miami Odds
Remi is pouring through tons of stats on each team. In fact, anytime the Cincinnati vs Miami trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme altitude rarely follow normal, predictable betting trends.
Cincinnati vs Miami Opening Odds
CIN Moneyline:
-130 MIA Moneyline: +111
CIN Spread: -1.5
MIA Spread: +1.5
Over/Under: 8
Cincinnati vs Miami Live Odds
Games | PTS | ML | SPR | O/U | |
---|---|---|---|---|---|
Sep 27, 2025 1:06PM EDT
Baltimore Orioles
New York Yankees
9/27/25 1:06PM
Orioles
Yankees
|
–
–
|
+190
-235
|
+1.5 (-110)
-1.5 (-110)
|
O 8.5 (-120)
U 8.5 (+100)
|
|
Sep 27, 2025 2:21PM EDT
St Louis Cardinals
Chicago Cubs
9/27/25 2:21PM
Cardinals
Cubs
|
–
–
|
-175
|
-1.5 (+115)
|
O 9.5 (-105)
U 9.5 (-115)
|
|
Sep 27, 2025 3:09PM EDT
Tampa Bay Rays
Toronto Blue Jays
9/27/25 3:09PM
Rays
Blue Jays
|
–
–
|
+130
-155
|
+1.5 (-155)
-1.5 (+130)
|
O 8.5 (-110)
U 8.5 (-110)
|
|
Sep 27, 2025 4:06PM EDT
Chicago White Sox
Washington Nationals
9/27/25 4:06PM
White Sox
Nationals
|
–
–
|
+100
-120
|
-1.5 (+165)
+1.5 (-200)
|
O 8.5 (-110)
U 8.5 (-110)
|
|
Sep 27, 2025 4:06PM EDT
Colorado Rockies
San Francisco Giants
9/27/25 4:06PM
Rockies
Giants
|
–
–
|
+185
-225
|
+1.5 (-110)
-1.5 (-110)
|
O 8 (-105)
U 8 (-115)
|
|
Sep 27, 2025 4:11PM EDT
New York Mets
Miami Marlins
9/27/25 4:11PM
Mets
Marlins
|
–
–
|
-130
+110
|
-1.5 (+125)
+1.5 (-150)
|
O 8.5 (-105)
U 8.5 (-115)
|
|
Sep 27, 2025 6:05PM EDT
Minnesota Twins
Philadelphia Phillies
9/27/25 6:05PM
Twins
Phillies
|
–
–
|
+170
-205
|
+1.5 (-120)
-1.5 (+100)
|
O 8.5 (-115)
U 8.5 (-105)
|
|
Sep 27, 2025 7:11PM EDT
Cincinnati Reds
Milwaukee Brewers
9/27/25 7:11PM
Reds
Brewers
|
–
–
|
+125
-150
|
+1.5 (-180)
-1.5 (+150)
|
O 8 (-105)
U 8 (-115)
|
|
Sep 27, 2025 7:15PM EDT
Pittsburgh Pirates
Atlanta Braves
9/27/25 7:15PM
Pirates
Braves
|
–
–
|
+140
-170
|
+1.5 (-155)
-1.5 (+130)
|
O 8 (-110)
U 8 (-110)
|
|
Sep 27, 2025 7:16PM EDT
Texas Rangers
Cleveland Guardians
9/27/25 7:16PM
Rangers
Guardians
|
–
–
|
+135
-165
|
+1.5 (-180)
-1.5 (+150)
|
O 7 (-120)
U 7 (+100)
|
|
Sep 27, 2025 8:40PM EDT
Arizona Diamondbacks
San Diego Padres
9/27/25 8:40PM
Diamondbacks
Padres
|
–
–
|
+115
-140
|
+1.5 (-190)
-1.5 (+155)
|
O 7.5 (-120)
U 7.5 (+100)
|
|
Sep 27, 2025 9:39PM EDT
Houston Astros
Los Angeles Angels
9/27/25 9:39PM
Astros
Angels
|
–
–
|
-165
+135
|
-1.5 (+105)
+1.5 (-125)
|
O 9 (+100)
U 9 (-120)
|
|
Sep 27, 2025 9:41PM EDT
Los Angeles Dodgers
Seattle Mariners
9/27/25 9:41PM
Dodgers
Mariners
|
–
–
|
+100
-120
|
-1.5 (+170)
+1.5 (-205)
|
O 7.5 (-110)
U 7.5 (-110)
|
|
Sep 27, 2025 10:05PM EDT
Kansas City Royals
Oakland Athletics
9/27/25 10:05PM
Royals
Athletics
|
–
–
|
+100
-120
|
-1.5 (+150)
+1.5 (-180)
|
O 10 (-110)
U 10 (-110)
|
MLB Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers Cincinnati Reds vs. Miami Marlins on April 21, 2025 at loanDepot park.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.
