Indiana vs Penn State Prediction — AI Finds CAN'T MISS CFB Lines & Props (Nov 08)

Updated: 2025-11-01T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The Indiana Hoosiers travel to face the Penn State Nittany Lions on November 8, 2025 in a pivotal Big Ten showdown where Indiana arrives undefeated and Penn State looks to reverse a troubling slide. The stakes are high as Indiana seeks to validate its championship-caliber ascent and Penn State scrambles to regain identity amid a season’s worth of turbulence.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Nov 08, 2025

Start Time: 1:00 PM EST​

Venue: West Shore Home Field at Beaver Stadium​

Nittany Lions Record: (3-5)

Hoosiers Record: (9-0)

OPENING ODDS

IND Moneyline: -725

PSU Moneyline: +510

IND Spread: -14.5

PSU Spread: +14.5

Over/Under: 49.5

IND
Betting Trends

  • Indiana has covered in roughly 62.5% of their games this season, posting an average margin of +13.3 points above the spread in those contests.

PSU
Betting Trends

  • Penn State’s ATS performance is dismal: they sit at 1-6-0 ATS this season, reflecting both their on-field struggles and inability to live up to expectations for bettors.

MATCHUP TRENDS

  • Indiana’s upward trajectory and dominant metrics make them both a strong straight-up and ATS pick, while Penn State’s home-underdog status and poor ATS history raise red flags for bettors. The contrast between Indiana’s elite performance (scoring 46.4 ppg, allowing 10.9) and Penn State’s downturn (scoring 31.5 ppg, allowing 21.8) creates a clear edge for Indiana in the betting market.

IND vs. PSU
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: K. Allen over 68.5 Rushing Yards.

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Indiana vs Penn State Prediction & Odds:
Free CFB Betting Insights for 11/8/25

The November 8, 2025 Big Ten clash between the Indiana Hoosiers and the Penn State Nittany Lions at Beaver Stadium sets up as a fascinating battle between a surging program and a fading traditional powerhouse, with momentum, discipline, and consistency tilting heavily toward the visiting Hoosiers. Indiana enters this matchup as one of the surprise juggernauts of the 2025 season, riding an undefeated record and displaying one of the nation’s most balanced statistical profiles. Under head coach Curt Cignetti, the Hoosiers have been transformed into a disciplined, efficient machine, averaging 46.4 points per game while allowing just 10.9—a scoring differential that underscores their dominance in all three phases of football. Quarterback Fernando Mendoza has emerged as the steady hand of this offense, combining poise and accuracy with mobility that keeps defenses honest. He’s been complemented by a deep supporting cast that includes a strong offensive line anchored by Carter Smith and a versatile receiving corps led by Cam Camper and Omar Cooper Jr., who consistently stretch the field and exploit single coverage. On the ground, Jaylin Lucas and Trent Howland have carried the load, with Lucas in particular providing explosive plays both as a runner and in the return game. Indiana’s offensive efficiency, particularly on third downs and in the red zone, has made them nearly impossible to slow down once they establish rhythm. Their defense, meanwhile, has been just as impressive. The Hoosiers rank among the top ten nationally in takeaways and rushing defense, with linebacker Dasan McCullough and safety Louis Moore leading a unit that thrives on physicality and discipline.

