Guardians vs. Royals
Prediction, Odds & Props
Mar 27 | MLB AI Picks

Updated: 2025-03-25T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The Cleveland Guardians and Kansas City Royals are set to open their 2025 MLB seasons with a matchup at Kauffman Stadium on March 27, 2025, at 4:10 p.m. ET. Both teams aim to build upon their 2024 performances and establish early momentum in the AL Central division.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Mar 27, 2025

Start Time: 4:10 PM EST​

Venue: Kauffman Stadium​

Royals Record: (0-0)

Guardians Record: (0-0)

OPENING ODDS

CLE Moneyline: +110

KC Moneyline: -130

CLE Spread: +1.5

KC Spread: -1.5

Over/Under: 7.5

CLE
Betting Trends

  • In the 2024 season, the Guardians had a record of 5-8 against the Royals.

KC
Betting Trends

  • The Royals concluded the 2024 season with an 86-76 record, surpassing expectations and securing a wild-card berth.

MATCHUP TRENDS

  • The Royals’ remarkable turnaround in 2024, improving from a 106-loss season to winning a postseason series, marked the first time in MLB’s 123-year history that a team achieved such a feat.

CLE vs. KC
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: J. Ramirez over 6 Fantasy Score.

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Cleveland vs Kansas City Prediction & Odds:
Free MLB Betting Insights for 3/27/25

The 2025 MLB season opener between the Cleveland Guardians and the Kansas City Royals promises to be a compelling contest, as both teams seek to assert their dominance in the competitive AL Central division. The Guardians, reigning division champions, aim to defend their title, while the Royals look to build upon their impressive 2024 campaign that saw them secure a wild-card berth. Cleveland’s offense continues to be anchored by star third baseman José Ramírez, whose consistent performance remains pivotal to the team’s success. The Guardians have made strategic roster adjustments, including trading All-Star first baseman Josh Naylor to the Arizona Diamondbacks for pitcher Slade Cecconi, and re-signing veteran Carlos Santana, who enjoyed a successful stint with the Minnesota Twins in 2024. These moves aim to bolster both their lineup and pitching depth. On the mound, the Guardians will rely on a rotation that includes promising arms like Gavin Williams, who is expected to play a significant role in the team’s pitching staff.

The bullpen remains a strength, led by closer Emmanuel Clase, whose dominance in the late innings provides a reliable safety net. The Royals enter the 2025 season with renewed confidence following their historic turnaround in 2024. Key offseason acquisitions such as pitchers Seth Lugo and Michael Wacha, along with outfielder Hunter Renfroe, have strengthened the roster. The emergence of young star Bobby Witt Jr., who posted a remarkable 9.4 bWAR in 2024, has been instrumental in revitalizing the team’s offense. Kansas City’s pitching staff is headlined by Cole Ragans, acquired from the Texas Rangers, who has shown the potential to be a reliable ace. Seth Lugo, coming off a standout 2024 season, adds depth to the rotation. The bullpen features veteran relievers like Will Smith and Chris Stratton, providing experience and stability in high-leverage situations. Defensively, both teams have emphasized improvement. The Guardians’ infield, with Ramírez at third and Andrés Giménez at second, offers a solid foundation. The Royals benefit from the leadership of veteran catcher Salvador Perez, whose experience is invaluable in managing the pitching staff. As the teams take the field for Opening Day, fans can anticipate a competitive game that may set the tone for their respective seasons. The Guardians will look to leverage their blend of seasoned veterans and emerging talent, while the Royals aim to continue their upward trajectory and establish themselves as formidable contenders in the division.

Cleveland Guardians MLB Preview

The Cleveland Guardians enter the 2025 season as the reigning American League Central champions, determined to defend their division crown and extend their recent success despite some key changes to the roster. After finishing 89-73 in 2024 and capturing the AL Central title, the Guardians were eliminated early in the playoffs, but their young core and resilient playing style have made them a consistent presence in postseason conversations. Led by manager Stephen Vogt, who enters his second season at the helm, Cleveland emphasizes pitching, defense, and contact hitting — trademarks that remain integral to their identity entering Opening Day against the Kansas City Royals. While the offseason saw the departure of first baseman Josh Naylor via trade to Arizona, the Guardians quickly addressed the gap by reacquiring veteran slugger Carlos Santana, who returns to Cleveland after hitting 23 home runs with Minnesota last season. Santana’s presence not only provides offensive power from both sides of the plate but also brings invaluable veteran leadership to a clubhouse full of emerging talent. The offense continues to revolve around perennial MVP candidate José Ramírez, who remains one of the most complete players in baseball. In 2024, Ramírez slashed .281/.361/.502 with 29 home runs, 102 RBIs, and 27 stolen bases, showcasing his unique blend of power, speed, and plate discipline. Surrounding him is a lineup that includes Andrés Giménez, a Gold Glove second baseman who adds speed and gap power, and breakout catcher Bo Naylor, who added 19 home runs and significantly improved his defense last year. Center fielder Myles Straw, known for his elite speed and glove, offers range in the outfield and consistent on-base ability near the bottom of the lineup.

