Guardians vs. Angels
Prediction, Odds & Props
Apr 06 | MLB AI Picks
Updated: 2025-04-04T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
On April 6, 2025, the Cleveland Guardians (3-4) will conclude their three-game series against the Los Angeles Angels (4-3) at Angel Stadium in Anaheim. Both teams have had mixed performances in their opening series, aiming to secure a decisive victory to bolster their early-season records.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

GAME INFO
Date: Apr 06, 2025
Start Time: 4:07 PM EST
Venue: Angel Stadium of Anaheim
Angels Record: (5-3)
Guardians Record: (3-5)
OPENING ODDS
CLE Moneyline: -123
LAA Moneyline: +103
CLE Spread: -1.5
LAA Spread: +1.5
Over/Under: 9
CLE
Betting Trends
- The Guardians have covered the spread in 2 of their last 7 games, resulting in a 28.6% success rate.
LAA
Betting Trends
- The Angels have covered the spread in 5 of their last 6 games, achieving an 83.3% success rate.
MATCHUP TRENDS
- The Guardians have been underdogs in six games this season, winning two, indicating a 33.3% success rate in covering the spread when not favored.
CLE vs. LAA
Best Prop Bet
- Remi's searched hard and found the best prop for this matchup: J. Ramirez over 7.5 Fantasy Score.
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Cleveland vs Los Angeles Angels Prediction & Odds:
Free MLB Betting Insights for 4/6/25
In contrast, the Los Angeles Angels have been strong early in the season, posting a 4-3 record. The Angels have been led by their ace, Shohei Ohtani, and slugger Mike Trout, who continues to deliver offensively. The Angels’ offense has been more explosive than the Guardians’, averaging 5.86 runs per game, and they have benefitted from contributions across the lineup. Mike Trout remains the face of the team, providing leadership and consistency, but the addition of players like Nolan Schanuel has added depth to their batting order. The Angels will look for big performances from their star players to power them through this game. On the mound, Tyler Anderson (0-0, 5.40 ERA) will start for the Angels. Anderson has shown potential but has struggled with consistency, posting an ERA higher than what he would prefer. He will need to be more efficient in this game, focusing on command and minimizing walks against a team like the Guardians that can take advantage of base runners. The Angels’ bullpen has been effective so far, and with pitchers like José Quijada and Jimmy Herget at their disposal, they will be ready to close out the game if necessary. The Angels also have a strong defensive lineup, with standout performances in the outfield and infield, making them difficult to break down. Manager Phil Nevin will want to make sure his team executes efficiently, especially in situations where the Guardians could capitalize on mistakes. If the Angels can generate offense from their key players, get a strong performance from Anderson, and close out with their bullpen, they should be able to win the series and solidify their position in the competitive AL West. For the Guardians, this game is a critical opportunity to get back on track, and they will need to find consistent pitching and more support from their lineup to upset the Angels at home.
Bo Bo Bo Bo.#GuardsBall pic.twitter.com/RAXnCZMZ4u
— Cleveland Guardians (@CleGuardians) April 6, 2025
Cleveland Guardians MLB Preview
The Cleveland Guardians (3-4) will look to bounce back from a rough start to the 2025 season as they face the Los Angeles Angels on April 6, 2025, at Angel Stadium. After a somewhat inconsistent opening to the season, the Guardians need to find their rhythm, especially offensively. The Guardians’ lineup, while capable of big moments, has struggled with sustained production. José Ramírez, as always, has been the focal point of the offense, delivering solid at-bats and providing some much-needed consistency in the lineup. His leadership, both offensively and defensively, remains a key asset for the team. However, for the Guardians to truly compete, other hitters like Steven Kwan, Josh Naylor, and Amed Rosario need to contribute more consistently. The lack of production from players in the middle of the order has placed additional pressure on their pitching staff to keep games close. On the mound, the Guardians will turn to Luis Ortiz, who has faced struggles early in the season with an ERA of 13.50. Ortiz has the potential to be an important part of the rotation but will need to greatly improve his command and consistency. Against a high-powered Angels offense, Ortiz will need to stay sharp and minimize mistakes, as the Angels have the ability to capitalize on any lapses. While the Guardians’ pitching staff as a whole has had some solid moments, they have not been able to maintain a dominant presence in games. If Ortiz can’t provide a quality start, the Guardians’ bullpen, which has shown flashes of promise, may be forced to take on more work. This will be a challenge, as the bullpen has been overtaxed in earlier games, which could hurt their effectiveness down the stretch.
