Giants vs. Astros
Prediction, Odds & Props
Apr 02 | MLB AI Picks

Updated: 2025-03-31T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The San Francisco Giants will face the Houston Astros on April 2, 2025, at Daikin Park in Houston, Texas. This game marks the conclusion of a three-game series between the two teams.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Apr 02, 2025

Start Time: 4:10 PM EST​

Venue: Daikin Park​

Astros Record: (2-3)

Giants Record: (4-1)

OPENING ODDS

SF Moneyline: +142

HOU Moneyline: -168

SF Spread: +1.5

HOU Spread: -1.5

Over/Under: 8

SF
Betting Trends

  • The Giants have covered the spread in 65% of their recent games.

HOU
Betting Trends

  • The Astros have a .480 winning percentage against the Giants over 63 seasons, with 354 wins and 384 losses.

MATCHUP TRENDS

  • In recent years, the Giants have won two out of three games in each of the past three series against the Astros.

SF vs. HOU
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: T. Fitzgerald over 0.5 Total Bases.

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San Francisco vs Houston Prediction & Odds:
Free MLB Betting Insights for 4/2/25

The April 2, 2025, matchup between the San Francisco Giants and the Houston Astros at Daikin Park offers a compelling interleague showdown between two franchises navigating transitional periods, albeit from very different starting points. The Giants enter this game riding some early-season momentum, while the Astros are still trying to shake off an offensive slump that has defined their rough opening week. As the final game in this three-game series, this contest holds added weight for both clubs looking to establish their identity in the first month of the 2025 season. San Francisco has started the season with quiet confidence. After years of retooling, the Giants seem to be finally striking the right balance between established veterans and promising young players. Their infield overhaul—with the additions of Matt Chapman at third and Willy Adames at short—has significantly upgraded both their power potential and defensive reliability. Heliot Ramos and Mike Yastrzemski have also been valuable contributors in the outfield, while Thairo Estrada has provided timely hits and consistent glove work up the middle. Their early play suggests a club that’s turned a corner from its inconsistent recent seasons. On the mound for San Francisco is Jordan Hicks, a hard-throwing right-hander and Houston native who will be making a homecoming of sorts in this start. Previously viewed primarily as a reliever with the Cardinals, Hicks was transitioned into a starting role and signed by the Giants with the intent to stretch him out.

He brings triple-digit velocity and an improved slider, and has reportedly worked on refining his command during spring training. This start will test his stamina and pitch efficiency, especially against a Houston lineup known for patience and contact hitting—even if it’s been slow out of the gate. The Astros, meanwhile, have started 2025 in unfamiliar territory: the bottom of the league in run production. Through their first four games, they’ve managed just eight runs, with only one home run and two doubles. That’s a shocking stat line for a team that has defined offensive explosiveness over the past decade. The departures of Kyle Tucker (now raking with the Cubs), Alex Bregman, and Justin Verlander have left both a leadership and performance gap. In response, Houston has added pieces like Christian Walker, Cam Smith, and Brendan Rodgers, while also shifting longtime second baseman Jose Altuve to left field. The Astros will counter Hicks with Ronel Blanco on the mound. Blanco quietly emerged as a reliable starter in 2024, finishing with a 15-7 record and a 3.31 ERA. He’ll need to neutralize the power bats in the Giants’ lineup while buying time for the Houston offense to find its rhythm. If Blanco can get through the middle innings without damage, the Astros bullpen—still considered one of the more versatile in the AL—will have a chance to close the door. This game pits a surging Giants team trying to cement themselves as legit NL contenders against an Astros squad eager to remind everyone that their dynasty may not be over just yet. With Houston’s offense desperate to wake up and San Francisco’s revamped roster gaining confidence, this finale could be a springboard—or a serious warning sign—for both teams moving forward.

