Michigan State vs Indiana Prediction — AI Finds CAN'T MISS CFB Lines & Props (Oct 18)

Updated: 2025-10-11T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

Michigan State (3-3, 0-3 Big Ten) travels to Bloomington to face Indiana (5-0, 2-0) on October 18 in a high-stakes conference matchup. Indiana enters with momentum and an offense firing behind transfer quarterback Fernando Mendoza, while Michigan State seeks to rebound after a lopsided loss to UCLA.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Oct 18, 2025

Start Time: 3:30 PM EST​

Venue: Memorial Stadium​

Hoosiers Record: (6-0)

Spartans Record: (3-3)

OPENING ODDS

MICHST Moneyline: +1575

IND Moneyline: -4348

MICHST Spread: +26.5

IND Spread: -26.5

Over/Under: 53.5

MICHST
Betting Trends

  • On the road, MSU has had trouble covering Big Ten games this season, especially when their offense is inconsistent or turnovers mount.

IND
Betting Trends

  • At home, Indiana has generally exceeded expectations, especially in 2025, with strong offensive performances and roster continuity translating into covers.

MATCHUP TRENDS

  • Indiana’s offense has consistently produced over 40 points this season in wins, which tends to push totals upward; in contrast, MSU’s defensive lapses have led to over-movement in previous matchups, making live total movement and alternate lines worth watching.

MICHST vs. IND
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: F. Mendoza over 2.5 Passing Touchdowns.

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Michigan State vs Indiana Prediction & Odds:
Free CFB Betting Insights for 10/18/25

The matchup between the Michigan State Spartans and the Indiana Hoosiers on October 18, 2025, at Memorial Stadium in Bloomington offers a compelling Big Ten showdown between two teams trending in different directions but equally desperate to prove their mettle in conference play. Indiana enters the contest riding a wave of confidence after an impressive start to the season under head coach Curt Cignetti, whose system has injected new life into the Hoosiers’ offense. Quarterback Fernando Mendoza has emerged as one of the more efficient passers in the conference, demonstrating sharp decision-making and command of Cignetti’s balanced offensive scheme. His chemistry with wide receiver Elijah Sarratt has been the key to Indiana’s ability to sustain drives and generate explosive plays, while running back Roman Hemby provides balance as a reliable between-the-tackles runner. The Hoosiers’ offensive line has been one of the quiet strengths of their unit, consistently protecting Mendoza and giving him time to push the ball downfield. Defensively, Indiana has displayed an opportunistic mindset, forcing turnovers and winning red-zone battles that have helped them control the pace of games. The challenge for the Hoosiers this week will be maintaining that consistency against a Michigan State squad that, while inconsistent, has enough raw talent to make things interesting. The Spartans, led by second-year head coach Jonathan Smith, have shown flashes of improvement but continue to struggle with offensive rhythm and defensive containment.

Quarterback Aidan Chiles has all the physical tools to lead the offense, but his accuracy and composure under pressure have been issues in key moments. Running back Makhi Frazier anchors the ground game, and his ability to establish early down success will be critical to keeping the Hoosiers’ defense honest. Michigan State’s offensive line must improve after allowing too many pressures in recent weeks, as Indiana’s defensive front—led by their relentless edge rushers—will look to disrupt Chiles’ timing from the outset. On the other side of the ball, the Spartans’ defense has shown flashes of toughness, particularly against the run, but has been burned by lapses in coverage and poor tackling in space. Their ability to pressure Mendoza without compromising coverage integrity could determine whether they stay competitive late into the game. Expect Indiana to lean on quick tempo and efficient play-calling to wear down Michigan State’s defense, while the Spartans will look to slow the pace, control possession, and force turnovers to swing momentum. This game may not have national implications, but for both programs, it represents a defining moment in their respective rebuilds—Indiana fighting to validate its legitimacy as a rising Big Ten contender, and Michigan State striving to prove it’s not regressing in a conference that punishes inconsistency. If Indiana’s offense maintains its rhythm and the defense continues its opportunistic play, the Hoosiers could take command early. But if Michigan State finds stability and wins the battle in the trenches, this matchup could turn into a hard-fought Big Ten grinder that’s decided late in the fourth quarter.

