BYU vs Iowa State Prediction — AI Finds CAN'T MISS CFB Lines & Props (Oct 25)
Updated: 2025-10-18T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The BYU Cougars visit the Iowa State Cyclones on October 25, 2025 in Ames in what looks to be a high-stakes Big 12 battle with postseason implications for both sides. With BYU riding an undefeated start and Iowa State eager to regain momentum after recent stumbles, this contest promises to hinge on turnover margins, special teams plays and which side can assert its identity under pressure.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.
GAME INFO
Date: Oct 25, 2025
Start Time: 3:30 PM EST
Venue: Jack Trice Stadium
Cyclones Record: (5-2)
Cougars Record: (7-0)
OPENING ODDS
BYU Moneyline: +114
IOWAST Moneyline: -137
BYU Spread: +2.5
IOWAST Spread: -2.5
Over/Under: 49.5
BYU
Betting Trends
- The Cougars come into this game with a favorable ATS trend on the road, showing an improved performance when traveling long distances and facing ranked opponents, which bodes well given the 700 + mile trip to Ames and the fiery Big 12 environment.
IOWAST
Betting Trends
- Iowa State, meanwhile, has been strong at home in recent seasons, posting an ATS mark north of .600 in their Jack Trice Stadium floor games where they control tempo and leverage crowd noise—but that edge has slightly eroded in 2025 with a few games slipping late under opponent pressure.
MATCHUP TRENDS
- Of particular note: games where Iowa State allows a third-down conversion rate above 45% or gives up more than 0.05 explosive plays per offensive snap (20+ yards) have almost universally trended overs. BYU’s uptempo offense, averaging over 2.3 plays per tackle over the past three contests, intersects neatly with that vulnerability. Further, BYU defensive sets that blitz more than 20% of drop-backs have forced Big 12 opponents into sub-50% red-zone TD conversion rates this season—a trend Iowa State must guard at home.
BYU vs. IOWAST
Best Prop Bet
- Remi's searched hard and found the best prop for this matchup: B. Eskildsen under 43.5 Receiving Yard.
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BYU vs Iowa State Prediction & Odds:
Free CFB Betting Insights for 10/25/25
The October 25, 2025, matchup between the BYU Cougars and the Iowa State Cyclones at Jack Trice Stadium promises to be one of the more intriguing games of Week 9, pitting BYU’s explosive offensive versatility against Iowa State’s disciplined, hard-nosed defensive structure. BYU enters the contest as one of the Big 12’s most balanced and efficient programs under head coach Kalani Sitake, blending tempo-based offense with a physical defensive approach that has quietly made them a legitimate conference contender. Quarterback Bear Bachmeier has emerged as a breakout performer in his first full season as the starter, displaying mature decision-making and consistent pocket awareness while leading an offense that ranks in the top 20 nationally in explosive play rate and red-zone efficiency. His chemistry with receivers Kody Epps and Chase Roberts has been the foundation of BYU’s passing game, as both wideouts have proven reliable on intermediate routes and vertical shots, while running back LJ Martin provides an inside-outside rushing threat that keeps defenses honest. Iowa State, meanwhile, has found its rhythm under Matt Campbell after an uneven start to the season, led by quarterback Rocco Becht, who has demonstrated poise and steady command of the offense while cutting down on turnovers and leaning into a balanced scheme. Becht’s connection with dynamic receiver Jayden Higgins and tight end Benjamin Brahmer has given the Cyclones a reliable one-two punch through the air, while running back Abu Sama III continues to anchor their ground attack with efficiency and burst.
Defensively, the Cyclones remain one of the most fundamentally sound units in the Big 12, anchored by a deep defensive line and linebackers who thrive on gap discipline and forcing opponents into predictable passing downs. Iowa State ranks among the top 25 nationally in opponent third-down conversion rate and continues to excel in red-zone defense, allowing touchdowns on fewer than 60% of opponent trips inside the 20. However, their secondary has occasionally struggled with teams that utilize heavy motion and tempo, which plays directly into BYU’s offensive philosophy. The Cougars’ defense, led by linebacker Isaiah Glasker and safety Crew Wakley, will be tested by Iowa State’s patient offensive style and pre-snap shifts designed to create mismatches against zone coverage. The chess match between BYU’s pass rush and Iowa State’s offensive line, which has allowed just six sacks over the past four games, will be critical in determining whether the Cyclones can sustain long drives or fall behind the pace of BYU’s scoring rhythm. Turnovers and situational execution—especially in the red zone and on third downs—will likely define this contest, as both programs have thrived when they control time of possession. Ultimately, this game represents a clash of styles: BYU’s uptempo, balanced offense against Iowa State’s methodical, defensive-minded approach. If BYU can set the tempo early and force the Cyclones to play from behind, the Cougars’ offensive efficiency and ability to hit big plays downfield could prove decisive. Conversely, if Iowa State can slow the game, dominate the trenches, and win the field-position battle with disciplined execution, the home crowd in Ames could give them the edge in what should be a physical, competitive, and tactically rich Big 12 showdown.
