Cubs vs. Diamondbacks
Prediction, Odds & Props
Mar 29 | MLB AI Picks

Updated: 2025-03-27T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The Chicago Cubs are set to face the Arizona Diamondbacks on March 29, 2025, at Chase Field in Phoenix, Arizona. This matchup marks the third game in a four-game series between the two teams.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Mar 29, 2025

Start Time: 8:10 PM EST​

Venue: Chase Field​

Diamondbacks Record: (1-1)

Cubs Record: (1-3)

OPENING ODDS

CHC Moneyline: +101

ARI Moneyline: -121

CHC Spread: +1.5

ARI Spread: -1.5

Over/Under: 8.5

CHC
Betting Trends

  • In the 2024 season, the Cubs had a 48.9% win rate in games where they were favored on the moneyline, with a record of 22-23.

ARI
Betting Trends

  • The Diamondbacks concluded the 2024 season with a 55.2% win rate as underdogs, winning 32 out of 58 such games.

MATCHUP TRENDS

  • Historically, the Diamondbacks have held an advantage over the Cubs, winning six of their last ten meetings. Additionally, the total runs scored went under the projected total in seven of those ten games.

CHC vs. ARI
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: S. Suzuki over 0.5 Total Bases.

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Chicago Cubs vs Arizona Prediction & Odds:
Free MLB Betting Insights for 3/29/25

The upcoming game between the Chicago Cubs and the Arizona Diamondbacks on March 29, 2025, at Chase Field, presents an intriguing contest between two teams with postseason aspirations. Both organizations have made significant offseason moves to bolster their rosters, setting the stage for a competitive series. The Cubs enter this matchup with a revamped lineup featuring key additions aimed at enhancing both their offensive and defensive capabilities. The departure of Cody Bellinger in the offseason raised concerns among fans, but the front office addressed these by strengthening the bullpen and adding depth to the rotation. Players like Kyle Tucker, Miguel Amaya, and Pete Crow-Armstrong are expected to make significant contributions this season. The starting rotation, featuring Shōta Imanaga, Justin Steele, Jameson Taillon, Matthew Boyd, and Ben Brown, is anticipated to perform well. The Cubs’ bullpen, which was a major issue in 2024, has seen improvements and is expected to be more reliable this season. With the National League Central division appearing relatively weakened, the Cubs are poised for a potential 90-win season, aiming for a postseason run. On the other side, the Diamondbacks are determined to return to the postseason after narrowly missing out in 2024. Their offseason was highlighted by the acquisition of ace right-hander Corbin Burnes, who signed a significant $210 million contract to lead the rotation alongside Zac Gallen and Merrill Kelly. Offensively, the Diamondbacks are banking on the continued development of young outfielder Corbin Carroll, who had a promising rookie season, and the consistent performance of veterans like Ketel Marte and Eugenio Suárez.

The team aims to capitalize on their home-field advantage at Chase Field, where they have historically performed well against the Cubs. The pitching matchup for this game features Cubs’ left-hander Shōta Imanaga making his season debut against Diamondbacks’ right-hander Brandon Pfaadt. Imanaga, a highly touted acquisition from Japan, brings a diverse pitch arsenal and is expected to play a pivotal role in the Cubs’ rotation. Pfaadt, on the other hand, is looking to build upon his experiences from the previous season and establish himself as a reliable starter for Arizona. Defensively, both teams have made adjustments to enhance their fielding efficiency. The Cubs’ infield defense is bolstered by the presence of Nico Hoerner at second base, although he is currently recovering from forearm surgery and is expected to miss the early part of the season. In his absence, players like Jon Berti or Vidal Brujan may fill in. The outfield defense is strengthened by the addition of Pete Crow-Armstrong, known for his exceptional range and glove work. The Diamondbacks counter with a solid defensive lineup featuring Marte’s versatility and Carroll’s speed in the outfield, aiming to limit the Cubs’ offensive opportunities. In terms of betting trends, the Diamondbacks have a slight historical edge over the Cubs, winning six of their last ten meetings. Additionally, seven of those ten games have gone under the projected total, indicating a tendency towards lower-scoring affairs when these teams clash. Bettors may consider these trends when evaluating over/under wagers for this matchup. Overall, this game promises to be a closely contested battle between two teams eager to assert themselves early in the season. Fans can anticipate a blend of strategic pitching, dynamic offense, and solid defense as the Cubs and Diamondbacks vie for supremacy in this pivotal early-season matchup.

