Notre Dame vs Stanford Prediction — AI Finds CAN'T MISS CFB Lines & Props (Nov 29)

Updated: 2025-11-22T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

Notre Dame closes its regular season on November 29 by heading west to face Stanford in Palo Alto — the Fighting Irish aim to finish strong and cement their status among the national contenders while Stanford, at home, looks to disrupt that narrative and salvage pride in a difficult season. With rivalry history, bowl implications, and playoff hopes on the line, this game blends tradition with high stakes and could deliver a classic upset-or-confirmation scenario.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Nov 29, 2025

Start Time: 11:30 PM EST​

Venue: Stanford Stadium​

Cardinal Record: (4-7)

Fighting Irish Record: (9-2)

OPENING ODDS

ND Moneyline: -11111

STNFRD Moneyline: +2667

ND Spread: -32.5

STNFRD Spread: +32.5

Over/Under: 51.5

ND
Betting Trends

  • Notre Dame comes into this game as a heavy favorite — across 2025 they’ve covered the spread in most games but have occasionally flirted with volatility when their pass protection or turnover margin faltered; overall, as a well-rounded team with offensive balance and defensive stability, they remain one of the more dependable ATS sides when favored.

STNFRD
Betting Trends

  • Stanford, with a 4–7 2025 record and just 1–6 in away games, has struggled ATS, even at home — their season has been marked by inconsistency, especially on offense, which makes them a questionable pick despite hosting a major opponent.

MATCHUP TRENDS

  • Opening lines show Notre Dame as roughly a 32.5-point favorite with an over/under total around 51.5, signaling expectations of a dominant Irish win and a game tilted heavily toward offense from the visitor, though the large spread leaves open the question of whether Stanford can at least cover or keep things relatively respectable.

ND vs. STNFRD
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: J. Love under 138.5 Rushing Yards.

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Notre Dame vs Stanford Prediction & Odds:
Free CFB Betting Insights for 11/29/25

The November 29, 2025 matchup between Notre Dame and Stanford brings together two programs on sharply different trajectories, with Notre Dame entering the regular-season finale as a 9–2 powerhouse still polishing its postseason résumé, and Stanford arriving at 4–7 looking to salvage pride, measure progress, and disrupt the national narrative by delivering a late-season shock on home turf. Notre Dame travels west with a balanced and disciplined identity built on efficient quarterback play, strong offensive line cohesion, and a ground game capable of controlling tempo when needed, while their defense offers a reliable backbone that thrives on gap integrity, physical tackling, and limiting explosive plays, making them one of the steadier national performers throughout 2025. Their primary task in Palo Alto will be to avoid complacency, resist the natural temptation to look past a struggling opponent, and maintain sharpness in execution, particularly in pass protection and turnover margin, areas that have occasionally wavered during stretches of the season. Stanford faces a daunting challenge but enters the game with the underdog’s freedom and the emotional boost of playing at home in front of a fanbase eager to see competitiveness in a rivalry that has historically delivered both drama and unpredictability. The Cardinal’s path to staying competitive relies heavily on their ability to establish offensive rhythm early: their run game must find traction behind an improving but still inconsistent offensive line, while their quarterback must avoid forcing deep shots into coverage and instead lean on quick reads, play-action, and controlled passing concepts that minimize exposure to Notre Dame’s disciplined defense.