The Guardians are also counting on continued development from outfielder Steven Kwan, whose contact-heavy, high-OBP approach complements the lineup’s speed-based identity. Pitching remains the true backbone of the Guardians’ success. The rotation is led by second-year right-hander Gavin Williams, who posted a 3.42 ERA and 165 strikeouts over 153 innings in his rookie season. Triston McKenzie, when healthy, is another key piece who brings strikeout stuff and a deep arsenal. While Shane Bieber was shut down late last season due to shoulder concerns, his progress during spring training has provided hope he can return to form as the season progresses. The bullpen, anchored by All-Star closer Emmanuel Clase, is among the best in baseball. Clase, with his 100 mph cutter and pinpoint control, saved 39 games last season and continues to dominate the ninth inning. Supporting arms like Trevor Stephan, Sam Hentges, and Eli Morgan give Vogt flexibility to bridge the gap from the starters to the late innings. Despite having a 5-8 head-to-head record against the Royals in 2024, Cleveland comes into the Opening Day matchup with a deep, experienced roster and confidence built from last year’s success. Betting trends favor the Guardians in division matchups where they can leverage their pitching depth, and with strong defensive efficiency and team speed, they match up well even against rising clubs like Kansas City. Opening the season on the road against a rejuvenated Royals squad will be a litmus test, but the Guardians’ combination of elite pitching, defensive fundamentals, and veteran stability gives them every reason to believe they can start 2025 with a win and another playoff run on the horizon.

The Cleveland Guardians and Kansas City Royals are set to open their 2025 MLB seasons with a matchup at Kauffman Stadium on March 27, 2025, at 4:10 p.m. ET. Both teams aim to build upon their 2024 performances and establish early momentum in the AL Central division. Cleveland vs Kansas City AI Prediction: Free MLB Betting Insights for Mar 27. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Kansas City Royals MLB Preview

The Kansas City Royals enter the 2025 MLB season with a confidence and energy not felt in years, following one of the most remarkable turnarounds in baseball history. After suffering 106 losses in 2023, the Royals flipped the script in 2024 with an 86-76 record, securing an American League Wild Card spot and winning their first playoff series since their 2015 World Series title. That historic turnaround, the first of its kind in MLB’s 123-year history, has completely shifted the narrative surrounding the team, transforming them from perennial rebuilders into legitimate contenders. Under manager Matt Quatraro, the Royals have established a clear identity rooted in player development, pitching depth, speed, and a clubhouse culture focused on cohesion and accountability. Opening Day against the division-rival Cleveland Guardians is more than just the first game—it’s an opportunity for Kansas City to declare that last year was no fluke and that they are here to stay. The heartbeat of the Royals is shortstop Bobby Witt Jr., who enters 2025 as one of the most electrifying young stars in baseball. In 2024, Witt delivered a breakout campaign, slashing .313/.365/.560 with 32 home runs, 49 stolen bases, and a 9.4 bWAR, making him one of the top-five position players in the league. His combination of elite speed, power, and defensive range at shortstop makes him the face of the franchise and a dark horse MVP candidate. Witt is supported by key veteran bats such as catcher Salvador Perez, who remains a vital leader in the clubhouse and a steady source of power behind the plate, and newly acquired slugger Hunter Renfroe, whose 25-homer potential adds needed thump to the middle of the lineup. Infielders Michael Massey and Maikel Garcia bring athleticism and defensive stability, while second baseman Jonathan India, acquired in an offseason deal, adds a disciplined bat and former Rookie of the Year pedigree to an already dynamic group.

The Royals’ rotation quietly developed into a strength last year and looks even stronger heading into 2025. The ace of the staff is left-hander Cole Ragans, acquired from Texas in 2023, who exploded onto the scene in 2024 with a 2.97 ERA, 186 strikeouts, and a WHIP under 1.10 over 155 innings. Ragans pairs electric stuff with a fearless mentality, making him a perfect Opening Day starter. Behind him, veterans Seth Lugo and Michael Wacha were added in free agency to provide stability, innings, and postseason experience. Wacha, in particular, posted a 3.25 ERA with the Padres last year and remains effective when healthy. The bullpen is anchored by Will Smith, who has pitched in high-leverage roles for postseason teams across both leagues, and Chris Stratton, a versatile right-hander who can fill multiple relief roles. The team also expects a full season from hard-throwing righty James McArthur, who could develop into a future closer. Defensively, the Royals ranked among the best in the league in efficiency and range last season and are expected to improve even further with better health and continuity. Kauffman Stadium favors athletic teams built on speed and defense, and Kansas City has tailored its roster accordingly. This roster construction, combined with balanced offense and a deepened pitching staff, positions the Royals to compete for the AL Central crown. Hosting the reigning division champion Guardians on Opening Day gives Kansas City the perfect stage to showcase their growth. A win in front of their home fans would signal that the Royals’ 2024 breakthrough wasn’t just an anomaly—but the beginning of a new competitive era.

