Nebraska vs Penn State Prediction — AI Finds CAN'T MISS CFB Lines & Props (Nov 22)
Updated: 2025-11-15T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The upcoming November 22, 2025 matchup between the Nebraska Cornhuskers and the Penn State Nittany Lions pits Nebraska’s resurgent offense and disciplined tempo control on the road against Penn State’s home-field identity, with the Huskers looking to extend their momentum and the Nittany Lions aiming to reassert their stature in a pivotal late‐season Big Ten clash.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.
GAME INFO
Date: Nov 22, 2025
Start Time: 8:00 PM EST
Venue: West Shore Home Field at Beaver Stadium
Nittany Lions Record: (4-6)
Cornhuskers Record: (7-3)
OPENING ODDS
NEB Moneyline: +278
PSU Moneyline: -355
NEB Spread: +9.5
PSU Spread: -9.5
Over/Under: 44.5
NEB
Betting Trends
- Nebraska has averaged approximately 32.5 points per game and allowed around 19.9 points per game through their first ten games in 2025.
PSU
Betting Trends
- Penn State is averaging roughly 30.4 points per game while allowing approximately 21.1 points per game in 2025.
MATCHUP TRENDS
- The line opens with Penn State as an 8.5-point favorite at home, and the total is set around 44 points. Given Nebraska’s better defensive numbers and Penn State’s slightly above-average offensive output, this contest offers potential value on Nebraska covering or the total hitting over if Nebraska’s offense continues its efficiency and tempo on the road.
NEB vs. PSU
Best Prop Bet
- Remi's searched hard and found the best prop for this matchup: E. Grunkemeyer under 181.5 Passing Yards.
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Nebraska vs Penn State Prediction & Odds:
Free CFB Betting Insights for 11/22/25
The upcoming November 22, 2025 matchup between Nebraska and Penn State arrives as one of the more intriguing late-season Big Ten showdowns, with Nebraska entering as the more statistically balanced and efficient team while Penn State leans on home-field intensity, physicality, and the urgency of salvaging a challenging season. Nebraska comes in with a revitalized offensive identity built on efficient early-down execution, balanced run-pass distribution, and a scoring profile that consistently places pressure on opposing defenses, averaging more than thirty points per game while allowing fewer than twenty. Their success this season has been defined by sustaining drives, protecting the football, and winning hidden-yardage battles that tilt field position, allowing their defense to dictate tempo and force opponents into disadvantageous situations. Penn State, despite a less impressive record, remains a fundamentally sound program capable of punishing mistakes, controlling the line of scrimmage when rhythm develops, and leveraging crowd energy to create pressure moments that disrupt timing-based offenses like Nebraska’s. The Nittany Lions’ best path to success lies in establishing physicality early—running the ball with consistency, setting up manageable third downs, and using play-action to test Nebraska’s linebackers and safeties.
Nebraska must counter by staying ahead of schedule, hitting explosive perimeter plays, and preventing Penn State from dragging the contest into a grind-heavy style that compresses possessions and limits Nebraska’s tempo. Defensively, the Huskers must remain disciplined, particularly against Penn State’s downhill run game and structured passing concepts that rely on intermediate timing. Meanwhile, Penn State’s defense must prevent Nebraska from dictating pace and must eliminate missed tackles that could turn short gains into drive-stretching plays. Special teams and hidden yardage may ultimately determine the outcome, as both programs depend heavily on field-position leverage to maximize their respective offensive strengths. Nebraska’s advantage grows in a higher-tempo, multi-possession game, while Penn State thrives if they can turn this into a controlled, methodical matchup. Ultimately, the contest hinges on whether Nebraska can impose its efficient, balanced identity in a hostile environment or whether Penn State can leverage emotion, defensive intensity, and situational control to keep the Huskers boxed into a slower, more physical style of football.
Get live CFB odds and precise AI CFB picks, predictions, and cover probabilities.