Get live CFB odds and precise AI CFB picks, predictions, and cover probabilities.

Michigan State Spartans CFB Preview

The Michigan State Spartans enter this Week 8 Big Ten matchup against Indiana looking to rebound and reclaim some identity after a season marked by inconsistency and growing pains under head coach Jonathan Smith. The Spartans have flashed potential on both sides of the ball but have yet to sustain it over four quarters, particularly against disciplined opponents like the Hoosiers. Offensively, sophomore quarterback Aidan Chiles continues to be the centerpiece of Smith’s rebuild. His arm strength and mobility are evident, but decision-making under pressure has been a recurring issue. When he’s in rhythm, Chiles can stretch defenses vertically and make plays off-script, but turnovers and stalled drives have limited Michigan State’s scoring efficiency. Expect offensive coordinator Brian Lindgren to emphasize quick passes, rollouts, and designed runs to help Chiles settle early and mitigate Indiana’s aggressive pass rush. Running back Makhi Frazier remains the tone-setter for the offense, averaging over four yards per carry and serving as a stabilizing force when the passing game stalls. His ability to keep the offense ahead of schedule on early downs could be key in opening up play-action opportunities. The offensive line, however, remains a work in progress, having struggled with pass protection and run consistency against the Big Ten’s more physical fronts. Against Indiana, that unit will need to play its most disciplined game yet, particularly against an opportunistic defense known for its speed and pursuit. Defensively, the Spartans are still developing chemistry but have shown bright spots.

The front seven, led by linemen Alex VanSumeren and Grady Kelly, can be disruptive when they win leverage battles, while linebacker Jordan Hall has shown strong instincts and tackling range. The Spartans’ biggest challenge will be containing Indiana’s dynamic offense, which has proven capable of both explosive downfield strikes and long, methodical drives. Michigan State’s secondary, which has given up too many chunk plays this season, must tighten coverage and communicate effectively against quarterback Fernando Mendoza’s precision passing attack. Look for the Spartans to mix up their coverage shells, use disguised blitzes, and try to create pressure with their front four rather than relying heavily on the blitz, as overcommitting could expose them to big plays. On special teams, kicker Jonathan Kim remains reliable, while punter Ryan Eckley continues to flip field position—a vital advantage for a team that thrives on keeping games close. For Michigan State to stay competitive, they’ll need to limit penalties, win time of possession, and capitalize on red-zone chances. This is a pivotal test for the Spartans, not only in the standings but in showing resilience amid adversity. If Chiles can protect the football, Frazier can find traction on the ground, and the defense can generate a few momentum-shifting stops, Michigan State has the tools to turn this into a tight, physical contest. However, if they fall behind early or struggle with execution, the Hoosiers’ offensive tempo could make it another long afternoon in Bloomington.

Michigan State (3-3, 0-3 Big Ten) travels to Bloomington to face Indiana (5-0, 2-0) on October 18 in a high-stakes conference matchup. Indiana enters with momentum and an offense firing behind transfer quarterback Fernando Mendoza, while Michigan State seeks to rebound after a lopsided loss to UCLA. Michigan State vs Indiana AI Prediction: Free CFB Betting Insights for Oct 18. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Indiana Hoosiers CFB Preview

