Alabama vs South Carolina Prediction — AI Finds CAN'T MISS CFB Lines & Props (Oct 25)

Updated: 2025-10-18T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The Alabama Crimson Tide visit the South Carolina Gamecocks on October 25, 2025 in Columbia, with Alabama riding a 6-1 overall mark and stepping into this SEC clash as a dominant force. South Carolina (3-4) faces a pivotal moment to reclaim momentum at home, but the Tide’s loaded roster and national ambitions create a stark contrast in trajectories.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Oct 25, 2025

Start Time: 3:30 PM EST​

Venue: Williams-Brice Stadium​

Gamecocks Record: (3-4)

Crimson Tide Record: (6-1)

OPENING ODDS

BAMA Moneyline: -581

SC Moneyline: +420

BAMA Spread: -13.5

SC Spread: +13.5

Over/Under: 46.5

BAMA
Betting Trends

  • Alabama enters this game with an ATS (against-the-spread) performance trending strong thanks to their +9 turnover margin—ranking fourth in FBS—coupled with one of the nation’s lowest penalty yard averages (45.3 per game) as Alabama focuses on sharp execution and ball-security.

SC
Betting Trends

  • South Carolina has struggled ATS this season, with their defense sitting 116th in opponent third-down conversion percentage (44.4 %) and the offense handing over opportunities inside the red zone, converting just 71.4%. Those inefficiencies have weighed down their ATS potential at home.

MATCHUP TRENDS

  • This matchup highlights stark complementary metrics: Alabama is fourth nationally in turnover margin, third in red-zone defense (opponents score just 64.7 % of trips), and seventh in average time of possession (33:36), while South Carolina ranks 129th in red-zone offense and offers conversion vulnerability in third-down and situational defense. The Gamecocks’ mountain becomes steeper given Alabama’s capability to control game tempo, win the turnover battle and force mistakes—key ATS predictors.

BAMA vs. SC
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: R. Faison over 33.5 Rushing Yards.

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Alabama vs South Carolina Prediction & Odds:
Free CFB Betting Insights for 10/25/25

The Week 9 SEC matchup between the Alabama Crimson Tide and the South Carolina Gamecocks on October 25, 2025, at Williams-Brice Stadium sets up as a test of control and composure versus chaos. Alabama enters the contest as one of the nation’s most complete teams, boasting a 6-1 record and a defense that once again ranks among the top 10 nationally in scoring and red-zone efficiency. Under head coach Kalen DeBoer, the Crimson Tide have combined their traditional defensive toughness with a revitalized offensive identity led by quarterback Ty Simpson, who has matured into one of the SEC’s most efficient passers. Simpson’s ability to operate with precision—posting over 1,900 yards, 18 touchdowns, and a completion rate above 70%—has given Alabama a dynamic edge it lacked a year ago. Wide receiver Germie Bernard has become the go-to playmaker with over 470 yards and five touchdowns, while Isaiah Horton and Kobe Prentice provide consistent support in DeBoer’s spread concepts. The run game, powered by Jamarion Miller and Justice Haynes, adds physicality and clock control, complementing an offensive line that has steadily improved in protection. Defensively, Alabama’s front seven remains elite, led by the disruptive presence of linebacker Deontae Lawson and edge rusher Quandarrius Robinson, who have anchored a unit that allows fewer than 17 points per game and ranks top five nationally in red-zone defense.