Chicago Cubs Cubs MLB Preview

The Chicago Cubs enter their March 29, 2025, matchup against the Arizona Diamondbacks at Chase Field carrying both the weight of last season’s near-miss and the optimism of a strengthened roster aimed squarely at postseason contention in the National League Central. After finishing the 2024 campaign at 83-79 and narrowly missing the playoffs, the Cubs front office took an aggressive stance in the offseason, making several key acquisitions and structural improvements designed to shore up the rotation, stabilize the bullpen, and reinforce the lineup following the departure of star outfielder Cody Bellinger. Leading those offseason moves was the signing of Japanese southpaw Shōta Imanaga, who brings international pedigree, a diverse pitch mix, and top-of-the-rotation potential; Imanaga is set to make his regular-season debut in this game and is expected to be a major factor in the Cubs’ campaign going forward. Alongside Imanaga, the rotation includes breakout lefty Justin Steele, veteran right-hander Jameson Taillon, newly added Matthew Boyd, and young flamethrower Ben Brown, creating a staff that can challenge any opponent with a variety of looks and pitch styles. The bullpen, which was a persistent problem in 2024, has also been revamped and is expected to feature more depth and defined roles with the addition of experienced arms and the continued growth of relievers like Adbert Alzolay and Julian Merryweather.

Offensively, the Cubs will look to cover the absence of Bellinger with a mix of young talent and proven contributors, headlined by slugging first baseman Michael Busch, who was acquired in a trade and is projected to bring both power and patience to the middle of the order. Seiya Suzuki, who closed 2024 with a strong second half, returns as the everyday right fielder and is expected to take on a greater offensive load, while Ian Happ continues to provide stability and versatility in left field. The infield will be anchored by Nico Hoerner—once healthy following early-season forearm surgery—and Dansby Swanson, whose defense and leadership remain invaluable to the club. Until Hoerner’s return, offseason additions like Jon Berti and Vidal Bruján are expected to fill key roles at second base and provide speed and flexibility off the bench. One of the biggest developments is the elevation of top prospect Pete Crow-Armstrong, who is expected to start regularly in center field and brings elite defensive ability and base-stealing speed, even as his bat continues to adjust to major league pitching. The Cubs are also excited about the upside of catcher Miguel Amaya, whose growing comfort behind the plate and raw offensive skills give Chicago a promising long-term option at the position. Managed by Craig Counsell in his first full season with the club, the Cubs are embracing a more aggressive and situationally aware brand of baseball focused on run prevention, smart baserunning, and lineup flexibility. Although the Diamondbacks hold a slight edge in recent head-to-head meetings, Chicago’s revamped roster, improved pitching depth, and renewed energy suggest they are ready to compete with playoff-caliber teams on the road and are hungry to prove that 2025 is the year they reclaim their place atop the National League landscape.

The Chicago Cubs are set to face the Arizona Diamondbacks on March 29, 2025, at Chase Field in Phoenix, Arizona. This matchup marks the third game in a four-game series between the two teams. Chicago Cubs vs Arizona AI Prediction: Free MLB Betting Insights for Mar 29. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Arizona Diamondbacks MLB Preview

The Arizona Diamondbacks enter their March 29, 2025, home matchup against the Chicago Cubs with strong expectations and a retooled roster aiming to return to the postseason after narrowly missing out in 2024. The D-backs, who just a year ago fell one game short of securing a National League Wild Card spot, responded with an aggressive offseason highlighted by the blockbuster signing of former Cy Young Award winner Corbin Burnes, who joins Zac Gallen and Merrill Kelly in what now stands as one of the National League’s top rotations. Burnes’ $210 million deal makes him the new ace in the desert, providing Arizona with a dominant right-hander capable of stopping any lineup in its tracks, while Kelly continues to serve as a model of consistency, and Gallen brings frontline strikeout stuff and All-Star credentials. Brandon Pfaadt, the expected starter against the Cubs, will look to solidify his role at the back end of the rotation after showing flashes of brilliance in 2024, and Eduardo Rodríguez rounds out a group that can eat innings and keep games close. Offensively, the Diamondbacks are counting on young superstar Corbin Carroll to continue his ascent after a sensational rookie season that featured elite speed, defensive excellence, and a knack for getting on base. Carroll, who hit .288 with 22 home runs and 45 stolen bases in 2024, is expected to serve as the leadoff sparkplug, setting the table for a deep lineup that includes veteran contributors like Ketel Marte and Eugenio Suárez.