Defensively, the Guardians have been solid but have had moments of inconsistency, particularly in the outfield. Their infield defense, led by Ramírez at third base, has been one of the team’s strengths, and they will need to continue executing fundamental plays to avoid giving the Angels extra opportunities. The Guardians will also need to be aggressive on the base paths, as they are a team that thrives when creating scoring chances through small ball and speed. This will be crucial against a team like the Angels that can score quickly. Cleveland’s pitching staff will be key in this game; the Guardians will need to keep the game close early and give their offense a chance to build momentum. With the Angels’ potent offense and strong pitching staff, the Guardians will have to work hard to remain in the game, especially against a team that can generate offense from multiple sources. A win would be a significant boost for the Guardians, giving them momentum and confidence as they continue to work through their early-season struggles. However, to secure the victory, they will need to improve across the board — from hitting and pitching to defense — and hope that Ortiz can rise to the occasion and provide a much-needed performance on the mound. A strong, complete game from the Guardians could set them on the path to greater consistency and help them stay competitive in the AL Central.

Credit: USA TODAY/IMAGN
Los Angeles Angels Angels MLB Preview
The Los Angeles Angels (4-3) come into the final game of their series against the Cleveland Guardians on April 6, 2025, with strong momentum after a solid start to the season. Offensively, the Angels have been firing on all cylinders, averaging 5.86 runs per game. This offensive explosion has been led by perennial All-Star Mike Trout, who continues to be one of the best players in baseball, contributing both power and on-base ability. In addition to Trout’s leadership, the Angels have received key contributions from new additions like Nolan Schanuel, whose bat has added depth to an already potent lineup. The depth of the lineup has been critical for the Angels, as they have been able to generate consistent runs even when certain hitters go cold. Beyond Trout, the likes of Shohei Ohtani, Taylor Ward, and Jared Walsh have also been producing in key moments. The balance in the lineup has allowed the Angels to be aggressive at the plate, and they will look to continue that approach in this game against the Guardians. On the mound, the Angels will be led by Tyler Anderson, who takes the ball for the final game of the series. Anderson has posted a 5.40 ERA so far this season, and while he has shown potential, his consistency has been an issue. Against a Guardians team that has been offensively inconsistent, Anderson will need to be sharp. His ability to control the game and avoid giving up too many base runners will be key to keeping the Guardians’ offense in check. Anderson has the potential to go deep into the game and give the Angels’ bullpen a much-needed break, which will be essential for them as the season progresses.
The bullpen, which features strong arms like José Quijada and Jimmy Herget, has been effective in the early going, but the Angels will be looking for Anderson to minimize the bullpen’s workload. If Anderson can deliver a quality start, the bullpen will have the chance to close the game out with confidence. Defensively, the Angels have been solid, with key players like shortstop David Fletcher and third baseman Anthony Rendon anchoring the infield. Trout’s presence in center field is always a valuable asset, and he continues to be a standout defensively as well as offensively. The Angels’ ability to execute plays and minimize mistakes has been a strength, and they’ll need to maintain that level of discipline against a Guardians team that can capitalize on any errors. Manager Phil Nevin will likely emphasize strong defense, pitching depth, and timely hitting as the Angels look to secure a win and a series victory against the Guardians. With their strong offensive depth and a solid pitching staff, the Angels are positioned well to continue their early-season success, but they must avoid complacency. A win would further solidify their standing in the highly competitive AL West and give them added confidence as they prepare for the challenges ahead. This game is important for the Angels to prove they can maintain consistency, particularly with a pitching staff that can be shaky at times, and it presents an excellent opportunity to continue building on their early-season success.
😇 first home win 😇 pic.twitter.com/DzaBc4mGHD
— Los Angeles Angels (@Angels) April 6, 2025
Cleveland vs. Los Angeles Angels Prop Picks (AI)
Cleveland vs. Los Angeles Angels Prediction (AI)

Remi, our AI sports genius, has been pouring over exorbitant amounts of data from every past game between the Guardians and Angels and using recursive machine learning and industry leading AI to boil down the data to a single cover probability.
The Algorithm has been most focused on the linear correlation of weight knucklehead sportsbettors regularly put on coaching factors between a Guardians team going up against a possibly improved Angels team. It appears the true game analytics might reflect a moderate lean against one Vegas line in particular.
Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.
Below is our current AI Cleveland vs Los Angeles Angels picks, computer picks Guardians vs Angels, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
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MLB | 9/26 | DET@BOS | UNLOCK THIS PICK | 5 |
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MLB | 9/26 | BAL@NYY | UNLOCK THIS PICK | 4 |
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MLB | 9/26 | ARI@SD | UNLOCK THIS PICK | 4 |
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MLB | 9/26 | NYM@MIA | UNLOCK THIS PICK | 1 |
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MLB | 9/26 | NYM@MIA | GET FREE PICK NOW | 1 | – | |
MLB | 9/26 | COL@SF | UNLOCK THIS PICK | 0 |
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.