The Tide’s ability to win at the line of scrimmage and force turnovers—sporting a +9 differential—makes them one of the nation’s toughest teams to outlast. South Carolina, meanwhile, faces a tall order as Shane Beamer’s team enters 3-4, still struggling to find rhythm on offense while showing defensive inconsistencies that have cost them winnable games. Quarterback LaNorris Sellers has flashed potential with his dual-threat ability but has struggled with efficiency against pressure, while running back Rahsul Faison’s 4.4 yards per carry have not been enough to balance the offense. The Gamecocks’ receiving corps, led by Nyck Harbor and Luke Doty, will need to win matchups against Alabama’s physical secondary—a task few have managed this season. Defensively, South Carolina must find a way to contain Simpson’s passing and disrupt Alabama’s rhythm in early downs, as the Tide rank top-10 nationally in third-down conversions and time of possession. Alabama’s special teams, anchored by kicker Will Reichard and a disciplined return unit, further tilt the advantage toward the visitors. South Carolina has been more competitive at home, but the Gamecocks’ defensive inefficiency on third downs and red-zone failures—ranking outside the top 100 nationally—make this matchup one of attrition. For Alabama, the key will be maintaining focus and discipline in a potentially hostile environment, while South Carolina must lean on early energy, crowd momentum, and turnover opportunities to stay competitive. On paper, Alabama’s balance, depth, and execution make them heavy favorites, and unless the Gamecocks can create chaos with turnovers or special teams plays, the Tide are positioned to control the tempo and extend their SEC dominance with another convincing victory.

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Alabama Crimson Tide CFB Preview

The Alabama Crimson Tide enter their October 25, 2025, matchup at South Carolina as one of the nation’s most balanced and efficient football teams, embodying the structured dominance that has long defined the program while adding modern offensive precision under head coach Kalen DeBoer. Quarterback Ty Simpson has come into his own in his second year as the starter, ranking among the SEC’s leaders in completion percentage and passing efficiency, while showing the composure and field command necessary to thrive in DeBoer’s pro-spread system. Through seven games, Simpson has thrown for over 1,900 yards and 18 touchdowns with just three interceptions, effectively distributing the ball across a talented receiving corps led by Germie Bernard, Isaiah Horton, and Kobe Prentice. Bernard has developed into a true vertical weapon, using his combination of speed and route nuance to stretch defenses and open space for others. Alabama’s running back tandem of Jamarion Miller and Justice Haynes gives the Tide balance, with Miller’s burst complementing Haynes’ power in short-yardage situations. What separates this Alabama team from others, however, is its ability to control tempo and dictate game flow, averaging over 33 minutes of possession per game while maintaining a top-10 third-down conversion rate. The offensive line, anchored by Kadyn Proctor, has steadily improved in both run blocking and pass protection, allowing Simpson to operate comfortably and take calculated deep shots.

Defensively, Alabama remains a juggernaut, built around a front seven that dominates the trenches and a secondary that thrives on physicality and anticipation. Linebacker Deontae Lawson and edge rusher Quandarrius Robinson lead a unit that ranks top five nationally in red-zone defense, allowing scores on just 64% of opponents’ trips inside the 20. Their +9 turnover margin underscores the Tide’s discipline and opportunism—traits that make them especially dangerous on the road. South Carolina’s offense, led by quarterback LaNorris Sellers, will face relentless pressure from Alabama’s defensive front, which ranks near the top of the SEC in sacks and tackles for loss. Expect Alabama’s secondary, headlined by Kool-Aid McKinstry and Malachi Moore, to challenge the Gamecocks’ receivers at the line, forcing tight throwing windows and contested catches. Special teams, as always, remain a quiet advantage for the Tide, with veteran kicker Will Reichard continuing to provide consistency in long-range field goals and touchbacks. For Alabama, this game represents more than a routine road trip—it’s a chance to reinforce their playoff credentials, maintain momentum in the SEC standings, and continue proving that the DeBoer era has successfully bridged efficiency and explosiveness. As long as the Tide play to their identity—minimizing turnovers, winning the line of scrimmage, and sustaining drives—this game should serve as another methodical step toward their postseason ambitions, with Alabama’s execution and depth overwhelming South Carolina’s inconsistencies in what projects as a lopsided but disciplined road performance.