They’ve held opponents under 300 total yards per game and consistently win the field position battle thanks to elite special teams play. On the opposite sideline, Penn State has endured a frustrating and underwhelming campaign under head coach James Franklin, entering this game with a 3–5 record and reeling from inconsistent performances on both sides of the ball. Once a model of Big Ten stability, the Nittany Lions have struggled to find offensive rhythm and defensive toughness, averaging just 31.5 points per game while giving up 21.8—a stark decline from their 2023 and 2024 standards. Quarterback Drew Allar, once heralded as a future star, has battled turnovers and erratic play behind an offensive line that has struggled to protect him. The running back tandem of Nick Singleton and Kaytron Allen remains talented, but they’ve found fewer running lanes behind a unit that hasn’t consistently generated push against physical defenses. Defensively, Penn State’s front seven led by Abdul Carter and Dani Dennis-Sutton has been aggressive but undisciplined at times, prone to giving up big plays on the ground and struggling on third downs. Against Indiana, they’ll be tasked with containing Mendoza’s dual-threat capabilities and preventing Lucas from gashing them on early downs. From a tactical standpoint, Penn State will need to slow the pace, dominate time of possession, and create turnovers to have any chance of pulling an upset. Indiana, by contrast, will look to dictate tempo early, spreading the field horizontally and forcing the Nittany Lions’ linebackers into space where they’ve been vulnerable. Special teams could also play a decisive role—Indiana’s kicking game has been reliable, while Penn State’s coverage units have faltered in key moments this year. From a betting standpoint, the Hoosiers’ 62.5% ATS record and dominant scoring differential make them the far safer play. Indiana has covered in nearly every contest this season, while Penn State’s 1–6 ATS record underscores how often they’ve fallen short of expectations, particularly at home. The Hoosiers’ blend of precision offense, opportunistic defense, and steady leadership gives them all the ingredients to not just win, but win convincingly. Expect Indiana to take control early with quick strikes through the air, complement it with a steady rushing attack, and rely on their defense to suffocate Penn State’s inconsistent offense. The Nittany Lions may keep it close in the first half with crowd energy, but over four quarters, Indiana’s efficiency, confidence, and execution should overwhelm a Penn State team still searching for answers, pushing the Hoosiers closer to an improbable Big Ten title run.

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Indiana Hoosiers CFB Preview

The Indiana Hoosiers travel to Beaver Stadium on November 8, 2025, carrying the momentum of an undefeated season and one of the most complete resumes in college football under head coach Curt Cignetti. This program has undergone a remarkable transformation since his arrival, shifting from a perennial Big Ten afterthought to a legitimate conference and national contender. Indiana enters this matchup averaging 46.4 points per game while allowing just 10.9—numbers that reflect a level of dominance few teams can match. The Hoosiers’ success begins with balance and execution. Quarterback Fernando Mendoza has been sensational, combining accuracy with athleticism to manage an offense that has thrived on versatility and rhythm. Mendoza’s decision-making has been elite, as he’s thrown for over 2,200 yards with minimal turnovers, while using his mobility to extend plays and neutralize opposing pass rushes. His chemistry with wideouts Cam Camper and Omar Cooper Jr. gives Indiana explosive potential on the perimeter, while tight end James Bomba has been a reliable safety valve in short-yardage and red-zone situations. The Hoosiers’ offensive line, anchored by left tackle Carter Smith, has provided exceptional protection and created consistent running lanes for backs Jaylin Lucas and Trent Howland. Lucas, in particular, has emerged as a game-changer—his shiftiness and acceleration make him one of the most dangerous open-field players in the conference, and his impact extends to special teams where he’s already notched multiple long returns. Against Penn State’s defense, Indiana will aim to establish tempo early, using motion and spread formations to stress the Nittany Lions’ linebackers and secondary. The key for Indiana’s offense will be maintaining its balance—mixing early-down runs to keep Penn State’s front seven honest while attacking downfield when opportunities arise.

On defense, Indiana has built its identity on physicality and discipline. Linebacker Dasan McCullough and safety Louis Moore headline a unit that has excelled at limiting big plays and forcing turnovers. The defensive line, led by Andre Carter and Nick James, has been dominant against the run, holding opponents to under 100 rushing yards per game, while the secondary has allowed opposing quarterbacks a completion rate under 55%. Against Penn State quarterback Drew Allar, who has struggled with accuracy under pressure, the Hoosiers will look to disguise coverages and force him into tight-window throws. The game plan will center on shutting down the run tandem of Nick Singleton and Kaytron Allen, forcing Penn State to rely on a passing game that has been inconsistent at best. Indiana’s defensive speed should allow them to neutralize perimeter screens and RPOs, which have been staples of Penn State’s offense. Special teams, often an overlooked component, has been a major strength for the Hoosiers this season. Kicker Chris Freeman has been near perfect inside 45 yards, while Lucas’s return ability gives Indiana a chance to flip field position at any moment. From a betting perspective, Indiana’s 62.5% ATS record speaks to their reliability—they not only win but often do so convincingly, covering spreads by an average of over 13 points. Their efficiency and turnover margin, among the best in the Big Ten, make them a difficult team to fade, even in a hostile environment like Happy Valley. For Indiana to maintain their unbeaten run, they must stay disciplined, avoid costly penalties, and control the tempo from the opening series. If Mendoza stays poised and the defense maintains its usual dominance on third downs, the Hoosiers should have little trouble dictating the pace and pulling away in the second half. This game represents another opportunity for Indiana to prove their legitimacy on a national stage—and with their confidence, depth, and balance, they look fully equipped to seize it.