Get live CFB odds and precise AI CFB picks, predictions, and cover probabilities.
gave ‘em something to talk about
— BYU FOOTBALL (@BYUfootball) October 20, 2025
pic.twitter.com/8dwAqi9Xk3
BYU Cougars CFB Preview
The BYU Cougars head to Ames riding a wave of confidence and cohesion as they continue to establish themselves as one of the more complete teams in the Big 12 this season. Under head coach Kalani Sitake, BYU has managed to blend its traditional physicality with a modern offensive scheme built on pace, precision, and balance. Quarterback Bear Bachmeier has been the engine behind their success, maturing quickly in his first full season as the starter by combining composure with creativity. His ability to extend plays and distribute the ball across multiple targets has elevated an offense that thrives on tempo and efficiency, ranking among the league’s best in both yards per play and explosive pass rate. Wide receivers Kody Epps and Chase Roberts have developed into a dependable duo, capable of stretching defenses vertically and converting in high-leverage moments, while running back LJ Martin has brought stability and versatility to the backfield. Martin’s combination of vision and power complements BYU’s offensive line, which has steadily improved in both pass protection and run blocking. The Cougars’ offense has been particularly dangerous when sustaining drives, using pre-snap motion and quick tempo to manipulate coverages and create mismatches in space. Defensively, BYU continues to emphasize discipline and opportunism. Linebacker Isaiah Glasker leads a front seven that has excelled in creating pressure without overcommitting to blitzes, allowing the secondary to stay structured and limit deep shots.
Defensive coordinator Jay Hill has built a unit that bends but rarely breaks, emphasizing red-zone execution and third-down efficiency. The Cougars’ defense has forced multiple turnovers in five of their last six games, a key factor in flipping field position and keeping opponents uncomfortable. The major challenge in this matchup will be handling Iowa State’s steady offensive rhythm and strong home-field advantage. Jack Trice Stadium is one of the most difficult environments in the Big 12, and BYU’s ability to maintain composure on third downs and in the red zone will be critical. The Cougars have historically struggled on the road when their tempo is disrupted, so sustaining offensive rhythm while avoiding costly penalties and turnovers will be essential. On special teams, BYU’s kicking and coverage units have shown consistency, with Ryan Rehkow’s punting often flipping field position in key moments. Sitake’s emphasis on complementary football will again be central to BYU’s game plan—dominate possession, capitalize on turnovers, and protect Bachmeier from unnecessary hits. If the Cougars can keep the chains moving and force Iowa State to chase points, their offensive efficiency and defensive balance could neutralize the home-field edge. A win in Ames would not only solidify BYU’s place in the Big 12 title picture but also reinforce their evolution from an independent powerhouse into a conference contender capable of winning tough games on the road through discipline, preparation, and poise.
Credit: USA TODAY/IMAGN
Iowa State Cyclones CFB Preview
The Iowa State Cyclones enter their October 25 matchup against BYU at Jack Trice Stadium with a renewed sense of urgency and an opportunity to make a statement in front of their home crowd. Under head coach Matt Campbell, Iowa State has built a reputation for resilience, physicality, and methodical execution, and this game will test whether those core principles can withstand the pressure of a dynamic, uptempo BYU offense. Quarterback Rocco Becht has grown into a steady and confident leader, demonstrating improved decision-making and a strong grasp of offensive timing that has allowed the Cyclones to sustain drives and manage the clock effectively. His chemistry with wide receiver Jayden Higgins and tight end Benjamin Brahmer continues to drive the passing attack, while running back Abu Sama III has emerged as a legitimate difference-maker, capable of gashing defenses with both his burst and vision between the tackles. The Cyclones’ offensive line, though tested by several strong defensive fronts this season, remains disciplined in its protection schemes, giving Becht enough time to read defenses and find open windows on intermediate routes. Still, the challenge against BYU’s aggressive front seven, led by linebacker Isaiah Glasker, will require the Cyclones to stay balanced offensively, mixing zone runs, play-action, and pre-snap motion to neutralize the Cougars’ speed.