Guardians Betting Trends
The Guardians have covered the spread in 2 of their last 7 games, resulting in a 28.6% success rate.
Angels Betting Trends
The Angels have covered the spread in 5 of their last 6 games, achieving an 83.3% success rate.
Guardians vs. Angels Matchup Trends
The Guardians have been underdogs in six games this season, winning two, indicating a 33.3% success rate in covering the spread when not favored.
Cleveland vs. Los Angeles Angels Game Info
What time does Cleveland vs Los Angeles Angels start on April 06, 2025?
Cleveland vs Los Angeles Angels starts on April 06, 2025 at 4:07 PM EST.
Where is Cleveland vs Los Angeles Angels being played?
Venue: Angel Stadium of Anaheim.
What are the opening odds for Cleveland vs Los Angeles Angels?
Spread: Los Angeles Angels +1.5
Moneyline: Cleveland -123, Los Angeles Angels +103
Over/Under: 9
What are the records for Cleveland vs Los Angeles Angels?
Cleveland: (3-5) | Los Angeles Angels: (5-3)
What is the AI best bet for Cleveland vs Los Angeles Angels?
Remi's searched hard and found the best prop for this matchup: J. Ramirez over 7.5 Fantasy Score.. Prices move—always shop for the best number.
What are Cleveland vs Los Angeles Angels trending bets?
The Guardians have been underdogs in six games this season, winning two, indicating a 33.3% success rate in covering the spread when not favored.
What are Cleveland trending bets?
CLE trend: The Guardians have covered the spread in 2 of their last 7 games, resulting in a 28.6% success rate.
What are Los Angeles Angels trending bets?
LAA trend: The Angels have covered the spread in 5 of their last 6 games, achieving an 83.3% success rate.
Where can I find AI Picks for Cleveland vs Los Angeles Angels?
See our latest MLB picks and odds pages for 2025 to compare prices before you bet.
Cleveland vs. Los Angeles Angels Odds
AI algorithm Remi is pouring through mountains of data points on each team. In fact, anytime the Cleveland vs Los Angeles Angels trends are analyzed, there’s always several intriguing trends to key in on. Not to mention games played at extreme altitude seemingly never follow normal, predictable patterns.
Cleveland vs Los Angeles Angels Opening Odds
CLE Moneyline:
-123 LAA Moneyline: +103
CLE Spread: -1.5
LAA Spread: +1.5
Over/Under: 9
Cleveland vs Los Angeles Angels Live Odds
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U 9 (-120)
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U 8.5 (-110)
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O 8.5 (-110)
U 8.5 (-110)
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Sep 27, 2025 4:06PM EDT
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+192
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+1.5 (-110)
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O 8 (-105)
U 8 (-115)
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Sep 27, 2025 4:11PM EDT
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-130
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O 8 (-120)
U 8 (+100)
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Sep 27, 2025 4:11PM EDT
Detroit Tigers
Boston Red Sox
9/27/25 4:11PM
Tigers
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–
–
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+110
-130
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+1.5 (-190)
-1.5 (+158)
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O 9 (+100)
U 9 (-120)
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Sep 27, 2025 6:05PM EDT
Minnesota Twins
Philadelphia Phillies
9/27/25 6:05PM
Twins
Phillies
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–
–
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+175
-210
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+1.5 (-120)
-1.5 (+100)
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O 8.5 (-115)
U 8.5 (-105)
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Sep 27, 2025 7:11PM EDT
Cincinnati Reds
Milwaukee Brewers
9/27/25 7:11PM
Reds
Brewers
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–
–
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+115
-135
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+1.5 (-190)
-1.5 (+158)
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O 7.5 (-120)
U 7.5 (+100)
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Sep 27, 2025 7:15PM EDT
Pittsburgh Pirates
Atlanta Braves
9/27/25 7:15PM
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+150
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+1.5 (-145)
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O 8 (-110)
U 8 (-110)
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Sep 27, 2025 7:16PM EDT
Texas Rangers
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9/27/25 7:16PM
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+122
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+1.5 (-190)
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O 7 (-120)
U 7 (+100)
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Sep 27, 2025 8:40PM EDT
Arizona Diamondbacks
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9/27/25 8:40PM
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–
–
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+118
-140
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+1.5 (-190)
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O 7.5 (-115)
U 7.5 (-105)
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Sep 27, 2025 9:39PM EDT
Houston Astros
Los Angeles Angels
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–
–
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-145
+122
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-1.5 (+115)
+1.5 (-135)
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O 9 (-110)
U 9 (-110)
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Sep 27, 2025 9:41PM EDT
Los Angeles Dodgers
Seattle Mariners
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Dodgers
Mariners
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–
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+110
-130
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+1.5 (-205)
-1.5 (+170)
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O 7 (-120)
U 7 (+100)
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Sep 27, 2025 10:05PM EDT
Kansas City Royals
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–
–
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+100
-120
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+1.5 (-195)
-1.5 (+162)
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O 10 (-110)
U 10 (-110)
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MLB Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers Cleveland Guardians vs. Los Angeles Angels Angels on April 06, 2025 at Angel Stadium of Anaheim.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.
