Purdue vs Northwestern Prediction — AI Finds CAN'T MISS CFB Lines & Props (Oct 18)
Updated: 2025-10-11T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
Purdue (2-4) travels to Evanston to face Northwestern (4-2) on October 18, with the Wildcats entering as a modest favorite. The line reflects Purdue’s struggles and Northwestern’s recent uptick in consistency, while the total suggests the market expects a moderate offensive output from both sides.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.
GAME INFO
Date: Oct 18, 2025
Start Time: 3:00 PM EST
Venue: Lanny and Sharon Martin Lakeside Facility
Wildcats Record: (4-2)
Boilermakers Record: (2-4)
OPENING ODDS
PURDUE Moneyline: +159
NWEST Moneyline: -191
PURDUE Spread: +3.5
NWEST Spread: -3.5
Over/Under: 48.5
PURDUE
Betting Trends
- Purdue’s ATS record this season is mixed overall, and on the road they’ve struggled to cover, especially in Big Ten games where they are often underdog or challenged in matchups.
NWEST
Betting Trends
- Northwestern tends to perform well versus the spread at home, particularly in conference play, using their defensive identity and home-field edge to keep games tighter than lines suggest.
MATCHUP TRENDS
- Purdue’s recent games have featured large swings in scoring from quarter to quarter, making live betting profitable, while Northwestern’s defense has forced turnovers in four of their six games — in tight Big Ten matchups, those takeaways often decide spreads.
PURDUE vs. NWEST
Best Prop Bet
- Remi's searched hard and found the best prop for this matchup: R. Browne over 212.5 Passing Yards.
LIVE CFB ODDS
CFB ODDS COMPARISON
WANT MORE AI PICKS?
VS. SPREAD
374-287
NET UNITS
(INCL VIG & EXEC)
+829.4
NET PROFIT
(INCL VIG & EXEC)
$100/UNIT
$82,943
VS. SPREAD
1680-1416
NET UNITS
(INCL VIG)
+450.6
NET PROFIT
(INCL VIG)
$100/UNIT
$45,057
AI SPORTS PICK PRODUCTS
Create a Free Account
‘Create an Account’ to Get Remi’s Picks Today. Remi Finds New Picks
Remi calculates the probability a team will cover the line. Remi Works 24/7
Remi uses this probability to assign units to each pick.
Get Remi's AI Picks
Get Remi’s Top AI Sports Picks sent direct to your inbox.
Hedge Meaning in Betting | 4 Obvious Times to Hedge
Learn about hedge betting to manage risk and secure profits. Understand...
What is a Push in Betting? | 3 Ways To Use To Your Advantage
Understand what a push in betting means, how it happens in...
What Does the + and – Mean in Sports Betting? | 5 Easy Tips
Learn the basics of sports betting odds, what the plus (+)...
Purdue vs Northwestern Prediction & Odds:
Free CFB Betting Insights for 10/18/25
The Big Ten West showdown between the Purdue Boilermakers and the Northwestern Wildcats on October 18, 2025, brings together two teams with very different trajectories but similar levels of urgency as the season crosses its midpoint. Purdue enters the matchup searching for consistency under head coach Ryan Walters, whose second year at the helm has been marked by uneven performances and a young roster still learning how to finish close games. Northwestern, on the other hand, has continued its resurgence under David Braun, who has engineered one of the more remarkable program stabilizations in recent conference memory. The Wildcats have leaned heavily on their defense and situational discipline to stay competitive in a division where margins are always razor-thin. This matchup will feature contrasting identities — Purdue’s pass-heavy, explosive-oriented offense against Northwestern’s methodical, defense-first style that thrives on controlling pace and field position. Purdue quarterback Hudson Card has flashed NFL-caliber arm strength and decision-making, but inconsistency in protection and a lack of balance in the running game have often forced him into unfavorable situations. His connection with wideouts like Deion Burks and TJ Sheffield gives the Boilermakers the ability to stretch the field, but turnovers and stalled drives have haunted them throughout the season. Running back Devin Mockobee remains the most reliable weapon, capable of grinding out yards after contact, yet his success depends largely on an offensive line that has struggled to open holes against physical fronts.
