LSU vs Vanderbilt Prediction — AI Finds CAN'T MISS CFB Lines & Props (Oct 18)
Updated: 2025-10-11T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
LSU travels to Nashville on October 18, 2025, to take on Vanderbilt in a matchup that pits the Tigers’ high expectations against the Commodores’ home-stadium resolve. LSU has faced growing scrutiny over offensive stagnation and turnover issues, while Vanderbilt is intent on proving that their emergence in 2024 was no fluke and that they can compete in the SEC’s middle tier.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.
GAME INFO
Date: Oct 18, 2025
Start Time: 12:00 PM EST
Venue: FirstBank Stadium
Commodores Record: (5-1)
Tigers Record: (5-1)
OPENING ODDS
LSU Moneyline: -110
VANDY Moneyline: -110
LSU Spread: +1.5
VANDY Spread: -1.5
Over/Under: 47.5
LSU
Betting Trends
- LSU has hovered around mediocre ATS performance in 2025, topping out at a split cover rate in many projections—too many games hinge on whether their offense can break out or fall stagnant.
VANDY
Betting Trends
- Vanderbilt has been surprisingly sharp at home ATS, especially in SEC play, leveraging familiarity and crowd energy to stay within reach even when outmatched on paper.
MATCHUP TRENDS
- In LSU’s losses this season, their inability to produce in “points per quality drive” has hurt them badly—when their run game is failing (they rank 125th in rushing success rate), they trend toward failing to cover.
LSU vs. VANDY
Best Prop Bet
- Remi's searched hard and found the best prop for this matchup: S. Alexander under 47.5 Rushing Yards.
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LSU vs Vanderbilt Prediction & Odds:
Free CFB Betting Insights for 10/18/25
Quarterback Diego Pavia’s poise and decision-making have elevated Vanderbilt’s offense, allowing them to control tempo and limit turnovers. His ability to use his legs and create plays outside the pocket gives Vanderbilt a dimension that will test LSU’s defensive discipline. The Commodores’ defense has also quietly developed into a scrappy, opportunistic unit that capitalizes on mistakes, with a front that pressures quarterbacks without compromising coverage integrity. The matchup will hinge on whether Vanderbilt’s offensive line can withstand LSU’s relentless pass rush and whether their defense can contain the Tigers’ explosive passing game. Special teams could also play a pivotal role, as both sides have shown inconsistency in coverage and kicking this season. For LSU, this game represents a chance to prove that they can dominate lesser competition on the road, while for Vanderbilt, it’s an opportunity to show that their recent improvements are sustainable against elite SEC talent. Expect LSU to attack early with vertical passing and tempo to set the tone, while Vanderbilt counters with methodical drives and a focus on winning third downs. If LSU’s defense can limit big plays and their offense avoids turnovers, they have the firepower to take control by the second half. But if Vanderbilt can slow the pace, win time of possession, and force LSU into uncomfortable situations, this could turn into one of Week 8’s most surprising nail-biters.
Every level of this defense comes to play pic.twitter.com/fGJLbiD5MW
— LSU Football (@LSUfootball) October 14, 2025
LSU Tigers CFB Preview
The LSU Tigers head to Nashville looking to make a statement and regain their footing in SEC play after an up-and-down start that has tested both their depth and discipline. Head coach Brian Kelly knows this is a pivotal stretch for his team, one that demands sharper execution and fewer self-inflicted wounds. The Tigers’ offense has showcased moments of elite explosiveness, led by a quarterback capable of making every throw on the field and a talented group of receivers who can turn routine plays into highlight-reel gains. LSU’s passing attack has been among the more productive in the conference, but inconsistency on the ground has made their offensive approach somewhat one-dimensional. The running game, once a hallmark of LSU football, has struggled to find rhythm behind an offensive line that has been uneven in both run blocking and pass protection. Kelly and offensive coordinator Mike Denbrock have emphasized a more balanced approach, hoping to reestablish physicality up front and create manageable down-and-distance scenarios. Defensively, LSU still possesses the kind of athleticism and power that can dictate games when firing on all cylinders. Their front seven, anchored by disruptive edge rushers and fast-reacting linebackers, excels at creating pressure and collapsing pockets, but the secondary has been prone to giving up chunk plays when the pass rush doesn’t get home.
