Ohio State vs Michigan Prediction — AI Finds CAN'T MISS CFB Lines & Props (Nov 29)

Updated: 2025-11-22T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

Ohio State Buckeyes travel to Michigan Wolverines on November 29, 2025, for the latest chapter in the storied rivalry known as “The Game.” With Ohio State undefeated and riding national title-hopes while Michigan aims to defend home turf and extend its recent dominance, the clash promises high stakes, raw emotion, and the unpredictable intensity of rivalry week.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Nov 29, 2025

Start Time: 1:00 PM EST​

Venue: Michigan Stadium​

Wolverines Record: (9-2)

Buckeyes Record: (11-0)

OPENING ODDS

OHIOST Moneyline: -422

MICH Moneyline: +325

OHIOST Spread: -10.5

MICH Spread: +10.5

Over/Under: 44.5

OHIOST
Betting Trends

  • Ohio State, at 11–0, has covered the spread in 8 of their 10 games so far this season, reflecting growing confidence in both their explosive offense and disciplined defense even when playing under pressure.

MICH
Betting Trends

  • Michigan arrives at 9–2 and is battling mixed results against the spread — they’ve covered in roughly 4 of their last 6 games — showing flashes of dominance but also vulnerability when facing high-powered offenses or sustained pressure at home.

MATCHUP TRENDS

  • Opening lines place Ohio State as an 11.5-point favorite with the over/under at 44.5 points — signaling oddsmakers expect a controlled, defensively oriented game rather than a shootout, while still acknowledging Ohio State’s offensive firepower and Michigan’s home-field potential to keep things close.

OHIOST vs. MICH
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: D. McCulley over 28.5 Receiving Yards.

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Ohio State vs Michigan Prediction & Odds:
Free CFB Betting Insights for 11/29/25

The November 29 clash between Ohio State and Michigan arrives as one of the most anticipated editions of “The Game” in years, carrying national championship implications, playoff consequences, and the emotional weight of a rivalry defined by generations of pressure, pride, and shifting dominance, with Ohio State entering undefeated and Michigan determined to defend its home turf and reassert its physical identity. Ohio State’s 2025 campaign has been shaped by balance across all phases, pairing an explosive yet controlled offense with one of the nation’s most suffocating defenses, a combination that has allowed the Buckeyes to dictate tempo, dominate field position, and minimize mistakes even against disciplined opponents. Their quarterback play has been consistent and efficient, enabling a well-structured passing attack supported by a run game capable of both wearing down fronts and breaking chunk plays when defensive spacing falters, giving Ohio State a versatility that makes them difficult to disrupt. Their defense, long known for its aggression and technical precision, has evolved into an elite unit that thrives on gap discipline, crisp tackling, and the ability to generate pressure with rotation rather than reckless blitzing, creating an environment where opponents struggle to sustain drives or produce explosive moments. Michigan, meanwhile, enters as a physical, resilient 9–2 squad that has overcome volatility, relying on trench strength, defensive composure, and a calculated offense designed to control tempo, protect the football, and wear down opponents through methodical execution. Playing in Ann Arbor gives Michigan a distinct emotional advantage, as home-field intensity often heightens their defensive sharpness and fuels the kind of early momentum swings that can pressure even the most poise-driven teams.

For Michigan to challenge Ohio State’s unbeaten run, they must win the battle at the line of scrimmage, control clock through a steady run game, avoid third-and-long situations that feed Ohio State’s pass rush, and generate enough passing consistency to prevent the Buckeyes from stacking the box or dictating coverage. Defensively, the Wolverines must focus on disciplined tackling, tight coverage communication, and preventing explosive plays that can quickly erode crowd energy or shift momentum in Ohio State’s favor. For the Buckeyes, the formula lies in controlling pace, maintaining balance, and limiting self-inflicted errors, as rivalry games often hinge on turnovers, penalties, and miscommunication rather than simple statistical superiority. Special teams, an often overlooked but historically decisive phase in this matchup, could play a pivotal role, as field-position swings, long returns, and high-leverage kicks frequently determine momentum in low-scoring, physical contests. Emotionally, the pressure is immense on both sides: Ohio State plays for perfection and postseason destiny, while Michigan fights for pride, validation, and the chance to derail its rival’s championship aspirations. Ultimately, this edition of “The Game” will be decided by discipline, composure, execution under duress, and which side can impose its preferred style of football over four quarters, with Ohio State holding structural advantages but Michigan possessing the rivalry-tested grit to turn this heavyweight duel into a dramatic, unpredictable battle worthy of its storied legacy.

