Virginia vs Duke Prediction — AI Finds CAN'T MISS CFB Lines & Props (Nov 15)
Updated: 2025-11-08T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The Duke Blue Devils host the Virginia Cavaliers on November 15, 2025, in an ACC showdown between two teams aiming to close their seasons on a positive note. Duke enters as a heavy favorite at home behind a balanced offense and disciplined defense, while Virginia looks to play spoiler and snap a late-season skid.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.
GAME INFO
Date: Nov 15, 2025
Start Time: 4:30 PM EST
Venue: Brooks Field at Wallace Wade Stadium
Blue Devils Record: (5-4)
Cavaliers Record: (8-2)
OPENING ODDS
UVA Moneyline: +190
DUKE Moneyline: -233
UVA Spread: +6.5
DUKE Spread: -6.5
Over/Under: 57.5
UVA
Betting Trends
- Virginia has covered in just 3 of its last 9 games, struggling to meet betting expectations, particularly against ranked or defensively strong opponents.
DUKE
Betting Trends
- Duke has been one of the more reliable ACC teams at home, covering the spread in 6 of its last 8 home contests thanks to a resilient defense and efficient quarterback play.
MATCHUP TRENDS
- Historically, Duke has covered the spread in four of the last five matchups against Virginia, often capitalizing on turnovers and second-half adjustments. With Duke’s improved scoring defense and Virginia’s inconsistent offense, the odds lean toward another Blue Devils cover.
UVA vs. DUKE
Best Prop Bet
- Remi's searched hard and found the best prop for this matchup: C. Ross under 44.5 Receiving Yards.
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Virginia vs Duke Prediction & Odds:
Free CFB Betting Insights for 11/15/25
The November 15, 2025 ACC showdown between the Virginia Cavaliers and the Duke Blue Devils at Wallace Wade Stadium in Durham brings together two programs heading in opposite directions, with Duke surging toward another bowl appearance and Virginia still searching for stability under Tony Elliott. Duke, led by head coach Manny Diaz, has built a reputation this season as one of the most fundamentally sound and well-rounded teams in the ACC, boasting a 7-3 record entering the contest. Their identity is defined by balance — a disciplined defense that allows just 20.2 points per game and an offense that scores over 31 points per contest. Quarterback Maalik Murphy has been a revelation, seamlessly transitioning into Duke’s system with composure and precision, throwing for over 2,400 yards and 18 touchdowns while maintaining one of the lowest interception rates in the conference. He’s complemented by a deep backfield led by Jordan Waters, who’s rushed for nearly 1,000 yards and 10 touchdowns, while Jaquez Moore adds an explosive element on outside runs and passing plays. Duke’s offensive line, anchored by veterans Graham Barton and Maurice McIntyre, has provided outstanding protection and has been the cornerstone of their success. Wideouts Jalon Calhoun and Sahmir Hagans have emerged as reliable targets, combining for more than 1,200 receiving yards and showcasing strong chemistry with Murphy. The Blue Devils’ defense has been just as formidable, ranking among the ACC’s best in takeaways and red-zone efficiency. Linebacker Tre Freeman leads the team in tackles, and defensive lineman DeWayne Carter continues to wreak havoc in the trenches, while safety Jaylen Stinson’s coverage and physicality make the secondary one of Duke’s biggest strengths. Virginia, meanwhile, enters at 3-7 and continues to struggle with consistency, though flashes of promise have come from young quarterback Anthony Colandrea, who’s thrown for over 2,000 yards with 13 touchdowns but has also tossed 10 interceptions.