This matchup against Vanderbilt presents an opportunity for LSU’s defense to reassert dominance by controlling the line of scrimmage and forcing turnovers, especially against a quarterback like Diego Pavia who thrives when allowed to extend plays. The key will be maintaining gap discipline and tackling efficiency—two areas that have occasionally betrayed the Tigers in big moments. On special teams, LSU has the tools to flip field position but must eliminate mistakes that have cost them momentum in previous games. From a psychological standpoint, this is a “prove it” game for LSU—a chance to silence critics who’ve questioned their consistency and to demonstrate that their talent can translate into complete, four-quarter performances. Expect Kelly to push for a fast start, leveraging quick-strike plays to test Vanderbilt’s secondary and establish rhythm early. If the Tigers can minimize penalties, protect the football, and play with the physical edge that has historically defined their best teams, they should have the upper hand. However, overlooking Vanderbilt could be dangerous; the Commodores have made a habit of staying competitive longer than expected. For LSU to emerge victorious, they must pair their offensive firepower with defensive focus and rediscover the discipline that turns potential into performance. This game, while seemingly straightforward on paper, could define the Tigers’ confidence heading into the heart of their SEC schedule.
Credit: USA TODAY/IMAGN
Vanderbilt Commodores CFB Preview
The Vanderbilt Commodores enter their Week 8 showdown against LSU at FirstBank Stadium with renewed confidence and the poise of a program that believes it can compete against anyone in the SEC. Head coach Clark Lea’s rebuild in Nashville has been deliberate but effective, turning the Commodores from an easy out into a team that plays with grit, structure, and belief. Vanderbilt’s offensive identity has evolved into a balanced, well-executed scheme built around efficiency and versatility. Quarterback Diego Pavia, a dual-threat transfer who has quickly become the heartbeat of the offense, provides stability under center with his ability to improvise and extend plays when protection breaks down. His composure and quick processing have helped Vanderbilt improve its third-down conversion rate, while his connection with receivers Jayden McGowan and London Humphreys has given the passing game a dangerous edge. The run game, powered by Sedrick Alexander and the emergence of a physical offensive line, has been instrumental in keeping defenses honest and setting up play-action opportunities. Against an LSU defense built on speed and pressure, Vanderbilt’s offensive line will face one of its toughest assignments of the season—keeping Pavia upright and maintaining clean pockets long enough to allow routes to develop. Defensively, Vanderbilt’s transformation under Lea has been just as noteworthy.
The Commodores are more disciplined, more aggressive, and much better at limiting big plays than in previous seasons. Their front seven, led by CJ Taylor and Langston Patterson, has developed into a sturdy unit that thrives on gap control and tackling efficiency. The secondary, featuring experienced playmakers like De’Rickey Wright, has made strides in coverage, showing improved communication and recognition that allows them to stay competitive even against more talented opponents. Against LSU’s explosive offense, Vanderbilt’s focus will be on containment—forcing the Tigers to sustain long drives and capitalizing on any mistakes they make under pressure. Special teams could also play a crucial role, as Vanderbilt’s kicking game, led by Jacob Borcila, has been consistent from mid-range while their return units have provided much-needed field position advantages. Lea’s challenge will be getting his team to match LSU’s physicality without losing composure, something Vanderbilt has managed well in close contests this season. Expect Vanderbilt to lean on ball control and tempo management to neutralize LSU’s athletic edge. Sustained drives, smart play-calling, and red-zone execution will be key to staying within striking distance late in the game. The Commodores’ margin for error will be slim, but their continued improvement and home-field edge could make this matchup more competitive than the betting lines suggest. If Vanderbilt can force turnovers, maintain composure, and win the time-of-possession battle, they have the blueprint to hang with LSU deep into the fourth quarter and potentially pull off one of the SEC’s biggest surprises of Week 8.
