Rutgers vs Ohio State Prediction — AI Finds CAN'T MISS CFB Lines & Props (Nov 22)

Updated: 2025-11-15T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The Rutgers Scarlet Knights (5-5, 2-5 Big Ten) travel to face the undefeated and top-seeded Ohio State Buckeyes (10-0, 7-0 Big Ten) on November 22, 2025, in what looms as a mismatch but still offers Rutgers a final chance to salvage bowl eligibility and momentum for next season. Ohio State enters as a heavy favorite at home in Columbus with elite balanced performance across offense, defense and situational football, while Rutgers must show significant improvement on both sides of the ball to stay competitive in the matchup.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Nov 22, 2025

Start Time: 1:00 PM EST​

Venue: Ohio Stadium​

Buckeyes Record: (10-0)

Scarlet Knights Record: (5-5)

OPENING ODDS

RUT Moneyline: +2600

OHIOST Moneyline: -9091

RUT Spread: +31.5

OHIOST Spread: -31.5

Over/Under: 55.5

RUT
Betting Trends

  • Rutgers has had mixed results ATS this season, being underdogs in most games and covering fewer than half of their opportunities, which reflects a program still inconsistent and vulnerable in key situations. The combination of their improved offense but fragile defense means they’ve struggled to cover big spreads against stronger opponents.

OHIOST
Betting Trends

  • Ohio State boasts an excellent ATS record this year, covering in the vast majority of games and entering this contest with one of the best ATS marks nationally, which underscores that not only are they winning, but doing so in command of expectations. That kind of consistency in covering spreads at home against inferior opponents makes them especially difficult to bet against in this scenario.

MATCHUP TRENDS

  • Given Ohio State’s dominant form and Rutgers’ underdog status, the line has opened in the 30-point range with an over/under in the mid-50s, creating interesting angles: Rutgers may appeal as a cover option if they show any fight early, but Ohio State’s ability to dominate tempo and field position suggests that the total may lean under if the Buckeyes impose their style and control the game. Additionally, Rutgers’ defense has allowed near 30 points per game while Ohio State allows fewer than 8 points per game — a huge mismatch that may drive bettors to consider the underdog cover or the low-scoring outcome rather than a wide blowout.

RUT vs. OHIOST
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: J. Sayin over 274.5 Passing Yards.

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Rutgers vs Ohio State Prediction & Odds:
Free CFB Betting Insights for 11/22/25

The November 22, 2025 matchup between Rutgers and Ohio State presents one of the most lopsided statistical pairings of the Big Ten season, as the Scarlet Knights enter at 5–5 fighting for bowl eligibility while the Buckeyes storm in undefeated at 10–0, armed with one of the nation’s most dominant defenses and a balanced, explosive offense that has overwhelmed nearly every opponent on their schedule, and this contrast creates a matchup where Rutgers must play its most complete game of the season simply to remain competitive against a Buckeyes team that controls tempo, dictates field position, and suffocates opponents with relentless defensive precision. Ohio State’s statistical profile is staggering: allowing fewer than eight points per game while scoring nearly 38, they dominate early downs, win the turnover margin, create explosive gains, and routinely build multi-score leads before halftime, leaving opponents scrambling to adjust while struggling to match their physicality and depth, and against a Rutgers defense giving up nearly 30 points per contest the Buckeyes will see every opportunity to stretch the field, pound the run game, and force the Scarlet Knights into a pace they cannot match. Rutgers, however, does not enter empty-handed, as its offense has shown real development, with quarterback Athan Kaliakmanis surpassing 2,700 passing yards and running back Antwan Raymond eclipsing 1,000 rushing yards to form a capable tandem that can challenge opponents through varied looks and sustained drives when given time, but the challenge is replicating that production against the Big Ten’s most disciplined and athletic defense, which thrives on limiting explosive plays and forcing quarterbacks into hurried, off-platform throws that disrupt timing and rhythm. For Rutgers to make this competitive, they must control possessions early, avoid turnovers, convert third downs at a significantly higher rate than their season average, and find a way to generate early points that prevent Ohio State from leaning exclusively on its defense and dictating the entire flow of the game, and even then the margin for error remains extremely thin.