The Cavaliers’ offense averages 23 points per game but has been held under 20 in five contests due to an inconsistent offensive line and red-zone inefficiency. Running back Perris Jones, returning from injury, has been a bright spot, rushing for over 500 yards at a solid clip, while wideouts Malik Washington and Malachi Fields give Virginia a legitimate one-two punch in the passing game. Defensively, the Cavaliers have not been able to stop the run, giving up 180 yards per game on the ground and allowing opponents to sustain long drives that wear down their front seven. Linebackers Kam Robinson and James Jackson have played well, but the unit’s lack of depth and pass-rush pressure has left the secondary vulnerable to big plays. Against a balanced Duke offense that thrives on controlling time of possession and converting third downs, Virginia faces a daunting task. The key matchup will be Virginia’s secondary versus Duke’s efficient passing attack; if the Cavaliers can’t disrupt Murphy’s rhythm, the game could slip away early. Betting trends reinforce this divide — Duke has covered the spread in six of its last eight home games, while Virginia has covered in only three of its last nine overall. The Blue Devils’ dominance at home, combined with Virginia’s inconsistency on the road, makes this a difficult spot for the Cavaliers to generate an upset. Expect Duke to assert control early, using its physical line play and disciplined defense to set the tone. Virginia might stay competitive in the first half, but Duke’s depth, execution, and home-field advantage should prevail decisively. Prediction: Duke 34, Virginia 17, with the Blue Devils cruising to another convincing victory and strengthening their bowl positioning in the ACC standings.
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𝐍𝐨. 𝟏𝟗@CFBPlayoff #GoHoos 🔶⚔️🔷 pic.twitter.com/G6HLKWkoYH
— Virginia Football (@UVAFootball) November 12, 2025
Virginia Cavaliers CFB Preview
The Virginia Cavaliers travel to Durham to take on the Duke Blue Devils on November 15, 2025, hoping to play spoiler and end their season on a positive note after another year marked by inconsistency and growing pains. Under head coach Tony Elliott, Virginia sits at 3-7, a record that reflects flashes of competitiveness mixed with long stretches of frustration. Offensively, the Cavaliers have shown moments of progress behind sophomore quarterback Anthony Colandrea, whose arm strength and athleticism give the offense a spark. Colandrea has thrown for more than 2,000 yards and 13 touchdowns but has also committed 10 interceptions, a product of both youth and a lack of consistent pass protection. The offensive line has struggled all season, allowing steady pressure and limiting the ability to stretch the field vertically. Running back Perris Jones has been a bright spot since returning from injury, rushing for over 500 yards at an average of 4.7 yards per carry, providing some balance to an offense that averages just over 23 points per game. Wide receivers Malik Washington and Malachi Fields have been the driving forces in the passing game, combining for more than 1,500 yards and offering reliable targets who can move the chains. However, sustaining drives has been a recurring issue; Virginia converts only about 35% of its third-down attempts and struggles to finish possessions in the red zone, leading to missed scoring opportunities that have cost them several close games. Defensively, the Cavaliers have been unable to find consistency. They allow nearly 31 points per game and have struggled to stop the run, giving up close to 180 rushing yards per contest. The front seven, led by linebackers Kam Robinson and James Jackson, has talent but often wears down as the game progresses due to lack of depth and time of possession deficits.
Their pass rush, with just 17 sacks on the season, ranks near the bottom of the ACC, which could be problematic against a disciplined Duke offensive line that has allowed few pressures all year. In the secondary, cornerback Dre Walker and safety Jonas Sanker have shown improvement, but coverage breakdowns and missed tackles remain persistent problems. To stay competitive in this matchup, Virginia will need to play a nearly perfect game — control the ball, win the turnover battle, and limit Duke’s explosive plays. Offensively, Elliott will likely look to use short passes, screens, and quarterback rollouts to mitigate pressure and create manageable down-and-distance situations. Defensively, Virginia must prioritize stopping Duke’s ground game early, forcing quarterback Maalik Murphy into third-and-long scenarios where they can pressure him into mistakes. Special teams will also be critical; kicker Will Bettridge has been dependable, but inconsistent punting and coverage could put Virginia at a field-position disadvantage. Historically, Virginia has had difficulty on the road, covering the spread in just three of its last nine games, and that trend reflects their inability to finish games in hostile environments. Still, the Cavaliers are a scrappy, prideful group that plays hard even when outmatched. Their best hope lies in starting fast and catching Duke off guard with aggressive play-calling early, perhaps generating momentum through turnovers or special-teams plays. If Colandrea can protect the football and Washington and Fields can find openings in Duke’s disciplined secondary, Virginia could keep the game within reach for a half. However, the combination of Duke’s home-field advantage, superior defense, and offensive efficiency will likely wear the Cavaliers down over four quarters. Expect Virginia to compete with heart but ultimately fall short against a deeper, more polished opponent. Prediction: Duke 34, Virginia 17, as the Cavaliers’ effort isn’t enough to overcome their execution issues and defensive shortcomings.
