Twins vs Cardinals Prediction — AI Finds CAN'T MISS MLB Lines & Props (Mar 29)

Updated: 2025-03-27T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The Minnesota Twins are set to face the St. Louis Cardinals on March 29, 2025, at Busch Stadium in St. Louis. Both teams aim to start the season strong, with the Twins looking to capitalize on their offensive strengths and the Cardinals focusing on their pitching depth.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Mar 29, 2025

Start Time: 2:15 PM EST​

Venue: Busch Stadium​

Cardinals Record: (1-0)

Twins Record: (0-1)

OPENING ODDS

MIN Moneyline: -123

STL Moneyline: +104

MIN Spread: -1.5

STL Spread: +1.5

Over/Under: 7.5

MIN
Betting Trends

  • In the 2024 season, the Twins were favored in 106 games, winning 59, which equates to a 55.7% success rate.

STL
Betting Trends

  • The Cardinals played as underdogs in 82 games during the 2024 season, securing victory in 42 of those contests, resulting in a 51.2% win rate.

MATCHUP TRENDS

  • The Twins have demonstrated a strong performance when favored, winning 55.7% of such games in the 2024 season.

MIN vs. STL
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: J. Walker over 0.5 Hits+Runs+RBI.

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Minnesota vs St. Louis Prediction & Odds:
Free MLB Betting Insights for 3/29/25

The upcoming matchup between the Minnesota Twins and the St. Louis Cardinals on March 29, 2025, at Busch Stadium, promises to be a compelling contest as both teams seek to establish early-season momentum. The Twins, coming off an 82-80 record in 2024, have made strategic adjustments to enhance their performance. Central to their success is the health and productivity of key hitters Carlos Correa, Byron Buxton, and Royce Lewis, who collectively missed significant time due to injuries last season. Their presence in the lineup is crucial for the Twins to improve upon their offensive output. The Cardinals, finishing 2024 with an 83-79 record, have focused on bolstering their pitching staff. The departure of Paul Goldschmidt to the New York Yankees leaves a void in their lineup, placing additional pressure on Nolan Arenado to lead the offense. Arenado, who hit 16 home runs in 2024, will need to elevate his performance to compensate for the loss of Goldschmidt’s production. On the mound, the Twins are expected to start right-hander Pablo López, who secured 15 wins in 2024 despite posting his highest ERA since 2019.

López’s ability to rebound and provide stability to the rotation will be pivotal for Minnesota’s success. The Cardinals are likely to counter with veteran righty Sonny Gray, known for his consistency and experience, aiming to set a positive tone for the season. Defensively, both teams have areas to address. The Cardinals ranked 20th in ERA (4.15) during the 2024 season, indicating room for improvement in their pitching effectiveness. The Twins, while demonstrating strong pitching depth, will need to ensure their bullpen can maintain leads and close out games effectively. This game also marks the beginning of a six-game road trip for the Twins, encompassing three games in St. Louis followed by three against the Chicago White Sox. Starting the season on the road presents challenges, but a strong showing could provide the momentum needed for a successful campaign. In summary, the March 29 matchup between the Minnesota Twins and the St. Louis Cardinals is set to be an intriguing early-season encounter. Both teams have made significant adjustments and will be eager to showcase their improvements. Fans can anticipate a competitive game as these clubs strive to set a positive trajectory for the 2025 season.

Minnesota Twins MLB Preview

The Minnesota Twins come into their March 29, 2025, matchup against the St. Louis Cardinals at Busch Stadium with renewed energy and a clear mission to reassert themselves as a playoff contender following an uneven 82-80 finish in the 2024 season that saw flashes of brilliance undermined by persistent injury troubles and offensive inconsistency. The return to full health of franchise cornerstones Carlos Correa, Byron Buxton, and Royce Lewis represents perhaps the biggest upgrade the Twins could have hoped for heading into the new season, as all three missed significant time last year and are now back to provide leadership, defensive strength, and dynamic offensive production. Correa, the steady shortstop and veteran presence, looks to rebound from a down offensive year while anchoring the infield, Buxton remains one of baseball’s most electrifying athletes when healthy and is returning to center field duties after primarily serving as a DH last season, and Lewis brings young star potential at the hot corner, having shown his impact in limited time with clutch hitting and high baseball IQ. The lineup is further supported by Max Kepler, who found his power stroke late last season, and Edouard Julien, who is developing into a reliable on-base threat at the top of the order. Joey Gallo and Matt Wallner offer left-handed pop, giving manager Rocco Baldelli the ability to mix and match based on opposing pitching.