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LEAN | %WIN | UNITS | RESULT |
---|---|---|---|---|
NYM@CHC | NYM -110 | 54.1% | 3 | WIN |
HOU@ATH | ATH +118 | 50.8% | 4 | WIN |
NYM@CHC | OVER 7 | 54.5% | 3 | WIN |
STL@SF | OVER 7.5 | 55.9% | 5 | LOSS |
KC@LAA | TYLER TOLBERT UNDER 1.5 BASES | 54.4% | 4 | WIN |
MIL@SD | UNDER 9 | 54.7% | 4 | WIN |
MIA@PHI | KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS | 53.3% | 3 | WIN |
WAS@NYM | OVER 8.5 | 56.1% | 6 | LOSS |
LAA@COL | COL +108 | 50.5% | 3 | WIN |
TOR@KC | UNDER 9 | 54.7% | 4 | LOSS |
SEA@KC | KC +1.5 | 62.3% | 5 | LOSS |
NYY@MIN | OVER 9 | 55.1% | 4 | WIN |
MIA@COL | OVER 10.5 | 55.0% | 4 | WIN |
MIA@COL | AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS | 54.3% | 4 | WIN |
SEA@KC | BOBBY WITT UNDER 0.5 SINGLES | 54.4% | 4 | LOSS |
PHI@LAD | LAD -113 | 54.7% | 4 | LOSS |
NYY@BOS | OVER 7.5 | 54.3% | 3 | WIN |
KC@PHI | PHI -130 | 58.3% | 4 | WIN |
LAD@SF | OVER 7.5 | 54.7% | 4 | LOSS |
NYM@PHI | PHI -122 | 55.6% | 4 | WIN |
KC@CLE | KC -104 | 52.0% | 3 | WIN |
CIN@SD | JAKE CRONEWORTH OVER 0.5 HITS | 53.1% | 3 | WIN |
WAS@MIA | MIA -123 | 55.2% | 4 | LOSS |
LAA@KC | UNDER 9.5 | 54.9% | 3 | WIN |
TEX@ARI | UNDER 9 | 54.2% | 4 | WIN |
SF@COL | UNDER 11.5 | 56.4% | 6 | LOSS |
SF@COL | RAFAEL DEVERS OVER 1.5 BASES | 56.1% | 6 | WIN |
MIA@WAS | WAS -110 | 54.4% | 4 | WIN |
NYM@DET | OVER 8.5 | 54.5% | 4 | WIN |
TEX@ARI | UNDER 9.5 | 56.4% | 6 | WIN |
TEX@ARI | ALEJANDRO OSUNA UNDER 1.5 BASES | 54.1% | 4 | LOSS |
ATL@CHC | CHC -116 | 55.1% | 3 | WIN |
PHI@MIL | OVER 8.5 | 55.0% | 3 | WIN |
ARI@LAD | SHOHEI OHTANI OVER 2.5 BASES | 54.2% | 4 | WIN |
SEA@CLE | CLE +1.5 | 57.2% | 3 | WIN |
CHC@SF | CHC -105 | 54.1% | 4 | LOSS |
NYY@CHW | RYAN MCMAHON OVER 0.5 BASES | 54.1% | 4 | WIN |
PHI@NYM | OVER 8.5 | 55.6% | 4 | LOSS |
LAA@TEX | LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS | 54.1% | 4 | LOSS |
KC@CHW | KC -109 | 54.2% | 4 | WIN |
SD@SEA | DYLAN CEASE OVER 16.5 OUTS | 53.9% | 3 | LOSS |
SD@SEA | UNDER 8.5 | 54.4% | 4 | LOSS |
MIN@TOR | JOE RYAN UNDER 2.5 EARNED RUNS | 54.1% | 4 | LOSS |
SF@MIL | MIL +100 | 54.0% | 6 | LOSS |
TOR@MIA | MIA +1.5 | 62.0% | 6 | WIN |
CHC@LAA | OVER 9.5 | 54.9% | 4 | LOSS |
BOS@NYY | CARLOS RODON UNDER 4.5 HITS ALLOWED | 54.2% | 4 | WIN |
KC@DET | DET -115 | 56.1% | 5 | WIN |
CHC@LAA | LAA +1.5 | 57.6% | 5 | LOSS |
CIN@ARI | KEBRYAN HAYES STRIKEOUTS UNDER 0.5 | 56.2% | 6 | WIN |
LAD@SD | SD +110 | 50.9% | 6 | WIN |