The November 1, 2025 showdown between the Penn State Nittany Lions and the Ohio State Buckeyes at Ohio Stadium in Columbus stands as one of the most anticipated games of the Big Ten season and a defining moment in the College Football Playoff race. Ohio State enters the matchup unbeaten and firing on all cylinders, once again boasting one of the most balanced and dominant rosters in the nation. Head coach Ryan Day’s team has built its success around a suffocating defense that ranks among the nation’s elite, allowing just 5.9 points per game, while the offense remains explosive and efficient under quarterback Julian Sajin. Sajin, in his first full season as the starter, has been surgical—completing over 80% of his passes for more than 1,800 yards and 19 touchdowns with minimal turnovers. His chemistry with wideouts such as Emeka Egbuka and Carnell Tate has fueled a Buckeye passing attack that keeps defenses on their heels, while the ground game, powered by TreVeyon Henderson and Quinshon Judkins, provides balance and physicality. The Buckeyes’ offensive line, long a strength of the program, has excelled in both pass protection and run blocking, giving Sajin time to dissect defenses while opening consistent running lanes. Meanwhile, the Ohio State defense has evolved into an immovable force—anchored by linebacker C.J. Hicks and edge rusher Jack Sawyer, who lead a unit that ranks among the best nationally in third-down stops, red-zone defense, and limiting explosive plays. Their secondary, featuring safety Caleb Downs and cornerback Denzel Burke, has suffocated opposing quarterbacks and limited downfield completions, allowing this defense to dictate tempo and field position every week. On the other sideline, Penn State arrives in Columbus desperate for a turnaround. The Nittany Lions, sitting at 3–4, have lost four straight and are in the midst of a confidence crisis under head coach James Franklin.

Once lauded for balance and toughness, Penn State’s offense has sputtered, averaging 34 points per game overall but struggling against quality opponents. Quarterback Drew Allar, a former five-star recruit, has shown flashes of talent but has been hampered by conservative play-calling and inconsistency in protection. Running backs Nick Singleton and Kaytron Allen remain the backbone of the offense, combining for nearly 1,200 rushing yards this season, but their production has often been neutralized by predictable schemes and an inability to create chunk plays through the air. Defensively, Penn State still features NFL-caliber talent, led by defensive end Chop Robinson and linebacker Abdul Carter, but the unit has been overworked due to the offense’s inefficiency and frequent three-and-outs. Against Ohio State’s precision offense, this defense must play its best game of the season—winning on first downs, forcing turnovers, and holding the Buckeyes to field goals rather than touchdowns. The key matchup lies in the trenches: Penn State’s defensive front must disrupt Sajin’s rhythm and prevent Ohio State from establishing its running game early, while their offensive line must find a way to handle the relentless Buckeye pass rush. From a betting perspective, Ohio State opened as a heavy favorite at around -20.5, a reflection of the gap between the programs’ current trajectories. With the total hovering near 43.5, oddsmakers anticipate a defensively controlled game, and the under may hold value given Ohio State’s elite defense and Penn State’s scoring struggles. For Penn State, victory depends on execution, ball control, and taking advantage of any rare Buckeye mistakes, while for Ohio State, this is a chance to make another emphatic statement of dominance in front of a home crowd that has seen years of heartbreak turn to confidence under Day. Expect a physical, one-sided affair where Ohio State’s depth, precision, and discipline overpower a Penn State team that will fight hard but ultimately lack the firepower to keep up. The Buckeyes’ defense should dictate the tone, and Sajin’s continued mastery will likely seal a decisive win that strengthens Ohio State’s case as a national title favorite.