Marte, one of the most versatile and underrated infielders in the National League, remains the heart of the lineup with his gap power and ability to play multiple positions, while Suárez adds a legitimate power threat after hitting 29 home runs last season. The Diamondbacks also improved their infield defense and contact hitting by integrating players like Geraldo Perdomo and Jordan Lawlar, both of whom bring youth and athleticism. In the outfield, Jake McCarthy and Alek Thomas provide additional speed and range, giving Arizona one of the most defensively sound outfield units in baseball. Behind the plate, Gabriel Moreno has emerged as a reliable backstop with strong game-calling skills and offensive upside, further stabilizing the team’s core. Arizona’s bullpen, which struggled with consistency in 2024, has been bolstered with added depth, including the emergence of relievers like Kevin Ginkel and the acquisition of high-leverage arms in the offseason. Manager Torey Lovullo remains a steady hand at the helm, known for his player-first approach and ability to maximize his roster’s strengths. The Diamondbacks finished with a winning record at Chase Field last season and have traditionally fared well at home against the Cubs, winning six of their last ten meetings in Arizona. As they continue their four-game series against Chicago, the Diamondbacks are aiming to capitalize on their home-field advantage and maintain early momentum in what they hope will be a playoff-caliber season. With a strong blend of youth, experience, and pitching depth, Arizona is positioned not only to contend in the NL West but also to make serious noise in the postseason conversation if all elements click in 2025.

Chicago Cubs vs. Arizona Prop Picks (AI)

AI algorithm Remi is pouring through mountains of stats on each team. In fact, anytime the Cubs and Diamondbacks play there’s always several intriguing angles to key in on. Not to mention games played at Chase Field in Mar can often follow normal, predictable betting trends.
Remi's searched hard and found the best prop for this matchup: S. Suzuki over 0.5 Total Bases.

Chicago Cubs vs. Arizona Prediction (AI)

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Remi, our AI sports algorithm, has been pouring over exorbitant amounts of data from every simulation between the Cubs and Diamondbacks and using recursive machine learning and kick-ass AI to examine the data to a single cover probability.

Oddly enough, we’ve seen the AI has been most focused on the linear correlation of factor knucklehead sportsbettors tend to put on player performance factors between a Cubs team going up against a possibly healthy Diamondbacks team. Trends look to say the true game analytics might reflect a slight lean against one Vegas line in particular.

Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.

Below is our current AI Chicago Cubs vs Arizona picks, computer picks Cubs vs Diamondbacks, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.

Cubs Betting Trends

In the 2024 season, the Cubs had a 48.9% win rate in games where they were favored on the moneyline, with a record of 22-23.

Diamondbacks Betting Trends

The Diamondbacks concluded the 2024 season with a 55.2% win rate as underdogs, winning 32 out of 58 such games.

Cubs vs. Diamondbacks Matchup Trends

Historically, the Diamondbacks have held an advantage over the Cubs, winning six of their last ten meetings. Additionally, the total runs scored went under the projected total in seven of those ten games.

Chicago Cubs vs. Arizona Game Info

Chicago Cubs vs Arizona starts on March 29, 2025 at 8:10 PM EST.

Spread: Arizona -1.5
Moneyline: Chicago Cubs +101, Arizona -121
Over/Under: 8.5

Chicago Cubs: (1-3)  |  Arizona: (1-1)

Remi's searched hard and found the best prop for this matchup: S. Suzuki over 0.5 Total Bases.. Prices move—always shop for the best number.

Historically, the Diamondbacks have held an advantage over the Cubs, winning six of their last ten meetings. Additionally, the total runs scored went under the projected total in seven of those ten games.

CHC trend: In the 2024 season, the Cubs had a 48.9% win rate in games where they were favored on the moneyline, with a record of 22-23.

ARI trend: The Diamondbacks concluded the 2024 season with a 55.2% win rate as underdogs, winning 32 out of 58 such games.

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

Chicago Cubs vs. Arizona Odds

AI algorithm Remi is pouring through mountains of data on each line. In fact, anytime the Chicago Cubs vs Arizona trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme temps seemingly never follow normal, predictable betting trends.

Chicago Cubs vs Arizona Opening Odds

CHC Moneyline: +101
ARI Moneyline: -121
CHC Spread: +1.5
ARI Spread: -1.5
Over/Under: 8.5

Chicago Cubs vs Arizona Live Odds

Games PTS ML SPR O/U
Sep 27, 2025 1:06PM EDT
Baltimore Orioles
New York Yankees
9/27/25 1:06PM
Orioles
Yankees
+196
-240
+1.5 (-105)
-1.5 (-115)
O 9 (-105)
U 9 (-115)
Sep 27, 2025 2:21PM EDT
St Louis Cardinals
Chicago Cubs
9/27/25 2:21PM
Cardinals
Cubs
 