Ohio State’s offensive versatility further complicates matters, as their ability to shift seamlessly between power running, vertical passing, and controlled mid-range rhythm attacks allows them to attack defensive weaknesses from multiple angles, and Rutgers’ inconsistencies in coverage, tackling, and red-zone resilience leave them vulnerable to both long scoring drives and sudden chunk-play touchdowns that can quickly deflate momentum. The Buckeyes also carry the advantage of home-field intensity inside Ohio Stadium, where their crowd amplifies pressure on visiting offenses, accelerates communication breakdowns, and creates the kind of environment where an underdog must stay poised through every snap to prevent the game from slipping away early. The matchup ultimately centers on whether Rutgers can sustain enough offensive success to avoid falling behind by multiple scores, because once Ohio State forces a one-dimensional approach, their defensive front and secondary cohesion typically close the door quickly. While Rutgers’ offensive improvements offer some encouragement for early competitiveness, Ohio State’s balance, depth, and overwhelming defensive superiority make them the clear favorite to control the contest from start to finish, leaving Rutgers working not only to chase an upset but to prove that their growth can translate into a respectable performance against one of the sport’s elite programs.

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Rutgers Scarlet Knights CFB Preview

Rutgers enters its November 22, 2025 road matchup at Ohio State with a 5–5 record and the sobering understanding that this represents their toughest assignment of the season, as they step into Ohio Stadium to face an undefeated Buckeyes squad boasting elite talent, overwhelming depth, and statistical dominance on both sides of the ball, and the Scarlet Knights must deliver one of their most complete, disciplined, and emotionally steady performances of the year simply to remain competitive. Offensively, Rutgers has taken meaningful strides in 2025, led by quarterback Athan Kaliakmanis, who has surpassed 2,700 passing yards with steady decision-making, improved accuracy, and the ability to push the ball vertically; supported by the powerful running of Antwan Raymond, who has eclipsed the 1,000-yard mark, the Scarlet Knights possess a balanced attack capable of creating explosive gains when protection holds and early-down efficiency keeps the playbook open. However, sustaining that balance against an Ohio State defense allowing fewer than eight points per game and ranking among the nation’s best in third-down defense, red-zone efficiency, and explosive-play prevention requires a level of execution Rutgers has yet to consistently demonstrate. The Scarlet Knights must avoid early deficits, as falling behind by two scores against the Buckeyes forces opponents into predictable passing situations where Ohio State’s defensive front can pin its ears back and overwhelm protection schemes, and maintaining rhythm early becomes vital to preserving any upset hopes. Rutgers also enters aware that their defensive vulnerabilities—allowing nearly 30 points per game—create substantial risk against an Ohio State offense averaging almost 38 points and capable of scoring through power run concepts, play-action strikes, and tempo-driven drives that stress opponents both physically and mentally.

To stay in the game, Rutgers must find ways to limit chunk plays, generate pressure without overcommitting, and eliminate the coverage breakdowns that have plagued them at multiple points this season; even modest defensive success would increase their chances of maintaining competitive field position and giving their offense opportunities to sustain drives. Special teams could represent a rare pathway to momentum for the Scarlet Knights, as flipping the field, stealing a possession, or generating a spark through returns may compensate for talent and depth disparities, but such plays must be matched with clean execution elsewhere, as Ohio State’s ability to capitalize on mistakes is unmatched within the Big Ten. Beyond tactics, the emotional and psychological approach matters deeply: Rutgers must embrace its underdog identity, play freely without fear of mistakes, and avoid the spiral that has affected many teams overwhelmed early in Columbus. For a program fighting for bowl eligibility, this matchup serves as both a test of resilience and a measuring stick for growth under Greg Schiano; a victory would be program-altering, but even a competitive showing would signal meaningful progress. Ultimately, Rutgers carries enough offensive firepower to produce moments of success, but their defensive inconsistencies and Ohio State’s overwhelming strengths create a steep uphill road that demands precision, toughness, and four quarters of elevated football to stay within reach.