Stanford’s defense must play its most complete game of the season, using disciplined pressure, proper leverage, and strong tackling to prevent Notre Dame from settling into its usual balanced flow that wears down opponents over four quarters. If the Cardinal can force the Irish into third-and-longs, create one or two key turnovers, or benefit from special-teams swings, they could extend the game beyond expectations and apply pressure to a Notre Dame team carrying the weight of postseason implications. Special teams and field position may play a significant role, especially for Stanford, which needs every possible edge to shorten the field for its offense and prevent Notre Dame from building early separation that could put the game out of reach quickly. Emotionally, the Irish must stay grounded and composed in a cross-country environment where travel fatigue, late-season injury management, and the looming postseason can easily disrupt focus if not addressed with professionalism and urgency. Ultimately, Notre Dame enters with clear advantages across roster depth, scheme discipline, and season-long consistency, but the volatility of rivalry-adjacent finales and the unpredictability of a desperate home underdog create enough variables to prevent complacency. If Notre Dame executes to its standard—protecting the football, sustaining balanced drives, and letting its defense control momentum—it should emerge with a convincing win; but if Stanford capitalizes on Irish miscues and uses emotion, tempo, and field position to its benefit, the Cardinal could force a far more dramatic conclusion to both teams’ regular seasons than the records alone would suggest.

Get live CFB odds and precise AI CFB picks, predictions, and cover probabilities.

Notre Dame Fighting Irish CFB Preview

Notre Dame enters its November 29 road trip to Stanford carrying the confidence of a 9–2 season, the polish of a program with national aspirations, and the discipline of a team that understands the importance of closing the regular season with focus and precision rather than complacency. Traveling cross-country presents natural challenges — time-zone shifts, unfamiliar rhythm, and the physical toll of late-season football — but the Irish arrive with an offensive and defensive identity built to withstand those pressures. Offensively, Notre Dame thrives on balance, combining a steady, efficient rushing attack with a quarterback who has shown command, poise, and strong decision-making throughout the year. Their offensive line has been one of the team’s most reliable units, capable of controlling the trenches, protecting the quarterback, and opening running lanes that allow the Irish to dictate tempo. Against a Stanford defense that has struggled with consistency, maintaining that foundation is essential: minimizing negative plays, avoiding turnovers, and staying ahead of the chains will help Notre Dame sustain long drives, drain clock, and wear down the Cardinal front. Their passing game excels when built on timing and progression-based reads, and the wide receiver corps’ ability to separate vertically or win in intermediate areas gives the Irish multiple pathways to explosive plays if Stanford overcommits to stopping the run. Defensively, Notre Dame brings a disciplined, cohesive unit that has excelled all season in limiting big plays, closing running lanes, and forcing opponents into predictable passing situations where their pass rush and secondary discipline shine.

Against a Stanford offense that has been uneven and turnover-prone at times, the Irish defense will look to assert control early, disrupt timing, generate pressure without sacrificing structural integrity, and force the Cardinal quarterback into hurried decisions or stalled drives. Special teams provide another advantage for Notre Dame, as consistent kicking, stable coverage units, and reliable punting can prevent Stanford from gaining hidden-yardage edges that often fuel underdog momentum. Emotionally, Notre Dame must approach this matchup with maturity — ignoring the heavy-favorite narrative and instead treating the game as a chance to reinforce its standard of discipline, physicality, and execution. The coaching staff will stress situational sharpness, including red-zone efficiency, third-down conversions, and ball security, knowing that Stanford’s upset path relies heavily on Notre Dame mistakes rather than schematic dominance. If the Irish execute with their usual blend of control, physicality, and patience, they possess every structural advantage needed to manage crowd energy, silence early Stanford enthusiasm, and guide the game into a controlled flow that limits unpredictability. Ultimately, Notre Dame arrives as a complete team capable of imposing its will through balanced offense, reliable defense, and strong fundamentals, and if they maintain that identity on the road, they are well positioned to end the regular season with a decisive performance that strengthens their postseason standing and reinforces their status as one of the nation’s most consistent programs.

