Angels vs. White Sox
Prediction, Odds & Props
Mar 27 | MLB AI Picks

Updated: 2025-03-25T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The Los Angeles Angels will kick off their 2025 MLB season on the road against the Chicago White Sox at Guaranteed Rate Field on March 27, 2025, with the first pitch scheduled for 4:10 p.m. ET. Both teams are eager to start the season on a positive note after challenging campaigns in 2024.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Mar 27, 2025

Start Time: 4:10 PM EST​

Venue: Rate Field​

White Sox Record: (0-0)

Angels Record: (0-0)

OPENING ODDS

LAA Moneyline: -154

CHW Moneyline: +129

LAA Spread: -1.5

CHW Spread: +1.5

Over/Under: 8

LAA
Betting Trends

  • In the 2024 season, the Angels struggled when favored, winning only 33.3% of games as moneyline favorites (8 out of 24).

CHW
Betting Trends

  • The White Sox faced difficulties as underdogs in 2024, securing victories in just 21.1% of such games (31 out of 147).

MATCHUP TRENDS

  • The total has gone UNDER in 5 of the White Sox’s last 5 games against the Angels, indicating a trend toward low-scoring encounters between these teams.

LAA vs. CHW
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: L. Robert over 0.5 Total Bases.

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Los Angeles Angels vs Chicago White Sox Prediction & Odds:
Free MLB Betting Insights for 3/27/25

The 2025 MLB season opener features the Los Angeles Angels visiting the Chicago White Sox at Guaranteed Rate Field. Both teams are looking to rebound from disappointing 2024 seasons, with the Angels finishing at 63-99 and the White Sox at 41-121. This Opening Day matchup provides an opportunity for both clubs to set a new tone for the year ahead. The Angels will send left-hander Yusei Kikuchi to the mound. Kikuchi, entering his second season with Los Angeles, aims to provide stability to a rotation that struggled with consistency last year. In 2024, he posted a 4.32 ERA with 150 strikeouts over 160 innings. The Angels’ bullpen has also been bolstered with offseason acquisitions aimed at improving late-game performance. Offensively, the Angels continue to rely on their core lineup, featuring Mike Trout and Anthony Rendon. Trout, despite battling injuries in recent seasons, remains a formidable presence at the plate, while Rendon looks to bounce back after a subpar 2024. The team has also emphasized improving contact rates and reducing strikeouts, addressing areas that hindered offensive production last season. The White Sox will counter with right-hander Sean Burke as their Opening Day starter. Burke, a promising young arm, is making his first Opening Day start after showing potential during his late-season call-up in 2024.

The White Sox are hopeful that Burke can be a cornerstone in their rebuilding rotation. Chicago’s lineup features a mix of veterans and emerging talent. Andrew Vaughn and Luis Robert Jr. are expected to lead the offensive charge, while prospects like Colson Montgomery may see increased roles as the season progresses. The team’s focus during the offseason has been on player development and integrating young talent into the major league roster. Betting odds for the game favor the Angels, with a moneyline of -153, while the White Sox are listed at +128. The over/under is set at 8 runs, reflecting expectations of a moderately low-scoring game. As both teams take the field, fans can anticipate a competitive game that may set the tone for their respective seasons. The Angels will look to leverage their experienced roster and Kikuchi’s performance on the mound, while the White Sox aim to showcase their developing talent and capitalize on home-field advantage to secure a victory.