The Alabama Crimson Tide visit the South Carolina Gamecocks on October 25, 2025 in Columbia, with Alabama riding a 6-1 overall mark and stepping into this SEC clash as a dominant force. South Carolina (3-4) faces a pivotal moment to reclaim momentum at home, but the Tide’s loaded roster and national ambitions create a stark contrast in trajectories. Alabama vs South Carolina AI Prediction: Free CFB Betting Insights for Oct 25. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

South Carolina Gamecocks CFB Preview

The South Carolina Gamecocks return to Williams-Brice Stadium on October 25, 2025, knowing they face one of their toughest challenges of the season as they host the powerhouse Alabama Crimson Tide. Under head coach Shane Beamer, the Gamecocks have made strides in recruiting and competitiveness, but inconsistency on both sides of the ball has defined their 3-4 start. Offensively, quarterback LaNorris Sellers continues to showcase flashes of potential as a dual-threat weapon, capable of extending plays with his legs and delivering accurate passes when given time, but his protection has been inconsistent, with South Carolina ranking near the bottom of the SEC in sacks allowed. Sellers has thrown for just over 1,100 yards with five touchdowns, while his mobility has been a saving grace in offsetting a stagnant running game. Rahsul Faison leads the backfield with 281 yards on the ground, but the Gamecocks’ inability to establish the run—averaging just 3.7 yards per carry—has made them one-dimensional against elite defensive lines like Alabama’s. In the passing game, athletic receiver Nyck Harbor remains a bright spot, giving South Carolina a true vertical threat, while veteran Luke Doty and freshman Mazeo Bennett add reliability in short-area routes.

To compete with Alabama’s defense, which allows fewer than 17 points per game, the Gamecocks will need to string together quick, efficient drives and capitalize on any red-zone opportunities—something they’ve struggled with all year, ranking 129th nationally in red-zone conversion rate at 71.4%. Defensively, South Carolina has talent but has yet to find consistency under defensive coordinator Clayton White. The front seven, anchored by linebacker Debo Williams and defensive lineman T.J. Sanders, must find ways to pressure Ty Simpson without leaving gaps in coverage, a challenge that has plagued this defense all season. The Gamecocks have given up too many chunk plays—particularly on third downs—ranking 116th nationally in opponent conversion rate (44.4%), a concerning figure against an Alabama team that thrives on sustaining drives and controlling the clock. In the secondary, Daryl Porter Jr. and O’Donnell Fortune will be tested early and often by Simpson’s precision passing and Alabama’s deep receiving corps. To pull off an upset or even stay competitive, South Carolina must play its cleanest, most disciplined football of the year—limiting penalties, winning early downs, and feeding off the energy of the home crowd. Beamer’s group has shown flashes of fight in Columbia before, but against an Alabama team that punishes mistakes, moral victories won’t suffice. The key lies in creating chaos—forcing turnovers, delivering special-teams plays, and manufacturing short fields for Sellers and the offense. While the odds are steep, this matchup gives South Carolina a chance to measure itself against the SEC’s gold standard. If the Gamecocks can find balance, sustain drives, and keep their defense off the field, they can at least turn what appears to be a one-sided matchup into a spirited contest that tests their growth and resilience heading into the back half of the season.

Alabama vs South Carolina Prop Picks (AI)

Remi is pouring through loads of data on each line. In fact, anytime the Crimson Tide and Gamecocks play there’s always several intriguing angles to key in on. Not to mention games played at Williams-Brice Stadium in Oct seemingly never follow normal, predictable patterns.

Remi's searched hard and found the best prop for this matchup: R. Faison over 33.5 Rushing Yards.

Alabama vs South Carolina Prediction (AI)

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Remi, our AI sports algorithm, has been pouring over millions of data from every angle between the Crimson Tide and Gamecocks and using recursive machine learning and kick-ass AI to boil down the data to a single cover probability.

Remi has been most keyed in on the unproportionally assigned emphasis knucklehead sportsbettors tend to put on coaching factors between a Crimson Tide team going up against a possibly deflated Gamecocks team. Trends look to say the true game analytics appear to reflect a slight lean against one Vegas line in particular.

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Below is our current AI Alabama vs South Carolina picks, computer picks Crimson Tide vs Gamecocks, best bets, model edges, confidence ratings.

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Alabama Betting Trends

Alabama enters this game with an ATS (against-the-spread) performance trending strong thanks to their +9 turnover margin—ranking fourth in FBS—coupled with one of the nation’s lowest penalty yard averages (45.3 per game) as Alabama focuses on sharp execution and ball-security.