Back at it. pic.twitter.com/t0U6TFNeCX
— #17 Vanderbilt Football (@VandyFootball) October 13, 2025
LSU vs. Vanderbilt Prop Picks (AI)
LSU vs. Vanderbilt Prediction (AI)
Remi, our AI sports genius, has been pouring over mountains of data from every simulation between the Tigers and Commodores and using recursive machine learning and cutting-edge AI to boil down the data to a single cover probability.
The Algorithm has been most focused on the unproportionally assigned factor human bettors tend to put on player performance factors between a Tigers team going up against a possibly improved Commodores team. In reality, the true game analytics might reflect a moderate lean against one Vegas line specifically.
Unlock this in-depth AI prediction and all of our CFB AI picks for FREE now.
Below is our current AI LSU vs Vanderbilt picks, computer picks Tigers vs Commodores, best bets, model edges, confidence ratings.
| DATE | GAME | LEAN | %WIN | UNITS | LEVEL | |
|---|---|---|---|---|---|---|
| ACTIVE PICKS LOCKED - SEE NOW | ||||||
These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full CFB schedule.
Tigers Betting Trends
LSU has hovered around mediocre ATS performance in 2025, topping out at a split cover rate in many projections—too many games hinge on whether their offense can break out or fall stagnant.
Commodores Betting Trends
Vanderbilt has been surprisingly sharp at home ATS, especially in SEC play, leveraging familiarity and crowd energy to stay within reach even when outmatched on paper.
Tigers vs. Commodores Matchup Trends
In LSU’s losses this season, their inability to produce in “points per quality drive” has hurt them badly—when their run game is failing (they rank 125th in rushing success rate), they trend toward failing to cover.
LSU vs. Vanderbilt Game Info
What time does LSU vs Vanderbilt start on October 18, 2025?
LSU vs Vanderbilt starts on October 18, 2025 at 12:00 PM EST.
Where is LSU vs Vanderbilt being played?
Venue: FirstBank Stadium.
What are the opening odds for LSU vs Vanderbilt?
Spread: Vanderbilt -1.5
Moneyline: LSU -110, Vanderbilt -110
Over/Under: 47.5
What are the records for LSU vs Vanderbilt?
LSU: (5-1) | Vanderbilt: (5-1)
What is the AI best bet for LSU vs Vanderbilt?
Remi's searched hard and found the best prop for this matchup: S. Alexander under 47.5 Rushing Yards.. Prices move—always shop for the best number.
What are LSU vs Vanderbilt trending bets?
In LSU’s losses this season, their inability to produce in “points per quality drive” has hurt them badly—when their run game is failing (they rank 125th in rushing success rate), they trend toward failing to cover.
What are LSU trending bets?
LSU trend: LSU has hovered around mediocre ATS performance in 2025, topping out at a split cover rate in many projections—too many games hinge on whether their offense can break out or fall stagnant.
What are Vanderbilt trending bets?
VANDY trend: Vanderbilt has been surprisingly sharp at home ATS, especially in SEC play, leveraging familiarity and crowd energy to stay within reach even when outmatched on paper.
Where can I find AI Picks for LSU vs Vanderbilt?
See our latest CFB picks and odds pages for 2025 to compare prices before you bet.
LSU vs. Vanderbilt Odds
AI algorithm Remi is pouring through tons of data on each team. In fact, anytime the LSU vs Vanderbilt trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme temps rarely follow normal, predictable betting trends.