Get live CFB odds and precise AI CFB picks, predictions, and cover probabilities.

Ohio State Buckeyes CFB Preview

The November 29 clash between Ohio State and Michigan arrives as one of the most anticipated editions of “The Game” in years, carrying national championship implications, playoff consequences, and the emotional weight of a rivalry defined by generations of pressure, pride, and shifting dominance, with Ohio State entering undefeated and Michigan determined to defend its home turf and reassert its physical identity. Ohio State’s 2025 campaign has been shaped by balance across all phases, pairing an explosive yet controlled offense with one of the nation’s most suffocating defenses, a combination that has allowed the Buckeyes to dictate tempo, dominate field position, and minimize mistakes even against disciplined opponents. Their quarterback play has been consistent and efficient, enabling a well-structured passing attack supported by a run game capable of both wearing down fronts and breaking chunk plays when defensive spacing falters, giving Ohio State a versatility that makes them difficult to disrupt. Their defense, long known for its aggression and technical precision, has evolved into an elite unit that thrives on gap discipline, crisp tackling, and the ability to generate pressure with rotation rather than reckless blitzing, creating an environment where opponents struggle to sustain drives or produce explosive moments. Michigan, meanwhile, enters as a physical, resilient 9–2 squad that has overcome volatility, relying on trench strength, defensive composure, and a calculated offense designed to control tempo, protect the football, and wear down opponents through methodical execution. Playing in Ann Arbor gives Michigan a distinct emotional advantage, as home-field intensity often heightens their defensive sharpness and fuels the kind of early momentum swings that can pressure even the most poise-driven teams.

For Michigan to challenge Ohio State’s unbeaten run, they must win the battle at the line of scrimmage, control clock through a steady run game, avoid third-and-long situations that feed Ohio State’s pass rush, and generate enough passing consistency to prevent the Buckeyes from stacking the box or dictating coverage. Defensively, the Wolverines must focus on disciplined tackling, tight coverage communication, and preventing explosive plays that can quickly erode crowd energy or shift momentum in Ohio State’s favor. For the Buckeyes, the formula lies in controlling pace, maintaining balance, and limiting self-inflicted errors, as rivalry games often hinge on turnovers, penalties, and miscommunication rather than simple statistical superiority. Special teams, an often overlooked but historically decisive phase in this matchup, could play a pivotal role, as field-position swings, long returns, and high-leverage kicks frequently determine momentum in low-scoring, physical contests. Emotionally, the pressure is immense on both sides: Ohio State plays for perfection and postseason destiny, while Michigan fights for pride, validation, and the chance to derail its rival’s championship aspirations. Ultimately, this edition of “The Game” will be decided by discipline, composure, execution under duress, and which side can impose its preferred style of football over four quarters, with Ohio State holding structural advantages but Michigan possessing the rivalry-tested grit to turn this heavyweight duel into a dramatic, unpredictable battle worthy of its storied legacy.