-178
 
-1.5 (+115)
O 9.5 (+100)
U 9.5 (-120)
Sep 27, 2025 3:09PM EDT
Tampa Bay Rays
Toronto Blue Jays
9/27/25 3:09PM
Rays
Blue Jays
+135
-160
+1.5 (-155)
-1.5 (+130)
O 8.5 (-105)
U 8.5 (-115)
Sep 27, 2025 4:05PM EDT
Chicago White Sox
Washington Nationals
9/27/25 4:05PM
White Sox
Nationals
+100
-120
+1.5 (-205)
-1.5 (+170)
O 8.5 (-115)
U 8.5 (-105)
Sep 27, 2025 4:06PM EDT
Colorado Rockies
San Francisco Giants
9/27/25 4:06PM
Rockies
Giants
+196
-240
+1.5 (-110)
-1.5 (-110)
O 8 (-105)
U 8 (-115)
Sep 27, 2025 4:11PM EDT
New York Mets
Miami Marlins
9/27/25 4:11PM
Mets
Marlins
-130
+110
-1.5 (+130)
+1.5 (-155)
O 8 (-115)
U 8 (-105)
Sep 27, 2025 4:11PM EDT
Detroit Tigers
Boston Red Sox
9/27/25 4:11PM
Tigers
Red Sox
+110
-130
+1.5 (-190)
-1.5 (+158)
O 9 (+100)
U 9 (-120)
Sep 27, 2025 6:05PM EDT
Minnesota Twins
Philadelphia Phillies
9/27/25 6:05PM
Twins
Phillies
+175
-210
+1.5 (-120)
-1.5 (+100)
O 8.5 (-115)
U 8.5 (-105)
Sep 27, 2025 7:11PM EDT
Cincinnati Reds
Milwaukee Brewers
9/27/25 7:11PM
Reds
Brewers
+115
-135
+1.5 (-190)
-1.5 (+158)
O 7.5 (-120)
U 7.5 (+100)
Sep 27, 2025 7:15PM EDT
Pittsburgh Pirates
Atlanta Braves
9/27/25 7:15PM
Pirates
Braves
+150
-178
+1.5 (-145)
-1.5 (+122)
O 8 (-110)
U 8 (-110)
Sep 27, 2025 7:16PM EDT
Texas Rangers
Cleveland Guardians
9/27/25 7:16PM
Rangers
Guardians
+122
-145
+1.5 (-190)
-1.5 (+158)
O 7 (-120)
U 7 (+100)
Sep 27, 2025 8:40PM EDT
Arizona Diamondbacks
San Diego Padres
9/27/25 8:40PM
Diamondbacks
Padres
+118
-140
+1.5 (-190)
-1.5 (+158)
O 7.5 (-115)
U 7.5 (-105)
Sep 27, 2025 9:39PM EDT
Houston Astros
Los Angeles Angels
9/27/25 9:39PM
Astros
Angels
-140
+118
-1.5 (+115)
+1.5 (-135)
O 9 (-110)
U 9 (-110)
Sep 27, 2025 9:41PM EDT
Los Angeles Dodgers
Seattle Mariners
9/27/25 9:41PM
Dodgers
Mariners
+100
-120
+1.5 (-220)
-1.5 (+180)
O 7 (-120)
U 7 (+100)
Sep 27, 2025 10:05PM EDT
Kansas City Royals
Oakland Athletics
9/27/25 10:05PM
Royals
Athletics
+100
-120
+1.5 (-195)
-1.5 (+162)
O 10 (-115)
U 10 (-105)

MLB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Chicago Cubs Cubs vs. Arizona Diamondbacks on March 29, 2025 at Chase Field.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
ARI@SD SD -131 57.3% 4 WIN
DET@BOS BOS -115 56.4% 5 WIN
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN
CHC@SF CHC -105 54.1% 4 LOSS
NYY@CHW RYAN MCMAHON OVER 0.5 BASES 54.1% 4 WIN
PHI@NYM OVER 8.5 55.6% 4 LOSS
LAA@TEX LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS 54.1% 4 LOSS
KC@CHW KC -109 54.2% 4 WIN
SD@SEA DYLAN CEASE OVER 16.5 OUTS 53.9% 3 LOSS
SD@SEA UNDER 8.5 54.4% 4 LOSS
MIN@TOR JOE RYAN UNDER 2.5 EARNED RUNS 54.1% 4 LOSS
SF@MIL MIL +100 54.0% 6 LOSS
TOR@MIA MIA +1.5 62.0% 6 WIN
CHC@LAA OVER 9.5 54.9% 4 LOSS
BOS@NYY CARLOS RODON UNDER 4.5 HITS ALLOWED 54.2% 4 WIN
KC@DET DET -115 56.1% 5 WIN
CHC@LAA LAA +1.5 57.6% 5 LOSS