Astros vs. Twins
Prediction, Odds & Props
Apr 05 | MLB AI Picks

Updated: 2025-04-03T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The Houston Astros are set to face the Minnesota Twins on April 5, 2025, at Target Field in Minneapolis, Minnesota. Both teams aim to gain momentum early in the season, making this matchup crucial for setting the tone in their respective divisions.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Apr 05, 2025

Start Time: 2:10 PM EST​

Venue: Target Field​

Twins Record: (2-5)

Astros Record: (3-4)

OPENING ODDS

HOU Moneyline: +106

MIN Moneyline: -125

HOU Spread: +1.5

MIN Spread: -1.5

Over/Under: 7.5

HOU
Betting Trends

  • As of April 5, 2025, the Houston Astros have a record of 2-4.

MIN
Betting Trends

  • The Minnesota Twins also hold a 2-4 record as of this date.

MATCHUP TRENDS

  • Both teams have identical records, indicating a potentially evenly matched game. Historically, their head-to-head matchups have been competitive, suggesting this game could be closely contested.

HOU vs. MIN
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: B. Buxton over 0.5 Total Bases.

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Houston vs Minnesota Prediction & Odds:
Free MLB Betting Insights for 4/5/25

The April 5, 2025, matchup between the Houston Astros and the Minnesota Twins at Target Field is shaping up to be a compelling early-season clash between two teams still seeking consistency. This is the second game in a three-game set, and both clubs are aiming to establish momentum as the regular season picks up pace. The Astros enter the contest with a 3-4 record, coming off a stretch of tight, low-scoring games where their pitching has held strong but offensive output has lagged at times. Meanwhile, the Twins are 2-5 and already facing pressure to tighten up defensively and get their bats going. The projected starters are right-hander Spencer Arrighetti for Houston and Bailey Ober for Minnesota. Arrighetti delivered a solid first start, allowing only one run in six innings, and looks to build on that foundation. Ober, however, was shelled in his previous outing, lasting only a single inning and surrendering six runs—he’ll be under scrutiny to bounce back in front of the home crowd. This game presents an interesting contrast in team dynamics. The Astros, while not yet firing on all cylinders, have a more stable lineup with proven veterans like Jose Altuve, Alex Bregman, and Yordan Alvarez. They’ve shown flashes of offensive potential but are still working on finding rhythm, particularly with runners in scoring position. Their team batting average sits around .240, bolstered by timely extra-base hits and the occasional long ball. On the mound, Houston’s pitching staff has been their biggest asset.

Arrighetti’s early-season command and poise have given manager Joe Espada confidence, and the bullpen—featuring Ryan Pressly and Bryan Abreu—has been relatively effective in closing out games. That said, the Astros are also dealing with early inconsistency in the middle innings, where leads have been squandered in previous outings. For the Twins, the urgency is a bit more palpable. Offensively, they’ve struggled mightily, batting just .184 as a team and ranking near the bottom of the league in runs scored. Carlos Correa has started reasonably well and remains a central figure in their lineup, but sluggers like Byron Buxton and Max Kepler need to produce if Minnesota hopes to climb out of the early hole. Their pitching, too, has been a sore spot, with Ober’s ERA inflated by a brutal opening appearance. The bullpen has been asked to shoulder a heavier-than-expected load and has not always responded well. However, playing at home gives Minnesota a slight edge—they’ve traditionally fared better at Target Field and have covered the spread in four of their last five home games against Houston. The Twins will need to capitalize on any opportunities they’re given and play clean defense, as mistakes have cost them dearly in recent matchups. Overall, this game hinges on whether Houston’s reliable pitching can suppress Minnesota’s desperate offense, or if the Twins can turn the page and find a spark to ignite their season.

Houston Astros MLB Preview

The Houston Astros enter their April 5, 2025, matchup against the Minnesota Twins with something to prove after a rocky start to the season that has left them at 2-4 and reeling from a three-game sweep by the San Francisco Giants. A perennial postseason threat and one of baseball’s most well-rounded rosters, Houston has not looked the part early in the 2025 campaign. While it’s far too early for panic in the clubhouse, the Astros are clearly feeling the urgency to get back on track, especially in a road game against a resurging Minnesota team that has begun to regain its footing. This contest at Target Field is as much a mental test as a physical one—Houston must show that their early struggles are merely a blip and not the start of an identity crisis. Known for their professionalism and consistency, the Astros are looking to reset the tone, starting with more disciplined play on both sides of the ball. Spencer Arrighetti will take the mound for Houston, making his second start of the season after an uneven debut in which he showed flashes of promise but was hindered by pitch count inefficiency and command lapses. As one of the Astros’ top pitching prospects, Arrighetti brings a fastball with movement and a slider that can induce weak contact when located well. His first outing didn’t live up to expectations, but given his upside and the team’s long-term confidence in his development, this game represents an opportunity for redemption. He’ll need to be especially sharp against a Twins lineup that has begun to find its rhythm and features power-speed threats like Byron Buxton and steady bats like Carlos Correa. If Arrighetti can work through the first few innings without damage and limit walks, it will go a long way in settling the team and conserving the already stretched bullpen.