Credit: USA TODAY/IMAGN
Duke Blue Devils CFB Preview
The Duke Blue Devils return to Wallace Wade Stadium on November 15, 2025, in control of their own postseason destiny, entering this matchup against the Virginia Cavaliers with a 7-3 record and one of the most balanced teams in the ACC. Under head coach Manny Diaz, Duke has continued its transformation into a program defined by physicality, defensive discipline, and offensive balance. The Blue Devils’ formula for success this season has been simple yet effective — dominate the trenches, win time of possession, and capitalize on opponents’ mistakes. Offensively, Duke averages around 31 points per game, led by quarterback Maalik Murphy, who has displayed maturity beyond his years. Murphy has thrown for over 2,400 yards and 18 touchdowns while maintaining one of the lowest interception rates in the conference, proving himself capable of both stretching defenses vertically and managing tempo efficiently. He benefits from a strong supporting cast that includes running back Jordan Waters, who’s rushed for nearly 1,000 yards and 10 touchdowns, and Jaquez Moore, whose burst and versatility provide an ideal complement. The offensive line, anchored by Graham Barton and Maurice McIntyre, has been dominant in both pass protection and run blocking, giving Duke the consistency needed to sustain long drives. Wideouts Jalon Calhoun and Sahmir Hagans lead a deep receiver group that thrives on timing routes and yards after the catch, helping Duke maintain balance and unpredictability. Defensively, the Blue Devils have been one of the ACC’s most formidable units, allowing just 20.2 points per game and excelling in both red-zone defense and third-down efficiency. Linebacker Tre Freeman has emerged as the heart of the defense with his tackling and leadership, while defensive lineman DeWayne Carter continues to set the tone up front, combining power and quickness to disrupt plays in the backfield.
The secondary, featuring standout safety Jaylen Stinson and cornerback Chandler Rivers, has excelled at limiting big plays and forcing turnovers, ranking among the ACC’s leaders in interceptions. Duke’s defensive identity is built on gap integrity and discipline — they rarely beat themselves with penalties or blown coverages, and they thrive in high-leverage moments. The Blue Devils’ special teams have also played a crucial role in their success, with kicker Todd Pelino proving reliable inside 45 yards and the return units consistently flipping field position. At home, Duke has been particularly dominant, covering the spread in six of its last eight home games and holding opponents to under 17 points per contest on average. The key for Duke in this matchup will be maintaining focus and avoiding complacency against a Virginia team that, while struggling, has playmakers capable of striking quickly if given opportunities. Expect the Blue Devils to lean heavily on their rushing attack early, using Waters and Moore to control tempo and wear down Virginia’s defensive front, which has allowed nearly 180 rushing yards per game. Murphy will look to build on that foundation with efficient play-action passing, targeting Calhoun and Hagans against a vulnerable Cavalier secondary that has struggled to contain big plays. Defensively, Duke’s goal will be to pressure Virginia quarterback Anthony Colandrea into mistakes, as turnovers have plagued the Cavaliers all season. With superior depth, coaching, and execution, Duke has all the advantages necessary to take command early and maintain control throughout. A balanced offensive effort paired with another stout defensive performance should keep the Blue Devils in complete control as they close in on another bowl berth. Prediction: Duke 34, Virginia 17, as Duke’s discipline, balance, and home-field dominance once again prove too much for a struggling opponent.