Defensively, Iowa State remains one of the most structured units in the Big 12, defined by communication, positioning, and physical tackling. Anchored by a deep and experienced defensive line, the Cyclones excel at setting the edge and forcing opponents into uncomfortable down-and-distance situations. Their ability to generate interior pressure without resorting to heavy blitzing has been a major factor in holding opponents below their season averages in both yards per play and red-zone efficiency. Linebacker Caleb Bacon and safety Beau Freyler have been instrumental in maintaining this unit’s consistency, particularly in disrupting intermediate passing lanes and preventing explosive plays. Against BYU, that discipline will be tested by the Cougars’ heavy use of tempo and misdirection, which can expose defenses that rely too heavily on pre-snap reads. Iowa State’s secondary must stay sharp against quarterback Bear Bachmeier’s quick-release passing attack, as the Cougars excel at stretching the field horizontally before striking vertically. On special teams, the Cyclones have made strides, with kicker Chase Contreraz providing stability in close games, though punt coverage remains an area of concern. The key for Iowa State will be controlling time of possession, winning early downs, and forcing BYU into third-and-long situations, where their pass rush can have the greatest impact. Campbell’s teams traditionally thrive in games where they can dictate tempo and wear opponents down with physical play and mental toughness, and that blueprint will once again serve as their best path to victory. If the Cyclones can establish their run game, protect Becht from early pressure, and leverage their defensive structure to limit big plays, they’ll be in prime position to defend their home turf and notch a signature win that could redefine their season trajectory.
⭐️Midseason All-American Team⭐️@OrangeDomonique | @TheAthletic pic.twitter.com/EM0jO4yqeD
— Iowa State Football (@CycloneFB) October 16, 2025
BYU vs Iowa State Prop Picks (AI)
Remi is pouring through mountains of datapoints on each line. In fact, anytime the Cougars and Cyclones play there’s always several intriguing angles to key in on. Not to mention games played at Jack Trice Stadium in Oct can often follow normal, predictable patterns.
BYU vs Iowa State Prediction (AI)
Remi, our AI sports algorithm, has been pouring over millions of data from every simulation between the Cougars and Cyclones and using recursive machine learning and impressive AI to analyze the data to a single cover probability.
Interestingly enough, the data has been most fixated on the growing factor human bettors often put on BYU’s strength factors between a Cougars team going up against a possibly tired Cyclones team. In reality, the true game analytics might reflect a slight lean against one Vegas line in particular.
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Below is our current AI BYU vs Iowa State picks, computer picks Cougars vs Cyclones, best bets, model edges, confidence ratings.
| DATE | GAME | LEAN | %WIN | UNITS | LEVEL | |
|---|---|---|---|---|---|---|
| ACTIVE PICKS LOCKED - SEE NOW | ||||||
These picks update as information changes—injury reports, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full CFB schedule.
BYU Betting Trends
The Cougars come into this game with a favorable ATS trend on the road, showing an improved performance when traveling long distances and facing ranked opponents, which bodes well given the 700 + mile trip to Ames and the fiery Big 12 environment.
Iowa State Betting Trends
Iowa State, meanwhile, has been strong at home in recent seasons, posting an ATS mark north of .600 in their Jack Trice Stadium floor games where they control tempo and leverage crowd noise—but that edge has slightly eroded in 2025 with a few games slipping late under opponent pressure.
Cougars vs. Cyclones Matchup Trends
Of particular note: games where Iowa State allows a third-down conversion rate above 45% or gives up more than 0.05 explosive plays per offensive snap (20+ yards) have almost universally trended overs. BYU’s uptempo offense, averaging over 2.3 plays per tackle over the past three contests, intersects neatly with that vulnerability. Further, BYU defensive sets that blitz more than 20% of drop-backs have forced Big 12 opponents into sub-50% red-zone TD conversion rates this season—a trend Iowa State must guard at home.
BYU vs. Iowa State Game Info
BYU vs Iowa State starts on October 25, 2025 at 3:30 PM EST.
Venue: Jack Trice Stadium.
Spread: Iowa State -2.5
Moneyline: BYU +114, Iowa State -137
Over/Under: 49.5
BYU: (7-0) | Iowa State: (5-2)
Remi's searched hard and found the best prop for this matchup: B. Eskildsen under 43.5 Receiving Yard.. Prices move—always shop for the best number.
Of particular note: games where Iowa State allows a third-down conversion rate above 45% or gives up more than 0.05 explosive plays per offensive snap (20+ yards) have almost universally trended overs. BYU’s uptempo offense, averaging over 2.3 plays per tackle over the past three contests, intersects neatly with that vulnerability. Further, BYU defensive sets that blitz more than 20% of drop-backs have forced Big 12 opponents into sub-50% red-zone TD conversion rates this season—a trend Iowa State must guard at home.