Offensively, the Astros are still waiting for their core to ignite. Yordan Alvarez remains the central engine of the lineup, but even he hasn’t quite caught fire yet. When Alvarez is locked in, few hitters in the league can match his combination of bat speed and plate coverage. Jose Altuve, Alex Bregman, and Kyle Tucker round out one of the most experienced and talented lineups in the game, but collectively, they’ve struggled with runners in scoring position and haven’t been able to sustain rallies. Patience and pitch selection will be key against Bailey Ober, who excels at getting weak contact and keeping hitters off balance. If the Astros can string together at-bats, get into hitters’ counts, and force the Twins to dig into their bullpen early, they’ll tilt the game in their favor. Defensively, Houston’s early-season miscues have cost them dearly—miscommunication on fly balls, errant throws, and infield lapses have allowed opponents extra chances that top-tier teams usually avoid giving. The infield duo of Altuve and Peña is experienced and athletic, but they’ll need to lead by example to tighten things up and regain the team’s defensive rhythm. Outfield coverage, particularly with new rotations and positioning adjustments, will also be key against the Twins’ aggressive base running. With their backs slightly against the wall and questions being asked externally, the Astros are in need of a crisp, controlled, and mature performance. A win at Target Field wouldn’t just end a losing skid—it would restore faith that this Houston team is still among the class of the American League, capable of responding under pressure and correcting course before it’s too late.

The Houston Astros are set to face the Minnesota Twins on April 5, 2025, at Target Field in Minneapolis, Minnesota. Both teams aim to gain momentum early in the season, making this matchup crucial for setting the tone in their respective divisions. Houston vs Minnesota AI Prediction: Free MLB Betting Insights for Apr 05. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Minnesota Twins MLB Preview

The Houston Astros step into their April 5, 2025 matchup against the Minnesota Twins looking to halt a three-game losing streak and reset the tone of their season before it slips further. After being swept by the San Francisco Giants, the Astros have dropped to 2-4 on the year—a record that doesn’t fully reflect the team’s potential but does underline some early-season concerns. Houston has long been considered a powerhouse in the American League, boasting a deep lineup and veteran leadership, but their slow start has exposed some lingering questions, particularly surrounding bullpen depth and offensive consistency. While it’s too early to panic, a fourth consecutive loss would begin to raise alarm bells in a highly competitive AL West. Their challenge now is to respond like contenders do—on the road, against a rejuvenated Twins club hungry to build on recent momentum. Spencer Arrighetti gets the start for Houston, and this outing carries significant weight for both the pitcher and the club. In his first appearance of the season, Arrighetti showed flashes of promise with his live fastball and developing secondary pitches, but control issues and pitch count management limited his effectiveness. He’ll need to demonstrate better command and work deeper into the game, especially with the Astros’ bullpen under strain from recent overuse. The organization is high on Arrighetti’s upside, believing he can grow into a mid-rotation role, but against a Twins lineup that just woke up offensively in a sweep of the White Sox, the margin for error will be slim. If Arrighetti can give Houston five or six innings of composed, efficient pitching, it would be a major boost for a team searching for stability on the mound.