PFF ACC Team of the Week 👏 pic.twitter.com/vawgvtkLkF
— Duke Football (@DukeFOOTBALL) November 11, 2025
Virginia vs Duke Prop Picks (AI)
AI algorithm Remi is pouring through mountains of data on each player. In fact, anytime the Cavaliers and Blue Devils play there’s always several intriguing trends to key in on. Not to mention games played at Brooks Field at Wallace Wade Stadium in Nov almost always follow normal, predictable betting trends.
Virginia vs Duke Prediction (AI)
Remi, our AI sports wizard, has been pouring over millions of data from every past game between the Cavaliers and Blue Devils and using recursive machine learning and cutting-edge AI to boil down the data to a single cover probability.
Oddly enough, we’ve seen the AI has been most keyed in on the linear correlation of factor knucklehead sportsbettors tend to put on coaching factors between a Cavaliers team going up against a possibly strong Blue Devils team. It appears the true game analytics appear to reflect a slight lean against one Vegas line specifically.
Unlock this in-depth AI prediction and all of our CFB AI picks for FREE now.
Below is our current AI Virginia vs Duke picks, computer picks Cavaliers vs Blue Devils, best bets, model edges, confidence ratings.
| DATE | GAME | LEAN | %WIN | UNITS | LEVEL | |
|---|---|---|---|---|---|---|
| ACTIVE PICKS LOCKED - SEE NOW | ||||||
These picks update as information changes—injury reports, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full CFB schedule.
Virginia Betting Trends
Virginia has covered in just 3 of its last 9 games, struggling to meet betting expectations, particularly against ranked or defensively strong opponents.
Duke Betting Trends
Duke has been one of the more reliable ACC teams at home, covering the spread in 6 of its last 8 home contests thanks to a resilient defense and efficient quarterback play.
Cavaliers vs. Blue Devils Matchup Trends
Historically, Duke has covered the spread in four of the last five matchups against Virginia, often capitalizing on turnovers and second-half adjustments. With Duke’s improved scoring defense and Virginia’s inconsistent offense, the odds lean toward another Blue Devils cover.
Virginia vs. Duke Game Info
Virginia vs Duke starts on November 15, 2025 at 4:30 PM EST.
Venue: Brooks Field at Wallace Wade Stadium.
Spread: Duke -6.5
Moneyline: Virginia +190, Duke -233
Over/Under: 57.5
Virginia: (8-2) | Duke: (5-4)
Remi's searched hard and found the best prop for this matchup: C. Ross under 44.5 Receiving Yards.. Prices move—always shop for the best number.
Historically, Duke has covered the spread in four of the last five matchups against Virginia, often capitalizing on turnovers and second-half adjustments. With Duke’s improved scoring defense and Virginia’s inconsistent offense, the odds lean toward another Blue Devils cover.
UVA trend: Virginia has covered in just 3 of its last 9 games, struggling to meet betting expectations, particularly against ranked or defensively strong opponents.
DUKE trend: Duke has been one of the more reliable ACC teams at home, covering the spread in 6 of its last 8 home contests thanks to a resilient defense and efficient quarterback play.
See our latest CFB picks and odds pages for 2025 to compare prices before you bet.
Virginia vs. Duke Odds
AI algorithm Remi is pouring through tons of data points on each line. In fact, anytime the Virginia vs Duke trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme temps seemingly never follow normal, predictable patterns.