The Indiana Hoosiers return to Memorial Stadium on October 18, 2025, riding a wave of confidence and stability that has defined Curt Cignetti’s second season at the helm. Under Cignetti’s direction, Indiana has transitioned from a rebuilding program into a legitimate Big Ten contender, and this matchup against Michigan State provides another opportunity to reinforce their progress. Quarterback Fernando Mendoza has been the heart of the Hoosiers’ offensive surge, combining accuracy, composure, and leadership in a system that perfectly suits his strengths. Completing over 70 percent of his passes with a strong touchdown-to-interception ratio, Mendoza has turned Indiana’s passing game into one of the most efficient in the conference. His ability to spread the ball across multiple targets—most notably wide receiver Elijah Sarratt, whose blend of size and route precision has made him a matchup nightmare—has elevated the entire unit. Running back Roman Hemby brings balance and toughness to the offense, thriving in zone-run concepts and providing a reliable safety valve in the passing game. Behind an offensive line that ranks among the Big Ten’s best in pass protection and adjusted line yards, Indiana’s attack thrives on rhythm and versatility, capable of both grinding out drives and hitting explosive plays. The Hoosiers’ offensive play-calling has been calculated yet aggressive, often using tempo and pre-snap motion to exploit mismatches and wear down defenses—a formula that should challenge Michigan State’s young secondary and inconsistent front seven. Defensively, Indiana has taken on Cignetti’s disciplined, opportunistic identity.

The front line, anchored by disruptive edge rusher Lanell Carr and interior stalwart Andre Carter, has been relentless in generating pressure and collapsing pockets, while the linebackers—led by Aaron Casey—have excelled in tackling and coverage responsibilities. The secondary, featuring playmakers such as cornerback Jamier Johnson and safety Phillip Dunnam, has been particularly sharp in zone concepts, limiting explosive plays and capitalizing on turnovers. Expect defensive coordinator Bryant Haines to dial up creative looks designed to confuse Michigan State quarterback Aidan Chiles, mixing zone pressures with delayed blitzes to test his composure. Indiana’s special teams also remain a quiet strength; kicker Chris Freeman has been dependable from distance, and the return units provide field-position advantages that often swing momentum. More importantly, Indiana’s home-field environment has become a genuine asset, with a confident crowd energizing a team that feeds off tempo and early momentum. The key for the Hoosiers will be maintaining composure and execution—avoiding penalties, finishing red-zone trips with touchdowns, and staying ahead of the chains. If Mendoza continues to orchestrate the offense with precision and the defense maintains its disruptive presence, Indiana has every reason to believe they can dictate tempo and pull away late. This team has grown into one that plays complementary football—offense, defense, and special teams working seamlessly—and that cohesion could prove decisive as the Hoosiers look to continue their rise in the Big Ten and secure another crucial conference victory at home.

Michigan State vs Indiana Prop Picks (AI)

AI algorithm Remi is pouring through tons of stats on each line. In fact, anytime the Spartans and Hoosiers play there’s always several intriguing angles to key in on. Not to mention games played at Memorial Stadium in Oct can often follow normal, predictable betting trends.

Remi's searched hard and found the best prop for this matchup: F. Mendoza over 2.5 Passing Touchdowns.

Michigan State vs Indiana Prediction (AI)

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Remi, our AI sports algorithm, has been pouring over mountains of data from every facet between the Spartans and Hoosiers and using recursive machine learning and cutting-edge AI to crunch the data to a single cover probability.

Interestingly enough, the data has been most watching on the trending weight human bettors regularly put on player performance factors between a Spartans team going up against a possibly healthy Hoosiers team. In reality, the true game analytics might reflect a moderate lean against one Vegas line in particular.

Unlock this in-depth AI prediction and all of our CFB AI picks for FREE now.

Below is our current AI Michigan State vs Indiana picks, computer picks Spartans vs Hoosiers, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
CFB 12/5 NOTEX@TULANE UNLOCK THIS PICK 7 VAULT v4 Locked VAULT v4
CFB 12/5 UNLV@BOISE UNLOCK THIS PICK 6 VAULT v2 Locked VAULT v2
CFB 12/5 NOTEX@TULANE UNLOCK THIS PICK 2 INTEL Locked INTEL

These picks update as information changes—injury reports, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full CFB schedule.