The Indiana Hoosiers travel to face the Penn State Nittany Lions on November 8, 2025 in a pivotal Big Ten showdown where Indiana arrives undefeated and Penn State looks to reverse a troubling slide. The stakes are high as Indiana seeks to validate its championship-caliber ascent and Penn State scrambles to regain identity amid a season’s worth of turbulence. Indiana vs Penn State AI Prediction: Free CFB Betting Insights for Nov 08. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Penn State Nittany Lions CFB Preview

The Penn State Nittany Lions return to Beaver Stadium on November 8, 2025, in desperate need of a statement performance to salvage a disappointing season and restore pride in front of their home crowd. Under head coach James Franklin, the Lions have endured one of their most inconsistent campaigns in recent memory, entering this matchup at 3–5 overall and struggling to find continuity on both sides of the ball. Once renowned for their defensive dominance and efficient offense, Penn State has slipped into mediocrity, averaging 31.5 points per game while surrendering 21.8—a glaring gap for a team expected to contend for a Big Ten title. The offense, led by quarterback Drew Allar, has been erratic and turnover-prone, as Allar’s flashes of brilliance have often been undone by inaccuracy and pressure-related mistakes. His supporting cast, while talented, hasn’t delivered to expectations. Wide receivers KeAndre Lambert-Smith and Omari Evans have shown promise but have struggled with consistency and separation, while tight end Tyler Warren remains a reliable but underutilized weapon in critical downs. The running back duo of Nick Singleton and Kaytron Allen, once among the most feared in the nation, has been held in check too often behind an offensive line that has failed to consistently establish dominance at the line of scrimmage. Against Indiana’s formidable defense, Penn State’s offensive strategy must revolve around re-establishing the run and utilizing play-action to take pressure off Allar. If Singleton and Allen can find rhythm early, Penn State can slow the game down, control tempo, and keep Indiana’s explosive offense off the field.

Defensively, Penn State remains talented but has regressed in key moments. Linebackers Abdul Carter and Kobe King anchor a front seven that can be disruptive, but too often the defense has struggled with gap discipline and tackling, especially against fast-paced offenses. The defensive line, led by Dani Dennis-Sutton and Zane Durant, will need to create consistent pressure on Indiana quarterback Fernando Mendoza, who has thrived this season behind a steady offensive line and quick reads. The secondary, featuring safeties Jaylen Reed and KJ Winston Jr., has the talent to match up athletically but will face a significant challenge against Indiana’s speed at receiver, particularly Cam Camper and Jaylin Lucas in space. For Penn State to stay competitive, the defense must limit explosive plays and generate takeaways—a category where they’ve been uncharacteristically quiet this year. Special teams could be a factor, as Penn State has one of the better punting units in the Big Ten, but their return game has been pedestrian compared to the Hoosiers’. From a betting standpoint, Penn State’s 1–6 ATS record tells the story of a team that has repeatedly fallen short of expectations, often starting slow and failing to cover spreads even in victories. At home, however, the Nittany Lions have traditionally fed off the energy of the “White Out” atmosphere, and they’ll need that emotional boost against a well-coached, balanced Indiana squad. The path to an upset or at least a respectable showing lies in establishing physicality early, winning time of possession, and forcing Indiana into longer drives. If Allar can protect the football and the defense can generate early momentum with sacks or turnovers, Penn State could keep this closer than expected. But to do so, they must play with urgency and discipline—traits that have eluded them much of the season. This game represents more than just another conference contest; it’s a chance for Penn State to prove that their program still has fight left, even as Indiana arrives with all the momentum and confidence. To pull off the upset, the Nittany Lions must rediscover their defensive identity, execute with precision, and lean on their home crowd to rekindle the swagger that once made Beaver Stadium one of college football’s most feared venues.

Indiana vs Penn State Prop Picks (AI)

AI algorithm Remi is pouring through tons of data on each team. In fact, anytime the Hoosiers and Nittany Lions play there’s always several intriguing trends to key in on. Not to mention games played at West Shore Home Field at Beaver Stadium in Nov can often follow normal, predictable betting trends.

Remi's searched hard and found the best prop for this matchup: K. Allen over 68.5 Rushing Yards.