LSU vs Vanderbilt Opening Odds
LSU Moneyline:
-110 VANDY Moneyline: -110
LSU Spread: +1.5
VANDY Spread: -1.5
Over/Under: 47.5
LSU vs Vanderbilt Live Odds
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O 50 (-110)
U 50 (-110)
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Nov 14, 2025 9:00PM EST
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–
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+1300
-3000
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O 44 (-110)
U 44 (-110)
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Nov 15, 2025 12:00PM EST
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+235
-280
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+7 (-110)
-7 (-110)
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O 63.5 (-110)
U 63.5 (-110)
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Nov 15, 2025 12:00PM EST
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MICH
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-500
+390
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-13 (-110)
+13 (-110)
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O 41 (-110)
U 41 (-110)
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Nov 15, 2025 12:00PM EST
UTSA Roadrunners
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–
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-1100
+700
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+18.5 (-110)
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O 59.5 (-110)
U 59.5 (-110)
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Nov 15, 2025 12:00PM EST
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-385
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O 65 (-110)
U 65 (-110)
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Nov 15, 2025 12:00PM EST
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O 56.5 (-110)
U 56.5 (-110)
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O 50.5 (-110)
U 50.5 (-110)
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Nov 15, 2025 12:00PM EST
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-400
+320
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O 55 (-110)
U 55 (-110)
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Nov 15, 2025 12:00PM EST
South Carolina Gamecocks
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+780
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O 48 (-110)
U 48 (-110)
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Nov 15, 2025 12:00PM EST
Wisconsin Badgers
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O 44 (-110)
U 44 (-110)
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O 56 (-110)
U 56 (-110)
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U 48.5 (-110)
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U 47.5 (-110)
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U 52.5 (-115)
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O 55.5 (-110)
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Nov 15, 2025 3:30PM EST
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Georgia Tech Yellow Jackets
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O 58.5 (-110)
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Nov 15, 2025 3:30PM EST
Penn State Nittany Lions
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O 50 (-110)
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MTSU Blue Raiders
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O 56 (-110)
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O 58 (-110)
U 58 (-110)
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+210
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O 49.5 (-110)
U 49.5 (-110)
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Nov 15, 2025 3:30PM EST
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–
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-1500
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-21 (-110)
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O 54 (-110)
U 54 (-110)
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Nov 15, 2025 3:30PM EST
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+175
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+175
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U 46.5 (-110)