Offensively, the Astros still possess one of the most dangerous cores in baseball, though early returns have been modest. Yordan Alvarez remains the centerpiece of their lineup—a powerful lefty capable of changing games with one swing. He’s yet to go on one of his trademark tears, but history suggests it’s only a matter of time. Jose Altuve and Alex Bregman also anchor the top of the order, though both have had quiet starts to the season. The Astros’ offensive struggles have largely stemmed from situational hitting—missed opportunities with runners in scoring position and an inability to sustain rallies. Cleaning up those issues will be key against Bailey Ober, a disciplined strike-thrower who doesn’t often beat himself with walks. Look for the Astros to work deeper counts and force Ober into high-stress innings early if they hope to wear him down and get into the bullpen. Defensively, Houston must return to the crisp execution that has defined their recent playoff-caliber teams. Misplays and mental errors have crept in during the losing streak, costing them key innings and putting additional stress on the pitching staff. The infield duo of Altuve and Jeremy Peña remains one of the strongest in the league, but the outfield—dealing with some roster changes—has lacked the usual cohesion. If the Astros want to rebound, they must play clean baseball and rely on their veterans to set the tone. This game is about more than ending a losing streak—it’s about reinforcing identity. If Houston brings their trademark intensity, they remain the more complete team and can escape Target Field with a needed win and a reset of momentum.

Houston vs. Minnesota Prop Picks (AI)

AI algorithm Remi is pouring through tons of stats on each player. In fact, anytime the Astros and Twins play there’s always several intriguing observations to key in on. Not to mention games played at Target Field in Apr seemingly never follow normal, predictable patterns.
Remi's searched hard and found the best prop for this matchup: B. Buxton over 0.5 Total Bases.

Houston vs. Minnesota Prediction (AI)

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Remi, our AI sports algorithm, has been pouring over tons of data from every facet between the Astros and Twins and using recursive machine learning and industry leading AI to examine the data to a single cover probability.

Oddly enough, we’ve seen the AI has been most focused on the unproportionally assigned emphasis knucklehead sportsbettors regularly put on player performance factors between a Astros team going up against a possibly tired Twins team. We’ve found the true game analytics appear to reflect a slight lean against one Vegas line in particular.

Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.

Below is our current AI Houston vs Minnesota picks, computer picks Astros vs Twins, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
MLB 9/26 DET@BOS UNLOCK THIS PICK 5 EXECUTIVE Locked EXECUTIVE
MLB 9/26 BAL@NYY UNLOCK THIS PICK 4 INTEL Locked INTEL
MLB 9/26 ARI@SD UNLOCK THIS PICK 4 EXECUTIVE Locked EXECUTIVE
MLB 9/26 NYM@MIA UNLOCK THIS PICK 1 INTEL Locked INTEL
MLB 9/26 NYM@MIA GET FREE PICK NOW 1
MLB 9/26 COL@SF UNLOCK THIS PICK 0 INTEL Locked INTEL

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.

Astros Betting Trends

As of April 5, 2025, the Houston Astros have a record of 2-4.

Twins Betting Trends

The Minnesota Twins also hold a 2-4 record as of this date.

Astros vs. Twins Matchup Trends

Both teams have identical records, indicating a potentially evenly matched game. Historically, their head-to-head matchups have been competitive, suggesting this game could be closely contested.

Houston vs. Minnesota Game Info

Houston vs Minnesota starts on April 05, 2025 at 2:10 PM EST.

Spread: Minnesota -1.5
Moneyline: Houston +106, Minnesota -125
Over/Under: 7.5

Houston: (3-4)  |  Minnesota: (2-5)

Remi's searched hard and found the best prop for this matchup: B. Buxton over 0.5 Total Bases.. Prices move—always shop for the best number.

Both teams have identical records, indicating a potentially evenly matched game. Historically, their head-to-head matchups have been competitive, suggesting this game could be closely contested.

HOU trend: As of April 5, 2025, the Houston Astros have a record of 2-4.

MIN trend: The Minnesota Twins also hold a 2-4 record as of this date.

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

Houston vs. Minnesota Odds

Remi is pouring through tons of data on each team. In fact, anytime the Houston vs Minnesota trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme hostile environments almost always follow normal, predictable patterns.

Houston vs Minnesota Opening Odds

HOU Moneyline: +106
MIN Moneyline: -125
HOU Spread: +1.5
MIN Spread: -1.5
Over/Under: 7.5

Houston vs Minnesota Live Odds

Games PTS ML SPR O/U
Sep 27, 2025 1:06PM EDT
Baltimore Orioles
New York Yankees
9/27/25 1:06PM
Orioles
Yankees
+190
-235
+1.5 (-110)
-1.5 (-110)
O 8.5 (-120)
U 8.5 (+100)
Sep 27, 2025 2:21PM EDT
St Louis Cardinals
Chicago Cubs
9/27/25 2:21PM
Cardinals
Cubs
 