Los Angeles Angels Angels MLB Preview

The Los Angeles Angels begin the 2025 MLB season with hopes of breaking free from a decade-long stretch of mediocrity and missed playoff appearances. After finishing 63-99 in 2024 and continuing their streak of playoff absences since 2014, the franchise enters the new season with tempered expectations but a sense of opportunity in a relatively open American League West. With Shohei Ohtani no longer in Anaheim, the team has fully transitioned into a post-Ohtani era, re-centering its organizational identity around longtime superstar Mike Trout and a restructured pitching staff. Trout, now entering his 14th full season, remains the face of the franchise, and although injuries have limited his availability in recent years, he’s still capable of elite production when healthy. The Angels have also shifted focus to building around youth and depth, including recent draft picks, younger position players, and a revamped rotation headlined by left-hander Yusei Kikuchi, who will take the mound on Opening Day against the Chicago White Sox. Kikuchi, entering his second season with the Angels after signing a two-year deal in 2024, is coming off a decent campaign where he posted a 4.32 ERA over 160 innings with 150 strikeouts. The Japanese southpaw brings experience and poise to a rotation that has struggled for years with inconsistency and durability issues. With Patrick Sandoval returning from injury and Reid Detmers continuing to develop, the Angels hope they’ve assembled a capable starting unit that can deliver quality innings. Their bullpen has also undergone a modest overhaul, highlighted by the acquisitions of veteran relievers aiming to stabilize the late innings. Carlos Estévez returns as the team’s likely closer, following a solid 2024 in which he notched 28 saves. Supporting him are right-hander Ben Joyce, known for his triple-digit fastball, and José Quijada, who is coming off Tommy John surgery but impressed in camp. Offensively, the Angels still have some firepower.

Trout headlines a lineup that also includes Anthony Rendon, who is looking to bounce back from another injury-plagued season. Rendon’s ability to stay on the field is crucial for the Angels, both financially and competitively, as he remains one of their highest-paid players. Taylor Ward and Mickey Moniak provide athleticism and slugging potential in the outfield, while Logan O’Hoppe, the young catcher acquired from Philadelphia, is expected to take a step forward in 2025 after flashing power and strong game-calling in limited time last year. The team also has high hopes for Nolan Schanuel, a former first-round pick who reached the majors quickly and could become a table-setter at the top of the order thanks to his excellent plate discipline and contact skills. Manager Ron Washington, hired during the offseason, brings a wealth of experience and a reputation for motivating young players and fostering defensive fundamentals. The 71-year-old former Rangers skipper returns to managing with a clear goal: instill discipline, hustle, and smarter baseball in a franchise that has too often underachieved. Washington’s impact was evident in spring training, with players praising the renewed energy and structured environment. Though the Angels were just 8-16 as moneyline favorites in 2024, and expectations remain modest, they enter the season looking to surprise. Their matchup against a rebuilding White Sox squad gives them a chance to start strong. If Kikuchi can deliver a quality start and the offense produces behind Trout and Ward, the Angels may walk away from Opening Day with a much-needed win and a small, but vital, spark to ignite their 2025 campaign.

The Los Angeles Angels will kick off their 2025 MLB season on the road against the Chicago White Sox at Guaranteed Rate Field on March 27, 2025, with the first pitch scheduled for 4:10 p.m. ET. Both teams are eager to start the season on a positive note after challenging campaigns in 2024. Los Angeles Angels vs Chicago White Sox AI Prediction: Free MLB Betting Insights for Mar 27. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Chicago White Sox White Sox MLB Preview

The Chicago White Sox enter the 2025 MLB season with a focus on rebuilding and integrating young talent into their roster. Following a challenging 2024 season that saw them finish with a 41-121 record, the team has made strategic moves to foster development and competitiveness. Leading the rotation is right-hander Sean Burke, who has been named the Opening Day starter. Burke, 24, showed promise during his late-season appearances in 2024, posting a 3.95 ERA over five starts. The organization is optimistic about his potential to anchor the rotation and provide consistent performances throughout the season. Offensively, the White Sox are relying on a combination of established players and emerging prospects. First baseman Andrew Vaughn, who led the team with 22 home runs and 75 RBIs in 2024, remains a central figure in the lineup. Outfielder Luis Robert Jr. adds speed and defensive prowess, aiming to build upon his .265 batting average and 18 stolen bases from last season. The infield sees the addition of prospect Colson Montgomery, a highly regarded shortstop who excelled in the minors with a .290 average and 15 home runs. His integration into the major league roster is part of the team’s broader strategy to develop homegrown talent. Defensively, the White Sox have emphasized improving fielding efficiency and reducing errors that plagued them in the previous season. Spring Training focused heavily on defensive drills and situational awareness to enhance overall team performance. The bullpen has undergone restructuring, with the acquisition of veteran relievers aimed at providing stability in late-game situations. Closer Liam Hendriks returns after a season hampered by injuries, looking to reclaim his All-Star form and anchor the relief corps. Off the field, the White Sox have been proactive in engaging fans and enhancing the game-day experience. Opening Day festivities include a ceremonial first pitch by NBA MVP Derrick Rose, player introductions via Ford Broncos, and a flyover by the Illinois Army National Guard. Promotional events throughout the opening series aim to rekindle fan enthusiasm and support. As the season unfolds, the White Sox are committed to a developmental approach, balancing competitiveness with the growth of their young players.

