Padres vs. Cubs
Prediction, Odds & Props
Apr 06 | MLB AI Picks

Updated: 2025-04-04T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

On April 6, 2025, the San Diego Padres (7-2) will face the Chicago Cubs (7-4) at Wrigley Field in Chicago. Both teams have started the season strongly, with the Padres aiming to maintain their perfect record and the Cubs looking to capitalize on their recent home opener success.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Apr 06, 2025

Start Time: 2:20 PM EST​

Venue: Wrigley Field​

Cubs Record: (7-4)

Padres Record: (7-2)

OPENING ODDS

SD Moneyline: +115

CHC Moneyline: -135

SD Spread: +1.5

CHC Spread: -1.5

Over/Under: 7.5

SD
Betting Trends

  • The Padres have been dominant against the spread this season, covering in 6 of their 7 games, resulting in a +6.6 unit gain, translating to an 81.99% return on investment (ROI).

CHC
Betting Trends

  • The Cubs have a mixed ATS record, covering in 5 of their 9 games, leading to a +1.0 unit gain and an 11.11% ROI.

MATCHUP TRENDS

  • The Padres have covered the spread in 6 of their 7 games this season, including a strong performance on the road, while the Cubs have shown resilience at home, covering the spread in 5 of their last 9 games, but have yet to dominate consistently against higher-caliber teams.

SD vs. CHC
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: K. Tucker over 0.5 Total Bases.

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San Diego vs Chicago Cubs Prediction & Odds:
Free MLB Betting Insights for 4/6/25

The San Diego Padres (7-0) and Chicago Cubs (7-4) are set to face off at Wrigley Field on April 6, 2025, with both teams looking to maintain their strong early-season performances. The Padres, fresh off a perfect 7-0 start, have been firing on all cylinders, combining a potent offense with stellar pitching. Offensively, the Padres have been powered by their dynamic stars, including Fernando Tatis Jr., Jackson Merrill, and Manny Machado. Tatis Jr., in particular, has been red-hot at the plate, producing consistent power and getting on base at an elite level, while Machado continues to be a rock in the lineup. Merrill, alongside veterans like Austin Nola and Eric Hosmer, adds depth to the Padres’ batting order, making them a difficult team to navigate for opposing pitchers. The Padres’ pitching staff has been exceptional, led by Randy Vásquez and Nick Pivetta. Vásquez has been the ace so far, providing reliable starts with the ability to overpower hitters. Pivetta, in a supporting role, has been effective in his outings, and the Padres’ bullpen has also been superb, allowing just one earned run since Opening Day. This combination of offensive power and dominant pitching has made the Padres one of the most well-rounded teams in the league early on. However, as they take to the road for this matchup against the Cubs, maintaining that consistency will be key. On the other side, the Chicago Cubs have had a strong start with a 7-4 record, but they are still looking for offensive consistency. Players like Nico Hoerner, who leads the team with a .333 batting average, and Patrick Wisdom, who brings power to the middle of the lineup, have been solid contributors.

However, the Cubs need more consistent production from others, especially the likes of Seiya Suzuki and Ian Happ, who have yet to fully find their rhythm. The Cubs’ pitching staff, which is typically a strength, has been a mixed bag so far. Ben Brown, who is expected to start for the Cubs, has had some struggles, posting an ERA of 5.87 through his first two starts. Brown has the potential to settle in and become a reliable starter, but he will need to work on limiting walks and keeping hitters off balance to have success against a strong Padres lineup. The Cubs’ bullpen has been solid in spots, but they will need to step up against a high-powered offense like San Diego’s. Manager David Ross will be hoping for better consistency from both the lineup and pitching staff as they face one of the top teams in the league. Wrigley Field provides a home-field advantage for the Cubs, and they will look to capitalize on that to gain some momentum. While the Cubs have been good at home, they will need to raise their game against the Padres, who have yet to lose a game this season. If the Cubs can get a quality start from Brown, find more consistency offensively, and leverage their bullpen effectively, they will have a shot at knocking off the Padres. This game is critical for both teams, as the Padres will look to continue their undefeated streak, while the Cubs aim to establish more consistency and take a step forward in the standings.