On defense, Purdue has shown improvement in spurts, particularly with a front seven that can pressure the quarterback, led by Nic Scourton’s edge presence, but secondary lapses have cost them dearly in key moments. Northwestern’s offense, led by quarterback Brendan Sullivan, has quietly improved thanks to an emphasis on efficiency rather than explosiveness. The Wildcats rely on a steady run game featuring Cam Porter and a quick passing attack that limits mistakes and plays to their defense’s strength. That defense, anchored by linebacker Bryce Gallagher and cornerback Cameron Mitchell, remains the heart of Northwestern’s identity — fundamentally sound, disciplined, and opportunistic. Expect the Wildcats to disguise coverages, bring timely pressure, and force Purdue to sustain long drives without the benefit of chunk plays. For Purdue, success will hinge on protecting Card and finding early offensive rhythm to keep the defense fresh. If Northwestern can force the Boilermakers into obvious passing downs, their pass rush could dictate the game’s tone. Both teams understand the stakes — a win keeps postseason aspirations alive, while a loss could accelerate doubts about offensive direction. This will likely be a gritty, field-position-driven battle where turnovers, third-down conversions, and red-zone execution decide the outcome. Purdue’s big-play potential gives it a puncher’s chance, but Northwestern’s discipline and home-field composure make them the safer bet to emerge from this clash with a crucial conference victory.
Get live CFB odds and precise AI CFB picks, predictions, and cover probabilities.
Locked for a noon kick on Big Ten Network vs. Rutgers 📺 pic.twitter.com/qpKgAWoi6R
— Purdue Football (@BoilerFootball) October 13, 2025
Purdue Boilermakers CFB Preview
The Purdue Boilermakers head to Evanston for a pivotal matchup against Northwestern on October 18, 2025, looking to shake off a stretch of uneven performances and reclaim the offensive rhythm that made them dangerous early in the season. Under head coach Ryan Walters, Purdue has shown flashes of improvement, particularly in its ability to move the ball through the air, but costly mistakes, red-zone inefficiency, and an inability to finish drives have kept them from turning potential into consistent success. Quarterback Hudson Card continues to be the centerpiece of the offense, offering a blend of arm talent, mobility, and composure that gives the Boilermakers a fighting chance in any game. Card’s chemistry with wideouts Deion Burks and TJ Sheffield has been a bright spot, as both receivers bring speed and route precision that can stretch defenses horizontally and vertically. However, the offensive line remains a question mark, having allowed too many pressures and struggling to establish consistent push in the running game. Running back Devin Mockobee, known for his burst and contact balance, has been productive when given space, but too often he’s been forced to create on his own behind a line that struggles against physical defensive fronts like Northwestern’s.
For Purdue to win on the road, balance will be key — they’ll need to sustain drives with effective early-down runs while using play action to keep the Wildcats’ linebackers off balance. Defensively, Purdue’s aggressive scheme under Walters will look to create chaos at the line of scrimmage and pressure Northwestern’s quarterback into hurried decisions. Edge rusher Nic Scourton leads the charge with his relentless motor and knack for disrupting timing, while linebacker Yanni Karlaftis anchors the second level with range and pursuit ability. The Boilermakers’ secondary, however, remains their most volatile unit, prone to giving up big plays when forced into man coverage for extended periods. Containing Northwestern’s short passing attack and tackling in space will be essential, as the Wildcats excel at turning modest gains into chain-moving plays. Purdue’s defensive front must also tighten its gap integrity to prevent running back Cam Porter from finding cutback lanes that can extend drives. On special teams, kicker Ben Freehill and punter Jack Ansell provide stability, but Purdue will need to avoid the hidden-yardage battles that Northwestern so often wins with field position. If Card can stay upright, protect the football, and convert key third downs, the Boilermakers have the tools to keep this contest close deep into the second half. However, their path to victory depends on execution and poise — areas that have wavered on the road. This game represents a gut-check moment for Purdue, one that will test their toughness, discipline, and ability to respond to adversity against one of the Big Ten’s most fundamentally sound programs.
Credit: USA TODAY/IMAGN
Northwestern Wildcats CFB Preview
The Northwestern Wildcats return to Ryan Field on October 18, 2025, looking to build upon a strong start to their Big Ten campaign and further establish themselves as one of the conference’s most improved programs under head coach David Braun. After exceeding expectations last season, Northwestern has carried that momentum into this year with a disciplined, well-balanced approach that prioritizes efficiency, situational awareness, and physical play on both sides of the ball. The Wildcats have developed a clear identity centered around tough defense and mistake-free offense, and those traits have helped them navigate tight games against more athletic opponents. Quarterback Brendan Sullivan has been steady and efficient, excelling in short-to-intermediate passing where he can utilize timing and accuracy rather than raw arm strength. His ability to manage the offense, make quick reads, and protect the football has been instrumental in Northwestern’s success. Sullivan’s top targets, including wide receiver AJ Henning and tight end Charlie Mangieri, have thrived in the system, consistently finding soft spots in coverage and extending drives. On the ground, running back Cam Porter remains a workhorse, providing dependable production between the tackles and helping control tempo. Behind a veteran offensive line that has improved its protection and run-blocking fundamentals, the Wildcats have been able to win the time-of-possession battle in several key games.