San Francisco Giants MLB Preview

The San Francisco Giants head into their April 2, 2025, matchup against the Houston Astros with a quiet confidence that’s been building since the offseason. While the Giants have flown under the radar in recent years, their front office made aggressive moves over the winter to reshape the roster, and the early returns suggest those bets may pay off. At 1–0 to start the season, the Giants are still largely untested, but their mix of veteran talent, young upside, and upgraded defense has the team believing this year could be a turning point. A strong road performance against the Astros would go a long way in cementing that belief. Offensively, the Giants are no longer the anemic lineup they were criticized for during stretches of 2023 and 2024. The additions of Matt Chapman and Willy Adames have transformed the infield into a legitimate source of power and stability. Chapman, a Gold Glove third baseman with 30-home-run upside, not only anchors the hot corner defensively but also adds a needed right-handed bat with postseason experience. Adames, meanwhile, gives the Giants a strong presence at shortstop—both in terms of leadership and clutch hitting. His ability to hit for power while playing solid defense makes him a valuable asset in tight, low-scoring games like the one they may find themselves in against Houston. In the outfield, the Giants have a reliable if not flashy trio. Mike Yastrzemski, Heliot Ramos, and Austin Slater offer defensive range and situational hitting, with Ramos in particular being a name to watch as he continues to develop at the major league level. Thairo Estrada has been a sparkplug in the lineup, capable of hitting at the top or bottom of the order, and offering contact, speed, and defensive versatility. Wilmer Flores continues to be a steady veteran bat, capable of filling in at first or DH and producing consistent at-bats against both righties and lefties.

Starting for San Francisco is Jordan Hicks, a converted reliever whose journey from flamethrowing bullpen arm to rotation piece is one of the more intriguing stories in baseball. Hicks, a Houston native, is making his first start of the season—and doing so in front of friends and family in his hometown. His fastball routinely touches 100 mph, but it’s his improved command and development of secondary pitches, especially a slider and changeup, that have scouts and fans optimistic. If Hicks can give the Giants five to six innings while limiting walks, his raw stuff can dominate even the best lineups—though he’ll need to be sharp against a Houston squad still trying to break out offensively. The Giants’ bullpen remains a strength, with Camilo Doval in the closer role and strong middle relief from Tyler Rogers and Luke Jackson. With the improved defense behind them, the pitching staff can now pitch to contact more confidently without worrying about unearned runs undermining strong outings. Overall, the Giants are a team on the rise. This early-season game against a historically elite Astros club is an opportunity to show that San Francisco’s new roster construction isn’t just theoretical—it’s functional. With better defense, a deeper lineup, and an electric starter on the mound, the Giants are quietly becoming a team worth watching in the National League. A win in Houston would be a powerful early message to the rest of the league.

The San Francisco Giants will face the Houston Astros on April 2, 2025, at Daikin Park in Houston, Texas. This game marks the conclusion of a three-game series between the two teams. San Francisco vs Houston AI Prediction: Free MLB Betting Insights for Apr 02. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Houston Astros MLB Preview

The Houston Astros enter their April 2, 2025, matchup against the San Francisco Giants under unusual early-season pressure. Once a dominant force in the American League, the Astros find themselves struggling to find their offensive rhythm, having scored just eight total runs in their first four games. That kind of output is a far cry from the high-powered, efficient lineups Houston fans have grown used to over the last decade. Though it’s still early, the lack of production has created unease and raised questions about whether the post-Kyle Tucker, post-Alex Bregman era can still carry the franchise to October. The most notable change this year has been the reshuffling of Houston’s core. With Tucker now in Chicago and off to a scorching start, the Astros’ front office responded by bringing in first baseman Christian Walker and rookie infielder Cam Smith, while also signing Brendan Rodgers to play second base. The decision to move José Altuve to left field marked the end of an era in some ways, but also showed a willingness to reimagine how the team is constructed. Altuve, still a leader in the clubhouse, has embraced the role shift and remains an offensive contributor, but there’s no doubt the lineup is thinner without the star power and home-run threat Tucker brought to the middle of the order. The Astros’ slow offensive start is especially concerning given their typically hot April form in previous seasons. Yordan Alvarez has been quiet, Jeremy Peña hasn’t found his groove yet, and the supporting cast hasn’t been able to fill the gap. Houston currently ranks at the bottom of the league in total bases, slugging percentage, and OPS—numbers that highlight just how out of sync this group has been.

If there’s a game where the bats need to come alive, it’s this one, especially against a Giants team that has historically given Houston trouble. Pitching, however, has been more of a bright spot. Starting pitcher Ronel Blanco, who takes the mound in this series finale, had a breakout 2024 season and is quickly becoming one of the more reliable arms in Houston’s rotation. Blanco went 15-7 last year with a 3.31 ERA, using a well-located fastball and sharp changeup to generate ground balls and weak contact. The Astros will need a strong outing from him to suppress a Giants lineup that features big bats like Matt Chapman, Wilmer Flores, and Willy Adames. Houston’s bullpen remains solid, anchored by Ryan Pressly and Bryan Abreu in the late innings. Though they’ve yet to be tested much this season due to the team’s lack of leads, the bullpen is expected to remain a strength if the offense can begin to give them situations to close out. Defensively, the Altuve move to left field has added some range and flexibility, though the infield chemistry is still forming. Brendan Rodgers is solid but still adjusting to Houston’s defensive schemes. Behind the plate, catcher Yainer Diaz is developing into a more consistent receiver and has shown flashes of offensive upside. Ultimately, this game represents a pivotal point for the Astros. A win would steady the narrative and give the team something to build on heading into the next series. But a continued offensive drought at home could signal deeper issues—and prompt early-season roster reevaluation. The crowd at Daikin Park will be watching closely, hoping for a spark from a team that needs to remind everyone they still know how to win.