San Diego Padres MLB Preview

The San Diego Padres (7-0) are coming off an impressive start to the 2025 season and will look to maintain their undefeated streak as they face the Chicago Cubs on April 6, 2025, at Wrigley Field. With a perfect 7-0 record, the Padres have been one of the most dominant teams early in the season, combining exceptional pitching with a potent offense. Leading the charge offensively is Fernando Tatis Jr., who has been a force at the plate, hitting for both average and power, and proving to be one of the most dangerous hitters in the league. Tatis’ ability to get on base and create scoring opportunities has been crucial to the Padres’ success. Alongside him, Manny Machado has continued to be a consistent performer, providing leadership in the heart of the lineup, and adding balance with his ability to drive in runs. The Padres’ offense has depth, with Jackson Merrill, Eric Hosmer, and Austin Nola contributing solid performances at key moments. The addition of veteran players to support their stars has given the Padres a well-rounded lineup that can beat teams in multiple ways, whether it’s through power hitting or timely situational hitting. On the mound, the Padres’ pitching staff has been one of the best in the league. Randy Vásquez has been a standout, delivering consistent, high-quality starts and showing the ability to overpower hitters with his fastball and breaking stuff. Nick Pivetta, another key piece in the rotation, has been effective, providing the Padres with reliable innings every time he takes the mound. This depth in pitching, combined with the team’s strong bullpen, has been a huge reason for their early success.

The bullpen, which has allowed just one earned run since Opening Day, has been lights out, with key contributors like Josh Hader delivering in high-leverage situations. The Padres’ combination of offense, pitching, and defense has made them one of the most well-rounded teams to start the season, and they will look to continue that in this road game. However, as they face the Cubs at Wrigley Field, the Padres will have to adjust to a road environment. While they have been dominant at home, they will need to maintain their consistency on the road, especially against a team like the Cubs, which has been solid early in the season. To keep their perfect record intact, the Padres will need to get a quality start from whichever pitcher takes the mound—likely Randy Vásquez in this game—and continue to produce offensively. While Tatis Jr. and Machado have been the obvious stars, the Padres will need contributions from their supporting players to keep things balanced and not rely solely on their top hitters. If the Padres can continue their dominant play and get solid pitching, they will have a good chance to extend their perfect start. This game is critical for them to maintain momentum and demonstrate that their early-season success is no fluke. With strong all-around play, the Padres will look to make a statement as they continue their road trip and solidify themselves as one of the teams to beat in 2025.

On April 6, 2025, the San Diego Padres (7-2) will face the Chicago Cubs (7-4) at Wrigley Field in Chicago. Both teams have started the season strongly, with the Padres aiming to maintain their perfect record and the Cubs looking to capitalize on their recent home opener success. San Diego vs Chicago Cubs AI Prediction: Free MLB Betting Insights for Apr 06. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Chicago Cubs Cubs MLB Preview

The Chicago Cubs (7-4) will look to build on their strong start to the 2025 season as they face off against the San Diego Padres on April 6, 2025, at Wrigley Field. After a solid performance in the early part of the season, the Cubs will be eager to capitalize on their home field advantage against one of the hottest teams in the league. Offensively, the Cubs have had key contributions from players like Nico Hoerner, who is leading the team with a .333 batting average, and Patrick Wisdom, who has been hitting for power. Hoerner’s ability to get on base and create scoring opportunities has been a significant factor in the Cubs’ success, while Wisdom has provided the power in the lineup to drive in runs. However, the Cubs need more consistent production from players like Ian Happ and Seiya Suzuki, both of whom have shown flashes of brilliance but have yet to fully find their rhythm at the plate. If the Cubs are going to compete with the Padres, they will need their entire lineup to step up and provide more support to their key hitters. On the mound, the Cubs will turn to Ben Brown, who will be tasked with shutting down the potent Padres offense. Brown has had a solid start to the season with a 5.87 ERA, but he will need to be sharper if he is to keep the Padres’ lineup, which features stars like Fernando Tatis Jr., Manny Machado, and Jackson Merrill, from getting going. Brown’s control has been an issue, and he will need to limit walks and keep his pitches in the strike zone against the aggressive Padres hitters. The Cubs’ bullpen, which has been a reliable asset early in the season, will also play a crucial role.

They will need to be sharp, especially in high-leverage situations, to avoid giving up late-game rallies. Manager David Ross will likely lean on his bullpen to close out any leads, but he will need to ensure his pitchers stay focused and avoid any lapses that could allow the Padres to capitalize on mistakes. Defensively, the Cubs have been solid, but they will need to continue playing mistake-free baseball, especially against a team like the Padres that can exploit any defensive errors. With a home-field advantage at Wrigley Field, the Cubs are confident in their ability to take on the Padres, but they will need to improve on their offensive consistency and get a strong performance from Brown on the mound. A win here would not only help them maintain their positive start to the season but also serve as a statement victory against one of the league’s top teams. The Cubs will need to put together a complete performance in all phases of the game—offense, defense, and pitching—if they are to take down the undefeated Padres. This game will be a good test for the Cubs as they aim to keep their early-season momentum going and show that they can compete with the league’s elite teams.