Notre Dame closes its regular season on November 29 by heading west to face Stanford in Palo Alto — the Fighting Irish aim to finish strong and cement their status among the national contenders while Stanford, at home, looks to disrupt that narrative and salvage pride in a difficult season. With rivalry history, bowl implications, and playoff hopes on the line, this game blends tradition with high stakes and could deliver a classic upset-or-confirmation scenario. Notre Dame vs Stanford AI Prediction: Free CFB Betting Insights for Nov 29. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Stanford Cardinal CFB Preview

Stanford enters its November 29 home finale against Notre Dame with the mindset of an underdog determined to salvage pride and close out a difficult 2025 season by channeling home-field energy, rivalry emotion, and disciplined execution into a competitive performance against one of the nation’s premier programs. The Cardinal’s offense has been inconsistent throughout the year, but playing at home offers them a chance to lean into a more controlled, balanced approach built around timing routes, quick reads, and a running game that, when functioning efficiently, helps them stay ahead of the chains and avoid predictable long-yardage situations that have frequently stalled their drives. Their quarterback must play with poise and patience, resisting the urge to force deep throws into tight windows and instead focusing on taking what Notre Dame’s disciplined defense allows, working methodically to sustain drives and protect the football. The offensive line, an area of ongoing development, will be central to Stanford’s hopes, as it must hold up against a strong Irish front that leverages physicality and gap integrity to reduce rushing lanes and pressure opposing quarterbacks; if the line can deliver stability, Stanford’s offense gains a fighting chance to find rhythm and keep Notre Dame’s offense off the field. Defensively, Stanford must embrace a bend-don’t-break philosophy that emphasizes disciplined tackling, consistent leverage, and smart pursuit, knowing that Notre Dame’s offensive versatility makes them dangerous at every level. The Cardinal will need to mix coverages, apply carefully timed pressures, and prevent the Irish from gaining the early-down success that fuels their balanced attack.

The front seven must stay gap-sound against the run and avoid overcommitting, while the secondary must communicate flawlessly to defend play-action and intermediate passing concepts that Notre Dame executes with precision. Special teams could provide Stanford with the edge required to stay competitive — disciplined coverage units, clean place-kicking, and strategic punting can tilt the field-position battle in their favor and create high-leverage opportunities that keep the Irish from fully controlling tempo. Emotionally, this game offers the Cardinal a valuable chance to rally behind senior players, honor the home crowd, and demonstrate that progress exists even in a season marked by adversity; managing that emotion with discipline rather than desperation will be critical in avoiding penalties, turnovers, or critical miscues. The coaching staff’s message will center on focusing on fundamentals, seizing momentum whenever possible, and eliminating self-inflicted setbacks that have defined several of their losses. If Stanford can sustain offensive drives, maintain defensive structure, and capitalize on any mistakes Notre Dame makes, they have a path to making this matchup far more competitive than the spread suggests. Ultimately, the Cardinal come into this rivalry-adjacent contest as clear underdogs, but their home environment, late-season urgency, and opportunity to disrupt Notre Dame’s postseason positioning give them genuine motivation to produce one of their most focused and resilient performances of the year.

Notre Dame vs Stanford Prop Picks (AI)

Remi is pouring through mountains of data on each team. In fact, anytime the Fighting Irish and Cardinal play there’s always several intriguing angles to key in on. Not to mention games played at Stanford Stadium in Nov rarely follow normal, predictable patterns.

Remi's searched hard and found the best prop for this matchup: J. Love under 138.5 Rushing Yards.

Notre Dame vs Stanford Prediction (AI)

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Remi, our AI sports genius, has been pouring over millions of data from every simulation between the Fighting Irish and Cardinal and using recursive machine learning and impressive AI to crunch the data to a single cover probability.

Interestingly enough, the data has been most focused on the trending weight knucklehead sportsbettors tend to put on coaching factors between a Fighting Irish team going up against a possibly tired Cardinal team. We’ve found the true game analytics appear to reflect a moderate lean against one Vegas line specifically.

Unlock this in-depth AI prediction and all of our CFB AI picks for FREE now.

Below is our current AI Notre Dame vs Stanford picks, computer picks Fighting Irish vs Cardinal, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
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These picks update as information changes—injury reports, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full CFB schedule.

Notre Dame Betting Trends

Notre Dame comes into this game as a heavy favorite — across 2025 they’ve covered the spread in most games but have occasionally flirted with volatility when their pass protection or turnover margin faltered; overall, as a well-rounded team with offensive balance and defensive stability, they remain one of the more dependable ATS sides when favored.