Defensively, Northwestern continues to shine as one of the Big Ten’s most cohesive units. Linebacker Bryce Gallagher anchors the group with his leadership and ability to diagnose plays quickly, while defensive end Sean McLaughlin provides steady pressure off the edge. The Wildcats’ defensive front is built on gap discipline and technique rather than sheer size, but their ability to collapse pockets and limit rushing lanes has made them a formidable challenge. The secondary, led by cornerback Cameron Mitchell and safety Rod Heard II, has been opportunistic, forcing timely turnovers and keeping explosive plays to a minimum. Against a Purdue team that relies heavily on quarterback Hudson Card and wideouts Deion Burks and TJ Sheffield, Northwestern’s defensive game plan will likely emphasize preventing deep shots and forcing the Boilermakers into long, methodical drives where mistakes are more likely. Special teams, often an overlooked strength, could also play a decisive role — the Wildcats have been exceptional in coverage and have a reliable kicking unit that consistently helps with field position. Home-field advantage has been a significant factor for Northwestern this season, as their crowd energy and defensive intensity tend to peak in Evanston. The key to victory will be maintaining offensive rhythm, winning on third downs, and continuing their elite red-zone defense that has frustrated opponents all season. If Northwestern can dictate pace, win the turnover battle, and avoid giving Purdue short fields, the Wildcats have every opportunity to secure another statement victory and strengthen their position as one of the Big Ten West’s most consistent and dangerous teams.
Back home. Back to business.
— Northwestern Football (@NUFBFamily) October 13, 2025
See you on the Lakefront. pic.twitter.com/CgmEXrTWa0
Purdue vs Northwestern Prop Picks (AI)
AI algorithm Remi is pouring through mountains of datapoints on each player. In fact, anytime the Boilermakers and Wildcats play there’s always several intriguing observations to key in on. Not to mention games played at Lanny and Sharon Martin Lakeside Facility in Oct seemingly never follow normal, predictable betting trends.
Purdue vs Northwestern Prediction (AI)
Remi, our AI sports wizard, has been pouring over tons of data from every angle between the Boilermakers and Wildcats and using recursive machine learning and impressive AI to examine the data to a single cover probability.
Oddly enough, we’ve seen the AI has been most fixated on the growing weight emotional bettors tend to put on Northwestern’s strength factors between a Boilermakers team going up against a possibly strong Wildcats team. It appears the true game analytics might reflect a strong lean against one Vegas line specifically.
Unlock this in-depth AI prediction and all of our CFB AI picks for FREE now.
Below is our current AI Purdue vs Northwestern picks, computer picks Boilermakers vs Wildcats, best bets, model edges, confidence ratings.
| DATE | GAME | LEAN | %WIN | UNITS | LEVEL | |
|---|---|---|---|---|---|---|
| ACTIVE PICKS LOCKED - SEE NOW | ||||||
These picks update as information changes—injury reports, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full CFB schedule.
Purdue Betting Trends
Purdue’s ATS record this season is mixed overall, and on the road they’ve struggled to cover, especially in Big Ten games where they are often underdog or challenged in matchups.
Northwestern Betting Trends
Northwestern tends to perform well versus the spread at home, particularly in conference play, using their defensive identity and home-field edge to keep games tighter than lines suggest.
Boilermakers vs. Wildcats Matchup Trends
Purdue’s recent games have featured large swings in scoring from quarter to quarter, making live betting profitable, while Northwestern’s defense has forced turnovers in four of their six games — in tight Big Ten matchups, those takeaways often decide spreads.
Purdue vs. Northwestern Game Info
Purdue vs Northwestern starts on October 18, 2025 at 3:00 PM EST.
Venue: Lanny and Sharon Martin Lakeside Facility.
Spread: Northwestern -3.5
Moneyline: Purdue +159, Northwestern -191
Over/Under: 48.5
Purdue: (2-4) | Northwestern: (4-2)
Remi's searched hard and found the best prop for this matchup: R. Browne over 212.5 Passing Yards.. Prices move—always shop for the best number.
Purdue’s recent games have featured large swings in scoring from quarter to quarter, making live betting profitable, while Northwestern’s defense has forced turnovers in four of their six games — in tight Big Ten matchups, those takeaways often decide spreads.