San Diego vs. Chicago Cubs Prop Picks (AI)

AI algorithm Remi is pouring through tons of stats on each line. In fact, anytime the Padres and Cubs play there’s always several intriguing angles to key in on. Not to mention games played at Wrigley Field in Apr almost always follow normal, predictable patterns.
Remi's searched hard and found the best prop for this matchup: K. Tucker over 0.5 Total Bases.

San Diego vs. Chicago Cubs Prediction (AI)

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Remi, our AI sports wizard, has been pouring over mountains of data from every facet between the Padres and Cubs and using recursive machine learning and kick-ass AI to boil down the data to a single cover probability.

The Algorithm has been most keyed in on the unproportionally assigned emphasis human bettors often put on Chicago Cubs’s strength factors between a Padres team going up against a possibly strong Cubs team. We’ve found the true game analytics might reflect a slight lean against one Vegas line specifically.

Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.

Below is our current AI San Diego vs Chicago Cubs picks, computer picks Padres vs Cubs, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
MLB 9/26 DET@BOS UNLOCK THIS PICK 5 EXECUTIVE Locked EXECUTIVE
MLB 9/26 BAL@NYY UNLOCK THIS PICK 4 INTEL Locked INTEL
MLB 9/26 ARI@SD UNLOCK THIS PICK 4 EXECUTIVE Locked EXECUTIVE
MLB 9/26 NYM@MIA UNLOCK THIS PICK 1 INTEL Locked INTEL
MLB 9/26 NYM@MIA GET FREE PICK NOW 1
MLB 9/26 COL@SF UNLOCK THIS PICK 0 INTEL Locked INTEL

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.

Padres Betting Trends

The Padres have been dominant against the spread this season, covering in 6 of their 7 games, resulting in a +6.6 unit gain, translating to an 81.99% return on investment (ROI).

Cubs Betting Trends

The Cubs have a mixed ATS record, covering in 5 of their 9 games, leading to a +1.0 unit gain and an 11.11% ROI.

Padres vs. Cubs Matchup Trends

The Padres have covered the spread in 6 of their 7 games this season, including a strong performance on the road, while the Cubs have shown resilience at home, covering the spread in 5 of their last 9 games, but have yet to dominate consistently against higher-caliber teams.

San Diego vs. Chicago Cubs Game Info

San Diego vs Chicago Cubs starts on April 06, 2025 at 2:20 PM EST.

Spread: Chicago Cubs -1.5
Moneyline: San Diego +115, Chicago Cubs -135
Over/Under: 7.5

San Diego: (7-2)  |  Chicago Cubs: (7-4)

Remi's searched hard and found the best prop for this matchup: K. Tucker over 0.5 Total Bases.. Prices move—always shop for the best number.

The Padres have covered the spread in 6 of their 7 games this season, including a strong performance on the road, while the Cubs have shown resilience at home, covering the spread in 5 of their last 9 games, but have yet to dominate consistently against higher-caliber teams.

SD trend: The Padres have been dominant against the spread this season, covering in 6 of their 7 games, resulting in a +6.6 unit gain, translating to an 81.99% return on investment (ROI).

CHC trend: The Cubs have a mixed ATS record, covering in 5 of their 9 games, leading to a +1.0 unit gain and an 11.11% ROI.

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

San Diego vs. Chicago Cubs Odds

Remi is pouring through mountains of data on each line. In fact, anytime the San Diego vs Chicago Cubs trends are analyzed, there’s always several intriguing trends to key in on. Not to mention games played at extreme temps seemingly never follow normal, predictable betting trends.

San Diego vs Chicago Cubs Opening Odds

SD Moneyline: +115
CHC Moneyline: -135
SD Spread: +1.5
CHC Spread: -1.5
Over/Under: 7.5

San Diego vs Chicago Cubs Live Odds

Games PTS ML SPR O/U
Sep 27, 2025 1:06PM EDT
Baltimore Orioles
New York Yankees
9/27/25 1:06PM
Orioles
Yankees
+190
-235
+1.5 (-110)
-1.5 (-110)
O 8.5 (-120)
U 8.5 (+100)
Sep 27, 2025 2:21PM EDT
St Louis Cardinals
Chicago Cubs
9/27/25 2:21PM
Cardinals
Cubs
 