Cleveland vs. Kansas City Prop Picks (AI)

Remi is pouring through mountains of stats on each player. In fact, anytime the Guardians and Royals play there’s always several intriguing trends to key in on. Not to mention games played at Kauffman Stadium in Mar rarely follow normal, predictable patterns.
Remi's searched hard and found the best prop for this matchup: J. Ramirez over 6 Fantasy Score.

Cleveland vs. Kansas City Prediction (AI)

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Remi, our AI sports wizard, has been pouring over tons of data from every simulation between the Guardians and Royals and using recursive machine learning and cutting-edge AI to boil down the data to a single cover probability.

Interestingly enough, the data has been most fixated on the trending factor emotional bettors often put on player performance factors between a Guardians team going up against a possibly tired Royals team. In reality, the true game analytics appear to reflect a slight lean against one Vegas line specifically.

Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.

Below is our current AI Cleveland vs Kansas City picks, computer picks Guardians vs Royals, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
MLB 9/26 DET@BOS UNLOCK THIS PICK 5 EXECUTIVE Locked EXECUTIVE
MLB 9/26 BAL@NYY UNLOCK THIS PICK 4 INTEL Locked INTEL
MLB 9/26 ARI@SD UNLOCK THIS PICK 4 EXECUTIVE Locked EXECUTIVE
MLB 9/26 NYM@MIA UNLOCK THIS PICK 1 INTEL Locked INTEL
MLB 9/26 NYM@MIA GET FREE PICK NOW 1
MLB 9/26 COL@SF UNLOCK THIS PICK 0 INTEL Locked INTEL

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.

Guardians Betting Trends

In the 2024 season, the Guardians had a record of 5-8 against the Royals.

Royals Betting Trends

The Royals concluded the 2024 season with an 86-76 record, surpassing expectations and securing a wild-card berth.

Guardians vs. Royals Matchup Trends

The Royals’ remarkable turnaround in 2024, improving from a 106-loss season to winning a postseason series, marked the first time in MLB’s 123-year history that a team achieved such a feat.

Cleveland vs. Kansas City Game Info

Cleveland vs Kansas City starts on March 27, 2025 at 4:10 PM EST.

Spread: Kansas City -1.5
Moneyline: Cleveland +110, Kansas City -130
Over/Under: 7.5

Cleveland: (0-0)  |  Kansas City: (0-0)

Remi's searched hard and found the best prop for this matchup: J. Ramirez over 6 Fantasy Score.. Prices move—always shop for the best number.

The Royals’ remarkable turnaround in 2024, improving from a 106-loss season to winning a postseason series, marked the first time in MLB’s 123-year history that a team achieved such a feat.

CLE trend: In the 2024 season, the Guardians had a record of 5-8 against the Royals.

KC trend: The Royals concluded the 2024 season with an 86-76 record, surpassing expectations and securing a wild-card berth.

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

Cleveland vs. Kansas City Odds

AI algorithm Remi is pouring through loads of data points on each player. In fact, anytime the Cleveland vs Kansas City trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme hostile environments rarely follow normal, predictable betting trends.

Cleveland vs Kansas City Opening Odds

CLE Moneyline: +110
KC Moneyline: -130
CLE Spread: +1.5
KC Spread: -1.5
Over/Under: 7.5

Cleveland vs Kansas City Live Odds

Games PTS ML SPR O/U
Sep 27, 2025 1:06PM EDT
Baltimore Orioles
New York Yankees
9/27/25 1:06PM
Orioles
Yankees
+190
-235
+1.5 (-110)
-1.5 (-110)
O 8.5 (-120)
U 8.5 (+100)
Sep 27, 2025 2:21PM EDT
St Louis Cardinals
Chicago Cubs
9/27/25 2:21PM
Cardinals
Cubs
 