| UVA Moneyline | +190 |
|---|---|
| DUKE Moneyline | -233 |
| UVA Spread | +6.5 |
| DUKE Spread | -6.5 |
| Over / Under | 57.5 |
Virginia vs Duke Live Odds
| Games | PTS | ML | SPR | O/U | |
|---|---|---|---|---|---|
|
Dec 5, 2025 7:00PM EST
Troy Trojans
James Madison Dukes
12/5/25 7PM
TROY
JMAD
|
–
–
|
+1300
-2500
|
+23.5 (-108)
-23.5 (-112)
|
O 46.5 (-110)
U 46.5 (-110)
|
|
|
Dec 5, 2025 7:00PM EST
Kennesaw State Owls
Jacksonville State Gamecocks
12/5/25 7PM
KENSAW
JAXST
|
–
–
|
-136
+116
|
-2.5 (-110)
+2.5 (-110)
|
O 60.5 (-110)
U 60.5 (-110)
|
|
|
Dec 5, 2025 8:00PM EST
North Texas Mean Green
Tulane Green Wave
12/5/25 8PM
NOTEX
TULANE
|
–
–
|
-134
+114
|
-2.5 (-112)
+2.5 (-108)
|
O 66.5 (-115)
U 66.5 (-105)
|
|
|
Dec 5, 2025 8:01PM EST
UNLV Rebels
Boise State Broncos
12/5/25 8:01PM
UNLV
BOISE
|
–
–
|
+184
-220
|
+5.5 (-110)
-5.5 (-110)
|
O 58.5 (-115)
U 58.5 (-105)
|
|
|
Dec 6, 2025 12:00PM EST
Miami Ohio Redhawks
Western Michigan Broncos
12/6/25 12PM
MIAOH
WMICH
|
–
–
|
-132
|
-1.5 (-115)
|
O 42.5 (-115)
U 42.5 (-105)
|
|
|
Dec 6, 2025 12:00PM EST
BYU Cougars
Texas Tech Red Raiders
12/6/25 12PM
BYU
TXTECH
|
–
–
|
+430
-560
|
+12.5 (-105)
-12.5 (-115)
|
O 49.5 (-108)
U 49.5 (-112)
|
|
|
Dec 6, 2025 4:00PM EST
Georgia Bulldogs
Alabama Crimson Tide
12/6/25 4PM
UGA
BAMA
|
–
–
|
-134
+114
|
-2.5 (-115)
+2.5 (-105)
|
O 48.5 (-106)
U 48.5 (-114)
|
|
|
Dec 6, 2025 8:00PM EST
Duke Blue Devils
Virginia Cavaliers
12/6/25 8PM
DUKE
UVA
|
–
–
|
+156
-186
|
+3.5 (-102)
-3.5 (-120)
|
O 57.5 (-115)
U 57.5 (-105)
|
|
|
Dec 6, 2025 8:01PM EST
Indiana Hoosiers
Ohio State Buckeyes
12/6/25 8:01PM
IND
OHIOST
|
–
–
|
+158
-188
|
+4.5 (-115)
-4.5 (-105)
|
O 47.5 (-114)
U 47.5 (-106)
|
|
|
Dec 13, 2025 3:00PM EST
Army Black Knights
Navy Midshipmen
12/13/25 3PM
ARMY
NAVY
|
–
–
|
+172
-210
|
+4.5 (-105)
-4.5 (-115)
|
O 38.5 (-110)
U 38.5 (-110)
|
CFB Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers Virginia Cavaliers vs. Duke Blue Devils on November 15, 2025 at Brooks Field at Wallace Wade Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our CFB odds pages, and compare prices before you place a bet.