The Rutgers Scarlet Knights (5-5, 2-5 Big Ten) travel to face the undefeated and top-seeded Ohio State Buckeyes (10-0, 7-0 Big Ten) on November 22, 2025, in what looms as a mismatch but still offers Rutgers a final chance to salvage bowl eligibility and momentum for next season. Ohio State enters as a heavy favorite at home in Columbus with elite balanced performance across offense, defense and situational football, while Rutgers must show significant improvement on both sides of the ball to stay competitive in the matchup. Rutgers vs Ohio State AI Prediction: Free CFB Betting Insights for Nov 22. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Ohio State Buckeyes CFB Preview

Ohio State enters its November 22, 2025 home matchup against Rutgers with a perfect 10–0 record, overwhelming statistical dominance, and the confidence of a program operating at a national-title standard, and the Buckeyes understand that maintaining sharpness, discipline, and momentum is essential as they push toward the postseason knowing that any lapse—however unlikely—could disrupt their pursuit of perfection. At Ohio Stadium, where crowd energy, communication efficiency, and tempo control heavily favor the Buckeyes, they bring an offense averaging nearly 38 points per game led by quarterback Julian Sayin and a deep supporting cast of receivers, tight ends, and backs capable of punishing defenses through both precision passing and a physical downhill run game that grinds down opponents over four quarters. Sayin’s command of the offense has elevated the Buckeyes’ efficiency on third down and in the red zone, translating into prolonged drives that suffocate opposing defenses, while the offensive line’s size and cohesion provide consistent protection and help maintain balance that prevents opponents from overloading against any single phase. Defensively, Ohio State has constructed one of the most suffocating units in the country, allowing under eight points per game with elite gap discipline, relentless pass-rush pressure, and a secondary that erases explosive-play attempts before they develop, forming a complete system that forces opponents into early mistakes and reduces their play-calling options. Against a Rutgers team that has shown offensive growth but continues to allow nearly 30 points per game, the Buckeyes expect to impose their will at the line of scrimmage, disrupt passing lanes, and collapse running lanes before they open, all while dictating field position and tempo in a way that leaves the Scarlet Knights with little room for error.

Still, Ohio State’s coaching staff will emphasize the importance of fast starts, clean execution, and avoiding the complacency that sometimes creeps into games where the talent gap is wide; setting the tone early not only eliminates upset potential but also provides opportunities to refine depth, manage workloads, and prepare for the season’s decisive stretch. Special teams—reliable, precise, and often overlooked—represent another advantage for Ohio State, as consistent kicking, strong coverage units, and a return game capable of flipping momentary opportunities into explosive gains further tilt the matchup. From a psychological standpoint, the Buckeyes will aim to maintain a businesslike approach, treating this as an opportunity to reinforce their identity, demonstrate maturity, and sharpen situational football rather than simply leaning on superior talent. For Rutgers, Ohio Stadium represents a daunting venue, but for Ohio State, it is a fortress where discipline, crowd intensity, and confidence merge to create one of the toughest environments in college football. If the Buckeyes execute to their standard—maintaining balance offensively, eliminating big-play attempts defensively, and turning drive after drive into points—the result should reinforce their status as the Big Ten’s dominant force and leave little doubt as to why they stand at the forefront of the national championship conversation.

Rutgers vs Ohio State Prop Picks (AI)

Remi is pouring through tons of data on each team. In fact, anytime the Scarlet Knights and Buckeyes play there’s always several intriguing angles to key in on. Not to mention games played at Ohio Stadium in Nov almost always follow normal, predictable betting trends.

Remi's searched hard and found the best prop for this matchup: J. Sayin over 274.5 Passing Yards.

Rutgers vs Ohio State Prediction (AI)

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Remi, our AI sports algorithm, has been pouring over millions of data from every simulation between the Scarlet Knights and Buckeyes and using recursive machine learning and cutting-edge AI to crunch the data to a single cover probability.

Interestingly enough, the data has been most watching on the growing emphasis human bettors regularly put on Ohio State’s strength factors between a Scarlet Knights team going up against a possibly healthy Buckeyes team. Trends look to say the true game analytics appear to reflect a strong lean against one Vegas line in particular.

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Below is our current AI Rutgers vs Ohio State picks, computer picks Scarlet Knights vs Buckeyes, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
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These picks update as information changes—injury reports, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full CFB schedule.