San Francisco vs. Houston Prop Picks (AI)

AI algorithm Remi is pouring through tons of datapoints on each team. In fact, anytime the Giants and Astros play there’s always several intriguing observations to key in on. Not to mention games played at Daikin Park in Apr rarely follow normal, predictable patterns.
Remi's searched hard and found the best prop for this matchup: T. Fitzgerald over 0.5 Total Bases.

San Francisco vs. Houston Prediction (AI)

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Remi, our AI sports genius, has been pouring over tons of data from every past game between the Giants and Astros and using recursive machine learning and industry leading AI to boil down the data to a single cover probability.

Oddly enough, we’ve seen the AI has been most keyed in on the trending emphasis human bettors often put on player performance factors between a Giants team going up against a possibly rested Astros team. In reality, the true game analytics might reflect a strong lean against one Vegas line specifically.

Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.

Below is our current AI San Francisco vs Houston picks, computer picks Giants vs Astros, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
MLB 9/26 DET@BOS UNLOCK THIS PICK 5 EXECUTIVE Locked EXECUTIVE
MLB 9/26 BAL@NYY UNLOCK THIS PICK 4 INTEL Locked INTEL
MLB 9/26 ARI@SD UNLOCK THIS PICK 4 EXECUTIVE Locked EXECUTIVE
MLB 9/26 NYM@MIA UNLOCK THIS PICK 1 INTEL Locked INTEL
MLB 9/26 NYM@MIA GET FREE PICK NOW 1
MLB 9/26 COL@SF UNLOCK THIS PICK 0 INTEL Locked INTEL

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.

Giants Betting Trends

The Giants have covered the spread in 65% of their recent games.

Astros Betting Trends

The Astros have a .480 winning percentage against the Giants over 63 seasons, with 354 wins and 384 losses.

Giants vs. Astros Matchup Trends

In recent years, the Giants have won two out of three games in each of the past three series against the Astros.

San Francisco vs. Houston Game Info

San Francisco vs Houston starts on April 02, 2025 at 4:10 PM EST.

Spread: Houston -1.5
Moneyline: San Francisco +142, Houston -168
Over/Under: 8

San Francisco: (4-1)  |  Houston: (2-3)

Remi's searched hard and found the best prop for this matchup: T. Fitzgerald over 0.5 Total Bases.. Prices move—always shop for the best number.

In recent years, the Giants have won two out of three games in each of the past three series against the Astros.

SF trend: The Giants have covered the spread in 65% of their recent games.

HOU trend: The Astros have a .480 winning percentage against the Giants over 63 seasons, with 354 wins and 384 losses.

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

San Francisco vs. Houston Odds

AI algorithm Remi is pouring through loads of data on each player. In fact, anytime the San Francisco vs Houston trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme altitude seemingly never follow normal, predictable betting trends.

San Francisco vs Houston Opening Odds

SF Moneyline: +142
HOU Moneyline: -168
SF Spread: +1.5
HOU Spread: -1.5
Over/Under: 8

San Francisco vs Houston Live Odds

Games PTS ML SPR O/U
Sep 27, 2025 1:06PM EDT
Baltimore Orioles
New York Yankees
9/27/25 1:06PM
Orioles
Yankees
+192
-235
+1.5 (-110)
-1.5 (-110)
O 9 (+100)
U 9 (-120)
Sep 27, 2025 2:21PM EDT
St Louis Cardinals
Chicago Cubs
9/27/25 2:21PM
Cardinals
Cubs
 