BYU trend: The Cougars come into this game with a favorable ATS trend on the road, showing an improved performance when traveling long distances and facing ranked opponents, which bodes well given the 700 + mile trip to Ames and the fiery Big 12 environment.
IOWAST trend: Iowa State, meanwhile, has been strong at home in recent seasons, posting an ATS mark north of .600 in their Jack Trice Stadium floor games where they control tempo and leverage crowd noise—but that edge has slightly eroded in 2025 with a few games slipping late under opponent pressure.
See our latest CFB picks and odds pages for 2025 to compare prices before you bet.
BYU vs. Iowa State Odds
AI algorithm Remi is pouring through mountains of data points on each team. In fact, anytime the BYU vs Iowa State trends are analyzed, there’s always several intriguing trends to key in on. Not to mention games played at extreme temps almost always follow normal, predictable patterns.
| BYU Moneyline | +114 |
|---|---|
| IOWAST Moneyline | -137 |
| BYU Spread | +2.5 |
| IOWAST Spread | -2.5 |
| Over / Under | 49.5 |
BYU vs Iowa State Live Odds
| Games | PTS | ML | SPR | O/U | |
|---|---|---|---|---|---|
|
Dec 5, 2025 7:00PM EST
Troy Trojans
James Madison Dukes
12/5/25 7PM
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JMAD
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–
–
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+1000
-2500
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+23.5 (-110)
-23.5 (-110)
|
O 46.5 (-110)
U 46.5 (-110)
|
|
|
Dec 5, 2025 7:00PM EST
Kennesaw State Owls
Jacksonville State Gamecocks
12/5/25 7PM
KENSAW
JAXST
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–
–
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-135
+115
|
-2.5 (-110)
+2.5 (-110)
|
O 60.5 (-110)
U 60.5 (-110)
|
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Dec 5, 2025 8:00PM EST
North Texas Mean Green
Tulane Green Wave
12/5/25 8PM
NOTEX
TULANE
|
–
–
|
-135
+115
|
-2.5 (-110)
+2.5 (-110)
|
O 66.5 (-105)
U 66.5 (-115)
|
|
|
Dec 5, 2025 8:01PM EST
UNLV Rebels
Boise State Broncos
12/5/25 8:01PM
UNLV
BOISE
|
–
–
|
+180
-220
|
+5 (-110)
-5 (-110)
|
O 59 (-110)
U 59 (-110)
|
|
|
Dec 6, 2025 12:00PM EST
Miami Ohio Redhawks
Western Michigan Broncos
12/6/25 12PM
MIAOH
WMICH
|
–
–
|
-125
|
-1.5 (-110)
|
O 43.5 (-105)
U 43.5 (-115)
|
|
|
Dec 6, 2025 12:00PM EST
BYU Cougars
Texas Tech Red Raiders
12/6/25 12PM
BYU
TXTECH
|
–
–
|
+390
-550
|
+12.5 (-110)
-12.5 (-110)
|
O 49.5 (-110)
U 49.5 (-110)
|
|
|
Dec 6, 2025 4:00PM EST
Georgia Bulldogs
Alabama Crimson Tide
12/6/25 4PM
UGA
BAMA
|
–
–
|
-135
+115
|
-2.5 (-110)
+2.5 (-110)
|
O 48 (-110)
U 48 (-110)
|
|
|
Dec 6, 2025 8:00PM EST
Duke Blue Devils
Virginia Cavaliers
12/6/25 8PM
DUKE
UVA
|
–
–
|
+155
-180
|
+4 (-110)
-4 (-110)
|
O 58 (-110)
U 58 (-110)
|
|
|
Dec 6, 2025 8:01PM EST
Indiana Hoosiers
Ohio State Buckeyes
12/6/25 8:01PM
IND
OHIOST
|
–
–
|
+160
-185
|
+4 (-110)
-4 (-110)
|
O 47.5 (-115)
U 47.5 (-105)
|
|
|
Dec 13, 2025 3:00PM EST
Army Black Knights
Navy Midshipmen
12/13/25 3PM
ARMY
NAVY
|
–
–
|
+165
-195
|
+4.5 (-110)
-4.5 (-110)
|
O 38 (-110)
U 38 (-110)
|
CFB Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers BYU Cougars vs. Iowa State Cyclones on October 25, 2025 at Jack Trice Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our CFB odds pages, and compare prices before you place a bet.