Michigan State Betting Trends

On the road, MSU has had trouble covering Big Ten games this season, especially when their offense is inconsistent or turnovers mount.

Indiana Betting Trends

At home, Indiana has generally exceeded expectations, especially in 2025, with strong offensive performances and roster continuity translating into covers.

Spartans vs. Hoosiers Matchup Trends

Indiana’s offense has consistently produced over 40 points this season in wins, which tends to push totals upward; in contrast, MSU’s defensive lapses have led to over-movement in previous matchups, making live total movement and alternate lines worth watching.

Michigan State vs. Indiana Game Info

October 18, 2025 • 3:30 PM EST • Memorial Stadium

Michigan State vs. Indiana Odds

AI algorithm Remi is pouring through mountains of data on each player. In fact, anytime the Michigan State vs Indiana trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme altitude seemingly never follow normal, predictable patterns.

Michigan State vs Indiana

Michigan State vs Indiana Live Odds

Games PTS ML SPR O/U
Dec 5, 2025 7:00PM EST
Troy Trojans
James Madison Dukes
12/5/25 7PM
TROY
JMAD
+1216
-2800
+23.5 (-104)
-23.5 (-116)
O 47 (-106)
U 47 (-114)
Dec 5, 2025 7:00PM EST
Kennesaw State Owls
Jacksonville State Gamecocks
12/5/25 7PM
KENSAW
JAXST
-142
+122
-2.5 (-118)
+2.5 (-102)
O 61 (-110)
U 61 (-110)
Dec 5, 2025 8:00PM EST
North Texas Mean Green
Tulane Green Wave
12/5/25 8PM
NOTEX
TULANE
-137
+117
-3 (+100)
+3 (-120)
O 67 (-112)
U 67 (-108)
Dec 5, 2025 8:01PM EST
UNLV Rebels
Boise State Broncos
12/5/25 8:01PM
UNLV
BOISE
+189
-225
+5.5 (-110)
-5.5 (-110)
O 59.5 (-114)
U 59.5 (-106)
Dec 6, 2025 12:00PM EST
Miami Ohio Redhawks
Western Michigan Broncos
12/6/25 12PM
MIAOH
WMICH
 
-125
 
-1.5 (-110)
O 43 (-110)
U 43 (-110)
Dec 6, 2025 12:00PM EST
BYU Cougars
Texas Tech Red Raiders
12/6/25 12PM
BYU
TXTECH
+383
-500
+12.5 (-114)
-12.5 (-106)
O 49 (-110)
U 49 (-110)
Dec 6, 2025 4:00PM EST
Georgia Bulldogs
Alabama Crimson Tide
12/6/25 4PM
UGA
BAMA
-135
+115
-2.5 (-110)
+2.5 (-110)
O 47.5 (-115)
U 47.5 (-105)
Dec 6, 2025 8:00PM EST
Duke Blue Devils
Virginia Cavaliers
12/6/25 8PM
DUKE
UVA
+161
-185
+4 (-110)
-4 (-110)
O 57.5 (-115)
U 57.5 (-105)
Dec 6, 2025 8:00PM EST
Indiana Hoosiers
Ohio State Buckeyes
12/6/25 8PM
IND
OHIOST
+168
-193
+4 (-110)
-4 (-110)
O 47 (-110)
U 47 (-110)
Dec 13, 2025 3:00PM EST
Army Black Knights
Navy Midshipmen
12/13/25 3PM
ARMY
NAVY
+177
-205
+5 (-110)
-5 (-110)
O 38.5 (-110)
U 38.5 (-110)

CFB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Michigan State Spartans vs. Indiana Hoosiers on October 18, 2025 at Memorial Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our CFB odds pages, and compare prices before you place a bet.