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Nov 15, 2025 4:00PM EST
Florida Atlantic Owls
Tulane Green Wave
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–
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+600
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O 63 (-110)
U 63 (-110)
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Nov 15, 2025 4:00PM EST
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+120
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O 59 (-110)
U 59 (-110)
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Nov 15, 2025 4:15PM EST
New Mexico State Aggies
Tennessee Volunteers
11/15/25 4:15PM
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–
–
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+8000
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+40 (-110)
-40 (-110)
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O 61.5 (-110)
U 61.5 (-110)
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Nov 15, 2025 4:30PM EST
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Wake Forest Demon Deacons
11/15/25 4:30PM
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–
–
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+190
-225
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+6 (-110)
-6 (-110)
|
O 39.5 (-110)
U 39.5 (-110)
|
|
|
Nov 15, 2025 5:00PM EST
Liberty Flames
FIU Panthers
11/15/25 5PM
LIB
FIU
|
–
–
|
-150
|
-3 (-115)
|
O 53 (-110)
U 53 (-110)
|
|
|
Nov 15, 2025 6:00PM EST
Coastal Carolina Chanticleers
Georgia Southern Eagles
11/15/25 6PM
COAST
GASO
|
–
–
|
+115
-135
|
+2.5 (-105)
-2.5 (-115)
|
O 61 (-110)
U 61 (-110)
|
|
|
Nov 15, 2025 7:00PM EST
Utah State Aggies
UNLV Rebels
11/15/25 7PM
UTAHST
UNLV
|
–
–
|
+200
-235
|
+6 (-110)
-6 (-110)
|
O 71 (-110)
U 71 (-110)
|
|
|
Nov 15, 2025 7:00PM EST
Florida Gators
Ole Miss Rebels
11/15/25 7PM
FLA
OLEMISS
|
–
–
|
+500
-700
|
+15.5 (-110)
-15.5 (-110)
|
O 53.5 (-110)
U 53.5 (-110)
|
|
|
Nov 15, 2025 7:00PM EST
Delaware Blue Hens
Sam Houston State Bearkats
11/15/25 7PM
DEL
SAMST
|
–
–
|
-355
+285
|
-9 (-115)
+9 (-105)
|
O 57 (-110)
U 57 (-110)
|
|
|
Nov 15, 2025 7:00PM EST
Utah Utes
Baylor Bears
11/15/25 7PM
UTAH
BAYLOR
|
–
–
|
-300
+250
|
-8 (-110)
+8 (-110)
|
O 60.5 (-110)
U 60.5 (-110)
|
|
|
Nov 15, 2025 7:00PM EST
Purdue Boilermakers
Washington Huskies
11/15/25 7PM
PURDUE
WASH
|
–
–
|
+600
-900
|
+17 (-110)
-17 (-110)
|
O 53 (-110)
U 53 (-110)
|
|
|
Nov 15, 2025 7:30PM EST
Virginia Tech Hokies
Florida State Seminoles
11/15/25 7:30PM
VATECH
FSU
|
–
–
|
+435
-565
|
+14 (-110)
-14 (-110)
|
O 55.5 (-105)
U 55.5 (-115)
|
|
|
Nov 15, 2025 7:30PM EST
Texas Longhorns
Georgia Bulldogs
11/15/25 7:30PM
TEXAS
UGA
|
–
–
|
+183
-215
|
+6 (-110)
-6 (-110)
|
O 48.5 (-110)
U 48.5 (-110)
|
|
|
Nov 15, 2025 7:30PM EST
UCLA Bruins
Ohio State Buckeyes
11/15/25 7:30PM
UCLA
OHIOST
|
–
–
|
+3000
-10000
|
+32 (-110)
-32 (-110)
|
O 48.5 (-110)
U 48.5 (-110)
|
|
|
Nov 15, 2025 7:45PM EST
Mississippi State Bulldogs
Missouri Tigers
11/15/25 7:45PM
MISSST
MIZZOU
|
–
–
|
+218
-260
|
+7 (-110)
-7 (-110)
|
O 51.5 (-110)
U 51.5 (-110)
|
|
|
Nov 15, 2025 8:00PM EST
Kennesaw State Owls
Jacksonville State Gamecocks
11/15/25 8PM
KENSAW
JAXST
|
–
–
|
-160
+138
|
-3 (-115)
+3 (-105)
|
O 54 (-110)
U 54 (-110)
|
|
|
Nov 15, 2025 10:00PM EST
Louisiana Tech Bulldogs
Washington State Cougars
11/15/25 10PM
LATECH
WASHST
|
–
–
|
+260
-320
|
+8 (-110)
-8 (-110)
|
O 45 (-110)
U 45 (-110)
|
|
|
Nov 15, 2025 10:15PM EST
TCU Horned Frogs
BYU Cougars
11/15/25 10:15PM
TCU
BYU
|
–
–
|
+159
-185
|
+4.5 (-110)
-4.5 (-110)
|
O 52.5 (-110)
U 52.5 (-110)
|
|
|
Nov 15, 2025 10:30PM EST
Boise State Broncos
San Diego State Aztecs
11/15/25 10:30PM
BOISE
SDGST
|
–
–
|
+115
-135
|
+3 (-115)
-3 (-105)
|
O 41 (-110)
U 41 (-110)
|
|
|
Nov 15, 2025 10:30PM EST
Wyoming Cowboys
Fresno State Bulldogs
11/15/25 10:30PM
WYO
FRESNO
|
–
–
|
+150
-175
|
+3.5 (-110)
-3.5 (-110)
|
O 39.5 (-110)
U 39.5 (-110)
|
|
|
Dec 6, 2025 8:00PM EST
Ohio State Buckeyes
Indiana Hoosiers
12/6/25 8PM
OHIOST
IND
|
–
–
|
-225
+180
|
-5.5 (-122)
+5.5 (+100)
|
O 49.5 (-110)
U 49.5 (-110)
|
CFB Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers LSU Tigers vs. Vanderbilt Commodores on October 18, 2025 at FirstBank Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our CFB odds pages, and compare prices before you place a bet.