PURDUE trend: Purdue’s ATS record this season is mixed overall, and on the road they’ve struggled to cover, especially in Big Ten games where they are often underdog or challenged in matchups.
NWEST trend: Northwestern tends to perform well versus the spread at home, particularly in conference play, using their defensive identity and home-field edge to keep games tighter than lines suggest.
See our latest CFB picks and odds pages for 2025 to compare prices before you bet.
Purdue vs. Northwestern Odds
AI algorithm Remi is pouring through loads of data on each player. In fact, anytime the Purdue vs Northwestern trends are analyzed, there’s always several intriguing trends to key in on. Not to mention games played at extreme hostile environments almost always follow normal, predictable betting trends.
| PURDUE Moneyline | +159 |
|---|---|
| NWEST Moneyline | -191 |
| PURDUE Spread | +3.5 |
| NWEST Spread | -3.5 |
| Over / Under | 48.5 |
Purdue vs Northwestern Live Odds
| Games | PTS | ML | SPR | O/U | |
|---|---|---|---|---|---|
|
Dec 5, 2025 7:00PM EST
Troy Trojans
James Madison Dukes
12/5/25 7PM
TROY
JMAD
|
–
–
|
+1196
-2700
|
+23 (-108)
-23 (-112)
|
O 47 (-112)
U 47 (-108)
|
|
|
Dec 5, 2025 7:00PM EST
Kennesaw State Owls
Jacksonville State Gamecocks
12/5/25 7PM
KENSAW
JAXST
|
–
–
|
-130
+110
|
-2.5 (-105)
+2.5 (-115)
|
O 60.5 (-110)
U 60.5 (-110)
|
|
|
Dec 5, 2025 8:00PM EST
North Texas Mean Green
Tulane Green Wave
12/5/25 8PM
NOTEX
TULANE
|
–
–
|
-142
+122
|
-2.5 (-118)
+2.5 (-102)
|
O 66.5 (-110)
U 66.5 (-110)
|
|
|
Dec 5, 2025 8:01PM EST
UNLV Rebels
Boise State Broncos
12/5/25 8:01PM
UNLV
BOISE
|
–
–
|
+174
-200
|
+4.5 (-103)
-4.5 (-117)
|
O 59.5 (-110)
U 59.5 (-110)
|
|
|
Dec 6, 2025 12:00PM EST
Miami Ohio Redhawks
Western Michigan Broncos
12/6/25 12PM
MIAOH
WMICH
|
–
–
|
-125
|
-1.5 (-112)
|
O 43 (-110)
U 43 (-110)
|
|
|
Dec 6, 2025 12:00PM EST
BYU Cougars
Texas Tech Red Raiders
12/6/25 12PM
BYU
TXTECH
|
–
–
|
+390
-510
|
+12.5 (-113)
-12.5 (-107)
|
O 49.5 (-110)
U 49.5 (-110)
|
|
|
Dec 6, 2025 4:00PM EST
Georgia Bulldogs
Alabama Crimson Tide
12/6/25 4PM
UGA
BAMA
|
–
–
|
-135
+115
|
-2.5 (-110)
+2.5 (-110)
|
O 47.5 (-115)
U 47.5 (-105)
|
|
|
Dec 6, 2025 8:00PM EST
Duke Blue Devils
Virginia Cavaliers
12/6/25 8PM
DUKE
UVA
|
–
–
|
+161
-185
|
+4 (-110)
-4 (-110)
|
O 57.5 (-115)
U 57.5 (-105)
|
|
|
Dec 6, 2025 8:01PM EST
Indiana Hoosiers
Ohio State Buckeyes
12/6/25 8:01PM
IND
OHIOST
|
–
–
|
+168
-193
|
+4 (-110)
-4 (-110)
|
O 48 (-110)
U 48 (-110)
|
|
|
Dec 13, 2025 3:00PM EST
Army Black Knights
Navy Midshipmen
12/13/25 3PM
ARMY
NAVY
|
–
–
|
+177
-205
|
+5 (-110)
-5 (-110)
|
O 38 (-110)
U 38 (-110)
|
CFB Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers Purdue Boilermakers vs. Northwestern Wildcats on October 18, 2025 at Lanny and Sharon Martin Lakeside Facility.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our CFB odds pages, and compare prices before you place a bet.
