Nebraska is priced like a team expected to control this opener from the start, with the spread sitting around -23.5 and the total near 47.5. That number reflects a major talent and quarterback advantage for the Huskers, who added former UNLV standout Anthony Colandrea after a 2025 season that unraveled late. Colandrea brings mobility and downfield production, but Nebraska still has to prove its rebuilt offense can create separation consistently. Ohio is a dangerous opponent for a large favorite because the Bobcats finished 9-4 last season, won four of their final five games, and return running back Duncan Brune after an eight-touchdown campaign. A steady rushing attack can compress possessions, limit Nebraska's offensive volume, and keep a big underdog inside the number even without threatening an upset. The handicap centers on Nebraska's ability to generate explosive plays and avoid stalled drives. If the Huskers force Ohio into obvious passing situations, the favorite can pull away. If Ohio stays efficient on early downs, the spread becomes much less comfortable.