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LEAN | %WIN | UNITS | RESULT |
---|---|---|---|---|
NYM@CHC | NYM -110 | 54.1% | 3 | WIN |
HOU@ATH | ATH +118 | 50.8% | 4 | WIN |
NYM@CHC | OVER 7 | 54.5% | 3 | WIN |
STL@SF | OVER 7.5 | 55.9% | 5 | LOSS |
KC@LAA | TYLER TOLBERT UNDER 1.5 BASES | 54.4% | 4 | WIN |
MIL@SD | UNDER 9 | 54.7% | 4 | WIN |
MIA@PHI | KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS | 53.3% | 3 | WIN |
WAS@NYM | OVER 8.5 | 56.1% | 6 | LOSS |
LAA@COL | COL +108 | 50.5% | 3 | WIN |
TOR@KC | UNDER 9 | 54.7% | 4 | LOSS |
SEA@KC | KC +1.5 | 62.3% | 5 | LOSS |
NYY@MIN | OVER 9 | 55.1% | 4 | WIN |
MIA@COL | OVER 10.5 | 55.0% | 4 | WIN |
MIA@COL | AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS | 54.3% | 4 | WIN |
SEA@KC | BOBBY WITT UNDER 0.5 SINGLES | 54.4% | 4 | LOSS |
PHI@LAD | LAD -113 | 54.7% | 4 | LOSS |
NYY@BOS | OVER 7.5 | 54.3% | 3 | WIN |
KC@PHI | PHI -130 | 58.3% | 4 | WIN |
LAD@SF | OVER 7.5 | 54.7% | 4 | LOSS |
NYM@PHI | PHI -122 | 55.6% | 4 | WIN |
KC@CLE | KC -104 | 52.0% | 3 | WIN |
CIN@SD | JAKE CRONEWORTH OVER 0.5 HITS | 53.1% | 3 | WIN |
WAS@MIA | MIA -123 | 55.2% | 4 | LOSS |
LAA@KC | UNDER 9.5 | 54.9% | 3 | WIN |
TEX@ARI | UNDER 9 | 54.2% | 4 | WIN |
SF@COL | UNDER 11.5 | 56.4% | 6 | LOSS |
SF@COL | RAFAEL DEVERS OVER 1.5 BASES | 56.1% | 6 | WIN |
MIA@WAS | WAS -110 | 54.4% | 4 | WIN |
NYM@DET | OVER 8.5 | 54.5% | 4 | WIN |
TEX@ARI | UNDER 9.5 | 56.4% | 6 | WIN |
TEX@ARI | ALEJANDRO OSUNA UNDER 1.5 BASES | 54.1% | 4 | LOSS |
ATL@CHC | CHC -116 | 55.1% | 3 | WIN |
PHI@MIL | OVER 8.5 | 55.0% | 3 | WIN |
ARI@LAD | SHOHEI OHTANI OVER 2.5 BASES | 54.2% | 4 | WIN |
SEA@CLE | CLE +1.5 | 57.2% | 3 | WIN |
CHC@SF | CHC -105 | 54.1% | 4 | LOSS |
NYY@CHW | RYAN MCMAHON OVER 0.5 BASES | 54.1% | 4 | WIN |
PHI@NYM | OVER 8.5 | 55.6% | 4 | LOSS |
LAA@TEX | LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS | 54.1% | 4 | LOSS |
KC@CHW | KC -109 | 54.2% | 4 | WIN |
SD@SEA | DYLAN CEASE OVER 16.5 OUTS | 53.9% | 3 | LOSS |
SD@SEA | UNDER 8.5 | 54.4% | 4 | LOSS |
MIN@TOR | JOE RYAN UNDER 2.5 EARNED RUNS | 54.1% | 4 | LOSS |
SF@MIL | MIL +100 | 54.0% | 6 | LOSS |
TOR@MIA | MIA +1.5 | 62.0% | 6 | WIN |
CHC@LAA | OVER 9.5 | 54.9% | 4 | LOSS |
BOS@NYY | CARLOS RODON UNDER 4.5 HITS ALLOWED | 54.2% | 4 | WIN |
KC@DET | DET -115 | 56.1% | 5 | WIN |
CHC@LAA | LAA +1.5 | 57.6% | 5 | LOSS |
CIN@ARI | KEBRYAN HAYES STRIKEOUTS UNDER 0.5 | 56.2% | 6 | WIN |
LAD@SD | SD +110 | 50.9% | 6 | WIN |