-175
 
-1.5 (+115)
O 9.5 (-105)
U 9.5 (-115)
Sep 27, 2025 3:09PM EDT
Tampa Bay Rays
Toronto Blue Jays
9/27/25 3:09PM
Rays
Blue Jays
+130
-155
+1.5 (-155)
-1.5 (+130)
O 8.5 (-110)
U 8.5 (-110)
Sep 27, 2025 4:06PM EDT
Chicago White Sox
Washington Nationals
9/27/25 4:06PM
White Sox
Nationals
+100
-120
-1.5 (+165)
+1.5 (-200)
O 8.5 (-110)
U 8.5 (-110)
Sep 27, 2025 4:06PM EDT
Colorado Rockies
San Francisco Giants
9/27/25 4:06PM
Rockies
Giants
+185
-225
+1.5 (-110)
-1.5 (-110)
O 8 (-105)
U 8 (-115)
Sep 27, 2025 4:11PM EDT
New York Mets
Miami Marlins
9/27/25 4:11PM
Mets
Marlins
-130
+110
-1.5 (+125)
+1.5 (-150)
O 8.5 (-105)
U 8.5 (-115)
Sep 27, 2025 6:05PM EDT
Minnesota Twins
Philadelphia Phillies
9/27/25 6:05PM
Twins
Phillies
+170
-205
+1.5 (-120)
-1.5 (+100)
O 8.5 (-115)
U 8.5 (-105)
Sep 27, 2025 7:11PM EDT
Cincinnati Reds
Milwaukee Brewers
9/27/25 7:11PM
Reds
Brewers
+125
-150
+1.5 (-180)
-1.5 (+150)
O 8 (-105)
U 8 (-115)
Sep 27, 2025 7:15PM EDT
Pittsburgh Pirates
Atlanta Braves
9/27/25 7:15PM
Pirates
Braves
+140
-170
+1.5 (-155)
-1.5 (+130)
O 8 (-110)
U 8 (-110)
Sep 27, 2025 7:16PM EDT
Texas Rangers
Cleveland Guardians
9/27/25 7:16PM
Rangers
Guardians
+135
-165
+1.5 (-180)
-1.5 (+150)
O 7 (-120)
U 7 (+100)
Sep 27, 2025 8:40PM EDT
Arizona Diamondbacks
San Diego Padres
9/27/25 8:40PM
Diamondbacks
Padres
+115
-140
+1.5 (-190)
-1.5 (+155)
O 7.5 (-120)
U 7.5 (+100)
Sep 27, 2025 9:39PM EDT
Houston Astros
Los Angeles Angels
9/27/25 9:39PM
Astros
Angels
-165
+135
-1.5 (+105)
+1.5 (-125)
O 9 (+100)
U 9 (-120)
Sep 27, 2025 9:41PM EDT
Los Angeles Dodgers
Seattle Mariners
9/27/25 9:41PM
Dodgers
Mariners
+100
-120
-1.5 (+170)
+1.5 (-205)
O 7.5 (-110)
U 7.5 (-110)
Sep 27, 2025 10:05PM EDT
Kansas City Royals
Oakland Athletics
9/27/25 10:05PM
Royals
Athletics
+100
-120
-1.5 (+150)
+1.5 (-180)
O 10 (-110)
U 10 (-110)

MLB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers San Diego Padres vs. Chicago Cubs Cubs on April 06, 2025 at Wrigley Field.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN
CHC@SF CHC -105 54.1% 4 LOSS
NYY@CHW RYAN MCMAHON OVER 0.5 BASES 54.1% 4 WIN
PHI@NYM OVER 8.5 55.6% 4 LOSS
LAA@TEX LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS 54.1% 4 LOSS
KC@CHW KC -109 54.2% 4 WIN
SD@SEA DYLAN CEASE OVER 16.5 OUTS 53.9% 3 LOSS
SD@SEA UNDER 8.5 54.4% 4 LOSS
MIN@TOR JOE RYAN UNDER 2.5 EARNED RUNS 54.1% 4 LOSS
SF@MIL MIL +100 54.0% 6 LOSS
TOR@MIA MIA +1.5 62.0% 6 WIN
CHC@LAA OVER 9.5 54.9% 4 LOSS
BOS@NYY CARLOS RODON UNDER 4.5 HITS ALLOWED 54.2% 4 WIN
KC@DET DET -115 56.1% 5 WIN
CHC@LAA LAA +1.5 57.6% 5 LOSS
CIN@ARI KEBRYAN HAYES STRIKEOUTS UNDER 0.5 56.2% 6 WIN
LAD@SD SD +110 50.9% 6 WIN