South Carolina Betting Trends

South Carolina has struggled ATS this season, with their defense sitting 116th in opponent third-down conversion percentage (44.4 %) and the offense handing over opportunities inside the red zone, converting just 71.4%. Those inefficiencies have weighed down their ATS potential at home.

Crimson Tide vs. Gamecocks Matchup Trends

This matchup highlights stark complementary metrics: Alabama is fourth nationally in turnover margin, third in red-zone defense (opponents score just 64.7 % of trips), and seventh in average time of possession (33:36), while South Carolina ranks 129th in red-zone offense and offers conversion vulnerability in third-down and situational defense. The Gamecocks’ mountain becomes steeper given Alabama’s capability to control game tempo, win the turnover battle and force mistakes—key ATS predictors.

Alabama vs. South Carolina Game Info

October 25, 2025 • 3:30 PM EST • Williams-Brice Stadium

Alabama vs. South Carolina Odds

AI algorithm Remi is pouring through loads of stats on each team. In fact, anytime the Alabama vs South Carolina trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme temps almost always follow normal, predictable betting trends.

Alabama vs South Carolina

Alabama vs South Carolina Live Odds

Games PTS ML SPR O/U
Dec 5, 2025 7:00PM EST
Troy Trojans
James Madison Dukes
12/5/25 7PM
TROY
JMAD
+1300
-2500
+23.5 (-108)
-23.5 (-112)
O 46.5 (-110)
U 46.5 (-110)
Dec 5, 2025 7:00PM EST
Kennesaw State Owls
Jacksonville State Gamecocks
12/5/25 7PM
KENSAW
JAXST
-136
+116
-2.5 (-110)
+2.5 (-110)
O 60.5 (-110)
U 60.5 (-110)
Dec 5, 2025 8:00PM EST
North Texas Mean Green
Tulane Green Wave
12/5/25 8PM
NOTEX
TULANE
-134
+114
-2.5 (-112)
+2.5 (-108)
O 66.5 (-115)
U 66.5 (-105)
Dec 5, 2025 8:01PM EST
UNLV Rebels
Boise State Broncos
12/5/25 8:01PM
UNLV
BOISE
+184
-220
+5.5 (-110)
-5.5 (-110)
O 58.5 (-115)
U 58.5 (-105)
Dec 6, 2025 12:00PM EST
Miami Ohio Redhawks
Western Michigan Broncos
12/6/25 12PM
MIAOH
WMICH
 
-132
 
-1.5 (-115)
O 42.5 (-115)
U 42.5 (-105)
Dec 6, 2025 12:00PM EST
BYU Cougars
Texas Tech Red Raiders
12/6/25 12PM
BYU
TXTECH
+430
-560
+12.5 (-105)
-12.5 (-115)
O 49.5 (-108)
U 49.5 (-112)
Dec 6, 2025 4:00PM EST
Georgia Bulldogs
Alabama Crimson Tide
12/6/25 4PM
UGA
BAMA
-134
+114
-2.5 (-115)
+2.5 (-105)
O 48.5 (-106)
U 48.5 (-114)
Dec 6, 2025 8:00PM EST
Duke Blue Devils
Virginia Cavaliers
12/6/25 8PM
DUKE
UVA
+156
-186
+3.5 (-102)
-3.5 (-120)
O 57.5 (-115)
U 57.5 (-105)
Dec 6, 2025 8:01PM EST
Indiana Hoosiers
Ohio State Buckeyes
12/6/25 8:01PM
IND
OHIOST
+158
-188
+4.5 (-115)
-4.5 (-105)
O 47.5 (-114)
U 47.5 (-106)
Dec 13, 2025 3:00PM EST
Army Black Knights
Navy Midshipmen
12/13/25 3PM
ARMY
NAVY
+172
-210
+4.5 (-105)
-4.5 (-115)
O 38.5 (-110)
U 38.5 (-110)

CFB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Alabama Crimson Tide vs. South Carolina Gamecocks on October 25, 2025 at Williams-Brice Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our CFB odds pages, and compare prices before you place a bet.