| LEAN | %WIN | UNITS | RESULT | |
|---|---|---|---|---|
| COLO@KSTATE | COLO +17.5 | 54.0% | 4 | WIN |
| PSU@RUT | RUT +14 | 52.8% | 1 | WIN |
| OHIOST@MICH | MICH +10.5 | 56.4% | 6 | LOSS |
| VATECH@UVA | VATECH +8 | 57.8% | 7 | LOSS |
| NWEST@ILL | LUKE ALTMYER UNDER 19.5 PASS COMP | 54.3% | 4 | WIN |
| ORE@WAS | DEMOND WILLIAMS JR UNDER 43.5 RUSH YDS | 55.2% | 5 | WIN |
| MIAMI@VATECH | VATECH +18.5 | 54.2% | 4 | WIN |
| GAST@TROY | TROY -9.5 | 55.7% | 5 | WIN |
| DEL@WAKE | DEL +18 | 56.7% | 6 | LOSS |
| NMEX@AF | NMEX -3.5 | 56.1% | 5 | WIN |
| WASHST@JMAD | WASHST +14.5 | 55.3% | 5 | WIN |
| ILL@WISC | WISC +9 | 55.1% | 5 | WIN |
| WKY@LSU | WKY +23.5 | 56.3% | 6 | WIN |
| WASH@UCLA | DEMOND WILLIAMS UNDER 27.5 PASS ATT | 56.3% | 6 | WIN |
| TCU@HOU | AMARE THOMAS OVER 69.5 RECV YDS | 55.2% | 5 | WIN |
| TEX@UGA | NATE FRAZIER UNDER 65.5 RUSH + REC YDS | 55.5% | 5 | WIN |
| PUR@WASH | ANTONIO HARRIS UNDER 73.5 RUSH + REC YDS | 54.1% | 4 | WIN |
| OKLA@BAMA | UNDER 46 | 52.4% | 2 | WIN |
| UVA@DUKE | DUKE -3.5 | 54.7% | 3 | LOSS |
| OKLA@BAMA | BAMA -6 | 54.5% | 3 | LOSS |
| OREGST@TULSA | OREGST -120 | 55.6% | 5 | LOSS |
| UTEP@MIZZST | MIZZST -5 | 54.3% | 4 | WIN |
| COLOST@NMEX | NMEX -14 | 57.1% | 6 | LOSS |
| PSU@MICHST | MICHST +7.5 | 56.5% | 6 | LOSS |
| MISSST@MIZZOU | MISSST +7.5 | 57.2% | 7 | LOSS |
| FAU@TULANE | FAU +17.5 | 56.0% | 6 | WIN |
| NCST@MIAMI | NCST +15.5 | 57.1% | 7 | LOSS |
| KENTST@AKRON | AKRON -6.5 | 55.4% | 5 | LOSS |
| JAXST@UTEP | JAXST -105 | 57.0% | 7 | WIN |
| FSU@CLEM | CLEM -118 | 57.1% | 5 | WIN |
| UNLV@COLOST | UNLV -4 | 55.2% | 5 | WIN |
| OREG@IOWA | IOWA +6.5 | 53.3% | 2 | WIN |
| NEB@UCLA | NEB +1.5 | 55.8% | 5 | WIN |
| KENSAW@NMEXST | NMEXST +10 | 56.5% | 6 | WIN |
| STNFRD@UNC | STNFRD +7.5 | 53.8% | 3 | WIN |
| DUKE@UCONN | UCONN +8.5 | 57.9% | 7 | WIN |
| NEVADA@UTAHST | NEVADA +9.5 | 55.9% | 5 | LOSS |
| SAMST@OREGST | SAMST +21 | 57.7% | 7 | WIN |
| NEB@UCLA | NICO IAMALEAVA UNDER 180.5 PASS YDS | 56.6% | 6 | LOSS |
| HOU@UCF | HOU -112 | 58.0% | 6 | WIN |
| GASTHRN@APPST | GASTHRN +180 | 36.5% | 2 | WIN |
| KENTST@BALLST | BALLST -2.5 | 54.5% | 4 | WIN |
| WAKE@FSU | WAKE +10.5 | 56.4% | 6 | LOSS |
| WYO@SDGST | SDGST -10.5 | 56.7% | 7 | WIN |
| OKLA@TENN | TENN -130 | 58.3% | 5 | LOSS |
| GATECH@NCST | GATECH -5 | 56.4% | 6 | LOSS |
| MIAMI@SMU | MIAMI -10 | 54.3% | 4 | LOSS |
| IND@MD | MD +21.5 | 54.6% | 4 | LOSS |
| CINCY@UTAH | CINCY +11 | 57.6% | 7 | LOSS |
| OLDDOM@LAMON | LAMON +17 | 58.4% | 8 | LOSS |
| VANDY@TEXAS | OVER 46.5 | 53.7% | 2 | WIN |