Add it to the list ✍️ @Emmett21Johnson has been named a semifinalist for the Doak Walker Award. pic.twitter.com/PbfjlOu1mF
— Nebraska Football (@HuskerFootball) November 18, 2025
Nebraska Cornhuskers CFB Preview
Nebraska enters its November 22, 2025 road matchup at Penn State with the confidence of a team that has found a stable and efficient identity on both sides of the ball, averaging strong offensive production while maintaining one of the more reliable defensive profiles in the Big Ten, giving the Huskers a legitimate chance to challenge even in a hostile environment like Beaver Stadium. Their offense operates through a balanced approach that blends steady rushing efficiency with a controlled passing game designed to stay ahead of the chains, sustain drives, and maintain tempo without relying on risky high-variance plays. Nebraska’s ability to convert third downs at a high rate and finish red-zone opportunities with touchdowns instead of field goals is central to their success, especially on the road where missed chances can quickly tilt momentum. A disciplined offensive line, combined with a quarterback who has avoided costly turnovers, has allowed Nebraska to dictate pace in most of its wins, and that formula becomes even more critical against a Penn State defense that thrives when opponents are forced into predictable passing situations. Defensively, Nebraska brings a structured, assignment-sound unit that limits yards per play, tackles well in space, and avoids giving up explosive plays—an essential trait when facing a Penn State offense that relies on rhythm and physicality to move the ball.
The Huskers will need to stay disciplined against the run, prevent intermediate play-action shots, and keep Penn State behind schedule to control the game flow. Special teams and hidden yardage will matter greatly; Nebraska must flip the field when possible, avoid penalties that erase field-position wins, and remain clean in coverage to prevent the type of momentum swings that often decide road games. Psychologically, Nebraska must embrace the urgency and grit required to win on the road in late November—remaining poised, avoiding emotional overreactions to crowd energy, and maintaining confidence even if Penn State delivers early punches. Their path to a road victory lies in controlling tempo, eliminating turnovers, finishing drives, and forcing Penn State to play from behind, where the Huskers’ defensive discipline becomes even more effective. If Nebraska can impose its balanced identity and maintain situational control, they have the structure to push for an upset; if they slip into long-yardage situations or lose the field-position battle, the environment will magnify every mistake.
Credit: USA TODAY/IMAGN
Penn State Nittany Lions CFB Preview
Penn State enters its November 22, 2025 home matchup against Nebraska determined to reassert its identity behind the energy of Beaver Stadium, leaning on physicality, defensive toughness, and situational execution to counter a Husker team that has shown strong balance and efficiency all season. The Nittany Lions’ offense, while not as explosive as Nebraska’s, thrives when it establishes the run early, allowing their play-action game to open intermediate windows and control the tempo of possessions. Their ability to generate manageable third downs is crucial, as extended drives not only wear down opposing defenses but also keep Nebraska’s offense off the field—preventing the Huskers from imposing their fast, rhythmic approach. Penn State’s offensive line must set the tone at the point of attack, creating enough push to keep Nebraska’s disciplined front seven from dictating the flow of the game. Defensively, the Nittany Lions hold one of their most meaningful advantages at home: crowd noise enhances their pass rush, disrupts opposing communication, and helps generate pressure that forces quarterbacks into hurried decisions. Penn State’s defense excels when it can force opponents into long-yardage situations, rally aggressively to the football, and eliminate explosive plays, all of which will be essential against Nebraska’s methodical, balanced offense.
The Nittany Lions must close down inside runs, prevent Nebraska from controlling tempo, and remain disciplined against play-action, which the Huskers use effectively to stay ahead of the chains. Special teams may quietly decide the game for Penn State, as their home execution historically provides elevated coverage discipline and field-position advantages that tilt hidden yards in their favor. Psychologically, Penn State benefits from the emotional momentum that accompanies late-season home games, and they must channel that intensity into clean execution rather than overaggression that leads to penalties or blown assignments. Their path to victory rests on controlling early downs, sustaining long possessions, capitalizing on any short fields generated by their defense, and forcing Nebraska into uncomfortable, reactionary football. If Penn State imposes its physical style, rides the home environment, and maintains discipline in all three phases, the Nittany Lions can neutralize Nebraska’s efficiency and turn the matchup toward their preferred pace and structure.