-175
 
-1.5 (+115)
O 9.5 (-105)
U 9.5 (-115)
Sep 27, 2025 3:09PM EDT
Tampa Bay Rays
Toronto Blue Jays
9/27/25 3:09PM
Rays
Blue Jays
+130
-155
+1.5 (-155)
-1.5 (+130)
O 8.5 (-110)
U 8.5 (-110)
Sep 27, 2025 4:06PM EDT
Chicago White Sox
Washington Nationals
9/27/25 4:06PM
White Sox
Nationals
+100
-120
-1.5 (+165)
+1.5 (-200)
O 8.5 (-110)
U 8.5 (-110)
Sep 27, 2025 4:06PM EDT
Colorado Rockies
San Francisco Giants
9/27/25 4:06PM
Rockies
Giants
+185
-225
+1.5 (-110)
-1.5 (-110)
O 8 (-105)
U 8 (-115)
Sep 27, 2025 4:11PM EDT
New York Mets
Miami Marlins
9/27/25 4:11PM
Mets
Marlins
-130
+110
-1.5 (+125)
+1.5 (-150)
O 8.5 (-105)
U 8.5 (-115)
Sep 27, 2025 6:05PM EDT
Minnesota Twins
Philadelphia Phillies
9/27/25 6:05PM
Twins
Phillies
+170
-205
+1.5 (-120)
-1.5 (+100)
O 8.5 (-115)
U 8.5 (-105)
Sep 27, 2025 7:11PM EDT
Cincinnati Reds
Milwaukee Brewers
9/27/25 7:11PM
Reds
Brewers
+125
-150
+1.5 (-180)
-1.5 (+150)
O 8 (-105)
U 8 (-115)
Sep 27, 2025 7:15PM EDT
Pittsburgh Pirates
Atlanta Braves
9/27/25 7:15PM
Pirates
Braves
+140
-170
+1.5 (-155)
-1.5 (+130)
O 8 (-110)
U 8 (-110)
Sep 27, 2025 7:16PM EDT
Texas Rangers
Cleveland Guardians
9/27/25 7:16PM
Rangers
Guardians
+135
-165
+1.5 (-180)
-1.5 (+150)
O 7 (-120)
U 7 (+100)
Sep 27, 2025 8:40PM EDT
Arizona Diamondbacks
San Diego Padres
9/27/25 8:40PM
Diamondbacks
Padres
+115
-140
+1.5 (-190)
-1.5 (+155)
O 7.5 (-120)
U 7.5 (+100)
Sep 27, 2025 9:39PM EDT
Houston Astros
Los Angeles Angels
9/27/25 9:39PM
Astros
Angels
-165
+135
-1.5 (+105)
+1.5 (-125)
O 9 (+100)
U 9 (-120)
Sep 27, 2025 9:41PM EDT
Los Angeles Dodgers
Seattle Mariners
9/27/25 9:41PM
Dodgers
Mariners
+100
-120
-1.5 (+170)
+1.5 (-205)
O 7.5 (-110)
U 7.5 (-110)
Sep 27, 2025 10:05PM EDT
Kansas City Royals
Oakland Athletics
9/27/25 10:05PM
Royals
Athletics
+100
-120
-1.5 (+150)
+1.5 (-180)
O 10 (-110)
U 10 (-110)

MLB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Houston Astros vs. Minnesota Twins on April 05, 2025 at Target Field.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN
CHC@SF CHC -105 54.1% 4 LOSS
NYY@CHW RYAN MCMAHON OVER 0.5 BASES 54.1% 4 WIN
PHI@NYM OVER 8.5 55.6% 4 LOSS
LAA@TEX LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS 54.1% 4 LOSS
KC@CHW KC -109 54.2% 4 WIN
SD@SEA DYLAN CEASE OVER 16.5 OUTS 53.9% 3 LOSS
SD@SEA UNDER 8.5 54.4% 4 LOSS
MIN@TOR JOE RYAN UNDER 2.5 EARNED RUNS 54.1% 4 LOSS
SF@MIL MIL +100 54.0% 6 LOSS
TOR@MIA MIA +1.5 62.0% 6 WIN
CHC@LAA OVER 9.5 54.9% 4 LOSS
BOS@NYY CARLOS RODON UNDER 4.5 HITS ALLOWED 54.2% 4 WIN
KC@DET DET -115 56.1% 5 WIN
CHC@LAA LAA +1.5 57.6% 5 LOSS
CIN@ARI KEBRYAN HAYES STRIKEOUTS UNDER 0.5 56.2% 6 WIN
LAD@SD SD +110 50.9% 6 WIN