Rutgers Betting Trends

Rutgers has had mixed results ATS this season, being underdogs in most games and covering fewer than half of their opportunities, which reflects a program still inconsistent and vulnerable in key situations. The combination of their improved offense but fragile defense means they’ve struggled to cover big spreads against stronger opponents.

Ohio State Betting Trends

Ohio State boasts an excellent ATS record this year, covering in the vast majority of games and entering this contest with one of the best ATS marks nationally, which underscores that not only are they winning, but doing so in command of expectations. That kind of consistency in covering spreads at home against inferior opponents makes them especially difficult to bet against in this scenario.

Scarlet Knights vs. Buckeyes Matchup Trends

Given Ohio State’s dominant form and Rutgers’ underdog status, the line has opened in the 30-point range with an over/under in the mid-50s, creating interesting angles: Rutgers may appeal as a cover option if they show any fight early, but Ohio State’s ability to dominate tempo and field position suggests that the total may lean under if the Buckeyes impose their style and control the game. Additionally, Rutgers’ defense has allowed near 30 points per game while Ohio State allows fewer than 8 points per game — a huge mismatch that may drive bettors to consider the underdog cover or the low-scoring outcome rather than a wide blowout.

Rutgers vs. Ohio State Game Info

November 22, 2025 • 1:00 PM EST • Ohio Stadium

Rutgers vs. Ohio State Odds

Remi is pouring through mountains of stats on each line. In fact, anytime the Rutgers vs Ohio State trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme travel distance can often follow normal, predictable betting trends.

Rutgers vs Ohio State

Rutgers vs Ohio State Live Odds

Games PTS ML SPR O/U
Dec 5, 2025 7:00PM EST
Troy Trojans
James Madison Dukes
12/5/25 7PM
TROY
JMAD
+1300
-2800
+23.5 (-108)
-23.5 (-112)
O 46.5 (-115)
U 46.5 (-105)
Dec 5, 2025 7:00PM EST
Kennesaw State Owls
Jacksonville State Gamecocks
12/5/25 7PM
KENSAW
JAXST
-135
+114
-2.5 (-110)
+2.5 (-110)
O 60.5 (-110)
U 60.5 (-110)
Dec 5, 2025 8:00PM EST
North Texas Mean Green
Tulane Green Wave
12/5/25 8PM
NOTEX
TULANE
-135
+114
-2.5 (-112)
+2.5 (-108)
O 66.5 (-112)
U 66.5 (-108)
Dec 5, 2025 8:01PM EST
UNLV Rebels
Boise State Broncos
12/5/25 8:01PM
UNLV
BOISE
+180
-218
+4.5 (-105)
-4.5 (-115)
O 59.5 (-105)
U 59.5 (-115)
Dec 6, 2025 12:00PM EST
Miami Ohio Redhawks
Western Michigan Broncos
12/6/25 12PM
MIAOH
WMICH
 
-122
 
-1.5 (-112)
O 43.5 (-108)
U 43.5 (-112)
Dec 6, 2025 12:00PM EST
BYU Cougars
Texas Tech Red Raiders
12/6/25 12PM
BYU
TXTECH
+400
-535
+12.5 (-108)
-12.5 (-112)
O 49.5 (-108)
U 49.5 (-112)
Dec 6, 2025 4:00PM EST
Georgia Bulldogs
Alabama Crimson Tide
12/6/25 4PM
UGA
BAMA
-135
+114
-2.5 (-110)
+2.5 (-110)
O 48.5 (-105)
U 48.5 (-115)
Dec 6, 2025 8:00PM EST
Duke Blue Devils
Virginia Cavaliers
12/6/25 8PM
DUKE
UVA
+150
-180
+4 (-112)
-4 (-108)
O 57.5 (-115)
U 57.5 (-105)
Dec 6, 2025 8:01PM EST
Indiana Hoosiers
Ohio State Buckeyes
12/6/25 8:01PM
IND
OHIOST
+164
-198
+4 (-110)
-4 (-110)
O 47.5 (-112)
U 47.5 (-108)
Dec 13, 2025 3:00PM EST
Army Black Knights
Navy Midshipmen
12/13/25 3PM
ARMY
NAVY
+164
-198
+4.5 (-108)
-4.5 (-112)
O 38.5 (+100)
U 38.5 (-120)

CFB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Rutgers Scarlet Knights vs. Ohio State Buckeyes on November 22, 2025 at Ohio Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our CFB odds pages, and compare prices before you place a bet.