On the mound, the Twins will send right-hander Pablo López to start against the Cardinals, following a 2024 season in which he earned 15 wins and threw over 180 innings but also recorded his highest ERA since 2019, largely due to a rough stretch in the second half. López worked extensively in the offseason to refine his changeup and improve his command in high-leverage situations, and he remains the staff’s ace thanks to his strike-throwing ability and calm demeanor. The Twins’ rotation behind him includes the promising Joe Ryan, who led the team in strikeouts last season, and veteran Chris Paddack, who is finally healthy after a long recovery from Tommy John surgery. The bullpen, long a strong suit for Minnesota, returns standout closer Jhoan Duran and late-inning weapons like Griffin Jax and Brock Stewart, forming a high-velocity, high-leverage trio capable of closing out tight games. The Twins emphasized improved base running, defensive positioning, and plate discipline during spring training, hoping to cut down on the inconsistency that plagued their offense last year. Opening the season on the road presents a tough challenge, especially in a ballpark like Busch Stadium, but the Twins view this series as a chance to set the tone early and shake off the bad habits of 2024. If López can deliver a quality start and the offense, led by a healthy trio of Correa, Buxton, and Lewis, finds rhythm against Cardinals starter Sonny Gray, Minnesota will have a solid opportunity to begin their six-game road trip with a statement win and establish themselves as a team ready to contend again in the American League Central.

The Minnesota Twins are set to face the St. Louis Cardinals on March 29, 2025, at Busch Stadium in St. Louis. Both teams aim to start the season strong, with the Twins looking to capitalize on their offensive strengths and the Cardinals focusing on their pitching depth. Minnesota vs St. Louis AI Prediction: Free MLB Betting Insights for Mar 29. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

St. Louis Cardinals MLB Preview

The St. Louis Cardinals enter the March 29, 2025, matchup against the Minnesota Twins at Busch Stadium looking to build early-season momentum after finishing the 2024 campaign with a respectable but ultimately underwhelming 83-79 record that left them short of the postseason in a competitive National League. The departure of longtime cornerstone Paul Goldschmidt, who signed with the New York Yankees in the offseason, marked a significant shift for the franchise and created a leadership and production gap in the lineup, one that third baseman Nolan Arenado is now expected to fill as the team’s offensive focal point. Arenado, who hit 16 home runs and drove in 73 runs in 2024, has acknowledged the need to elevate his performance, especially in the absence of Goldschmidt’s power bat, and he’ll be supported by emerging contributors like Alec Burleson, Brendan Donovan, and Lars Nootbaar, all of whom showed flashes of offensive potential last season. Burleson, in particular, is being counted on to make a leap after a strong spring training where he displayed improved plate discipline and gap-to-gap hitting. The Cardinals have also added depth to their infield and outfield rotations, giving manager Oliver Marmol more flexibility in lineups and matchups depending on opposing pitchers. On the mound, the team will turn to veteran right-hander Sonny Gray to start against Minnesota, following a solid 2024 campaign in which he posted an 11-8 record with a 3.91 ERA, while continuing to be one of the more reliable arms in the league in terms of innings and durability.

Gray’s ability to generate soft contact and command both sides of the plate makes him a steady presence at the front of the rotation, especially important early in the season as the bullpen settles into defined roles. Speaking of the bullpen, it was a point of concern last year, but offseason efforts to address those shortcomings appear promising, with improved depth and competition for high-leverage innings coming from both veteran holdovers and newly promoted relievers. The Cardinals also emphasized defense and fundamentals during spring training, aiming to clean up an area that proved costly in close games last season, and their staff continues to preach aggressive but smart base running and tighter defensive alignments. The atmosphere at Busch Stadium remains energized, and fans are eager to see how this reshaped roster performs against a Twins team that similarly seeks a bounce-back year. Opening the season at home offers a key opportunity to establish rhythm and confidence, particularly with divisional matchups looming in early April. While expectations are tempered slightly following the loss of a franchise icon, the Cardinals believe their balanced mix of veteran leadership, rising talent, and reliable pitching positions them to be a legitimate postseason contender once again. This game will serve as an early measuring stick not only for Arenado and Gray but also for the organization’s offseason blueprint and their ability to transition into a new era of Cardinals baseball with purpose and competitive fire.