The front office has been clear about their long-term vision: developing a core nucleus of homegrown players, creating a sustainable foundation, and avoiding the pitfalls of past free-agent-heavy strategies that failed to produce consistent success. That means Opening Day is not only about trying to secure a win against the Angels but also about evaluating how well players like Colson Montgomery, Oscar Colás, and Bryan Ramos can transition into everyday contributors at the big-league level. These players, along with others like Korey Lee behind the plate and Lenyn Sosa at second base, will have the opportunity to prove themselves in extended roles this season as Chicago rebuilds from the ground up. Manager Pedro Grifol, retained despite the team’s rough 2024 record, will play a key role in player development, daily preparation, and cultivating accountability across the roster. His emphasis during spring training has been on restoring confidence, consistency, and communication among the team’s younger players, while leaning on veterans like Vaughn, Robert Jr., and Hendriks to serve as clubhouse leaders. The front office also brought in a new analytics department to better assist with matchup-based decision-making and defensive alignments, aiming to bring the franchise up to speed with leaguewide best practices in data-driven coaching. On the pitching side, after the offseason departure of Dylan Cease, the White Sox will give several young arms a shot in the rotation. Sean Burke gets the Opening Day nod after a promising September, and his high-velocity fastball and slider combo give him the tools to be a strikeout-heavy starter. He will need to work on command and keeping the ball in the park, especially at Guaranteed Rate Field, one of the more hitter-friendly venues in MLB. The bullpen will back him up with arms like Gregory Santos and Tanner Banks, and the club hopes that Hendriks can return to being one of the elite closers in the game following his recovery from cancer and subsequent elbow soreness in 2024. From a betting standpoint, the White Sox were among the league’s worst in underdog situations last season, winning only 21.1% of the 147 games where they were not favored. However, they have played the Angels tightly in recent years, with the total going UNDER in each of their last five meetings. This suggests their games tend to be low-scoring, defensive battles — an area where the White Sox could thrive if their pitching outperforms expectations. Opening Day will be a good early indicator of whether the team’s offseason focus on defense, pitching depth, and player development can pay immediate dividends. More importantly, it provides the fans with a fresh start and a glimpse into the potential future of the franchise. Even if 2025 isn’t expected to be a playoff year, the White Sox are laying the foundation for something longer-term, and it all starts with showing progress — inning by inning, game by game — beginning with this home opener against the Angels.

Los Angeles Angels vs. Chicago White Sox Prop Picks (AI)

Remi is pouring through loads of datapoints on each team. In fact, anytime the Angels and White Sox play there’s always several intriguing observations to key in on. Not to mention games played at Rate Field in Mar seemingly never follow normal, predictable betting trends.
Remi's searched hard and found the best prop for this matchup: L. Robert over 0.5 Total Bases.

Los Angeles Angels vs. Chicago White Sox Prediction (AI)

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Remi, our AI sports genius, has been pouring over mountains of data from every past game between the Angels and White Sox and using recursive machine learning and cutting-edge AI to crunch the data to a single cover probability.

Remi has been most focused on the growing emphasis knucklehead sportsbettors regularly put on Los Angeles Angels’s strength factors between a Angels team going up against a possibly healthy White Sox team. It appears the true game analytics might reflect a moderate lean against one Vegas line specifically.

Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.