| LEAN | %WIN | UNITS | RESULT | |
|---|---|---|---|---|
| COLO@KSTATE | COLO +17.5 | 54.0% | 4 | WIN |
| PSU@RUT | RUT +14 | 52.8% | 1 | WIN |
| OHIOST@MICH | MICH +10.5 | 56.4% | 6 | LOSS |
| VATECH@UVA | VATECH +8 | 57.8% | 7 | LOSS |
| NWEST@ILL | LUKE ALTMYER UNDER 19.5 PASS COMP | 54.3% | 4 | WIN |
| ORE@WAS | DEMOND WILLIAMS JR UNDER 43.5 RUSH YDS | 55.2% | 5 | WIN |
| MIAMI@VATECH | VATECH +18.5 | 54.2% | 4 | WIN |
| GAST@TROY | TROY -9.5 | 55.7% | 5 | WIN |
| DEL@WAKE | DEL +18 | 56.7% | 6 | LOSS |
| NMEX@AF | NMEX -3.5 | 56.1% | 5 | WIN |
| WASHST@JMAD | WASHST +14.5 | 55.3% | 5 | WIN |
| ILL@WISC | WISC +9 | 55.1% | 5 | WIN |
| WKY@LSU | WKY +23.5 | 56.3% | 6 | WIN |
| WASH@UCLA | DEMOND WILLIAMS UNDER 27.5 PASS ATT | 56.3% | 6 | WIN |
| TCU@HOU | AMARE THOMAS OVER 69.5 RECV YDS | 55.2% | 5 | WIN |
| TEX@UGA | NATE FRAZIER UNDER 65.5 RUSH + REC YDS | 55.5% | 5 | WIN |
| PUR@WASH | ANTONIO HARRIS UNDER 73.5 RUSH + REC YDS | 54.1% | 4 | WIN |
| OKLA@BAMA | UNDER 46 | 52.4% | 2 | WIN |
| UVA@DUKE | DUKE -3.5 | 54.7% | 3 | LOSS |
| OKLA@BAMA | BAMA -6 | 54.5% | 3 | LOSS |
| OREGST@TULSA | OREGST -120 | 55.6% | 5 | LOSS |
| UTEP@MIZZST | MIZZST -5 | 54.3% | 4 | WIN |
| COLOST@NMEX | NMEX -14 | 57.1% | 6 | LOSS |
| PSU@MICHST | MICHST +7.5 | 56.5% | 6 | LOSS |
| MISSST@MIZZOU | MISSST +7.5 | 57.2% | 7 | LOSS |
| FAU@TULANE | FAU +17.5 | 56.0% | 6 | WIN |
| NCST@MIAMI | NCST +15.5 | 57.1% | 7 | LOSS |
| KENTST@AKRON | AKRON -6.5 | 55.4% | 5 | LOSS |
| JAXST@UTEP | JAXST -105 | 57.0% | 7 | WIN |
| FSU@CLEM | CLEM -118 | 57.1% | 5 | WIN |
| UNLV@COLOST | UNLV -4 | 55.2% | 5 | WIN |
| OREG@IOWA | IOWA +6.5 | 53.3% | 2 | WIN |
| NEB@UCLA | NEB +1.5 | 55.8% | 5 | WIN |
| KENSAW@NMEXST | NMEXST +10 | 56.5% | 6 | WIN |
| STNFRD@UNC | STNFRD +7.5 | 53.8% | 3 | WIN |
| DUKE@UCONN | UCONN +8.5 | 57.9% | 7 | WIN |
| NEVADA@UTAHST | NEVADA +9.5 | 55.9% | 5 | LOSS |
| SAMST@OREGST | SAMST +21 | 57.7% | 7 | WIN |
| NEB@UCLA | NICO IAMALEAVA UNDER 180.5 PASS YDS | 56.6% | 6 | LOSS |
| HOU@UCF | HOU -112 | 58.0% | 6 | WIN |
| GASTHRN@APPST | GASTHRN +180 | 36.5% | 2 | WIN |
| KENTST@BALLST | BALLST -2.5 | 54.5% | 4 | WIN |
| WAKE@FSU | WAKE +10.5 | 56.4% | 6 | LOSS |
| WYO@SDGST | SDGST -10.5 | 56.7% | 7 | WIN |
| OKLA@TENN | TENN -130 | 58.3% | 5 | LOSS |
| GATECH@NCST | GATECH -5 | 56.4% | 6 | LOSS |
| MIAMI@SMU | MIAMI -10 | 54.3% | 4 | LOSS |
| IND@MD | MD +21.5 | 54.6% | 4 | LOSS |
| CINCY@UTAH | CINCY +11 | 57.6% | 7 | LOSS |
| OLDDOM@LAMON | LAMON +17 | 58.4% | 8 | LOSS |
| VANDY@TEXAS | OVER 46.5 | 53.7% | 2 | WIN |