The November 14, 2025, ACC matchup between the Clemson Tigers and the Louisville Cardinals at L&N Federal Credit Union Stadium shapes up as one of the more intriguing late-season conference games, pitting a traditional power desperate to reestablish its footing against a surging program eyeing legitimacy in the College Football Playoff picture. Louisville enters the contest with a 7-1 record and a strong national ranking, playing with balance, confidence, and identity under head coach Jeff Brohm, while Clemson limps into the game at 3-5, searching for answers on both sides of the ball. The Tigers’ decline from perennial ACC dominance to mid-pack vulnerability has been defined by offensive stagnation and inconsistency under pressure. Quarterback Cade Klubnik has shown flashes of potential, but turnovers, questionable play-calling, and red-zone inefficiency have plagued an offense that ranks near the bottom of the ACC in scoring output. Clemson’s once-dominant run game, which historically featured a stable of explosive backs, has struggled to find footing behind an offensive line that has failed to control the line of scrimmage. Will Shipley remains the centerpiece of the offense, capable of turning any touch into a chunk play, but injuries and usage inconsistency have limited his impact. On defense, Clemson still possesses the talent to compete with anyone—the front seven, led by Barrett Carter and Peter Woods, remains stout against the run and capable of collapsing pockets—but communication lapses in the secondary and a tendency to give up momentum-changing plays have kept the unit from sustaining dominance. Louisville, meanwhile, has crafted one of the most complete teams in the ACC under Brohm’s leadership.

The Cardinals’ offense, guided by quarterback Jack Plummer, has evolved into a dynamic attack capable of scoring in multiple ways. Plummer’s chemistry with wideout Jamari Thrash has been electric, with the pair connecting for big plays downfield that stretch defenses vertically. The running back tandem of Jawhar Jordan and Isaac Guerendo provides the kind of balance that allows Louisville to dictate tempo and keep opposing defenses honest. Their offensive line has been physical and disciplined, excelling in both pass protection and short-yardage situations, giving Plummer time to work through his progressions. Defensively, Louisville has taken significant strides forward, ranking among the top three in the ACC in both scoring defense and takeaways. Linebacker T.J. Quinn and defensive end Ashton Gillotte anchor a unit that thrives on physicality and assignment discipline, while the secondary, led by Jarvis Brownlee Jr., has consistently forced turnovers in key moments. Clemson’s challenge will be finding ways to sustain drives and finish possessions against a Louisville defense that thrives on forcing punts and turnovers. Expect Louisville to test Clemson’s secondary early with play-action shots and motion-heavy looks designed to create confusion. The Tigers will need to counter by winning first down, establishing some semblance of a rushing attack, and keeping Klubnik comfortable in manageable down-and-distance situations. From a betting perspective, Louisville has been one of the nation’s most reliable teams against the spread, especially at home, covering over 60 percent of its games this season. Clemson, conversely, has been one of the least profitable, covering just a quarter of its contests and struggling mightily on the road. This statistical contrast underscores the broader trend: Louisville is ascending, consistent, and confident, while Clemson appears to be in transition, struggling to execute under pressure. The likely path to victory for Louisville lies in early tempo control, turnover avoidance, and capitalizing on red-zone opportunities. For Clemson to pull the upset, they’ll need their defense to play lights out, win special teams battles, and manufacture short fields for an offense that has struggled to sustain rhythm. Expect Louisville to dictate much of the action, leveraging home-field energy, offensive versatility, and defensive opportunism to keep Clemson off balance and close the door late.