Below is our current AI Los Angeles Angels vs Chicago White Sox picks, computer picks Angels vs White Sox, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
MLB 9/26 DET@BOS UNLOCK THIS PICK 5 EXECUTIVE Locked EXECUTIVE
MLB 9/26 BAL@NYY UNLOCK THIS PICK 4 INTEL Locked INTEL
MLB 9/26 ARI@SD UNLOCK THIS PICK 4 EXECUTIVE Locked EXECUTIVE
MLB 9/26 NYM@MIA UNLOCK THIS PICK 1 INTEL Locked INTEL
MLB 9/26 NYM@MIA GET FREE PICK NOW 1
MLB 9/26 COL@SF UNLOCK THIS PICK 0 INTEL Locked INTEL

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.

Angels Betting Trends

In the 2024 season, the Angels struggled when favored, winning only 33.3% of games as moneyline favorites (8 out of 24).

White Sox Betting Trends

The White Sox faced difficulties as underdogs in 2024, securing victories in just 21.1% of such games (31 out of 147).

Angels vs. White Sox Matchup Trends

The total has gone UNDER in 5 of the White Sox’s last 5 games against the Angels, indicating a trend toward low-scoring encounters between these teams.

Los Angeles Angels vs. Chicago White Sox Game Info

Los Angeles Angels vs Chicago White Sox starts on March 27, 2025 at 4:10 PM EST.

Spread: Chicago White Sox +1.5
Moneyline: Los Angeles Angels -154, Chicago White Sox +129
Over/Under: 8

Los Angeles Angels: (0-0)  |  Chicago White Sox: (0-0)

Remi's searched hard and found the best prop for this matchup: L. Robert over 0.5 Total Bases.. Prices move—always shop for the best number.

The total has gone UNDER in 5 of the White Sox’s last 5 games against the Angels, indicating a trend toward low-scoring encounters between these teams.

LAA trend: In the 2024 season, the Angels struggled when favored, winning only 33.3% of games as moneyline favorites (8 out of 24).

CHW trend: The White Sox faced difficulties as underdogs in 2024, securing victories in just 21.1% of such games (31 out of 147).

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

Los Angeles Angels vs. Chicago White Sox Odds

Remi is pouring through loads of data on each player. In fact, anytime the Los Angeles Angels vs Chicago White Sox trends are analyzed, there’s always several intriguing trends to key in on. Not to mention games played at extreme hostile environments almost always follow normal, predictable patterns.

Los Angeles Angels vs Chicago White Sox Opening Odds

LAA Moneyline: -154
CHW Moneyline: +129
LAA Spread: -1.5
CHW Spread: +1.5
Over/Under: 8

Los Angeles Angels vs Chicago White Sox Live Odds

Games PTS ML SPR O/U
Sep 27, 2025 1:06PM EDT
Baltimore Orioles
New York Yankees
9/27/25 1:06PM
Orioles
Yankees
+190
-235
+1.5 (-110)
-1.5 (-110)
O 8.5 (-120)
U 8.5 (+100)
Sep 27, 2025 2:21PM EDT
St Louis Cardinals
Chicago Cubs
9/27/25 2:21PM
Cardinals
Cubs
 