Saturday Night. #WeAre pic.twitter.com/Pvb5RXq1Fq
— Penn State Football (@PennStateFball) November 18, 2025
Nebraska vs Penn State Prop Picks (AI)
AI algorithm Remi is pouring through mountains of data on each line. In fact, anytime the Cornhuskers and Nittany Lions play there’s always several intriguing observations to key in on. Not to mention games played at West Shore Home Field at Beaver Stadium in Nov rarely follow normal, predictable betting trends.
Nebraska vs Penn State Prediction (AI)
Remi, our AI sports algorithm, has been pouring over tons of data from every angle between the Cornhuskers and Nittany Lions and using recursive machine learning and impressive AI to examine the data to a single cover probability.
The Algorithm has been most watching on the unproportionally assigned weight knucklehead sportsbettors tend to put on player performance factors between a Cornhuskers team going up against a possibly unhealthy Nittany Lions team. It appears the true game analytics appear to reflect a slight lean against one Vegas line in particular.
Unlock this in-depth AI prediction and all of our CFB AI picks for FREE now.
Below is our current AI Nebraska vs Penn State picks, computer picks Cornhuskers vs Nittany Lions, best bets, model edges, confidence ratings.
| DATE | GAME | LEAN | %WIN | UNITS | LEVEL | |
|---|---|---|---|---|---|---|
| ACTIVE PICKS LOCKED - SEE NOW | ||||||
These picks update as information changes—injury reports, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full CFB schedule.
Nebraska Betting Trends
Nebraska has averaged approximately 32.5 points per game and allowed around 19.9 points per game through their first ten games in 2025.
Penn State Betting Trends
Penn State is averaging roughly 30.4 points per game while allowing approximately 21.1 points per game in 2025.
Cornhuskers vs. Nittany Lions Matchup Trends
The line opens with Penn State as an 8.5-point favorite at home, and the total is set around 44 points. Given Nebraska’s better defensive numbers and Penn State’s slightly above-average offensive output, this contest offers potential value on Nebraska covering or the total hitting over if Nebraska’s offense continues its efficiency and tempo on the road.
Nebraska vs. Penn State Game Info
Nebraska vs Penn State starts on November 22, 2025 at 8:00 PM EST.
Venue: West Shore Home Field at Beaver Stadium.
Spread: Penn State -9.5
Moneyline: Nebraska +278, Penn State -355
Over/Under: 44.5
Nebraska: (7-3) | Penn State: (4-6)
Remi's searched hard and found the best prop for this matchup: E. Grunkemeyer under 181.5 Passing Yards.. Prices move—always shop for the best number.
The line opens with Penn State as an 8.5-point favorite at home, and the total is set around 44 points. Given Nebraska’s better defensive numbers and Penn State’s slightly above-average offensive output, this contest offers potential value on Nebraska covering or the total hitting over if Nebraska’s offense continues its efficiency and tempo on the road.
NEB trend: Nebraska has averaged approximately 32.5 points per game and allowed around 19.9 points per game through their first ten games in 2025.
PSU trend: Penn State is averaging roughly 30.4 points per game while allowing approximately 21.1 points per game in 2025.
See our latest CFB picks and odds pages for 2025 to compare prices before you bet.
Nebraska vs. Penn State Odds
AI algorithm Remi is pouring through loads of stats on each player. In fact, anytime the Nebraska vs Penn State trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme hostile environments can often follow normal, predictable patterns.