Stanford Betting Trends

Stanford, with a 4–7 2025 record and just 1–6 in away games, has struggled ATS, even at home — their season has been marked by inconsistency, especially on offense, which makes them a questionable pick despite hosting a major opponent.

Fighting Irish vs. Cardinal Matchup Trends

Opening lines show Notre Dame as roughly a 32.5-point favorite with an over/under total around 51.5, signaling expectations of a dominant Irish win and a game tilted heavily toward offense from the visitor, though the large spread leaves open the question of whether Stanford can at least cover or keep things relatively respectable.

Notre Dame vs. Stanford Game Info

November 29, 2025 • 11:30 PM EST • Stanford Stadium

Notre Dame vs. Stanford Odds

AI algorithm Remi is pouring through loads of data on each line. In fact, anytime the Notre Dame vs Stanford trends are analyzed, there’s always several intriguing trends to key in on. Not to mention games played at extreme travel distance rarely follow normal, predictable betting trends.

Notre Dame vs Stanford

Notre Dame vs Stanford Live Odds

Games PTS ML SPR O/U
Dec 5, 2025 7:00PM EST
Troy Trojans
James Madison Dukes
12/5/25 7PM
TROY
JMAD
+1258
-5049
+23.5 (-110)
-23.5 (-110)
O 47 (-110)
U 47 (-110)
Dec 5, 2025 7:00PM EST
Kennesaw State Owls
Jacksonville State Gamecocks
12/5/25 7PM
KENSAW
JAXST
-135
+110
-2.5 (-110)
+2.5 (-110)
O 60.5 (-110)
U 60.5 (-110)
Dec 5, 2025 8:00PM EST
North Texas Mean Green
Tulane Green Wave
12/5/25 8PM
NOTEX
TULANE
-136
+111
-2.5 (-110)
+2.5 (-110)
O 66.5 (-110)
U 66.5 (-110)
Dec 5, 2025 8:01PM EST
UNLV Rebels
Boise State Broncos
12/5/25 8:01PM
UNLV
BOISE
+170
-212
+5 (-110)
-5 (-110)
O 59 (-110)
U 59 (-110)
Dec 6, 2025 12:00PM EST
Miami Ohio Redhawks
Western Michigan Broncos
12/6/25 12PM
MIAOH
WMICH
 
-128
 
-2 (-110)
O 43.5 (-110)
U 43.5 (-110)
Dec 6, 2025 12:00PM EST
BYU Cougars
Texas Tech Red Raiders
12/6/25 12PM
BYU
TXTECH
+380
-526
+12.5 (-110)
-12.5 (-110)
O 49.5 (-110)
U 49.5 (-110)
Dec 6, 2025 4:00PM EST
Georgia Bulldogs
Alabama Crimson Tide
12/6/25 4PM
UGA
BAMA
-130
+106
-2 (-110)
+2 (-110)
O 48 (-110)
U 48 (-110)
Dec 6, 2025 8:00PM EST
Duke Blue Devils
Virginia Cavaliers
12/6/25 8PM
DUKE
UVA
+151
-187
+4 (-110)
-4 (-110)
O 58 (-110)
U 58 (-110)
Dec 6, 2025 8:01PM EST
Indiana Hoosiers
Ohio State Buckeyes
12/6/25 8:01PM
IND
OHIOST
+165
-200
+4 (-105)
-4 (-115)
O 47.5 (-115)
U 47.5 (-105)
Dec 13, 2025 3:00PM EST
Army Black Knights
Navy Midshipmen
12/13/25 3PM
ARMY
NAVY
+172
-216
+4.5 (-105)
-4.5 (-115)
O 38 (-110)
U 38 (-110)

CFB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Notre Dame Fighting Irish vs. Stanford Cardinal on November 29, 2025 at Stanford Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our CFB odds pages, and compare prices before you place a bet.