| LEAN | %WIN | UNITS | RESULT | |
|---|---|---|---|---|
| JAXST@UTEP | JAXST -105 | 57.0% | 7 | WIN |
| FSU@CLEM | CLEM -118 | 57.1% | 5 | WIN |
| UNLV@COLOST | UNLV -4 | 55.2% | 5 | WIN |
| OREG@IOWA | IOWA +6.5 | 53.3% | 2 | WIN |
| NEB@UCLA | NEB +1.5 | 55.8% | 5 | WIN |
| AUBURN@VANDY | AUBURN +6.5 | 56.2% | 6 | LOSS |
| KENSAW@NMEXST | NMEXST +10 | 56.5% | 6 | WIN |
| STNFRD@UNC | STNFRD +7.5 | 53.8% | 3 | WIN |
| DUKE@UCONN | UCONN +8.5 | 57.9% | 7 | WIN |
| NEVADA@UTAHST | NEVADA +9.5 | 55.9% | 5 | LOSS |
| SAMST@OREGST | SAMST +21 | 57.7% | 7 | WIN |
| NEB@UCLA | NICO IAMALEAVA UNDER 180.5 PASS YDS | 56.6% | 6 | LOSS |
| HOU@UCF | HOU -112 | 58.0% | 6 | WIN |
| GASTHRN@APPST | GASTHRN +180 | 36.5% | 2 | WIN |
| KENTST@BALLST | BALLST -2.5 | 54.5% | 4 | WIN |
| WAKE@FSU | WAKE +10.5 | 56.4% | 6 | LOSS |
| WYO@SDGST | SDGST -10.5 | 56.7% | 7 | WIN |
| OKLA@TENN | TENN -130 | 58.3% | 5 | LOSS |
| GATECH@NCST | GATECH -5 | 56.4% | 6 | LOSS |
| MIAMI@SMU | MIAMI -10 | 54.3% | 4 | LOSS |
| DEL@LIB | DEL +3.5 | 57.6% | 7 | LOSS |
| NMEXST@WKY | NMEXST +8.5 | 57.9% | 7 | LOSS |
| IND@MD | MD +21.5 | 54.6% | 4 | LOSS |
| CINCY@UTAH | CINCY +11 | 57.6% | 7 | LOSS |
| OLDDOM@LAMON | LAMON +17 | 58.4% | 8 | LOSS |
| VANDY@TEXAS | OVER 46.5 | 53.7% | 2 | WIN |
| MICHST@MINN | MAKHI FRAZIER UNDER 52.5 RUSH YDS | 55.2% | 5 | WIN |
| UNC@CUSE | UNC +110 | 50.4% | 2 | WIN |
| MRSHL@COASTAL | COASTAL +7 | 53.3% | 3 | WIN |
| FIU@MIZZST | FIU +3.5 | 53.9% | 3 | LOSS |
| TEXAM@LSU | MARCEL REED OVER 0.5 INT | 55.5% | 5 | WIN |
| RUT@PURDUE | RUT +103 | 54.0% | 4 | WIN |
| TOLEDO@WASHST | TOLEDO -110 | 56.1% | 6 | LOSS |
| AUBURN@ARK | ARK -128 | 60.5% | 8 | LOSS |
| NCST@PITT | NCST +6.5 | 54.9% | 4 | LOSS |
| OHIO@EMICH | EMICH +12 | 54.1% | 4 | WIN |
| TCU@WVU | WVU +16.5 | 54.6% | 4 | WIN |
| COLO@UTAH | COLO +14.5 | 57.7% | 7 | LOSS |
| HOU@ARIZST | HOU +7.5 | 57.1% | 7 | WIN |
| UVA@UNC | UNC +11.5 | 56.2% | 6 | WIN |
| MINN@IOWA | MINN +9.5 | 57.3% | 7 | LOSS |
| UCONN@RICE | RICE +10.5 | 57.1% | 6 | WIN |
| FAU@NAVY | FAU +14.5 | 56.7% | 6 | WIN |
| LAMON@USM | LAMON +13.5 | 56.4% | 6 | LOSS |
| BOISE@NEVADA | NEVADA +21.5 | 56.8% | 6 | WIN |
| SALA@GAST | GAST +6.5 | 54.3% | 4 | LOSS |
| MIZZST@NMEXST | MIZZST -108 | 54.4% | 4 | WIN |
| KENSAW@FIU | FIU +3 | 53.7% | 3 | LOSS |
| KENTST@TOLEDO | KENTST +24.5 | 56.9% | 6 | LOSS |
| OLDDOM@JMAD | JMAD -125 | 57.9% | 7 | WIN |
| TXTECH@ARIZST | TXTECH -6.5 | 54.2% | 4 | LOSS |