-180
 
-1.5 (+115)
O 9.5 (-105)
U 9.5 (-115)
Sep 27, 2025 3:09PM EDT
Tampa Bay Rays
Toronto Blue Jays
9/27/25 3:09PM
Rays
Blue Jays
+130
-155
+1.5 (-155)
-1.5 (+130)
O 8.5 (-110)
U 8.5 (-110)
Sep 27, 2025 4:06PM EDT
Chicago White Sox
Washington Nationals
9/27/25 4:06PM
White Sox
Nationals
+100
-120
-1.5 (+165)
+1.5 (-200)
O 8.5 (-110)
U 8.5 (-110)
Sep 27, 2025 4:06PM EDT
Colorado Rockies
San Francisco Giants
9/27/25 4:06PM
Rockies
Giants
+185
-225
+1.5 (-110)
-1.5 (-110)
O 8 (-105)
U 8 (-115)
Sep 27, 2025 4:11PM EDT
New York Mets
Miami Marlins
9/27/25 4:11PM
Mets
Marlins
-130
+110
-1.5 (+125)
+1.5 (-150)
O 8 (-115)
U 8 (-105)
Sep 27, 2025 4:11PM EDT
Detroit Tigers
Boston Red Sox
9/27/25 4:11PM
Tigers
Red Sox
+125
-150
+1.5 (-180)
-1.5 (+150)
O 9 (+100)
U 9 (-120)
Sep 27, 2025 6:05PM EDT
Minnesota Twins
Philadelphia Phillies
9/27/25 6:05PM
Twins
Phillies
+170
-205
+1.5 (-120)
-1.5 (+100)
O 8.5 (-115)
U 8.5 (-105)
Sep 27, 2025 7:11PM EDT
Cincinnati Reds
Milwaukee Brewers
9/27/25 7:11PM
Reds
Brewers
+125
-150
+1.5 (-180)
-1.5 (+150)
O 8 (-105)
U 8 (-115)
Sep 27, 2025 7:15PM EDT
Pittsburgh Pirates
Atlanta Braves
9/27/25 7:15PM
Pirates
Braves
+145
-175
+1.5 (-155)
-1.5 (+130)
O 8 (-110)
U 8 (-110)
Sep 27, 2025 7:16PM EDT
Texas Rangers
Cleveland Guardians
9/27/25 7:16PM
Rangers
Guardians
+135
-165
+1.5 (-180)
-1.5 (+150)
O 7 (-120)
U 7 (+100)
Sep 27, 2025 8:40PM EDT
Arizona Diamondbacks
San Diego Padres
9/27/25 8:40PM
Diamondbacks
Padres
+115
-140
+1.5 (-195)
-1.5 (+160)
O 7.5 (-120)
U 7.5 (+100)
Sep 27, 2025 9:39PM EDT
Houston Astros
Los Angeles Angels
9/27/25 9:39PM
Astros
Angels
-165
+135
-1.5 (+105)
+1.5 (-125)
O 9 (+100)
U 9 (-120)
Sep 27, 2025 9:41PM EDT
Los Angeles Dodgers
Seattle Mariners
9/27/25 9:41PM
Dodgers
Mariners
+105
-125
+1.5 (-205)
-1.5 (+170)
O 7.5 (+105)
U 7.5 (-125)
Sep 27, 2025 10:05PM EDT
Kansas City Royals
Oakland Athletics
9/27/25 10:05PM
Royals
Athletics
+100
-120
-1.5 (+150)
+1.5 (-180)
O 10 (-110)
U 10 (-110)

MLB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Los Angeles Angels Angels vs. Chicago White Sox White Sox on March 27, 2025 at Rate Field.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN
CHC@SF CHC -105 54.1% 4 LOSS
NYY@CHW RYAN MCMAHON OVER 0.5 BASES 54.1% 4 WIN
PHI@NYM OVER 8.5 55.6% 4 LOSS
LAA@TEX LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS 54.1% 4 LOSS
KC@CHW KC -109 54.2% 4 WIN
SD@SEA DYLAN CEASE OVER 16.5 OUTS 53.9% 3 LOSS
SD@SEA UNDER 8.5 54.4% 4 LOSS
MIN@TOR JOE RYAN UNDER 2.5 EARNED RUNS 54.1% 4 LOSS
SF@MIL MIL +100 54.0% 6 LOSS
TOR@MIA MIA +1.5 62.0% 6 WIN
CHC@LAA OVER 9.5 54.9% 4 LOSS
BOS@NYY CARLOS RODON UNDER 4.5 HITS ALLOWED 54.2% 4 WIN
KC@DET DET -115 56.1% 5 WIN
CHC@LAA LAA +1.5 57.6% 5 LOSS
CIN@ARI KEBRYAN HAYES STRIKEOUTS UNDER 0.5 56.2% 6 WIN
LAD@SD SD +110 50.9% 6 WIN