LEAN %WIN UNITS RESULT
COLO@KSTATE COLO +17.5 54.0% 4 WIN
PSU@RUT RUT +14 52.8% 1 WIN
OHIOST@MICH MICH +10.5 56.4% 6 LOSS
VATECH@UVA VATECH +8 57.8% 7 LOSS
NWEST@ILL LUKE ALTMYER UNDER 19.5 PASS COMP 54.3% 4 WIN
ORE@WAS DEMOND WILLIAMS JR UNDER 43.5 RUSH YDS 55.2% 5 WIN
MIAMI@VATECH VATECH +18.5 54.2% 4 WIN
GAST@TROY TROY -9.5 55.7% 5 WIN
DEL@WAKE DEL +18 56.7% 6 LOSS
NMEX@AF NMEX -3.5 56.1% 5 WIN
WASHST@JMAD WASHST +14.5 55.3% 5 WIN
ILL@WISC WISC +9 55.1% 5 WIN
WKY@LSU WKY +23.5 56.3% 6 WIN
WASH@UCLA DEMOND WILLIAMS UNDER 27.5 PASS ATT 56.3% 6 WIN
TCU@HOU AMARE THOMAS OVER 69.5 RECV YDS 55.2% 5 WIN
TEX@UGA NATE FRAZIER UNDER 65.5 RUSH + REC YDS 55.5% 5 WIN
PUR@WASH ANTONIO HARRIS UNDER 73.5 RUSH + REC YDS 54.1% 4 WIN
OKLA@BAMA UNDER 46 52.4% 2 WIN
UVA@DUKE DUKE -3.5 54.7% 3 LOSS
OKLA@BAMA BAMA -6 54.5% 3 LOSS
OREGST@TULSA OREGST -120 55.6% 5 LOSS
UTEP@MIZZST MIZZST -5 54.3% 4 WIN
COLOST@NMEX NMEX -14 57.1% 6 LOSS
PSU@MICHST MICHST +7.5 56.5% 6 LOSS
MISSST@MIZZOU MISSST +7.5 57.2% 7 LOSS
FAU@TULANE FAU +17.5 56.0% 6 WIN
NCST@MIAMI NCST +15.5 57.1% 7 LOSS
KENTST@AKRON AKRON -6.5 55.4% 5 LOSS
JAXST@UTEP JAXST -105 57.0% 7 WIN
FSU@CLEM CLEM -118 57.1% 5 WIN
UNLV@COLOST UNLV -4 55.2% 5 WIN
OREG@IOWA IOWA +6.5 53.3% 2 WIN
NEB@UCLA NEB +1.5 55.8% 5 WIN
KENSAW@NMEXST NMEXST +10 56.5% 6 WIN
STNFRD@UNC STNFRD +7.5 53.8% 3 WIN
DUKE@UCONN UCONN +8.5 57.9% 7 WIN
NEVADA@UTAHST NEVADA +9.5 55.9% 5 LOSS
SAMST@OREGST SAMST +21 57.7% 7 WIN
NEB@UCLA NICO IAMALEAVA UNDER 180.5 PASS YDS 56.6% 6 LOSS
HOU@UCF HOU -112 58.0% 6 WIN
GASTHRN@APPST GASTHRN +180 36.5% 2 WIN
KENTST@BALLST BALLST -2.5 54.5% 4 WIN
WAKE@FSU WAKE +10.5 56.4% 6 LOSS
WYO@SDGST SDGST -10.5 56.7% 7 WIN
OKLA@TENN TENN -130 58.3% 5 LOSS
GATECH@NCST GATECH -5 56.4% 6 LOSS
MIAMI@SMU MIAMI -10 54.3% 4 LOSS
IND@MD MD +21.5 54.6% 4 LOSS
CINCY@UTAH CINCY +11 57.6% 7 LOSS
OLDDOM@LAMON LAMON +17 58.4% 8 LOSS
VANDY@TEXAS OVER 46.5 53.7% 2 WIN