Ohio State Buckeyes travel to Michigan Wolverines on November 29, 2025, for the latest chapter in the storied rivalry known as “The Game.” With Ohio State undefeated and riding national title-hopes while Michigan aims to defend home turf and extend its recent dominance, the clash promises high stakes, raw emotion, and the unpredictable intensity of rivalry week. Ohio State vs Michigan AI Prediction: Free CFB Betting Insights for Nov 29. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Michigan Wolverines CFB Preview

Ohio State enters its November 29 road showdown at Michigan carrying the weight and confidence of an undefeated season, the pressure of national championship expectations, and the determination to reclaim control of a rivalry that has defined both the program’s identity and postseason trajectory for more than a century, making this one of the most important tests of composure and execution the Buckeyes will face all year. Their offense has emerged as one of the most balanced and efficient units in the country, powered by a quarterback who has taken significant strides in poise, accuracy, and decision-making, allowing Ohio State to stretch defenses horizontally and vertically through a well-structured passing game that complements a physical and explosive ground attack. The offensive line has been a stabilizing force, providing reliable pass protection while consistently generating push in the run game, enabling the Buckeyes to control tempo, stay ahead of the chains, and avoid the drive-killing pressures that have often plagued them in past trips to Ann Arbor. Their receiving corps remains elite, capable of winning matchups at every level of the field and turning routine catches into momentum-shifting gains, while the running backs provide both toughness between the tackles and the speed to exploit defensive overpursuit. Defensively, Ohio State brings a unit that has been nothing short of dominant, built on disciplined gap control, physical interior play, and a deep rotation of pass rushers who generate pressure without sacrificing coverage integrity. Their linebackers pursue with speed and precision, while the secondary has matured into a cohesive group that communicates effectively, minimizes explosive plays, and forces opponents to sustain long, methodical drives rather than relying on quick strikes.

This defensive identity will be critical against a Michigan offense designed to wear opponents down, control clock, and attack weaknesses patiently rather than explosively. Special teams provide another layer of stability for the Buckeyes, with reliable kicking, disciplined coverage, and the ability to influence field position in ways that subtly but decisively shape rivalry outcomes, particularly in what is expected to be a tightly contested, physical game. Mentally, Ohio State must manage the emotional volatility inherent in “The Game,” understanding that Michigan will feed off the home crowd’s intensity while looking to exploit any lapse in discipline, focus, or ball security. The Buckeyes must resist allowing rivalry tension to generate unnecessary penalties or forced throws, instead leaning on their structural strengths: balanced offense, physical defense, and situational sharpness. Their path to victory lies in protecting the football, finishing red-zone opportunities with touchdowns rather than field goals, maintaining gap integrity on defense, and responding to Michigan’s inevitable surges with composure rather than panic. If Ohio State executes with the same precision, physicality, and poise that have defined their season, they possess the depth, balance, and competitive edge necessary to leave Ann Arbor with a rivalry-defining road win and keep their championship aspirations intact.

Ohio State vs Michigan Prop Picks (AI)

Remi is pouring through loads of stats on each line. In fact, anytime the Buckeyes and Wolverines play there’s always several intriguing trends to key in on. Not to mention games played at Michigan Stadium in Nov can often follow normal, predictable betting trends.

Remi's searched hard and found the best prop for this matchup: D. McCulley over 28.5 Receiving Yards.

Ohio State vs Michigan Prediction (AI)

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Remi, our AI sports algorithm, has been pouring over mountains of data from every past game between the Buckeyes and Wolverines and using recursive machine learning and kick-ass AI to boil down the data to a single cover probability.

Oddly enough, we’ve seen the AI has been most focused on the growing weight human bettors tend to put on Michigan’s strength factors between a Buckeyes team going up against a possibly rested Wolverines team. Trends look to say the true game analytics might reflect a strong lean against one Vegas line specifically.

Unlock this in-depth AI prediction and all of our CFB AI picks for FREE now.

Below is our current AI Ohio State vs Michigan picks, computer picks Buckeyes vs Wolverines, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
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These picks update as information changes—injury reports, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full CFB schedule.

Ohio State Betting Trends

Ohio State, at 11–0, has covered the spread in 8 of their 10 games so far this season, reflecting growing confidence in both their explosive offense and disciplined defense even when playing under pressure.