LEAN %WIN UNITS RESULT
COLO@KSTATE COLO +17.5 54.0% 4 WIN
PSU@RUT RUT +14 52.8% 1 WIN
OHIOST@MICH MICH +10.5 56.4% 6 LOSS
VATECH@UVA VATECH +8 57.8% 7 LOSS
NWEST@ILL LUKE ALTMYER UNDER 19.5 PASS COMP 54.3% 4 WIN
ORE@WAS DEMOND WILLIAMS JR UNDER 43.5 RUSH YDS 55.2% 5 WIN
MIAMI@VATECH VATECH +18.5 54.2% 4 WIN
GAST@TROY TROY -9.5 55.7% 5 WIN
DEL@WAKE DEL +18 56.7% 6 LOSS
NMEX@AF NMEX -3.5 56.1% 5 WIN
WASHST@JMAD WASHST +14.5 55.3% 5 WIN
ILL@WISC WISC +9 55.1% 5 WIN
WKY@LSU WKY +23.5 56.3% 6 WIN
WASH@UCLA DEMOND WILLIAMS UNDER 27.5 PASS ATT 56.3% 6 WIN
TCU@HOU AMARE THOMAS OVER 69.5 RECV YDS 55.2% 5 WIN
TEX@UGA NATE FRAZIER UNDER 65.5 RUSH + REC YDS 55.5% 5 WIN
PUR@WASH ANTONIO HARRIS UNDER 73.5 RUSH + REC YDS 54.1% 4 WIN
OKLA@BAMA UNDER 46 52.4% 2 WIN
UVA@DUKE DUKE -3.5 54.7% 3 LOSS
OKLA@BAMA BAMA -6 54.5% 3 LOSS
OREGST@TULSA OREGST -120 55.6% 5 LOSS
UTEP@MIZZST MIZZST -5 54.3% 4 WIN
COLOST@NMEX NMEX -14 57.1% 6 LOSS
PSU@MICHST MICHST +7.5 56.5% 6 LOSS
MISSST@MIZZOU MISSST +7.5 57.2% 7 LOSS
FAU@TULANE FAU +17.5 56.0% 6 WIN
NCST@MIAMI NCST +15.5 57.1% 7 LOSS
KENTST@AKRON AKRON -6.5 55.4% 5 LOSS
JAXST@UTEP JAXST -105 57.0% 7 WIN
FSU@CLEM CLEM -118 57.1% 5 WIN
UNLV@COLOST UNLV -4 55.2% 5 WIN
OREG@IOWA IOWA +6.5 53.3% 2 WIN
NEB@UCLA NEB +1.5 55.8% 5 WIN
KENSAW@NMEXST NMEXST +10 56.5% 6 WIN
STNFRD@UNC STNFRD +7.5 53.8% 3 WIN
DUKE@UCONN UCONN +8.5 57.9% 7 WIN
NEVADA@UTAHST NEVADA +9.5 55.9% 5 LOSS
SAMST@OREGST SAMST +21 57.7% 7 WIN
NEB@UCLA NICO IAMALEAVA UNDER 180.5 PASS YDS 56.6% 6 LOSS
HOU@UCF HOU -112 58.0% 6 WIN
GASTHRN@APPST GASTHRN +180 36.5% 2 WIN
KENTST@BALLST BALLST -2.5 54.5% 4 WIN
WAKE@FSU WAKE +10.5 56.4% 6 LOSS
WYO@SDGST SDGST -10.5 56.7% 7 WIN
OKLA@TENN TENN -130 58.3% 5 LOSS
GATECH@NCST GATECH -5 56.4% 6 LOSS
MIAMI@SMU MIAMI -10 54.3% 4 LOSS
IND@MD MD +21.5 54.6% 4 LOSS
CINCY@UTAH CINCY +11 57.6% 7 LOSS
OLDDOM@LAMON LAMON +17 58.4% 8 LOSS
VANDY@TEXAS OVER 46.5 53.7% 2 WIN