LEAN %WIN UNITS RESULT
COLO@KSTATE COLO +17.5 54.0% 4 WIN
PSU@RUT RUT +14 52.8% 1 WIN
OHIOST@MICH MICH +10.5 56.4% 6 LOSS
VATECH@UVA VATECH +8 57.8% 7 LOSS
NWEST@ILL LUKE ALTMYER UNDER 19.5 PASS COMP 54.3% 4 WIN
ORE@WAS DEMOND WILLIAMS JR UNDER 43.5 RUSH YDS 55.2% 5 WIN
MIAMI@VATECH VATECH +18.5 54.2% 4 WIN
GAST@TROY TROY -9.5 55.7% 5 WIN
DEL@WAKE DEL +18 56.7% 6 LOSS
NMEX@AF NMEX -3.5 56.1% 5 WIN
WASHST@JMAD WASHST +14.5 55.3% 5 WIN
ILL@WISC WISC +9 55.1% 5 WIN
WKY@LSU WKY +23.5 56.3% 6 WIN
WASH@UCLA DEMOND WILLIAMS UNDER 27.5 PASS ATT 56.3% 6 WIN
TCU@HOU AMARE THOMAS OVER 69.5 RECV YDS 55.2% 5 WIN
TEX@UGA NATE FRAZIER UNDER 65.5 RUSH + REC YDS 55.5% 5 WIN
PUR@WASH ANTONIO HARRIS UNDER 73.5 RUSH + REC YDS 54.1% 4 WIN
OKLA@BAMA UNDER 46 52.4% 2 WIN
UVA@DUKE DUKE -3.5 54.7% 3 LOSS
OKLA@BAMA BAMA -6 54.5% 3 LOSS
OREGST@TULSA OREGST -120 55.6% 5 LOSS
UTEP@MIZZST MIZZST -5 54.3% 4 WIN
COLOST@NMEX NMEX -14 57.1% 6 LOSS
PSU@MICHST MICHST +7.5 56.5% 6 LOSS
MISSST@MIZZOU MISSST +7.5 57.2% 7 LOSS
FAU@TULANE FAU +17.5 56.0% 6 WIN
NCST@MIAMI NCST +15.5 57.1% 7 LOSS
KENTST@AKRON AKRON -6.5 55.4% 5 LOSS
JAXST@UTEP JAXST -105 57.0% 7 WIN
FSU@CLEM CLEM -118 57.1% 5 WIN
UNLV@COLOST UNLV -4 55.2% 5 WIN
OREG@IOWA IOWA +6.5 53.3% 2 WIN
NEB@UCLA NEB +1.5 55.8% 5 WIN
KENSAW@NMEXST NMEXST +10 56.5% 6 WIN
STNFRD@UNC STNFRD +7.5 53.8% 3 WIN
DUKE@UCONN UCONN +8.5 57.9% 7 WIN
NEVADA@UTAHST NEVADA +9.5 55.9% 5 LOSS
SAMST@OREGST SAMST +21 57.7% 7 WIN
NEB@UCLA NICO IAMALEAVA UNDER 180.5 PASS YDS 56.6% 6 LOSS
HOU@UCF HOU -112 58.0% 6 WIN
GASTHRN@APPST GASTHRN +180 36.5% 2 WIN
KENTST@BALLST BALLST -2.5 54.5% 4 WIN
WAKE@FSU WAKE +10.5 56.4% 6 LOSS
WYO@SDGST SDGST -10.5 56.7% 7 WIN
OKLA@TENN TENN -130 58.3% 5 LOSS
GATECH@NCST GATECH -5 56.4% 6 LOSS
MIAMI@SMU MIAMI -10 54.3% 4 LOSS
IND@MD MD +21.5 54.6% 4 LOSS
CINCY@UTAH CINCY +11 57.6% 7 LOSS
OLDDOM@LAMON LAMON +17 58.4% 8 LOSS
VANDY@TEXAS OVER 46.5 53.7% 2 WIN