Indiana vs Penn State Prediction (AI)

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Remi, our AI sports algorithm, has been pouring over mountains of data from every angle between the Hoosiers and Nittany Lions and using recursive machine learning and kick-ass AI to examine the data to a single cover probability.

Oddly enough, we’ve seen the AI has been most keyed in on the unproportionally assigned factor emotional bettors regularly put on player performance factors between a Hoosiers team going up against a possibly strong Nittany Lions team. Trends look to say the true game analytics appear to reflect a slight lean against one Vegas line specifically.

Unlock this in-depth AI prediction and all of our CFB AI picks for FREE now.

Below is our current AI Indiana vs Penn State picks, computer picks Hoosiers vs Nittany Lions, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
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These picks update as information changes—injury reports, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full CFB schedule.

Indiana Betting Trends

Indiana has covered in roughly 62.5% of their games this season, posting an average margin of +13.3 points above the spread in those contests.

Penn State Betting Trends

Penn State’s ATS performance is dismal: they sit at 1-6-0 ATS this season, reflecting both their on-field struggles and inability to live up to expectations for bettors.

Hoosiers vs. Nittany Lions Matchup Trends

Indiana’s upward trajectory and dominant metrics make them both a strong straight-up and ATS pick, while Penn State’s home-underdog status and poor ATS history raise red flags for bettors. The contrast between Indiana’s elite performance (scoring 46.4 ppg, allowing 10.9) and Penn State’s downturn (scoring 31.5 ppg, allowing 21.8) creates a clear edge for Indiana in the betting market.

Indiana vs. Penn State Game Info

November 08, 2025 • 1:00 PM EST • West Shore Home Field at Beaver Stadium

Indiana vs. Penn State Odds

AI algorithm Remi is pouring through tons of data points on each line. In fact, anytime the Indiana vs Penn State trends are analyzed, there’s always several intriguing trends to key in on. Not to mention games played at extreme hostile environments can often follow normal, predictable patterns.

Indiana vs Penn State

Indiana vs Penn State Live Odds

Games PTS ML SPR O/U
Dec 5, 2025 7:00PM EST
Troy Trojans
James Madison Dukes
12/5/25 7PM
TROY
JMAD
+1100
-2500
+23.5 (+102)
-23.5 (-122)
O 46.5 (-111)
U 46.5 (-111)
Dec 5, 2025 7:00PM EST
Kennesaw State Owls
Jacksonville State Gamecocks
12/5/25 7PM
KENSAW
JAXST
-136
+113
-2.5 (-113)
+2.5 (-108)
O 60.5 (-107)
U 60.5 (-113)
Dec 5, 2025 8:00PM EST
North Texas Mean Green
Tulane Green Wave
12/5/25 8PM
NOTEX
TULANE
-132
+110
-2.5 (-108)
+2.5 (-112)
O 66.5 (-115)
U 66.5 (-105)
Dec 5, 2025 8:01PM EST
UNLV Rebels
Boise State Broncos
12/5/25 8:01PM
UNLV
BOISE
+180
-218
+5.5 (-111)
-5.5 (-111)
O 59.5 (-110)
U 59.5 (-112)
Dec 6, 2025 12:00PM EST
Miami Ohio Redhawks
Western Michigan Broncos
12/6/25 12PM
MIAOH
WMICH
 
-124
 
-1.5 (-115)
O 43.5 (-105)
U 43.5 (-115)
Dec 6, 2025 12:00PM EST
BYU Cougars
Texas Tech Red Raiders
12/6/25 12PM
BYU
TXTECH
+390
-530
+12.5 (-110)
-12.5 (-111)
O 49.5 (-108)
U 49.5 (-112)
Dec 6, 2025 4:00PM EST
Georgia Bulldogs
Alabama Crimson Tide
12/6/25 4PM
UGA
BAMA
-136
+113
-2.5 (-113)
+2.5 (-107)
O 48.5 (-107)
U 48.5 (-114)
Dec 6, 2025 8:00PM EST
Duke Blue Devils
Virginia Cavaliers
12/6/25 8PM
DUKE
UVA
+152
-182
+4 (-109)
-4 (-110)
O 57.5 (-114)
U 57.5 (-106)
Dec 6, 2025 8:00PM EST
Indiana Hoosiers
Ohio State Buckeyes
12/6/25 8PM
IND
OHIOST
+161
-197
+4 (-108)
-4 (-112)
O 47 (-113)
U 47 (-107)
Dec 13, 2025 3:00PM EST
Army Black Knights
Navy Midshipmen
12/13/25 3PM
ARMY
NAVY
+164
-198
+4.5 (-108)
-4.5 (-112)
O 39.5 (-108)
U 39.5 (-112)

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This preview covers Indiana Hoosiers vs. Penn State Nittany Lions on November 08, 2025 at West Shore Home Field at Beaver Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our CFB odds pages, and compare prices before you place a bet.