| NEB Moneyline | +278 |
|---|---|
| PSU Moneyline | -355 |
| NEB Spread | +9.5 |
| PSU Spread | -9.5 |
| Over / Under | 44.5 |
Nebraska vs Penn State Live Odds
| Games | PTS | ML | SPR | O/U | |
|---|---|---|---|---|---|
|
Dec 5, 2025 7:00PM EST
Troy Trojans
James Madison Dukes
12/5/25 7PM
TROY
JMAD
|
–
–
|
+1258
-5049
|
+23.5 (-110)
-23.5 (-110)
|
O 47 (-110)
U 47 (-110)
|
|
|
Dec 5, 2025 7:00PM EST
Kennesaw State Owls
Jacksonville State Gamecocks
12/5/25 7PM
KENSAW
JAXST
|
–
–
|
-135
+110
|
-2.5 (-110)
+2.5 (-110)
|
O 60.5 (-110)
U 60.5 (-110)
|
|
|
Dec 5, 2025 8:00PM EST
North Texas Mean Green
Tulane Green Wave
12/5/25 8PM
NOTEX
TULANE
|
–
–
|
-136
+111
|
-2.5 (-110)
+2.5 (-110)
|
O 66.5 (-110)
U 66.5 (-110)
|
|
|
Dec 5, 2025 8:01PM EST
UNLV Rebels
Boise State Broncos
12/5/25 8:01PM
UNLV
BOISE
|
–
–
|
+170
-212
|
+5 (-110)
-5 (-110)
|
O 59 (-110)
U 59 (-110)
|
|
|
Dec 6, 2025 12:00PM EST
Miami Ohio Redhawks
Western Michigan Broncos
12/6/25 12PM
MIAOH
WMICH
|
–
–
|
-128
|
-2 (-110)
|
O 43.5 (-110)
U 43.5 (-110)
|
|
|
Dec 6, 2025 12:00PM EST
BYU Cougars
Texas Tech Red Raiders
12/6/25 12PM
BYU
TXTECH
|
–
–
|
+380
-526
|
+12.5 (-110)
-12.5 (-110)
|
O 49.5 (-110)
U 49.5 (-110)
|
|
|
Dec 6, 2025 4:00PM EST
Georgia Bulldogs
Alabama Crimson Tide
12/6/25 4PM
UGA
BAMA
|
–
–
|
-130
+106
|
-2 (-110)
+2 (-110)
|
O 48 (-110)
U 48 (-110)
|
|
|
Dec 6, 2025 8:00PM EST
Duke Blue Devils
Virginia Cavaliers
12/6/25 8PM
DUKE
UVA
|
–
–
|
+151
-187
|
+4 (-110)
-4 (-110)
|
O 58 (-110)
U 58 (-110)
|
|
|
Dec 6, 2025 8:01PM EST
Indiana Hoosiers
Ohio State Buckeyes
12/6/25 8:01PM
IND
OHIOST
|
–
–
|
+165
-200
|
+4 (-105)
-4 (-115)
|
O 47.5 (-115)
U 47.5 (-105)
|
|
|
Dec 13, 2025 3:00PM EST
Army Black Knights
Navy Midshipmen
12/13/25 3PM
ARMY
NAVY
|
–
–
|
+172
-216
|
+4.5 (-105)
-4.5 (-115)
|
O 38 (-110)
U 38 (-110)
|
CFB Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers Nebraska Cornhuskers vs. Penn State Nittany Lions on November 22, 2025 at West Shore Home Field at Beaver Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our CFB odds pages, and compare prices before you place a bet.