Michigan Betting Trends

Michigan arrives at 9–2 and is battling mixed results against the spread — they’ve covered in roughly 4 of their last 6 games — showing flashes of dominance but also vulnerability when facing high-powered offenses or sustained pressure at home.

Buckeyes vs. Wolverines Matchup Trends

Opening lines place Ohio State as an 11.5-point favorite with the over/under at 44.5 points — signaling oddsmakers expect a controlled, defensively oriented game rather than a shootout, while still acknowledging Ohio State’s offensive firepower and Michigan’s home-field potential to keep things close.

Ohio State vs. Michigan Game Info

November 29, 2025 • 1:00 PM EST • Michigan Stadium

Ohio State vs. Michigan Odds

Remi is pouring through tons of stats on each line. In fact, anytime the Ohio State vs Michigan trends are analyzed, there’s always several intriguing trends to key in on. Not to mention games played at extreme hostile environments almost always follow normal, predictable patterns.

Ohio State vs Michigan

Ohio State vs Michigan Live Odds

Games PTS ML SPR O/U
Dec 5, 2025 7:00PM EST
Troy Trojans
James Madison Dukes
12/5/25 7PM
TROY
JMAD
+1258
-5049
+23.5 (-110)
-23.5 (-110)
O 47 (-110)
U 47 (-110)
Dec 5, 2025 7:00PM EST
Kennesaw State Owls
Jacksonville State Gamecocks
12/5/25 7PM
KENSAW
JAXST
-135
+110
-2.5 (-110)
+2.5 (-110)
O 60.5 (-110)
U 60.5 (-110)
Dec 5, 2025 8:00PM EST
North Texas Mean Green
Tulane Green Wave
12/5/25 8PM
NOTEX
TULANE
-136
+111
-2.5 (-110)
+2.5 (-110)
O 66.5 (-110)
U 66.5 (-110)
Dec 5, 2025 8:01PM EST
UNLV Rebels
Boise State Broncos
12/5/25 8:01PM
UNLV
BOISE
+170
-212
+5 (-110)
-5 (-110)
O 59 (-110)
U 59 (-110)
Dec 6, 2025 12:00PM EST
Miami Ohio Redhawks
Western Michigan Broncos
12/6/25 12PM
MIAOH
WMICH
 
-128
 
-2 (-110)
O 43.5 (-110)
U 43.5 (-110)
Dec 6, 2025 12:00PM EST
BYU Cougars
Texas Tech Red Raiders
12/6/25 12PM
BYU
TXTECH
+380
-526
+12.5 (-110)
-12.5 (-110)
O 49.5 (-110)
U 49.5 (-110)
Dec 6, 2025 4:00PM EST
Georgia Bulldogs
Alabama Crimson Tide
12/6/25 4PM
UGA
BAMA
-130
+106
-2 (-110)
+2 (-110)
O 48 (-110)
U 48 (-110)
Dec 6, 2025 8:00PM EST
Duke Blue Devils
Virginia Cavaliers
12/6/25 8PM
DUKE
UVA
+151
-187
+4 (-110)
-4 (-110)
O 58 (-110)
U 58 (-110)
Dec 6, 2025 8:01PM EST
Indiana Hoosiers
Ohio State Buckeyes
12/6/25 8:01PM
IND
OHIOST
+165
-200
+4 (-105)
-4 (-115)
O 47.5 (-115)
U 47.5 (-105)
Dec 13, 2025 3:00PM EST
Army Black Knights
Navy Midshipmen
12/13/25 3PM
ARMY
NAVY
+172
-216
+4.5 (-105)
-4.5 (-115)
O 38 (-110)
U 38 (-110)

CFB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Ohio State Buckeyes vs. Michigan Wolverines on November 29, 2025 at Michigan Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our CFB odds pages, and compare prices before you place a bet.