Minnesota vs. St. Louis Prop Picks (AI)

AI algorithm Remi is pouring through loads of data on each player. In fact, anytime the Twins and Cardinals play there’s always several intriguing angles to key in on. Not to mention games played at Busch Stadium in Mar rarely follow normal, predictable patterns.
Remi's searched hard and found the best prop for this matchup: J. Walker over 0.5 Hits+Runs+RBI.

Minnesota vs. St. Louis Prediction (AI)

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Remi, our AI sports wizard, has been pouring over mountains of data from every past game between the Twins and Cardinals and using recursive machine learning and industry leading AI to boil down the data to a single cover probability.

Interestingly enough, the data has been most watching on the trending emphasis knucklehead sportsbettors regularly put on Minnesota’s strength factors between a Twins team going up against a possibly rested Cardinals team. We’ve found the true game analytics appear to reflect a slight lean against one Vegas line in particular.

Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.

Below is our current AI Minnesota vs St. Louis picks, computer picks Twins vs Cardinals, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.

Twins Betting Trends

In the 2024 season, the Twins were favored in 106 games, winning 59, which equates to a 55.7% success rate.

Cardinals Betting Trends

The Cardinals played as underdogs in 82 games during the 2024 season, securing victory in 42 of those contests, resulting in a 51.2% win rate.

Twins vs. Cardinals Matchup Trends

The Twins have demonstrated a strong performance when favored, winning 55.7% of such games in the 2024 season.

Minnesota vs. St. Louis Game Info

Minnesota vs St. Louis starts on March 29, 2025 at 2:15 PM EST.

Spread: St. Louis +1.5
Moneyline: Minnesota -123, St. Louis +104
Over/Under: 7.5

Minnesota: (0-1)  |  St. Louis: (1-0)

Remi's searched hard and found the best prop for this matchup: J. Walker over 0.5 Hits+Runs+RBI.. Prices move—always shop for the best number.

The Twins have demonstrated a strong performance when favored, winning 55.7% of such games in the 2024 season.

MIN trend: In the 2024 season, the Twins were favored in 106 games, winning 59, which equates to a 55.7% success rate.

STL trend: The Cardinals played as underdogs in 82 games during the 2024 season, securing victory in 42 of those contests, resulting in a 51.2% win rate.

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

Minnesota vs. St. Louis Odds

AI algorithm Remi is pouring through loads of data on each line. In fact, anytime the Minnesota vs St. Louis trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme altitude can often follow normal, predictable patterns.

Minnesota vs St. Louis Opening Odds

MIN Moneyline: -123
STL Moneyline: +104
MIN Spread: -1.5
STL Spread: +1.5
Over/Under: 7.5

Minnesota vs St. Louis Live Odds

Games PTS ML SPR O/U
Oct 19, 2025 8:04PM EDT
Seattle Mariners
Toronto Blue Jays
10/19/25 8:04PM
Mariners
Blue Jays
+112
-123
+1.5 (-195)
-1.5 (+171)
O 7.5 (-114)
U 7.5 (-101)

MLB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Minnesota Twins vs. St. Louis Cardinals on March 29, 2025 at Busch Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
TOR@SEA OVER 7 54.9% 3 WIN
LAD@MIL UNDER 7.5 56.6% 6 WIN
TOR@NYY OVER 8 54.9% 4 WIN
TOR@NYY CARLOS RODON OVER 1.5 TOTAL WALKS ALLOWED 53.3% 3 WIN
NYY@TOR OVER 7.5 54.8% 2 WIN
LAD@PHI OVER 7 53.8% 3 WIN
SD@CHC CHC -109 53.8% 3 WIN
SD@CHC OVER 7.5 54.5% 4 LOSS
SD@CHC CHC -111 54.8% 4 LOSS
CIN@LAD SHOHEI OHTANI OVER 1.5 BASES 53.5% 3 WIN
BOS@NYY OVER 7 53.8% 3 LOSS
CIN@LAD ELLY DE LA CRUZ OVER 0.5 BASES 54.4% 4 LOSS
ARI@SD SD -131 57.3% 4 WIN
DET@BOS BOS -115 56.4% 5 WIN
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN
CHC@SF CHC -105 54.1% 4 LOSS
NYY@CHW RYAN MCMAHON OVER 0.5 BASES 54.1% 4 WIN