| LEAN | %WIN | UNITS | RESULT | |
|---|---|---|---|---|
| COLO@KSTATE | COLO +17.5 | 54.0% | 4 | WIN |
| PSU@RUT | RUT +14 | 52.8% | 1 | WIN |
| OHIOST@MICH | MICH +10.5 | 56.4% | 6 | LOSS |
| VATECH@UVA | VATECH +8 | 57.8% | 7 | LOSS |
| NWEST@ILL | LUKE ALTMYER UNDER 19.5 PASS COMP | 54.3% | 4 | WIN |
| ORE@WAS | DEMOND WILLIAMS JR UNDER 43.5 RUSH YDS | 55.2% | 5 | WIN |
| MIAMI@VATECH | VATECH +18.5 | 54.2% | 4 | WIN |
| GAST@TROY | TROY -9.5 | 55.7% | 5 | WIN |
| DEL@WAKE | DEL +18 | 56.7% | 6 | LOSS |
| NMEX@AF | NMEX -3.5 | 56.1% | 5 | WIN |
| WASHST@JMAD | WASHST +14.5 | 55.3% | 5 | WIN |
| ILL@WISC | WISC +9 | 55.1% | 5 | WIN |
| WKY@LSU | WKY +23.5 | 56.3% | 6 | WIN |
| WASH@UCLA | DEMOND WILLIAMS UNDER 27.5 PASS ATT | 56.3% | 6 | WIN |
| TCU@HOU | AMARE THOMAS OVER 69.5 RECV YDS | 55.2% | 5 | WIN |
| TEX@UGA | NATE FRAZIER UNDER 65.5 RUSH + REC YDS | 55.5% | 5 | WIN |
| PUR@WASH | ANTONIO HARRIS UNDER 73.5 RUSH + REC YDS | 54.1% | 4 | WIN |
| OKLA@BAMA | UNDER 46 | 52.4% | 2 | WIN |
| UVA@DUKE | DUKE -3.5 | 54.7% | 3 | LOSS |
| OKLA@BAMA | BAMA -6 | 54.5% | 3 | LOSS |
| OREGST@TULSA | OREGST -120 | 55.6% | 5 | LOSS |
| UTEP@MIZZST | MIZZST -5 | 54.3% | 4 | WIN |
| COLOST@NMEX | NMEX -14 | 57.1% | 6 | LOSS |
| PSU@MICHST | MICHST +7.5 | 56.5% | 6 | LOSS |
| MISSST@MIZZOU | MISSST +7.5 | 57.2% | 7 | LOSS |
| FAU@TULANE | FAU +17.5 | 56.0% | 6 | WIN |
| NCST@MIAMI | NCST +15.5 | 57.1% | 7 | LOSS |
| KENTST@AKRON | AKRON -6.5 | 55.4% | 5 | LOSS |
| JAXST@UTEP | JAXST -105 | 57.0% | 7 | WIN |
| FSU@CLEM | CLEM -118 | 57.1% | 5 | WIN |
| UNLV@COLOST | UNLV -4 | 55.2% | 5 | WIN |
| OREG@IOWA | IOWA +6.5 | 53.3% | 2 | WIN |
| NEB@UCLA | NEB +1.5 | 55.8% | 5 | WIN |
| KENSAW@NMEXST | NMEXST +10 | 56.5% | 6 | WIN |
| STNFRD@UNC | STNFRD +7.5 | 53.8% | 3 | WIN |
| DUKE@UCONN | UCONN +8.5 | 57.9% | 7 | WIN |
| NEVADA@UTAHST | NEVADA +9.5 | 55.9% | 5 | LOSS |
| SAMST@OREGST | SAMST +21 | 57.7% | 7 | WIN |
| NEB@UCLA | NICO IAMALEAVA UNDER 180.5 PASS YDS | 56.6% | 6 | LOSS |
| HOU@UCF | HOU -112 | 58.0% | 6 | WIN |
| GASTHRN@APPST | GASTHRN +180 | 36.5% | 2 | WIN |
| KENTST@BALLST | BALLST -2.5 | 54.5% | 4 | WIN |
| WAKE@FSU | WAKE +10.5 | 56.4% | 6 | LOSS |
| WYO@SDGST | SDGST -10.5 | 56.7% | 7 | WIN |
| OKLA@TENN | TENN -130 | 58.3% | 5 | LOSS |
| GATECH@NCST | GATECH -5 | 56.4% | 6 | LOSS |
| MIAMI@SMU | MIAMI -10 | 54.3% | 4 | LOSS |
| IND@MD | MD +21.5 | 54.6% | 4 | LOSS |
| CINCY@UTAH | CINCY +11 | 57.6% | 7 | LOSS |
| OLDDOM@LAMON | LAMON +17 | 58.4% | 8 | LOSS |
| VANDY@TEXAS | OVER 46.5 | 53.7% | 2 | WIN |