-178
 
-1.5 (+115)
O 9.5 (+100)
U 9.5 (-120)
Sep 27, 2025 3:09PM EDT
Tampa Bay Rays
Toronto Blue Jays
9/27/25 3:09PM
Rays
Blue Jays
+135
-160
+1.5 (-160)
-1.5 (+135)
O 8.5 (-110)
U 8.5 (-110)
Sep 27, 2025 4:06PM EDT
Chicago White Sox
Washington Nationals
9/27/25 4:06PM
White Sox
Nationals
+100
-120
+1.5 (-205)
-1.5 (+170)
O 8.5 (-110)
U 8.5 (-110)
Sep 27, 2025 4:06PM EDT
Colorado Rockies
San Francisco Giants
9/27/25 4:06PM
Rockies
Giants
+192
-235
+1.5 (-110)
-1.5 (-110)
O 8 (-105)
U 8 (-115)
Sep 27, 2025 4:11PM EDT
New York Mets
Miami Marlins
9/27/25 4:11PM
Mets
Marlins
-130
+110
-1.5 (+130)
+1.5 (-155)
O 8 (-120)
U 8 (+100)
Sep 27, 2025 4:11PM EDT
Detroit Tigers
Boston Red Sox
9/27/25 4:11PM
Tigers
Red Sox
+110
-130
+1.5 (-190)
-1.5 (+158)
O 9 (+100)
U 9 (-120)
Sep 27, 2025 6:05PM EDT
Minnesota Twins
Philadelphia Phillies
9/27/25 6:05PM
Twins
Phillies
+175
-210
+1.5 (-120)
-1.5 (+100)
O 8.5 (-115)
U 8.5 (-105)
Sep 27, 2025 7:11PM EDT
Cincinnati Reds
Milwaukee Brewers
9/27/25 7:11PM
Reds
Brewers
+115
-135
+1.5 (-190)
-1.5 (+158)
O 7.5 (-120)
U 7.5 (+100)
Sep 27, 2025 7:15PM EDT
Pittsburgh Pirates
Atlanta Braves
9/27/25 7:15PM
Pirates
Braves
+150
-178
+1.5 (-145)
-1.5 (+122)
O 8 (-110)
U 8 (-110)
Sep 27, 2025 7:16PM EDT
Texas Rangers
Cleveland Guardians
9/27/25 7:16PM
Rangers
Guardians
+122
-145
+1.5 (-190)
-1.5 (+158)
O 7 (-120)
U 7 (+100)
Sep 27, 2025 8:40PM EDT
Arizona Diamondbacks
San Diego Padres
9/27/25 8:40PM
Diamondbacks
Padres
+118
-140
+1.5 (-190)
-1.5 (+158)
O 7.5 (-115)
U 7.5 (-105)
Sep 27, 2025 9:39PM EDT
Houston Astros
Los Angeles Angels
9/27/25 9:39PM
Astros
Angels
-145
+122
-1.5 (+115)
+1.5 (-135)
O 9 (-110)
U 9 (-110)
Sep 27, 2025 9:41PM EDT
Los Angeles Dodgers
Seattle Mariners
9/27/25 9:41PM
Dodgers
Mariners
+110
-130
+1.5 (-205)
-1.5 (+170)
O 7 (-120)
U 7 (+100)
Sep 27, 2025 10:05PM EDT
Kansas City Royals
Oakland Athletics
9/27/25 10:05PM
Royals
Athletics
+100
-120
+1.5 (-195)
-1.5 (+162)
O 10 (-110)
U 10 (-110)

MLB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers San Francisco Giants vs. Houston Astros on April 02, 2025 at Daikin Park.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN
CHC@SF CHC -105 54.1% 4 LOSS
NYY@CHW RYAN MCMAHON OVER 0.5 BASES 54.1% 4 WIN
PHI@NYM OVER 8.5 55.6% 4 LOSS
LAA@TEX LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS 54.1% 4 LOSS
KC@CHW KC -109 54.2% 4 WIN
SD@SEA DYLAN CEASE OVER 16.5 OUTS 53.9% 3 LOSS
SD@SEA UNDER 8.5 54.4% 4 LOSS
MIN@TOR JOE RYAN UNDER 2.5 EARNED RUNS 54.1% 4 LOSS
SF@MIL MIL +100 54.0% 6 LOSS
TOR@MIA MIA +1.5 62.0% 6 WIN
CHC@LAA OVER 9.5 54.9% 4 LOSS
BOS@NYY CARLOS RODON UNDER 4.5 HITS ALLOWED 54.2% 4 WIN
KC@DET DET -115 56.1% 5 WIN
CHC@LAA LAA +1.5 57.6% 5 LOSS
CIN@ARI KEBRYAN HAYES STRIKEOUTS UNDER 0.5 56.2% 6 WIN
LAD@SD SD +110 50.9% 6 WIN