LEAN %WIN UNITS RESULT
COLO@KSTATE COLO +17.5 54.0% 4 WIN
PSU@RUT RUT +14 52.8% 1 WIN
OHIOST@MICH MICH +10.5 56.4% 6 LOSS
VATECH@UVA VATECH +8 57.8% 7 LOSS
NWEST@ILL LUKE ALTMYER UNDER 19.5 PASS COMP 54.3% 4 WIN
ORE@WAS DEMOND WILLIAMS JR UNDER 43.5 RUSH YDS 55.2% 5 WIN
MIAMI@VATECH VATECH +18.5 54.2% 4 WIN
GAST@TROY TROY -9.5 55.7% 5 WIN
DEL@WAKE DEL +18 56.7% 6 LOSS
NMEX@AF NMEX -3.5 56.1% 5 WIN
WASHST@JMAD WASHST +14.5 55.3% 5 WIN
ILL@WISC WISC +9 55.1% 5 WIN
WKY@LSU WKY +23.5 56.3% 6 WIN
WASH@UCLA DEMOND WILLIAMS UNDER 27.5 PASS ATT 56.3% 6 WIN
TCU@HOU AMARE THOMAS OVER 69.5 RECV YDS 55.2% 5 WIN
TEX@UGA NATE FRAZIER UNDER 65.5 RUSH + REC YDS 55.5% 5 WIN
PUR@WASH ANTONIO HARRIS UNDER 73.5 RUSH + REC YDS 54.1% 4 WIN
OKLA@BAMA UNDER 46 52.4% 2 WIN
UVA@DUKE DUKE -3.5 54.7% 3 LOSS
OKLA@BAMA BAMA -6 54.5% 3 LOSS
OREGST@TULSA OREGST -120 55.6% 5 LOSS
UTEP@MIZZST MIZZST -5 54.3% 4 WIN
COLOST@NMEX NMEX -14 57.1% 6 LOSS
PSU@MICHST MICHST +7.5 56.5% 6 LOSS
MISSST@MIZZOU MISSST +7.5 57.2% 7 LOSS
FAU@TULANE FAU +17.5 56.0% 6 WIN
NCST@MIAMI NCST +15.5 57.1% 7 LOSS
KENTST@AKRON AKRON -6.5 55.4% 5 LOSS
JAXST@UTEP JAXST -105 57.0% 7 WIN
FSU@CLEM CLEM -118 57.1% 5 WIN
UNLV@COLOST UNLV -4 55.2% 5 WIN
OREG@IOWA IOWA +6.5 53.3% 2 WIN
NEB@UCLA NEB +1.5 55.8% 5 WIN
KENSAW@NMEXST NMEXST +10 56.5% 6 WIN
STNFRD@UNC STNFRD +7.5 53.8% 3 WIN
DUKE@UCONN UCONN +8.5 57.9% 7 WIN
NEVADA@UTAHST NEVADA +9.5 55.9% 5 LOSS
SAMST@OREGST SAMST +21 57.7% 7 WIN
NEB@UCLA NICO IAMALEAVA UNDER 180.5 PASS YDS 56.6% 6 LOSS
HOU@UCF HOU -112 58.0% 6 WIN
GASTHRN@APPST GASTHRN +180 36.5% 2 WIN
KENTST@BALLST BALLST -2.5 54.5% 4 WIN
WAKE@FSU WAKE +10.5 56.4% 6 LOSS
WYO@SDGST SDGST -10.5 56.7% 7 WIN
OKLA@TENN TENN -130 58.3% 5 LOSS
GATECH@NCST GATECH -5 56.4% 6 LOSS
MIAMI@SMU MIAMI -10 54.3% 4 LOSS
IND@MD MD +21.5 54.6% 4 LOSS
CINCY@UTAH CINCY +11 57.6% 7 LOSS
OLDDOM@LAMON LAMON +17 58.4% 8 LOSS
VANDY@TEXAS OVER 46.5 53.7% 2 WIN