LEAN %WIN UNITS RESULT
COLO@KSTATE COLO +17.5 54.0% 4 WIN
PSU@RUT RUT +14 52.8% 1 WIN
OHIOST@MICH MICH +10.5 56.4% 6 LOSS
VATECH@UVA VATECH +8 57.8% 7 LOSS
NWEST@ILL LUKE ALTMYER UNDER 19.5 PASS COMP 54.3% 4 WIN
ORE@WAS DEMOND WILLIAMS JR UNDER 43.5 RUSH YDS 55.2% 5 WIN
MIAMI@VATECH VATECH +18.5 54.2% 4 WIN
GAST@TROY TROY -9.5 55.7% 5 WIN
DEL@WAKE DEL +18 56.7% 6 LOSS
NMEX@AF NMEX -3.5 56.1% 5 WIN
WASHST@JMAD WASHST +14.5 55.3% 5 WIN
ILL@WISC WISC +9 55.1% 5 WIN
WKY@LSU WKY +23.5 56.3% 6 WIN
WASH@UCLA DEMOND WILLIAMS UNDER 27.5 PASS ATT 56.3% 6 WIN
TCU@HOU AMARE THOMAS OVER 69.5 RECV YDS 55.2% 5 WIN
TEX@UGA NATE FRAZIER UNDER 65.5 RUSH + REC YDS 55.5% 5 WIN
PUR@WASH ANTONIO HARRIS UNDER 73.5 RUSH + REC YDS 54.1% 4 WIN
OKLA@BAMA UNDER 46 52.4% 2 WIN
UVA@DUKE DUKE -3.5 54.7% 3 LOSS
OKLA@BAMA BAMA -6 54.5% 3 LOSS
OREGST@TULSA OREGST -120 55.6% 5 LOSS
UTEP@MIZZST MIZZST -5 54.3% 4 WIN
COLOST@NMEX NMEX -14 57.1% 6 LOSS
PSU@MICHST MICHST +7.5 56.5% 6 LOSS
MISSST@MIZZOU MISSST +7.5 57.2% 7 LOSS
FAU@TULANE FAU +17.5 56.0% 6 WIN
NCST@MIAMI NCST +15.5 57.1% 7 LOSS
KENTST@AKRON AKRON -6.5 55.4% 5 LOSS
JAXST@UTEP JAXST -105 57.0% 7 WIN
FSU@CLEM CLEM -118 57.1% 5 WIN
UNLV@COLOST UNLV -4 55.2% 5 WIN
OREG@IOWA IOWA +6.5 53.3% 2 WIN
NEB@UCLA NEB +1.5 55.8% 5 WIN
KENSAW@NMEXST NMEXST +10 56.5% 6 WIN
STNFRD@UNC STNFRD +7.5 53.8% 3 WIN
DUKE@UCONN UCONN +8.5 57.9% 7 WIN
NEVADA@UTAHST NEVADA +9.5 55.9% 5 LOSS
SAMST@OREGST SAMST +21 57.7% 7 WIN
NEB@UCLA NICO IAMALEAVA UNDER 180.5 PASS YDS 56.6% 6 LOSS
HOU@UCF HOU -112 58.0% 6 WIN
GASTHRN@APPST GASTHRN +180 36.5% 2 WIN
KENTST@BALLST BALLST -2.5 54.5% 4 WIN
WAKE@FSU WAKE +10.5 56.4% 6 LOSS
WYO@SDGST SDGST -10.5 56.7% 7 WIN
OKLA@TENN TENN -130 58.3% 5 LOSS
GATECH@NCST GATECH -5 56.4% 6 LOSS
MIAMI@SMU MIAMI -10 54.3% 4 LOSS
IND@MD MD +21.5 54.6% 4 LOSS
CINCY@UTAH CINCY +11 57.6% 7 LOSS
OLDDOM@LAMON LAMON +17 58.4% 8 LOSS
VANDY@TEXAS OVER 46.5 53.7% 2 WIN