-180
 
-1.5 (+115)
O 9.5 (-105)
U 9.5 (-115)
Sep 27, 2025 3:09PM EDT
Tampa Bay Rays
Toronto Blue Jays
9/27/25 3:09PM
Rays
Blue Jays
+130
-155
+1.5 (-155)
-1.5 (+130)
O 8.5 (-110)
U 8.5 (-110)
Sep 27, 2025 4:06PM EDT
Chicago White Sox
Washington Nationals
9/27/25 4:06PM
White Sox
Nationals
+100
-120
-1.5 (+165)
+1.5 (-200)
O 8.5 (-110)
U 8.5 (-110)
Sep 27, 2025 4:06PM EDT
Colorado Rockies
San Francisco Giants
9/27/25 4:06PM
Rockies
Giants
+185
-225
+1.5 (-110)
-1.5 (-110)
O 8 (-105)
U 8 (-115)
Sep 27, 2025 4:11PM EDT
New York Mets
Miami Marlins
9/27/25 4:11PM
Mets
Marlins
-130
+110
-1.5 (+125)
+1.5 (-150)
O 8 (-115)
U 8 (-105)
Sep 27, 2025 4:11PM EDT
Detroit Tigers
Boston Red Sox
9/27/25 4:11PM
Tigers
Red Sox
+125
-150
+1.5 (-180)
-1.5 (+150)
O 9 (+100)
U 9 (-120)
Sep 27, 2025 6:05PM EDT
Minnesota Twins
Philadelphia Phillies
9/27/25 6:05PM
Twins
Phillies
+170
-205
+1.5 (-120)
-1.5 (+100)
O 8.5 (-115)
U 8.5 (-105)
Sep 27, 2025 7:11PM EDT
Cincinnati Reds
Milwaukee Brewers
9/27/25 7:11PM
Reds
Brewers
+125
-150
+1.5 (-180)
-1.5 (+150)
O 8 (-105)
U 8 (-115)
Sep 27, 2025 7:15PM EDT
Pittsburgh Pirates
Atlanta Braves
9/27/25 7:15PM
Pirates
Braves
+145
-175
+1.5 (-155)
-1.5 (+130)
O 8 (-110)
U 8 (-110)
Sep 27, 2025 7:16PM EDT
Texas Rangers
Cleveland Guardians
9/27/25 7:16PM
Rangers
Guardians
+135
-165
+1.5 (-180)
-1.5 (+150)
O 7 (-120)
U 7 (+100)
Sep 27, 2025 8:40PM EDT
Arizona Diamondbacks
San Diego Padres
9/27/25 8:40PM
Diamondbacks
Padres
+115
-140
+1.5 (-195)
-1.5 (+160)
O 7.5 (-120)
U 7.5 (+100)
Sep 27, 2025 9:39PM EDT
Houston Astros
Los Angeles Angels
9/27/25 9:39PM
Astros
Angels
-165
+135
-1.5 (+105)
+1.5 (-125)
O 9 (+100)
U 9 (-120)
Sep 27, 2025 9:41PM EDT
Los Angeles Dodgers
Seattle Mariners
9/27/25 9:41PM
Dodgers
Mariners
+105
-125
+1.5 (-205)
-1.5 (+170)
O 7.5 (+105)
U 7.5 (-125)
Sep 27, 2025 10:05PM EDT
Kansas City Royals
Oakland Athletics
9/27/25 10:05PM
Royals
Athletics
+100
-120
-1.5 (+150)
+1.5 (-180)
O 10 (-110)
U 10 (-110)

MLB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Cleveland Guardians vs. Kansas City Royals on March 27, 2025 at Kauffman Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN
CHC@SF CHC -105 54.1% 4 LOSS
NYY@CHW RYAN MCMAHON OVER 0.5 BASES 54.1% 4 WIN
PHI@NYM OVER 8.5 55.6% 4 LOSS
LAA@TEX LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS 54.1% 4 LOSS
KC@CHW KC -109 54.2% 4 WIN
SD@SEA DYLAN CEASE OVER 16.5 OUTS 53.9% 3 LOSS
SD@SEA UNDER 8.5 54.4% 4 LOSS
MIN@TOR JOE RYAN UNDER 2.5 EARNED RUNS 54.1% 4 LOSS
SF@MIL MIL +100 54.0% 6 LOSS
TOR@MIA MIA +1.5 62.0% 6 WIN
CHC@LAA OVER 9.5 54.9% 4 LOSS
BOS@NYY CARLOS RODON UNDER 4.5 HITS ALLOWED 54.2% 4 WIN
KC@DET DET -115 56.1% 5 WIN
CHC@LAA LAA +1.5 57.6% 5 LOSS
CIN@ARI KEBRYAN HAYES STRIKEOUTS UNDER 0.5 56.2% 6 WIN
LAD@SD SD +110 50.9% 6 WIN