| LEAN | %WIN | UNITS | RESULT | |
|---|---|---|---|---|
| COLO@KSTATE | COLO +17.5 | 54.0% | 4 | WIN |
| PSU@RUT | RUT +14 | 52.8% | 1 | WIN |
| OHIOST@MICH | MICH +10.5 | 56.4% | 6 | LOSS |
| VATECH@UVA | VATECH +8 | 57.8% | 7 | LOSS |
| NWEST@ILL | LUKE ALTMYER UNDER 19.5 PASS COMP | 54.3% | 4 | WIN |
| ORE@WAS | DEMOND WILLIAMS JR UNDER 43.5 RUSH YDS | 55.2% | 5 | WIN |
| MIAMI@VATECH | VATECH +18.5 | 54.2% | 4 | WIN |
| GAST@TROY | TROY -9.5 | 55.7% | 5 | WIN |
| DEL@WAKE | DEL +18 | 56.7% | 6 | LOSS |
| NMEX@AF | NMEX -3.5 | 56.1% | 5 | WIN |
| WASHST@JMAD | WASHST +14.5 | 55.3% | 5 | WIN |
| ILL@WISC | WISC +9 | 55.1% | 5 | WIN |
| WKY@LSU | WKY +23.5 | 56.3% | 6 | WIN |
| WASH@UCLA | DEMOND WILLIAMS UNDER 27.5 PASS ATT | 56.3% | 6 | WIN |
| TCU@HOU | AMARE THOMAS OVER 69.5 RECV YDS | 55.2% | 5 | WIN |
| TEX@UGA | NATE FRAZIER UNDER 65.5 RUSH + REC YDS | 55.5% | 5 | WIN |
| PUR@WASH | ANTONIO HARRIS UNDER 73.5 RUSH + REC YDS | 54.1% | 4 | WIN |
| OKLA@BAMA | UNDER 46 | 52.4% | 2 | WIN |
| UVA@DUKE | DUKE -3.5 | 54.7% | 3 | LOSS |
| OKLA@BAMA | BAMA -6 | 54.5% | 3 | LOSS |
| OREGST@TULSA | OREGST -120 | 55.6% | 5 | LOSS |
| UTEP@MIZZST | MIZZST -5 | 54.3% | 4 | WIN |
| COLOST@NMEX | NMEX -14 | 57.1% | 6 | LOSS |
| PSU@MICHST | MICHST +7.5 | 56.5% | 6 | LOSS |
| MISSST@MIZZOU | MISSST +7.5 | 57.2% | 7 | LOSS |
| FAU@TULANE | FAU +17.5 | 56.0% | 6 | WIN |
| NCST@MIAMI | NCST +15.5 | 57.1% | 7 | LOSS |
| KENTST@AKRON | AKRON -6.5 | 55.4% | 5 | LOSS |
| JAXST@UTEP | JAXST -105 | 57.0% | 7 | WIN |
| FSU@CLEM | CLEM -118 | 57.1% | 5 | WIN |
| UNLV@COLOST | UNLV -4 | 55.2% | 5 | WIN |
| OREG@IOWA | IOWA +6.5 | 53.3% | 2 | WIN |
| NEB@UCLA | NEB +1.5 | 55.8% | 5 | WIN |
| KENSAW@NMEXST | NMEXST +10 | 56.5% | 6 | WIN |
| STNFRD@UNC | STNFRD +7.5 | 53.8% | 3 | WIN |
| DUKE@UCONN | UCONN +8.5 | 57.9% | 7 | WIN |
| NEVADA@UTAHST | NEVADA +9.5 | 55.9% | 5 | LOSS |
| SAMST@OREGST | SAMST +21 | 57.7% | 7 | WIN |
| NEB@UCLA | NICO IAMALEAVA UNDER 180.5 PASS YDS | 56.6% | 6 | LOSS |
| HOU@UCF | HOU -112 | 58.0% | 6 | WIN |
| GASTHRN@APPST | GASTHRN +180 | 36.5% | 2 | WIN |
| KENTST@BALLST | BALLST -2.5 | 54.5% | 4 | WIN |
| WAKE@FSU | WAKE +10.5 | 56.4% | 6 | LOSS |
| WYO@SDGST | SDGST -10.5 | 56.7% | 7 | WIN |
| OKLA@TENN | TENN -130 | 58.3% | 5 | LOSS |
| GATECH@NCST | GATECH -5 | 56.4% | 6 | LOSS |
| MIAMI@SMU | MIAMI -10 | 54.3% | 4 | LOSS |
| IND@MD | MD +21.5 | 54.6% | 4 | LOSS |
| CINCY@UTAH | CINCY +11 | 57.6% | 7 | LOSS |
| OLDDOM@LAMON | LAMON +17 | 58.4% | 8 | LOSS |
| VANDY@TEXAS | OVER 46.5 | 53.7% | 2 | WIN |