LEAN %WIN UNITS RESULT
COLO@KSTATE COLO +17.5 54.0% 4 WIN
PSU@RUT RUT +14 52.8% 1 WIN
OHIOST@MICH MICH +10.5 56.4% 6 LOSS
VATECH@UVA VATECH +8 57.8% 7 LOSS
NWEST@ILL LUKE ALTMYER UNDER 19.5 PASS COMP 54.3% 4 WIN
ORE@WAS DEMOND WILLIAMS JR UNDER 43.5 RUSH YDS 55.2% 5 WIN
MIAMI@VATECH VATECH +18.5 54.2% 4 WIN
GAST@TROY TROY -9.5 55.7% 5 WIN
DEL@WAKE DEL +18 56.7% 6 LOSS
NMEX@AF NMEX -3.5 56.1% 5 WIN
WASHST@JMAD WASHST +14.5 55.3% 5 WIN
ILL@WISC WISC +9 55.1% 5 WIN
WKY@LSU WKY +23.5 56.3% 6 WIN
WASH@UCLA DEMOND WILLIAMS UNDER 27.5 PASS ATT 56.3% 6 WIN
TCU@HOU AMARE THOMAS OVER 69.5 RECV YDS 55.2% 5 WIN
TEX@UGA NATE FRAZIER UNDER 65.5 RUSH + REC YDS 55.5% 5 WIN
PUR@WASH ANTONIO HARRIS UNDER 73.5 RUSH + REC YDS 54.1% 4 WIN
OKLA@BAMA UNDER 46 52.4% 2 WIN
UVA@DUKE DUKE -3.5 54.7% 3 LOSS
OKLA@BAMA BAMA -6 54.5% 3 LOSS
OREGST@TULSA OREGST -120 55.6% 5 LOSS
UTEP@MIZZST MIZZST -5 54.3% 4 WIN
COLOST@NMEX NMEX -14 57.1% 6 LOSS
PSU@MICHST MICHST +7.5 56.5% 6 LOSS
MISSST@MIZZOU MISSST +7.5 57.2% 7 LOSS
FAU@TULANE FAU +17.5 56.0% 6 WIN
NCST@MIAMI NCST +15.5 57.1% 7 LOSS
KENTST@AKRON AKRON -6.5 55.4% 5 LOSS
JAXST@UTEP JAXST -105 57.0% 7 WIN
FSU@CLEM CLEM -118 57.1% 5 WIN
UNLV@COLOST UNLV -4 55.2% 5 WIN
OREG@IOWA IOWA +6.5 53.3% 2 WIN
NEB@UCLA NEB +1.5 55.8% 5 WIN
KENSAW@NMEXST NMEXST +10 56.5% 6 WIN
STNFRD@UNC STNFRD +7.5 53.8% 3 WIN
DUKE@UCONN UCONN +8.5 57.9% 7 WIN
NEVADA@UTAHST NEVADA +9.5 55.9% 5 LOSS
SAMST@OREGST SAMST +21 57.7% 7 WIN
NEB@UCLA NICO IAMALEAVA UNDER 180.5 PASS YDS 56.6% 6 LOSS
HOU@UCF HOU -112 58.0% 6 WIN
GASTHRN@APPST GASTHRN +180 36.5% 2 WIN
KENTST@BALLST BALLST -2.5 54.5% 4 WIN
WAKE@FSU WAKE +10.5 56.4% 6 LOSS
WYO@SDGST SDGST -10.5 56.7% 7 WIN
OKLA@TENN TENN -130 58.3% 5 LOSS
GATECH@NCST GATECH -5 56.4% 6 LOSS
MIAMI@SMU MIAMI -10 54.3% 4 LOSS
IND@MD MD +21.5 54.6% 4 LOSS
CINCY@UTAH CINCY +11 57.6% 7 LOSS
OLDDOM@LAMON LAMON +17 58.4% 8 LOSS
VANDY@TEXAS OVER 46.5 53.7% 2 WIN